Cytoskeleton-associated protein CAP5.5, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton-associated protein CAP5.5, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X470_LEIDO

TriTrypDb:

LdBPK_310450.1 , LdCL_310009600 , LDHU3_31.0560

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 96
NetGPI	no	yes: 0, no: 97

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7X470

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X470

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	98
GO:0006807	nitrogen compound metabolic process	2	98
GO:0008152	metabolic process	1	98
GO:0019538	protein metabolic process	3	98
GO:0043170	macromolecule metabolic process	3	98
GO:0044238	primary metabolic process	2	98
GO:0071704	organic substance metabolic process	2	98
GO:1901564	organonitrogen compound metabolic process	3	98

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	98
GO:0004175	endopeptidase activity	4	98
GO:0004197	cysteine-type endopeptidase activity	5	98
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	98
GO:0008233	peptidase activity	3	98
GO:0008234	cysteine-type peptidase activity	4	98
GO:0016787	hydrolase activity	2	98
GO:0140096	catalytic activity, acting on a protein	2	98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.395
CLV_C14_Caspase3-7	498	502	PF00656	0.448
CLV_C14_Caspase3-7	536	540	PF00656	0.467
CLV_MEL_PAP_1	111	117	PF00089	0.278
CLV_NRD_NRD_1	37	39	PF00675	0.609
CLV_NRD_NRD_1	581	583	PF00675	0.465
CLV_PCSK_KEX2_1	577	579	PF00082	0.405
CLV_PCSK_KEX2_1	679	681	PF00082	0.480
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.410
CLV_PCSK_PC1ET2_1	679	681	PF00082	0.491
CLV_PCSK_PC7_1	675	681	PF00082	0.389
CLV_PCSK_SKI1_1	13	17	PF00082	0.633
CLV_PCSK_SKI1_1	294	298	PF00082	0.251
CLV_PCSK_SKI1_1	546	550	PF00082	0.468
CLV_PCSK_SKI1_1	567	571	PF00082	0.400
CLV_PCSK_SKI1_1	686	690	PF00082	0.411
DEG_APCC_DBOX_1	125	133	PF00400	0.175
DEG_APCC_DBOX_1	645	653	PF00400	0.234
DOC_CKS1_1	420	425	PF01111	0.452
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.446
DOC_MAPK_gen_1	447	453	PF00069	0.393
DOC_MAPK_gen_1	7	17	PF00069	0.426
DOC_PP1_RVXF_1	36	43	PF00149	0.364
DOC_PP1_RVXF_1	565	571	PF00149	0.414
DOC_PP2B_LxvP_1	588	591	PF13499	0.519
DOC_PP4_FxxP_1	535	538	PF00568	0.388
DOC_USP7_MATH_1	190	194	PF00917	0.488
DOC_USP7_MATH_1	25	29	PF00917	0.719
DOC_USP7_MATH_1	478	482	PF00917	0.499
DOC_USP7_MATH_1	562	566	PF00917	0.436
DOC_USP7_MATH_1	693	697	PF00917	0.455
DOC_USP7_UBL2_3	355	359	PF12436	0.451
DOC_USP7_UBL2_3	7	11	PF12436	0.563
DOC_WW_Pin1_4	210	215	PF00397	0.313
DOC_WW_Pin1_4	298	303	PF00397	0.386
DOC_WW_Pin1_4	379	384	PF00397	0.460
DOC_WW_Pin1_4	419	424	PF00397	0.465
LIG_14-3-3_CanoR_1	254	258	PF00244	0.479
LIG_14-3-3_CanoR_1	43	51	PF00244	0.622
LIG_14-3-3_CanoR_1	433	442	PF00244	0.525
LIG_14-3-3_CanoR_1	567	573	PF00244	0.310
LIG_BRCT_BRCA1_1	617	621	PF00533	0.418
LIG_BRCT_BRCA1_1	629	633	PF00533	0.334
LIG_BRCT_BRCA1_1	684	688	PF00533	0.461
LIG_FHA_1	146	152	PF00498	0.320
LIG_FHA_1	186	192	PF00498	0.451
LIG_FHA_1	211	217	PF00498	0.314
LIG_FHA_1	232	238	PF00498	0.478
LIG_FHA_1	244	250	PF00498	0.369
LIG_FHA_1	29	35	PF00498	0.565
LIG_FHA_1	348	354	PF00498	0.533
LIG_FHA_1	454	460	PF00498	0.459
LIG_FHA_1	564	570	PF00498	0.358
LIG_FHA_1	687	693	PF00498	0.356
LIG_FHA_2	234	240	PF00498	0.505
LIG_FHA_2	366	372	PF00498	0.399
LIG_FHA_2	559	565	PF00498	0.432
LIG_LIR_Apic_2	341	345	PF02991	0.482
LIG_LIR_Apic_2	654	659	PF02991	0.489
LIG_LIR_Gen_1	213	222	PF02991	0.205
LIG_LIR_Gen_1	331	339	PF02991	0.487
LIG_LIR_Gen_1	347	357	PF02991	0.438
LIG_LIR_Gen_1	363	372	PF02991	0.453
LIG_LIR_Gen_1	618	629	PF02991	0.395
LIG_LIR_Gen_1	638	649	PF02991	0.351
LIG_LIR_Nem_3	213	218	PF02991	0.235
LIG_LIR_Nem_3	347	352	PF02991	0.440
LIG_LIR_Nem_3	363	367	PF02991	0.451
LIG_LIR_Nem_3	618	624	PF02991	0.416
LIG_LIR_Nem_3	630	635	PF02991	0.342
LIG_LIR_Nem_3	638	644	PF02991	0.335
LIG_LIR_Nem_3	685	691	PF02991	0.419
LIG_LIR_Nem_3	95	101	PF02991	0.277
LIG_MAD2	567	575	PF02301	0.402
LIG_PDZ_Class_1	719	724	PF00595	0.434
LIG_Pex14_2	387	391	PF04695	0.443
LIG_Pex14_2	517	521	PF04695	0.449
LIG_SH2_CRK	310	314	PF00017	0.424
LIG_SH2_CRK	342	346	PF00017	0.475
LIG_SH2_CRK	357	361	PF00017	0.448
LIG_SH2_CRK	364	368	PF00017	0.447
LIG_SH2_CRK	446	450	PF00017	0.455
LIG_SH2_CRK	641	645	PF00017	0.403
LIG_SH2_CRK	656	660	PF00017	0.466
LIG_SH2_GRB2like	342	345	PF00017	0.347
LIG_SH2_NCK_1	342	346	PF00017	0.485
LIG_SH2_NCK_1	364	368	PF00017	0.469
LIG_SH2_NCK_1	656	660	PF00017	0.466
LIG_SH2_PTP2	215	218	PF00017	0.417
LIG_SH2_SRC	342	345	PF00017	0.500
LIG_SH2_SRC	660	663	PF00017	0.348
LIG_SH2_STAP1	107	111	PF00017	0.274
LIG_SH2_STAP1	455	459	PF00017	0.465
LIG_SH2_STAT5	215	218	PF00017	0.464
LIG_SH2_STAT5	248	251	PF00017	0.438
LIG_SH2_STAT5	328	331	PF00017	0.460
LIG_SH2_STAT5	430	433	PF00017	0.487
LIG_SH2_STAT5	455	458	PF00017	0.435
LIG_SH2_STAT5	527	530	PF00017	0.445
LIG_SH2_STAT5	660	663	PF00017	0.318
LIG_SH2_STAT5	691	694	PF00017	0.490
LIG_SH2_STAT5	718	721	PF00017	0.473
LIG_SH2_STAT5	83	86	PF00017	0.309
LIG_SH2_STAT5	99	102	PF00017	0.327
