Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X464_LEIDO

TriTrypDb:

LdBPK_310640.1 , LdCL_310012100 , LDHU3_31.0940

Length:

560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X464

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X464

Function

Biological processes
Term	Name	Level	Count
GO:0001514	selenocysteine incorporation	7	1
GO:0006414	translational elongation	5	1
GO:0006417	regulation of translation	6	1
GO:0006451	translational readthrough	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003729	mRNA binding	5	11
GO:0005488	binding	1	11
GO:0035368	selenocysteine insertion sequence binding	6	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003730	mRNA 3'-UTR binding	6	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	248	252	PF00656	0.743
CLV_C14_Caspase3-7	312	316	PF00656	0.449
CLV_NRD_NRD_1	158	160	PF00675	0.665
CLV_NRD_NRD_1	199	201	PF00675	0.489
CLV_NRD_NRD_1	209	211	PF00675	0.418
CLV_NRD_NRD_1	455	457	PF00675	0.558
CLV_PCSK_FUR_1	196	200	PF00082	0.507
CLV_PCSK_FUR_1	207	211	PF00082	0.523
CLV_PCSK_KEX2_1	158	160	PF00082	0.654
CLV_PCSK_KEX2_1	198	200	PF00082	0.443
CLV_PCSK_KEX2_1	209	211	PF00082	0.341
CLV_PCSK_KEX2_1	93	95	PF00082	0.481
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.458
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.505
CLV_PCSK_SKI1_1	210	214	PF00082	0.459
CLV_PCSK_SKI1_1	22	26	PF00082	0.797
CLV_PCSK_SKI1_1	338	342	PF00082	0.547
CLV_PCSK_SKI1_1	374	378	PF00082	0.365
CLV_PCSK_SKI1_1	399	403	PF00082	0.482
CLV_PCSK_SKI1_1	407	411	PF00082	0.442
CLV_PCSK_SKI1_1	457	461	PF00082	0.577
CLV_PCSK_SKI1_1	531	535	PF00082	0.474
CLV_PCSK_SKI1_1	542	546	PF00082	0.417
DEG_APCC_DBOX_1	404	412	PF00400	0.376
DEG_APCC_DBOX_1	530	538	PF00400	0.412
DEG_SPOP_SBC_1	134	138	PF00917	0.551
DEG_SPOP_SBC_1	28	32	PF00917	0.609
DEG_SPOP_SBC_1	323	327	PF00917	0.550
DOC_MAPK_gen_1	374	384	PF00069	0.397
DOC_MAPK_gen_1	385	394	PF00069	0.405
DOC_MAPK_gen_1	399	408	PF00069	0.421
DOC_MAPK_gen_1	515	524	PF00069	0.483
DOC_MAPK_MEF2A_6	402	410	PF00069	0.467
DOC_PP4_FxxP_1	261	264	PF00568	0.548
DOC_USP7_MATH_1	109	113	PF00917	0.590
DOC_USP7_MATH_1	134	138	PF00917	0.747
DOC_USP7_MATH_1	174	178	PF00917	0.441
DOC_USP7_MATH_1	220	224	PF00917	0.710
DOC_USP7_MATH_1	28	32	PF00917	0.738
DOC_USP7_MATH_1	322	326	PF00917	0.611
DOC_USP7_MATH_1	339	343	PF00917	0.540
DOC_USP7_MATH_1	431	435	PF00917	0.741
DOC_USP7_MATH_1	444	448	PF00917	0.681
DOC_USP7_MATH_1	451	455	PF00917	0.641
DOC_USP7_MATH_1	49	53	PF00917	0.666
DOC_USP7_MATH_1	514	518	PF00917	0.522
DOC_USP7_MATH_1	536	540	PF00917	0.349
DOC_USP7_MATH_1	58	62	PF00917	0.536
DOC_USP7_UBL2_3	21	25	PF12436	0.759
DOC_USP7_UBL2_3	453	457	PF12436	0.663
DOC_WW_Pin1_4	125	130	PF00397	0.669
DOC_WW_Pin1_4	29	34	PF00397	0.581
DOC_WW_Pin1_4	324	329	PF00397	0.700
DOC_WW_Pin1_4	442	447	PF00397	0.777
DOC_WW_Pin1_4	78	83	PF00397	0.624
LIG_14-3-3_CanoR_1	244	254	PF00244	0.583
LIG_14-3-3_CanoR_1	505	511	PF00244	0.534
LIG_14-3-3_CanoR_1	542	552	PF00244	0.413
LIG_BRCT_BRCA1_1	341	345	PF00533	0.498
LIG_CaM_IQ_9	201	217	PF13499	0.407
LIG_CaM_IQ_9	391	407	PF13499	0.470
LIG_FHA_1	349	355	PF00498	0.330
LIG_FHA_1	552	558	PF00498	0.550
LIG_FHA_2	155	161	PF00498	0.540
LIG_FHA_2	234	240	PF00498	0.701
LIG_FHA_2	310	316	PF00498	0.563
LIG_FHA_2	411	417	PF00498	0.521
LIG_FHA_2	460	466	PF00498	0.410
LIG_FHA_2	553	559	PF00498	0.518
LIG_LIR_Apic_2	260	264	PF02991	0.553
LIG_LIR_Gen_1	177	186	PF02991	0.400
LIG_LIR_Gen_1	360	370	PF02991	0.324
LIG_LIR_Nem_3	177	182	PF02991	0.371
LIG_LIR_Nem_3	257	261	PF02991	0.540
LIG_LIR_Nem_3	265	270	PF02991	0.486
LIG_LIR_Nem_3	283	289	PF02991	0.329
LIG_LIR_Nem_3	360	366	PF02991	0.340
LIG_LIR_Nem_3	509	513	PF02991	0.461
LIG_LIR_Nem_3	539	543	PF02991	0.387
LIG_LYPXL_yS_3	286	289	PF13949	0.464
LIG_MYND_3	119	123	PF01753	0.515
LIG_PCNA_yPIPBox_3	290	303	PF02747	0.344
LIG_PROFILIN_1	425	431	PF00235	0.470
LIG_SH2_NCK_1	163	167	PF00017	0.404
LIG_SH2_STAP1	163	167	PF00017	0.404
LIG_SH2_STAP1	510	514	PF00017	0.340
LIG_SH2_STAP1	540	544	PF00017	0.342
LIG_SH2_STAP1	548	552	PF00017	0.379
LIG_SH2_STAT3	370	373	PF00017	0.344
LIG_SH2_STAT5	256	259	PF00017	0.575
LIG_SH2_STAT5	349	352	PF00017	0.330
LIG_SH2_STAT5	390	393	PF00017	0.439
LIG_SH2_STAT5	543	546	PF00017	0.521
LIG_SH2_STAT5	548	551	PF00017	0.510
LIG_SH3_3	415	421	PF00018	0.592
LIG_SH3_3	422	428	PF00018	0.690
LIG_SH3_3	432	438	PF00018	0.519
LIG_SH3_3	473	479	PF00018	0.572
LIG_SUMO_SIM_par_1	407	414	PF11976	0.393
LIG_SxIP_EBH_1	318	327	PF03271	0.423
LIG_UBA3_1	365	371	PF00899	0.454
LIG_WRC_WIRS_1	258	263	PF05994	0.631
MOD_CDK_SPxxK_3	442	449	PF00069	0.586
MOD_CK1_1	112	118	PF00069	0.630
MOD_CK1_1	132	138	PF00069	0.740
MOD_CK1_1	233	239	PF00069	0.706
MOD_CK1_1	327	333	PF00069	0.635
MOD_CK1_1	452	458	PF00069	0.572
MOD_CK1_1	501	507	PF00069	0.370
MOD_CK2_1	134	140	PF00069	0.736
MOD_CK2_1	154	160	PF00069	0.596
MOD_CK2_1	410	416	PF00069	0.363
MOD_CK2_1	459	465	PF00069	0.422
MOD_CK2_1	552	558	PF00069	0.519
MOD_GlcNHglycan	114	117	PF01048	0.562
MOD_GlcNHglycan	248	251	PF01048	0.553
MOD_GlcNHglycan	275	278	PF01048	0.527
MOD_GlcNHglycan	422	425	PF01048	0.711
MOD_GlcNHglycan	446	449	PF01048	0.608
MOD_GlcNHglycan	60	63	PF01048	0.541
MOD_GSK3_1	125	132	PF00069	0.625
MOD_GSK3_1	140	147	PF00069	0.698
MOD_GSK3_1	174	181	PF00069	0.358
MOD_GSK3_1	226	233	PF00069	0.686
MOD_GSK3_1	242	249	PF00069	0.724
MOD_GSK3_1	28	35	PF00069	0.762
MOD_GSK3_1	323	330	PF00069	0.751
MOD_GSK3_1	348	355	PF00069	0.362
MOD_GSK3_1	440	447	PF00069	0.665
MOD_GSK3_1	5	12	PF00069	0.671
MOD_GSK3_1	54	61	PF00069	0.607
MOD_GSK3_1	542	549	PF00069	0.420
MOD_NEK2_1	232	237	PF00069	0.581
MOD_NEK2_1	333	338	PF00069	0.674
MOD_NEK2_1	340	345	PF00069	0.526
MOD_NEK2_1	361	366	PF00069	0.346
MOD_NEK2_1	498	503	PF00069	0.489
MOD_NEK2_1	552	557	PF00069	0.519
MOD_NEK2_1	9	14	PF00069	0.696
MOD_NEK2_2	174	179	PF00069	0.317
MOD_NEK2_2	459	464	PF00069	0.532
MOD_PIKK_1	161	167	PF00454	0.566
MOD_PIKK_1	333	339	PF00454	0.574
MOD_PIKK_1	49	55	PF00454	0.618
MOD_PKA_2	226	232	PF00069	0.687
MOD_PKA_2	243	249	PF00069	0.568
MOD_PKA_2	481	487	PF00069	0.691
MOD_PKA_2	506	512	PF00069	0.534
MOD_PKA_2	54	60	PF00069	0.725
MOD_PKA_2	87	93	PF00069	0.553
MOD_Plk_1	552	558	PF00069	0.485
MOD_Plk_2-3	140	146	PF00069	0.696
MOD_Plk_2-3	309	315	PF00069	0.496
MOD_Plk_4	174	180	PF00069	0.419
MOD_Plk_4	263	269	PF00069	0.501
MOD_Plk_4	316	322	PF00069	0.585
MOD_Plk_4	340	346	PF00069	0.579
MOD_Plk_4	41	47	PF00069	0.764
MOD_Plk_4	552	558	PF00069	0.414
MOD_ProDKin_1	125	131	PF00069	0.669
MOD_ProDKin_1	29	35	PF00069	0.580
MOD_ProDKin_1	324	330	PF00069	0.706
MOD_ProDKin_1	442	448	PF00069	0.775
MOD_ProDKin_1	78	84	PF00069	0.620
TRG_DiLeu_BaEn_1	465	470	PF01217	0.411
TRG_ENDOCYTIC_2	179	182	PF00928	0.370
TRG_ENDOCYTIC_2	258	261	PF00928	0.544
TRG_ENDOCYTIC_2	286	289	PF00928	0.464
TRG_ER_diArg_1	199	201	PF00400	0.477
TRG_ER_diArg_1	206	209	PF00400	0.479
TRG_ER_diArg_1	387	390	PF00400	0.356
TRG_ER_diArg_1	405	408	PF00400	0.205
TRG_ER_diArg_1	505	508	PF00400	0.402
TRG_ER_diArg_1	86	89	PF00400	0.593
TRG_NLS_MonoExtN_4	196	202	PF00514	0.463
TRG_NLS_MonoExtN_4	453	460	PF00514	0.539
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN8	Leptomonas seymouri	51%	100%
A0A1X0NJ63	Trypanosomatidae	27%	88%
A0A3R7LBH7	Trypanosoma rangeli	31%	99%
A4HJ40	Leishmania braziliensis	68%	100%
A4I6F5	Leishmania infantum	98%	100%
C9ZN70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B1L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q9BHF1	Leishmania major	91%	100%
V5BDV6	Trypanosoma cruzi	28%	94%