LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7X466_LEIDO
TriTrypDb:
LdBPK_310500.1 * , LdCL_310010500 , LDHU3_31.0730
Length:
384

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 4, no: 9
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

A0A3S7X466
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X466

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 181 183 PF00675 0.521
CLV_NRD_NRD_1 28 30 PF00675 0.601
CLV_PCSK_KEX2_1 125 127 PF00082 0.548
CLV_PCSK_KEX2_1 181 183 PF00082 0.525
CLV_PCSK_KEX2_1 192 194 PF00082 0.540
CLV_PCSK_KEX2_1 373 375 PF00082 0.470
CLV_PCSK_PC1ET2_1 125 127 PF00082 0.544
CLV_PCSK_PC1ET2_1 192 194 PF00082 0.516
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.498
CLV_PCSK_SKI1_1 220 224 PF00082 0.536
CLV_PCSK_SKI1_1 380 384 PF00082 0.451
CLV_PCSK_SKI1_1 97 101 PF00082 0.531
DEG_COP1_1 271 280 PF00400 0.226
DEG_Nend_Nbox_1 1 3 PF02207 0.579
DOC_CYCLIN_RxL_1 8 16 PF00134 0.440
DOC_MAPK_MEF2A_6 275 282 PF00069 0.288
DOC_MAPK_MEF2A_6 3 12 PF00069 0.414
DOC_USP7_MATH_1 154 158 PF00917 0.336
DOC_USP7_MATH_1 160 164 PF00917 0.338
DOC_USP7_MATH_1 268 272 PF00917 0.319
DOC_USP7_MATH_1 276 280 PF00917 0.326
DOC_USP7_UBL2_3 108 112 PF12436 0.235
DOC_USP7_UBL2_3 125 129 PF12436 0.253
DOC_WW_Pin1_4 199 204 PF00397 0.319
DOC_WW_Pin1_4 22 27 PF00397 0.420
DOC_WW_Pin1_4 31 36 PF00397 0.353
LIG_14-3-3_CanoR_1 131 139 PF00244 0.312
LIG_14-3-3_CanoR_1 161 165 PF00244 0.253
LIG_14-3-3_CanoR_1 167 173 PF00244 0.233
LIG_14-3-3_CanoR_1 181 185 PF00244 0.294
LIG_14-3-3_CanoR_1 3 10 PF00244 0.517
LIG_14-3-3_CanoR_1 301 306 PF00244 0.253
LIG_14-3-3_CanoR_1 39 43 PF00244 0.332
LIG_Actin_WH2_2 24 41 PF00022 0.337
LIG_APCC_ABBA_1 241 246 PF00400 0.351
LIG_BIR_III_4 148 152 PF00653 0.281
LIG_BRCT_BRCA1_1 278 282 PF00533 0.316
LIG_CaM_IQ_9 117 133 PF13499 0.337
LIG_deltaCOP1_diTrp_1 264 272 PF00928 0.331
LIG_eIF4E_1 95 101 PF01652 0.337
LIG_FHA_1 23 29 PF00498 0.398
LIG_FHA_1 3 9 PF00498 0.499
LIG_FHA_1 47 53 PF00498 0.289
LIG_FHA_1 60 66 PF00498 0.304
LIG_FHA_1 94 100 PF00498 0.347
LIG_FHA_2 102 108 PF00498 0.347
LIG_FHA_2 113 119 PF00498 0.320
LIG_FHA_2 360 366 PF00498 0.616
LIG_IRF3_LxIS_1 117 123 PF10401 0.316
LIG_KLC1_Yacidic_2 114 118 PF13176 0.226
LIG_LIR_Gen_1 133 144 PF02991 0.323
LIG_LIR_Gen_1 53 58 PF02991 0.323
LIG_LIR_Gen_1 72 80 PF02991 0.315
LIG_LIR_Gen_1 94 101 PF02991 0.376
LIG_LIR_Nem_3 111 116 PF02991 0.263
LIG_LIR_Nem_3 264 269 PF02991 0.328
LIG_LIR_Nem_3 279 285 PF02991 0.331
LIG_LIR_Nem_3 334 339 PF02991 0.579
LIG_LIR_Nem_3 53 57 PF02991 0.323
LIG_LIR_Nem_3 72 76 PF02991 0.315
LIG_LIR_Nem_3 94 98 PF02991 0.363
LIG_MAD2 11 19 PF02301 0.355
LIG_PCNA_yPIPBox_3 131 144 PF02747 0.314
LIG_Pex14_1 109 113 PF04695 0.337
LIG_Pex14_2 367 371 PF04695 0.631
LIG_SH2_CRK 73 77 PF00017 0.294
LIG_SH2_CRK 85 89 PF00017 0.294
LIG_SH2_CRK 95 99 PF00017 0.337
LIG_SH2_SRC 244 247 PF00017 0.337
LIG_SH2_SRC 285 288 PF00017 0.337
LIG_SH2_STAP1 113 117 PF00017 0.337
LIG_SH2_STAP1 244 248 PF00017 0.337
LIG_SH2_STAP1 73 77 PF00017 0.294
LIG_SH2_STAP1 85 89 PF00017 0.294
LIG_SH2_STAP1 95 99 PF00017 0.337