LIG_SH3_3	12	18	PF00018	0.589
LIG_SH3_3	139	145	PF00018	0.291
LIG_SH3_3	472	478	PF00018	0.419
LIG_SH3_3	611	617	PF00018	0.444
LIG_SH3_3	705	711	PF00018	0.338
LIG_SUMO_SIM_par_1	263	268	PF11976	0.561
LIG_SUMO_SIM_par_1	460	467	PF11976	0.550
LIG_SUMO_SIM_par_1	555	561	PF11976	0.373
LIG_SUMO_SIM_par_1	590	595	PF11976	0.351
LIG_SUMO_SIM_par_1	660	666	PF11976	0.407
LIG_TRAF2_1	33	36	PF00917	0.536
LIG_TRAF2_1	617	620	PF00917	0.404
LIG_TRAF2_1	695	698	PF00917	0.527
LIG_TRFH_1	641	645	PF08558	0.330
LIG_UBA3_1	569	577	PF00899	0.397
LIG_UBA3_1	88	94	PF00899	0.327
LIG_WRC_WIRS_1	329	334	PF05994	0.467
MOD_CDK_SPxxK_3	298	305	PF00069	0.415
MOD_CDK_SPxxK_3	379	386	PF00069	0.482
MOD_CK1_1	193	199	PF00069	0.467
MOD_CK1_1	28	34	PF00069	0.606
MOD_CK1_1	434	440	PF00069	0.489
MOD_CK1_1	490	496	PF00069	0.451
MOD_CK1_1	563	569	PF00069	0.446
MOD_CK1_1	6	12	PF00069	0.594
MOD_CK1_1	663	669	PF00069	0.464
MOD_CK2_1	233	239	PF00069	0.476
MOD_CK2_1	298	304	PF00069	0.430
MOD_CK2_1	30	36	PF00069	0.610
MOD_CK2_1	43	49	PF00069	0.426
MOD_CK2_1	558	564	PF00069	0.386
MOD_CK2_1	594	600	PF00069	0.367
MOD_CK2_1	692	698	PF00069	0.421
MOD_CMANNOS	518	521	PF00535	0.249
MOD_GlcNHglycan	152	155	PF01048	0.283
MOD_GlcNHglycan	23	26	PF01048	0.703
MOD_GlcNHglycan	378	382	PF01048	0.265
MOD_GlcNHglycan	413	416	PF01048	0.238
MOD_GlcNHglycan	45	48	PF01048	0.546
MOD_GlcNHglycan	554	557	PF01048	0.468
MOD_GlcNHglycan	665	668	PF01048	0.419
MOD_GlcNHglycan	700	703	PF01048	0.460
MOD_GSK3_1	21	28	PF00069	0.651
MOD_GSK3_1	243	250	PF00069	0.417
MOD_GSK3_1	479	486	PF00069	0.451
MOD_GSK3_1	558	565	PF00069	0.416
MOD_GSK3_1	608	615	PF00069	0.368
MOD_GSK3_1	627	634	PF00069	0.325
MOD_GSK3_1	682	689	PF00069	0.388
MOD_GSK3_1	714	721	PF00069	0.360
MOD_N-GLC_1	101	106	PF02516	0.292
MOD_N-GLC_1	180	185	PF02516	0.528
MOD_N-GLC_1	608	613	PF02516	0.398
MOD_N-GLC_2	71	73	PF02516	0.397
MOD_NEK2_1	274	279	PF00069	0.461
MOD_NEK2_1	348	353	PF00069	0.456
MOD_NEK2_1	360	365	PF00069	0.464
MOD_NEK2_1	411	416	PF00069	0.467
MOD_NEK2_1	431	436	PF00069	0.490
MOD_NEK2_1	453	458	PF00069	0.468
MOD_NEK2_1	549	554	PF00069	0.413
MOD_NEK2_1	558	563	PF00069	0.349
MOD_NEK2_1	570	575	PF00069	0.342
MOD_NEK2_1	594	599	PF00069	0.311
MOD_NEK2_2	109	114	PF00069	0.353
MOD_NEK2_2	145	150	PF00069	0.280
MOD_NMyristoyl	1	7	PF02799	0.480
MOD_PIKK_1	243	249	PF00454	0.517
MOD_PIKK_1	431	437	PF00454	0.537
MOD_PIKK_1	570	576	PF00454	0.353
MOD_PIKK_1	703	709	PF00454	0.473
MOD_PKA_2	159	165	PF00069	0.356
MOD_PKA_2	231	237	PF00069	0.440
MOD_PKA_2	243	249	PF00069	0.379
MOD_PKA_2	253	259	PF00069	0.414
MOD_PKA_2	479	485	PF00069	0.440
MOD_Plk_1	101	107	PF00069	0.301
MOD_Plk_1	522	528	PF00069	0.478
MOD_Plk_1	563	569	PF00069	0.368
MOD_Plk_1	608	614	PF00069	0.382
MOD_Plk_1	627	633	PF00069	0.356
MOD_Plk_2-3	233	239	PF00069	0.478
MOD_Plk_2-3	30	36	PF00069	0.380
MOD_Plk_4	274	280	PF00069	0.465
MOD_Plk_4	319	325	PF00069	0.484
MOD_Plk_4	348	354	PF00069	0.425
MOD_Plk_4	426	432	PF00069	0.491
MOD_Plk_4	467	473	PF00069	0.479
MOD_Plk_4	513	519	PF00069	0.456
MOD_Plk_4	627	633	PF00069	0.402
MOD_Plk_4	71	77	PF00069	0.376
MOD_Plk_4	714	720	PF00069	0.404
MOD_Plk_4	94	100	PF00069	0.314
MOD_ProDKin_1	210	216	PF00069	0.307
MOD_ProDKin_1	298	304	PF00069	0.386
MOD_ProDKin_1	379	385	PF00069	0.460
MOD_ProDKin_1	419	425	PF00069	0.465
MOD_SPalmitoyl_4	1	7	PF01529	0.507
MOD_SUMO_rev_2	6	12	PF00179	0.528
MOD_SUMO_rev_2	671	681	PF00179	0.299
TRG_DiLeu_BaEn_1	147	152	PF01217	0.368
TRG_DiLeu_BaEn_1	467	472	PF01217	0.488
TRG_DiLeu_BaEn_1	639	644	PF01217	0.431
TRG_DiLeu_BaEn_2	618	624	PF01217	0.387
TRG_ENDOCYTIC_2	215	218	PF00928	0.448
TRG_ENDOCYTIC_2	310	313	PF00928	0.442
TRG_ENDOCYTIC_2	357	360	PF00928	0.449
TRG_ENDOCYTIC_2	364	367	PF00928	0.446
TRG_ENDOCYTIC_2	446	449	PF00928	0.456
TRG_ENDOCYTIC_2	641	644	PF00928	0.307
TRG_NES_CRM1_1	259	270	PF08389	0.350
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	32%	100%
A0A0N1I8N2	Leptomonas seymouri	28%	74%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	34%	100%
A0A0N1IMH1	Leptomonas seymouri	31%	92%
A0A0N1P9P1	Leptomonas seymouri	36%	85%
A0A0N1PCA9	Leptomonas seymouri	30%	98%
A0A0N1PE91	Leptomonas seymouri	24%	81%
A0A0N1PFI4	Leptomonas seymouri	57%	93%
A0A0S4JLK6	Bodo saltans	30%	89%
A0A0S4JS70	Bodo saltans	25%	94%
A0A0S4KGT2	Bodo saltans	38%	96%
A0A1X0NJ61	Trypanosomatidae	32%	100%
A0A1X0NJK2	Trypanosomatidae	30%	95%
A0A1X0NJX8	Trypanosomatidae	32%	93%
A0A1X0NKT7	Trypanosomatidae	29%	91%
A0A1X0NKX8	Trypanosomatidae	38%	89%
A0A1X0NMT3	Trypanosomatidae	32%	85%
A0A1X0NW84	Trypanosomatidae	33%	100%
A0A1X0NW85	Trypanosomatidae	34%	100%
A0A1X0NW89	Trypanosomatidae	33%	84%
A0A1X0NWA6	Trypanosomatidae	29%	83%
A0A1X0NWW1	Trypanosomatidae	35%	100%
A0A3Q8IBS3	Leishmania donovani	35%	100%
A0A3Q8IDD4	Leishmania donovani	32%	100%
A0A3Q8IJT4	Leishmania donovani	27%	100%
A0A3S5H5A5	Leishmania donovani	33%	100%
A0A3S5ISG2	Trypanosoma rangeli	39%	94%
A0A3S7WW18	Leishmania donovani	36%	100%
A0A3S7WW41	Leishmania donovani	28%	100%
A0A3S7WW71	Leishmania donovani	33%	100%
A0A3S7X430	Leishmania donovani	30%	100%
A0A3S7X438	Leishmania donovani	32%	100%
