FtsJ-like methyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FtsJ-like methyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X469_LEIDO

TriTrypDb:

LdBPK_310680.1 , LdCL_310012500 , LDHU3_31.0980

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X469

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X469

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	13
GO:0032259	methylation	2	13
GO:0000154	rRNA modification	6	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0001510	RNA methylation	4	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:0051301	cell division	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0008168	methyltransferase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016741	transferase activity, transferring one-carbon groups	3	13
GO:0008171	O-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008650	rRNA (uridine-2'-O-)-methyltransferase activity	6	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016435	rRNA (guanine) methyltransferase activity	6	1
GO:0016436	rRNA (uridine) methyltransferase activity	6	1
GO:0062105	RNA 2'-O-methyltransferase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.380
CLV_NRD_NRD_1	162	164	PF00675	0.240
CLV_PCSK_KEX2_1	162	164	PF00082	0.233
CLV_PCSK_SKI1_1	228	232	PF00082	0.330
DEG_Nend_Nbox_1	1	3	PF02207	0.328
DEG_SPOP_SBC_1	101	105	PF00917	0.534
DEG_SPOP_SBC_1	192	196	PF00917	0.439
DOC_MAPK_DCC_7	193	203	PF00069	0.479
DOC_MAPK_gen_1	22	31	PF00069	0.516
DOC_MAPK_gen_1	274	284	PF00069	0.568
DOC_MAPK_RevD_3	148	163	PF00069	0.369
DOC_PP2B_LxvP_1	257	260	PF13499	0.410
DOC_PP4_FxxP_1	285	288	PF00568	0.465
DOC_USP7_MATH_1	175	179	PF00917	0.530
DOC_USP7_MATH_1	192	196	PF00917	0.375
DOC_USP7_MATH_1	232	236	PF00917	0.524
DOC_USP7_MATH_1	280	284	PF00917	0.590
DOC_WW_Pin1_4	102	107	PF00397	0.479
LIG_14-3-3_CanoR_1	100	106	PF00244	0.437
LIG_14-3-3_CanoR_1	108	117	PF00244	0.566
LIG_14-3-3_CanoR_1	137	142	PF00244	0.479
LIG_14-3-3_CanoR_1	187	192	PF00244	0.460
LIG_14-3-3_CanoR_1	193	201	PF00244	0.412
LIG_14-3-3_CanoR_1	24	29	PF00244	0.439
LIG_14-3-3_CanoR_1	256	260	PF00244	0.547
LIG_14-3-3_CanoR_1	277	283	PF00244	0.561
LIG_14-3-3_CanoR_1	3	11	PF00244	0.455
LIG_14-3-3_CanoR_1	87	93	PF00244	0.469
LIG_BIR_III_2	172	176	PF00653	0.439
LIG_BRCT_BRCA1_1	156	160	PF00533	0.457
LIG_FHA_1	117	123	PF00498	0.437
LIG_FHA_1	150	156	PF00498	0.489
LIG_FHA_1	218	224	PF00498	0.527
LIG_FHA_1	277	283	PF00498	0.463
LIG_FHA_2	25	31	PF00498	0.451
LIG_LIR_Apic_2	283	288	PF02991	0.415
LIG_LIR_Nem_3	15	20	PF02991	0.434
LIG_NRBOX	149	155	PF00104	0.523
LIG_SH2_PTP2	226	229	PF00017	0.369
LIG_SH2_STAT3	2	5	PF00017	0.523
LIG_SH2_STAT5	226	229	PF00017	0.382
LIG_SH2_STAT5	243	246	PF00017	0.419
LIG_SH3_3	257	263	PF00018	0.513
LIG_SH3_3	319	325	PF00018	0.452
LIG_SH3_3	53	59	PF00018	0.467
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.425
LIG_SUMO_SIM_par_1	151	157	PF11976	0.419
LIG_SUMO_SIM_par_1	60	65	PF11976	0.527
LIG_SUMO_SIM_par_1	9	15	PF11976	0.437
LIG_WW_3	105	109	PF00397	0.439
MOD_CDC14_SPxK_1	105	108	PF00782	0.479
MOD_CDK_SPxK_1	102	108	PF00069	0.479
MOD_CK1_1	112	118	PF00069	0.441
MOD_CK1_1	278	284	PF00069	0.596
MOD_CK2_1	176	182	PF00069	0.527
MOD_CK2_1	232	238	PF00069	0.528
MOD_GlcNHglycan	111	114	PF01048	0.267
MOD_GlcNHglycan	189	192	PF01048	0.322
MOD_GlcNHglycan	195	198	PF01048	0.319
MOD_GlcNHglycan	211	215	PF01048	0.283
MOD_GlcNHglycan	332	335	PF01048	0.719
MOD_GlcNHglycan	5	8	PF01048	0.233
MOD_GSK3_1	108	115	PF00069	0.477
MOD_GSK3_1	183	190	PF00069	0.516
MOD_GSK3_1	232	239	PF00069	0.532
MOD_GSK3_1	276	283	PF00069	0.540
MOD_NEK2_1	139	144	PF00069	0.418
MOD_NEK2_1	148	153	PF00069	0.434
MOD_NEK2_1	154	159	PF00069	0.479
MOD_NEK2_1	217	222	PF00069	0.511
MOD_NEK2_2	280	285	PF00069	0.479
MOD_OFUCOSY	304	311	PF10250	0.426
MOD_PIKK_1	217	223	PF00454	0.481
MOD_PK_1	137	143	PF00069	0.479
MOD_PKA_2	176	182	PF00069	0.561
MOD_PKA_2	183	189	PF00069	0.535
MOD_PKA_2	192	198	PF00069	0.472
MOD_PKA_2	23	29	PF00069	0.439
MOD_PKA_2	255	261	PF00069	0.495
MOD_PKA_2	276	282	PF00069	0.652
MOD_PKB_1	22	30	PF00069	0.439
MOD_Plk_2-3	65	71	PF00069	0.369
MOD_Plk_4	128	134	PF00069	0.436
MOD_Plk_4	149	155	PF00069	0.472
MOD_Plk_4	24	30	PF00069	0.492
MOD_Plk_4	280	286	PF00069	0.467
MOD_Plk_4	52	58	PF00069	0.365
MOD_Plk_4	94	100	PF00069	0.467
MOD_ProDKin_1	102	108	PF00069	0.479
TRG_ENDOCYTIC_2	17	20	PF00928	0.466
TRG_ENDOCYTIC_2	226	229	PF00928	0.447
TRG_ER_diArg_1	22	25	PF00400	0.369
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.169

