Uncharacterized protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania donovani

UniProt:

A0A3S7X483_LEIDO

TriTrypDb:

LdBPK_310830.1 , LdBPK_342900.1 , LdCL_310014100 , LDHU3_31.1240

Length:

649

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	19
GO:0110165	cellular anatomical entity	1	19

Phosphorylation

Promastigote/Amastigote: 66

Expansion

Sequence features

A0A3S7X483

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X483

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.617
CLV_C14_Caspase3-7	578	582	PF00656	0.503
CLV_C14_Caspase3-7	62	66	PF00656	0.353
CLV_NRD_NRD_1	299	301	PF00675	0.508
CLV_NRD_NRD_1	314	316	PF00675	0.352
CLV_NRD_NRD_1	353	355	PF00675	0.331
CLV_NRD_NRD_1	411	413	PF00675	0.432
CLV_NRD_NRD_1	62	64	PF00675	0.713
CLV_PCSK_KEX2_1	299	301	PF00082	0.511
CLV_PCSK_KEX2_1	353	355	PF00082	0.348
CLV_PCSK_KEX2_1	413	415	PF00082	0.439
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.449
CLV_PCSK_PC7_1	349	355	PF00082	0.341
CLV_PCSK_SKI1_1	176	180	PF00082	0.396
CLV_PCSK_SKI1_1	276	280	PF00082	0.551
CLV_PCSK_SKI1_1	404	408	PF00082	0.421
CLV_PCSK_SKI1_1	485	489	PF00082	0.469
CLV_PCSK_SKI1_1	636	640	PF00082	0.567
DEG_APCC_DBOX_1	484	492	PF00400	0.247
DOC_CDC14_PxL_1	82	90	PF14671	0.297
DOC_CYCLIN_RxL_1	273	281	PF00134	0.586
DOC_MAPK_gen_1	315	323	PF00069	0.592
DOC_MAPK_MEF2A_6	513	521	PF00069	0.397
DOC_PP1_RVXF_1	96	103	PF00149	0.338
DOC_PP2B_LxvP_1	88	91	PF13499	0.294
DOC_PP4_FxxP_1	13	16	PF00568	0.410
DOC_PP4_FxxP_1	335	338	PF00568	0.604
DOC_PP4_FxxP_1	49	52	PF00568	0.406
DOC_USP7_MATH_1	19	23	PF00917	0.514
DOC_USP7_MATH_1	197	201	PF00917	0.766
DOC_USP7_MATH_1	241	245	PF00917	0.633
DOC_USP7_MATH_1	405	409	PF00917	0.498
DOC_USP7_MATH_1	52	56	PF00917	0.611
DOC_USP7_UBL2_3	147	151	PF12436	0.545
LIG_14-3-3_CanoR_1	137	143	PF00244	0.562
LIG_14-3-3_CanoR_1	182	188	PF00244	0.769
LIG_14-3-3_CanoR_1	98	103	PF00244	0.355
LIG_Actin_WH2_2	78	96	PF00022	0.430
LIG_BH_BH3_1	460	476	PF00452	0.350
LIG_BIR_III_4	240	244	PF00653	0.675
LIG_eIF4E_1	116	122	PF01652	0.367
LIG_eIF4E_1	629	635	PF01652	0.470
LIG_FHA_1	117	123	PF00498	0.312
LIG_FHA_1	257	263	PF00498	0.598
LIG_FHA_1	395	401	PF00498	0.488
LIG_FHA_1	432	438	PF00498	0.343
LIG_FHA_1	498	504	PF00498	0.395
LIG_FHA_1	514	520	PF00498	0.337
LIG_FHA_1	556	562	PF00498	0.479
LIG_FHA_1	618	624	PF00498	0.430
LIG_FHA_2	1	7	PF00498	0.510
LIG_FHA_2	137	143	PF00498	0.550
LIG_FHA_2	251	257	PF00498	0.689
LIG_FHA_2	468	474	PF00498	0.354
LIG_FHA_2	588	594	PF00498	0.661
LIG_LIR_Apic_2	333	338	PF02991	0.592
LIG_LIR_Apic_2	46	52	PF02991	0.411
LIG_LIR_Gen_1	457	468	PF02991	0.404
LIG_LIR_Gen_1	620	630	PF02991	0.327
LIG_LIR_Nem_3	115	121	PF02991	0.379
LIG_LIR_Nem_3	141	146	PF02991	0.564
LIG_LIR_Nem_3	203	208	PF02991	0.792
LIG_LIR_Nem_3	457	463	PF02991	0.347
LIG_LIR_Nem_3	620	625	PF02991	0.379
LIG_NRBOX	633	639	PF00104	0.432
LIG_PCNA_PIPBox_1	367	376	PF02747	0.583
LIG_PCNA_yPIPBox_3	366	374	PF02747	0.600
LIG_Pex14_2	331	335	PF04695	0.573
LIG_Pex14_2	456	460	PF04695	0.407
LIG_PTB_Apo_2	498	505	PF02174	0.204
LIG_PTB_Phospho_1	498	504	PF10480	0.204
LIG_SH2_CRK	118	122	PF00017	0.338
LIG_SH2_CRK	371	375	PF00017	0.611
LIG_SH2_CRK	424	428	PF00017	0.519
LIG_SH2_CRK	504	508	PF00017	0.313
LIG_SH2_GRB2like	134	137	PF00017	0.564
LIG_SH2_PTP2	629	632	PF00017	0.233
LIG_SH2_STAP1	504	508	PF00017	0.399
LIG_SH2_STAT5	118	121	PF00017	0.348
LIG_SH2_STAT5	134	137	PF00017	0.560
LIG_SH2_STAT5	138	141	PF00017	0.589
LIG_SH2_STAT5	310	313	PF00017	0.627
LIG_SH2_STAT5	355	358	PF00017	0.545
LIG_SH2_STAT5	438	441	PF00017	0.391
LIG_SH2_STAT5	602	605	PF00017	0.618
LIG_SH2_STAT5	629	632	PF00017	0.446
LIG_SH3_1	105	111	PF00018	0.332
LIG_SH3_2	247	252	PF14604	0.573
LIG_SH3_3	101	107	PF00018	0.454
LIG_SH3_3	206	212	PF00018	0.650
LIG_SH3_3	244	250	PF00018	0.603
LIG_SH3_3	505	511	PF00018	0.446
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.506
LIG_SUMO_SIM_anti_2	610	615	PF11976	0.534
LIG_SUMO_SIM_anti_2	624	629	PF11976	0.397
LIG_SUMO_SIM_par_1	451	457	PF11976	0.284
LIG_SUMO_SIM_par_1	472	478	PF11976	0.599
LIG_TRAF2_1	415	418	PF00917	0.651
LIG_TRAF2_1	43	46	PF00917	0.493
LIG_TYR_ITIM	502	507	PF00017	0.399
LIG_TYR_ITIM	627	632	PF00017	0.483
LIG_UBA3_1	436	441	PF00899	0.456
LIG_UBA3_1	476	482	PF00899	0.459
LIG_UBA3_1	540	546	PF00899	0.386
LIG_UBA3_1	633	642	PF00899	0.427
LIG_WRC_WIRS_1	310	315	PF05994	0.579
LIG_WRC_WIRS_1	476	481	PF05994	0.571
LIG_WRC_WIRS_1	484	489	PF05994	0.397
MOD_CK1_1	123	129	PF00069	0.381
MOD_CK1_1	17	23	PF00069	0.603
MOD_CK1_1	186	192	PF00069	0.633
MOD_CK1_1	200	206	PF00069	0.642
MOD_CK1_1	469	475	PF00069	0.527
MOD_CK1_1	555	561	PF00069	0.658
MOD_CK2_1	250	256	PF00069	0.692
MOD_CK2_1	36	42	PF00069	0.487
MOD_CK2_1	405	411	PF00069	0.562
MOD_CK2_1	63	69	PF00069	0.386
MOD_GlcNHglycan	168	171	PF01048	0.626
MOD_GlcNHglycan	194	198	PF01048	0.599
MOD_GlcNHglycan	199	202	PF01048	0.604
MOD_GlcNHglycan	26	30	PF01048	0.701
MOD_GlcNHglycan	301	304	PF01048	0.443
MOD_GlcNHglycan	528	531	PF01048	0.433
MOD_GlcNHglycan	54	57	PF01048	0.623
MOD_GlcNHglycan	558	561	PF01048	0.358
MOD_GlcNHglycan	570	573	PF01048	0.299
MOD_GSK3_1	112	119	PF00069	0.434
MOD_GSK3_1	17	24	PF00069	0.491
MOD_GSK3_1	193	200	PF00069	0.805
MOD_GSK3_1	462	469	PF00069	0.436
MOD_GSK3_1	483	490	PF00069	0.396
MOD_GSK3_1	552	559	PF00069	0.550
MOD_GSK3_1	59	66	PF00069	0.498
MOD_GSK3_1	617	624	PF00069	0.382
MOD_N-GLC_1	542	547	PF02516	0.268
MOD_N-GLC_1	568	573	PF02516	0.318
MOD_N-GLC_1	59	64	PF02516	0.669
MOD_N-GLC_2	586	588	PF02516	0.422
MOD_NEK2_1	11	16	PF00069	0.554
MOD_NEK2_1	301	306	PF00069	0.656
MOD_NEK2_1	430	435	PF00069	0.359
MOD_NEK2_1	437	442	PF00069	0.355
MOD_NEK2_1	454	459	PF00069	0.358
MOD_NEK2_1	462	467	PF00069	0.362
MOD_NEK2_1	475	480	PF00069	0.575
MOD_NEK2_1	483	488	PF00069	0.363
MOD_NEK2_1	587	592	PF00069	0.560
MOD_NEK2_1	59	64	PF00069	0.486
MOD_NEK2_1	617	622	PF00069	0.384
MOD_NEK2_2	372	377	PF00069	0.591
MOD_OFUCOSY	570	577	PF10250	0.269
MOD_PIKK_1	195	201	PF00454	0.735
MOD_PK_1	225	231	PF00069	0.617
MOD_PK_1	63	69	PF00069	0.331
MOD_PKA_1	299	305	PF00069	0.600
MOD_PKA_1	63	69	PF00069	0.331
MOD_PKA_2	136	142	PF00069	0.557
MOD_PKA_2	299	305	PF00069	0.603
MOD_Plk_1	394	400	PF00069	0.590
MOD_Plk_1	513	519	PF00069	0.471
MOD_Plk_4	112	118	PF00069	0.401
MOD_Plk_4	120	126	PF00069	0.391
MOD_Plk_4	200	206	PF00069	0.763
MOD_Plk_4	309	315	PF00069	0.630
MOD_Plk_4	330	336	PF00069	0.594
MOD_Plk_4	443	449	PF00069	0.292
MOD_Plk_4	487	493	PF00069	0.347
MOD_Plk_4	503	509	PF00069	0.332
MOD_Plk_4	513	519	PF00069	0.355
MOD_SUMO_for_1	406	409	PF00179	0.616
MOD_SUMO_rev_2	408	415	PF00179	0.633
TRG_DiLeu_BaEn_1	395	400	PF01217	0.535
TRG_DiLeu_BaEn_1	514	519	PF01217	0.292
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.573
TRG_ENDOCYTIC_2	118	121	PF00928	0.355
TRG_ENDOCYTIC_2	310	313	PF00928	0.638
TRG_ENDOCYTIC_2	332	335	PF00928	0.560
TRG_ENDOCYTIC_2	371	374	PF00928	0.574
TRG_ENDOCYTIC_2	504	507	PF00928	0.331
TRG_ENDOCYTIC_2	550	553	PF00928	0.534
TRG_ENDOCYTIC_2	629	632	PF00928	0.463
TRG_ER_diArg_1	293	296	PF00400	0.730
TRG_ER_diArg_1	298	300	PF00400	0.683
TRG_ER_diArg_1	352	354	PF00400	0.527
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2M1	Leptomonas seymouri	37%	100%
A0A0N1HRT9	Leptomonas seymouri	40%	100%
A0A0N1P9A0	Leptomonas seymouri	33%	100%
A0A0N1PBU6	Leptomonas seymouri	33%	100%
A0A1X0P9W4	Trypanosomatidae	33%	100%
A0A3Q8IFF3	Leishmania donovani	82%	100%
A0A3Q8ISH4	Leishmania donovani	50%	99%
A0A3S7X888	Leishmania donovani	32%	100%
A4HB26	Leishmania braziliensis	33%	100%
A4HJ59	Leishmania braziliensis	48%	100%
A4HJ60	Leishmania braziliensis	41%	97%
A4I6H4	Leishmania infantum	100%	100%
A4I6H5	Leishmania infantum	51%	99%
A4IA83	Leishmania infantum	31%	100%
E9B1N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9B1N3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E9B596	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q6I2	Leishmania major	48%	97%
Q4Q6I3	Leishmania major	85%	100%