A0A3S7X460	Leishmania donovani	32%	100%
A0A3S7X463	Leishmania donovani	27%	100%
A0A422MYU1	Trypanosoma rangeli	34%	79%
A0A422MYX0	Trypanosoma rangeli	34%	100%
A4H3W4	Leishmania braziliensis	33%	100%
A4HE81	Leishmania braziliensis	32%	100%
A4HJ14	Leishmania braziliensis	29%	100%
A4HJ21	Leishmania braziliensis	26%	81%
A4HJ22	Leishmania braziliensis	31%	100%
A4HJ23	Leishmania braziliensis	69%	100%
A4HJ24	Leishmania braziliensis	33%	100%
A4HS39	Leishmania infantum	34%	100%
A4HYN0	Leishmania infantum	35%	100%
A4HYW1	Leishmania infantum	35%	71%
A4HYW2	Leishmania infantum	32%	100%
A4HYW3	Leishmania infantum	28%	100%
A4HYW4	Leishmania infantum	27%	100%
A4I1J4	Leishmania infantum	33%	100%
A4I6E4	Leishmania infantum	98%	100%
A4I6E6	Leishmania infantum	32%	100%
A4I6F0	Leishmania infantum	32%	100%
A4I6K4	Leishmania infantum	30%	100%
A4I6K5	Leishmania infantum	27%	100%
A4I6K6	Leishmania infantum	27%	100%
C9ZIE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	67%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	91%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	90%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	85%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
E8NHG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AIH1	Leishmania braziliensis	34%	100%
E9AIH3	Leishmania braziliensis	32%	100%
E9AIH4	Leishmania braziliensis	30%	100%
E9AIH6	Leishmania braziliensis	28%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AUQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B1J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	77%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
P16259	Rattus norvegicus	28%	88%
P20807	Homo sapiens	25%	88%
P43368	Sus scrofa	25%	88%
Q22036	Caenorhabditis elegans	25%	100%
Q4Q6L7	Leishmania major	33%	100%
Q4Q6L9	Leishmania major	90%	100%
Q4Q6M0	Leishmania major	31%	100%
Q4Q6M2	Leishmania major	25%	100%
Q4Q6M3	Leishmania major	28%	78%
Q4Q6M4	Leishmania major	30%	100%
Q4Q9U3	Leishmania major	32%	100%
Q4QCS6	Leishmania major	29%	100%
Q4QCS7	Leishmania major	33%	100%
Q4QCS8	Leishmania major	35%	100%
Q4QCS9	Leishmania major	35%	100%
Q64691	Mus musculus	28%	88%
Q9GLG7	Macaca fascicularis	26%	89%
Q9TTH8	Ovis aries	26%	88%
Q9U0T9	Leishmania major	33%	100%
V5AYJ1	Trypanosoma cruzi	33%	100%
V5B5I4	Trypanosoma cruzi	34%	86%
V5BA05	Trypanosoma cruzi	35%	100%
V5BEL3	Trypanosoma cruzi	34%	100%
V5BN20	Trypanosoma cruzi	33%	94%
V5D5V8	Trypanosoma cruzi	30%	98%
V5D9Y2	Trypanosoma cruzi	31%	85%
V5DES7	Trypanosoma cruzi	39%	91%