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S5	Leptomonas seymouri	53%	94%
A0A0S4IVN5	Bodo saltans	34%	100%
A0A0S4IYL1	Bodo saltans	33%	99%
A0A1X0NJE7	Trypanosomatidae	35%	100%
A0A3R7L564	Trypanosoma rangeli	38%	100%
A0A422NPF8	Trypanosoma rangeli	25%	89%
A0A451EJH4	Leishmania donovani	24%	73%
A1URN3	Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583)	26%	100%
A4H3D4	Leishmania braziliensis	24%	73%
A4HRN5	Leishmania infantum	24%	73%
A4I6F9	Leishmania infantum	99%	100%
A8GV60	Rickettsia bellii (strain OSU 85-389)	26%	100%
C9ZN77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9ACB3	Leishmania major	25%	73%
E9AIU3	Leishmania braziliensis	75%	100%
E9AJK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	74%
E9B1L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q1RHG3	Rickettsia bellii (strain RML369-C)	26%	100%
Q466Q1	Methanosarcina barkeri (strain Fusaro / DSM 804)	28%	100%
Q54VA8	Dictyostelium discoideum	23%	100%
Q6G0S9	Bartonella quintana (strain Toulouse)	24%	100%
Q6G4Z3	Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)	25%	100%
Q9BHC8	Leishmania major	91%	100%
Q9UI43	Homo sapiens	29%	100%
V5ANC5	Trypanosoma cruzi	38%	94%