Tir chaperone protein (CesT) family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X487_LEIDO

TriTrypDb:

LdBPK_310770.1 , LdCL_310013400 , LDHU3_31.1120

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X487

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X487

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0008104	protein localization	4	9
GO:0009306	protein secretion	4	9
GO:0009987	cellular process	1	9
GO:0015031	protein transport	4	9
GO:0030254	protein secretion by the type III secretion system	4	9
GO:0032940	secretion by cell	3	9
GO:0033036	macromolecule localization	2	9
GO:0035592	establishment of protein localization to extracellular region	4	9
GO:0045184	establishment of protein localization	3	9
GO:0046903	secretion	4	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0051641	cellular localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0070727	cellular macromolecule localization	3	9
GO:0071692	protein localization to extracellular region	5	9
GO:0071702	organic substance transport	4	9
GO:0071705	nitrogen compound transport	4	9
GO:0071806	protein transmembrane transport	3	9
GO:0140352	export from cell	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.504
CLV_C14_Caspase3-7	178	182	PF00656	0.506
CLV_NRD_NRD_1	112	114	PF00675	0.553
CLV_NRD_NRD_1	14	16	PF00675	0.424
CLV_NRD_NRD_1	172	174	PF00675	0.595
CLV_NRD_NRD_1	34	36	PF00675	0.397
CLV_PCSK_KEX2_1	112	114	PF00082	0.553
CLV_PCSK_KEX2_1	172	174	PF00082	0.595
CLV_PCSK_KEX2_1	34	36	PF00082	0.397
CLV_PCSK_SKI1_1	15	19	PF00082	0.352
CLV_PCSK_SKI1_1	205	209	PF00082	0.321
CLV_PCSK_SKI1_1	35	39	PF00082	0.372
CLV_PCSK_SKI1_1	4	8	PF00082	0.403
DEG_APCC_DBOX_1	21	29	PF00400	0.378
DEG_APCC_DBOX_1	246	254	PF00400	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.476
DEG_SPOP_SBC_1	279	283	PF00917	0.521
DOC_ANK_TNKS_1	164	171	PF00023	0.539
DOC_MAPK_gen_1	15	21	PF00069	0.394
DOC_MAPK_gen_1	247	255	PF00069	0.454
DOC_MAPK_MEF2A_6	196	203	PF00069	0.521
DOC_USP7_MATH_1	156	160	PF00917	0.623
DOC_USP7_MATH_1	186	190	PF00917	0.451
DOC_USP7_UBL2_3	187	191	PF12436	0.397
DOC_WW_Pin1_4	287	292	PF00397	0.457
LIG_14-3-3_CanoR_1	172	180	PF00244	0.690
LIG_14-3-3_CanoR_1	307	312	PF00244	0.510
LIG_14-3-3_CanoR_1	35	41	PF00244	0.404
LIG_APCC_ABBA_1	298	303	PF00400	0.479
LIG_BRCT_BRCA1_1	199	203	PF00533	0.454
LIG_BRCT_BRCA1_2	199	205	PF00533	0.509
LIG_eIF4E_1	231	237	PF01652	0.454
LIG_FHA_1	206	212	PF00498	0.454
LIG_FHA_1	225	231	PF00498	0.454
LIG_FHA_1	279	285	PF00498	0.467
LIG_FHA_2	113	119	PF00498	0.791
LIG_FHA_2	211	217	PF00498	0.521
LIG_GBD_Chelix_1	193	201	PF00786	0.305
LIG_Integrin_RGD_1	22	24	PF01839	0.411
LIG_Integrin_RGD_TGFB_3	22	28	PF01839	0.382
LIG_LIR_Apic_2	39	43	PF02991	0.407
LIG_LIR_Gen_1	214	225	PF02991	0.521
LIG_LIR_Nem_3	214	220	PF02991	0.521
LIG_SH2_CRK	233	237	PF00017	0.454
LIG_SH2_NCK_1	117	121	PF00017	0.584
LIG_SH2_NCK_1	223	227	PF00017	0.521
LIG_SH2_SRC	117	120	PF00017	0.597
LIG_SH2_SRC	223	226	PF00017	0.473
LIG_SH2_SRC	231	234	PF00017	0.434
LIG_SH2_STAP1	233	237	PF00017	0.454
LIG_SH2_STAP1	251	255	PF00017	0.454
LIG_SH2_STAT3	106	109	PF00017	0.682
LIG_SH2_STAT5	231	234	PF00017	0.454
LIG_SH2_STAT5	36	39	PF00017	0.446
LIG_SH3_3	152	158	PF00018	0.494
LIG_SH3_3	238	244	PF00018	0.505
LIG_SH3_3	79	85	PF00018	0.645
LIG_SUMO_SIM_par_1	276	283	PF11976	0.455
LIG_WW_3	162	166	PF00397	0.616
MOD_CK1_1	175	181	PF00069	0.647
MOD_CK1_1	235	241	PF00069	0.509
MOD_CK2_1	112	118	PF00069	0.787
MOD_Cter_Amidation	13	16	PF01082	0.424
MOD_GlcNHglycan	109	112	PF01048	0.785
MOD_GlcNHglycan	158	161	PF01048	0.638
MOD_GSK3_1	215	222	PF00069	0.454
MOD_GSK3_1	231	238	PF00069	0.454
MOD_N-GLC_1	205	210	PF02516	0.254
MOD_NEK2_1	197	202	PF00069	0.472
MOD_NEK2_1	255	260	PF00069	0.454
MOD_NEK2_1	280	285	PF00069	0.451
MOD_NEK2_1	301	306	PF00069	0.474
MOD_NEK2_1	55	60	PF00069	0.436
MOD_NEK2_2	186	191	PF00069	0.392
MOD_PIKK_1	112	118	PF00454	0.764
MOD_PIKK_1	270	276	PF00454	0.474
MOD_PKA_1	112	118	PF00069	0.554
MOD_PKA_1	172	178	PF00069	0.577
MOD_PKA_2	112	118	PF00069	0.777
MOD_PKA_2	172	178	PF00069	0.699
MOD_Plk_1	205	211	PF00069	0.454
MOD_Plk_1	215	221	PF00069	0.454
MOD_Plk_1	55	61	PF00069	0.420
MOD_Plk_4	232	238	PF00069	0.506
MOD_Plk_4	255	261	PF00069	0.454
MOD_Plk_4	301	307	PF00069	0.534
MOD_Plk_4	55	61	PF00069	0.430
MOD_ProDKin_1	287	293	PF00069	0.457
TRG_DiLeu_BaEn_1	44	49	PF01217	0.470
TRG_ENDOCYTIC_2	233	236	PF00928	0.454
TRG_ENDOCYTIC_2	251	254	PF00928	0.454
TRG_ER_diArg_1	172	174	PF00400	0.595
TRG_ER_diArg_1	33	35	PF00400	0.377
TRG_NES_CRM1_1	188	202	PF08389	0.340
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	53	57	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT22	Leptomonas seymouri	55%	95%
A0A1X0P075	Trypanosomatidae	44%	88%
A4HJ54	Leishmania braziliensis	74%	98%
A4I6G8	Leishmania infantum	100%	100%
E9B1M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q9BHG3	Leishmania major	92%	100%
V5BJ53	Trypanosoma cruzi	44%	90%