LIG_SH2_STAT5 116 119 PF00017 0.281
LIG_SH2_STAT5 307 310 PF00017 0.397
LIG_SH2_STAT5 33 36 PF00017 0.331
LIG_SH2_STAT5 336 339 PF00017 0.612
LIG_SH2_STAT5 95 98 PF00017 0.374
LIG_SH3_1 275 281 PF00018 0.337
LIG_SH3_3 247 253 PF00018 0.288
LIG_SH3_3 275 281 PF00018 0.331
LIG_SH3_3 73 79 PF00018 0.319
LIG_SUMO_SIM_anti_2 96 105 PF11976 0.331
LIG_SUMO_SIM_par_1 96 105 PF11976 0.331
LIG_WRC_WIRS_1 269 274 PF05994 0.298
LIG_WRC_WIRS_1 364 369 PF05994 0.542
MOD_CDK_SPxxK_3 22 29 PF00069 0.420
MOD_CK1_1 162 168 PF00069 0.369
MOD_CK1_1 202 208 PF00069 0.358
MOD_CK1_1 210 216 PF00069 0.369
MOD_CK1_1 226 232 PF00069 0.191
MOD_CK1_1 334 340 PF00069 0.566
MOD_CK2_1 112 118 PF00069 0.226
MOD_CK2_1 226 232 PF00069 0.351
MOD_CK2_1 357 363 PF00069 0.682
MOD_CK2_1 378 384 PF00069 0.694
MOD_GlcNHglycan 148 152 PF01048 0.522
MOD_GlcNHglycan 156 159 PF01048 0.514
MOD_GlcNHglycan 176 179 PF01048 0.488
MOD_GlcNHglycan 204 207 PF01048 0.475
MOD_GlcNHglycan 254 257 PF01048 0.562
MOD_GlcNHglycan 346 349 PF01048 0.520
MOD_GSK3_1 121 128 PF00069 0.357
MOD_GSK3_1 159 166 PF00069 0.383
MOD_GSK3_1 168 175 PF00069 0.255
MOD_GSK3_1 195 202 PF00069 0.349
MOD_GSK3_1 244 251 PF00069 0.337
MOD_GSK3_1 34 41 PF00069 0.346
MOD_GSK3_1 359 366 PF00069 0.700
MOD_GSK3_1 374 381 PF00069 0.647
MOD_LATS_1 221 227 PF00433 0.226
MOD_N-GLC_1 226 231 PF02516 0.426
MOD_NEK2_1 120 125 PF00069 0.316
MOD_NEK2_1 13 18 PF00069 0.443
MOD_NEK2_1 172 177 PF00069 0.376
MOD_NEK2_1 180 185 PF00069 0.276
MOD_NEK2_1 195 200 PF00069 0.337
MOD_NEK2_1 2 7 PF00069 0.493
MOD_NEK2_1 331 336 PF00069 0.564
MOD_NEK2_1 38 43 PF00069 0.331
MOD_NEK2_2 244 249 PF00069 0.316
MOD_PIKK_1 130 136 PF00454 0.309
MOD_PIKK_1 52 58 PF00454 0.348
MOD_PK_1 374 380 PF00069 0.660
MOD_PKA_1 125 131 PF00069 0.348
MOD_PKA_1 223 229 PF00069 0.226
MOD_PKA_2 125 131 PF00069 0.348
MOD_PKA_2 160 166 PF00069 0.272
MOD_PKA_2 180 186 PF00069 0.281
MOD_PKA_2 2 8 PF00069 0.530
MOD_PKA_2 213 219 PF00069 0.404
MOD_PKA_2 248 254 PF00069 0.315
MOD_PKA_2 351 357 PF00069 0.667
MOD_PKA_2 38 44 PF00069 0.337
MOD_Plk_1 244 250 PF00069 0.316
MOD_Plk_1 52 58 PF00069 0.395
MOD_Plk_2-3 363 369 PF00069 0.546
MOD_Plk_4 112 118 PF00069 0.372
MOD_Plk_4 13 19 PF00069 0.389
MOD_Plk_4 268 274 PF00069 0.298
MOD_Plk_4 317 323 PF00069 0.406
MOD_Plk_4 331 337 PF00069 0.497
MOD_ProDKin_1 199 205 PF00069 0.319
MOD_ProDKin_1 22 28 PF00069 0.420
MOD_ProDKin_1 31 37 PF00069 0.353
MOD_SUMO_for_1 222 225 PF00179 0.253
MOD_SUMO_rev_2 53 62 PF00179 0.313
TRG_DiLeu_BaEn_1 53 58 PF01217 0.323
TRG_ENDOCYTIC_2 73 76 PF00928 0.294
TRG_ENDOCYTIC_2 85 88 PF00928 0.294
TRG_ENDOCYTIC_2 95 98 PF00928 0.337
TRG_ER_diArg_1 180 182 PF00400 0.321

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 26% 88%
A0A0N0P958 Leptomonas seymouri 62% 97%
A0A3Q8IGS5 Leishmania donovani 26% 100%
A4HJ26 Leishmania braziliensis 80% 100%
A4HLE0 Leishmania braziliensis 27% 100%
A4I6E8 Leishmania infantum 99% 100%
A4I8U9 Leishmania infantum 26% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
Q4Q4A6 Leishmania major 26% 100%
Q4Q6L5 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS