Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X462_LEIDO

TriTrypDb:

LdBPK_310630.1 , LdCL_310012000 , LDHU3_31.0930

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X462

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X462

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.528
CLV_NRD_NRD_1	174	176	PF00675	0.768
CLV_NRD_NRD_1	231	233	PF00675	0.752
CLV_NRD_NRD_1	377	379	PF00675	0.500
CLV_NRD_NRD_1	68	70	PF00675	0.577
CLV_NRD_NRD_1	78	80	PF00675	0.569
CLV_PCSK_FUR_1	229	233	PF00082	0.660
CLV_PCSK_KEX2_1	231	233	PF00082	0.718
CLV_PCSK_KEX2_1	377	379	PF00082	0.504
CLV_PCSK_KEX2_1	68	70	PF00082	0.600
CLV_PCSK_KEX2_1	78	80	PF00082	0.585
CLV_PCSK_KEX2_1	82	84	PF00082	0.471
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.652
CLV_PCSK_PC7_1	78	84	PF00082	0.640
CLV_PCSK_SKI1_1	337	341	PF00082	0.625
CLV_PCSK_SKI1_1	348	352	PF00082	0.484
CLV_PCSK_SKI1_1	36	40	PF00082	0.652
CLV_Separin_Metazoa	72	76	PF03568	0.421
DEG_APCC_DBOX_1	336	344	PF00400	0.447
DOC_MAPK_gen_1	175	183	PF00069	0.488
DOC_MAPK_gen_1	288	297	PF00069	0.459
DOC_MAPK_gen_1	33	43	PF00069	0.355
DOC_MAPK_MEF2A_6	175	183	PF00069	0.479
DOC_MAPK_MEF2A_6	36	45	PF00069	0.337
DOC_USP7_MATH_1	169	173	PF00917	0.512
DOC_USP7_MATH_1	235	239	PF00917	0.534
DOC_USP7_MATH_1	62	66	PF00917	0.423
DOC_USP7_MATH_1	85	89	PF00917	0.385
DOC_USP7_UBL2_3	286	290	PF12436	0.501
DOC_WW_Pin1_4	105	110	PF00397	0.514
DOC_WW_Pin1_4	140	145	PF00397	0.403
DOC_WW_Pin1_4	200	205	PF00397	0.575
DOC_WW_Pin1_4	386	391	PF00397	0.749
DOC_WW_Pin1_4	412	417	PF00397	0.742
DOC_WW_Pin1_4	427	432	PF00397	0.792
DOC_WW_Pin1_4	438	443	PF00397	0.662
DOC_WW_Pin1_4	50	55	PF00397	0.505
LIG_14-3-3_CanoR_1	231	239	PF00244	0.547
LIG_14-3-3_CanoR_1	312	316	PF00244	0.504
LIG_14-3-3_CanoR_1	321	327	PF00244	0.467
LIG_14-3-3_CanoR_1	61	70	PF00244	0.519
LIG_Actin_WH2_2	332	350	PF00022	0.444
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.504
LIG_FHA_1	105	111	PF00498	0.466
LIG_FHA_1	121	127	PF00498	0.411
LIG_FHA_1	141	147	PF00498	0.429
LIG_FHA_1	358	364	PF00498	0.350
LIG_FHA_1	397	403	PF00498	0.818
LIG_FHA_1	62	68	PF00498	0.509
LIG_FHA_2	2	8	PF00498	0.594
LIG_FHA_2	220	226	PF00498	0.558
LIG_FHA_2	253	259	PF00498	0.479
LIG_FHA_2	434	440	PF00498	0.840
LIG_IRF3_LxIS_1	363	368	PF10401	0.501
LIG_LIR_Nem_3	238	242	PF02991	0.437
LIG_NRBOX	121	127	PF00104	0.334
LIG_NRBOX	69	75	PF00104	0.419
LIG_PCNA_PIPBox_1	133	142	PF02747	0.490
LIG_PDZ_Class_3	453	458	PF00595	0.724
LIG_Pex14_1	324	328	PF04695	0.471
LIG_SH2_PTP2	180	183	PF00017	0.494
LIG_SH2_SRC	180	183	PF00017	0.494
LIG_SH2_STAT3	113	116	PF00017	0.478
LIG_SH2_STAT3	139	142	PF00017	0.494
LIG_SH2_STAT5	139	142	PF00017	0.410
LIG_SH2_STAT5	180	183	PF00017	0.508
LIG_SH2_STAT5	315	318	PF00017	0.480
LIG_SH3_1	327	333	PF00018	0.464
LIG_SH3_3	103	109	PF00018	0.522
LIG_SH3_3	180	186	PF00018	0.568
LIG_SH3_3	327	333	PF00018	0.449
LIG_SH3_3	336	342	PF00018	0.384
LIG_SH3_3	367	373	PF00018	0.669
LIG_SH3_3	411	417	PF00018	0.784
LIG_SH3_3	437	443	PF00018	0.794
LIG_SUMO_SIM_par_1	355	360	PF11976	0.376
LIG_SUMO_SIM_par_1	362	368	PF11976	0.376
LIG_TRAF2_1	222	225	PF00917	0.573
LIG_TRAF2_1	436	439	PF00917	0.813
LIG_TRAF2_1	445	448	PF00917	0.751
LIG_UBA3_1	364	372	PF00899	0.360
MOD_CDC14_SPxK_1	108	111	PF00782	0.535
MOD_CDK_SPxK_1	105	111	PF00069	0.549
MOD_CK1_1	386	392	PF00069	0.670
MOD_CK1_1	441	447	PF00069	0.698
MOD_CK1_1	46	52	PF00069	0.628
MOD_CK1_1	6	12	PF00069	0.778
MOD_CK2_1	1	7	PF00069	0.769
MOD_CK2_1	219	225	PF00069	0.666
MOD_CK2_1	433	439	PF00069	0.771
MOD_CK2_1	441	447	PF00069	0.698
MOD_GlcNHglycan	233	236	PF01048	0.731
MOD_GlcNHglycan	247	250	PF01048	0.529
MOD_GlcNHglycan	278	281	PF01048	0.524
MOD_GlcNHglycan	290	293	PF01048	0.532
MOD_GlcNHglycan	396	399	PF01048	0.738
MOD_GlcNHglycan	7	11	PF01048	0.703
MOD_GSK3_1	138	145	PF00069	0.573
MOD_GSK3_1	149	156	PF00069	0.633
MOD_GSK3_1	215	222	PF00069	0.663
MOD_GSK3_1	231	238	PF00069	0.666
MOD_GSK3_1	386	393	PF00069	0.741
MOD_GSK3_1	396	403	PF00069	0.672
MOD_GSK3_1	438	445	PF00069	0.781
MOD_GSK3_1	45	52	PF00069	0.672
MOD_GSK3_1	85	92	PF00069	0.579
MOD_N-GLC_1	448	453	PF02516	0.561
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	244	249	PF00069	0.665
MOD_NEK2_1	276	281	PF00069	0.524
MOD_NEK2_1	335	340	PF00069	0.504
MOD_NEK2_1	365	370	PF00069	0.369
MOD_NEK2_1	43	48	PF00069	0.674
MOD_NEK2_1	89	94	PF00069	0.705
MOD_PIKK_1	138	144	PF00454	0.572
MOD_PIKK_1	92	98	PF00454	0.585
MOD_PKA_1	231	237	PF00069	0.699
MOD_PKA_2	120	126	PF00069	0.518
MOD_PKA_2	215	221	PF00069	0.742
MOD_PKA_2	230	236	PF00069	0.647
MOD_PKA_2	311	317	PF00069	0.616
MOD_PKA_2	60	66	PF00069	0.612
MOD_PKB_1	229	237	PF00069	0.663
MOD_PKB_1	378	386	PF00069	0.570
MOD_Plk_1	210	216	PF00069	0.786
MOD_Plk_1	85	91	PF00069	0.552
MOD_Plk_4	210	216	PF00069	0.786
MOD_Plk_4	311	317	PF00069	0.635
MOD_Plk_4	352	358	PF00069	0.448
MOD_Plk_4	371	377	PF00069	0.516
MOD_ProDKin_1	105	111	PF00069	0.646
MOD_ProDKin_1	140	146	PF00069	0.494
MOD_ProDKin_1	200	206	PF00069	0.736
MOD_ProDKin_1	386	392	PF00069	0.704
MOD_ProDKin_1	412	418	PF00069	0.691
MOD_ProDKin_1	427	433	PF00069	0.761
MOD_ProDKin_1	438	444	PF00069	0.579
MOD_ProDKin_1	50	56	PF00069	0.638
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.512
TRG_ENDOCYTIC_2	180	183	PF00928	0.721
TRG_ER_diArg_1	376	378	PF00400	0.622
TRG_ER_diArg_1	67	69	PF00400	0.497
TRG_ER_diArg_1	78	80	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU0	Leptomonas seymouri	44%	99%
A4HJ39	Leishmania braziliensis	70%	98%
A4I6F4	Leishmania infantum	100%	100%
C9ZN69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B1L1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q9BHF0	Leishmania major	87%	100%