Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X461_LEIDO

TriTrypDb:

LdBPK_310650.1 , LdCL_310012200 , LDHU3_31.0950

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X461

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X461

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.509
CLV_C14_Caspase3-7	463	467	PF00656	0.585
CLV_C14_Caspase3-7	776	780	PF00656	0.581
CLV_NRD_NRD_1	148	150	PF00675	0.556
CLV_NRD_NRD_1	154	156	PF00675	0.517
CLV_NRD_NRD_1	184	186	PF00675	0.484
CLV_NRD_NRD_1	34	36	PF00675	0.618
CLV_NRD_NRD_1	622	624	PF00675	0.531
CLV_NRD_NRD_1	735	737	PF00675	0.658
CLV_PCSK_FUR_1	645	649	PF00082	0.651
CLV_PCSK_KEX2_1	147	149	PF00082	0.638
CLV_PCSK_KEX2_1	622	624	PF00082	0.528
CLV_PCSK_KEX2_1	647	649	PF00082	0.656
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.656
CLV_PCSK_SKI1_1	148	152	PF00082	0.609
CLV_PCSK_SKI1_1	155	159	PF00082	0.596
CLV_PCSK_SKI1_1	221	225	PF00082	0.551
CLV_PCSK_SKI1_1	459	463	PF00082	0.607
CLV_PCSK_SKI1_1	609	613	PF00082	0.497
DEG_APCC_KENBOX_2	666	670	PF00400	0.585
DEG_Nend_UBRbox_2	1	3	PF02207	0.661
DEG_SCF_FBW7_2	172	177	PF00400	0.575
DEG_SCF_FBW7_2	725	732	PF00400	0.620
DEG_SPOP_SBC_1	44	48	PF00917	0.559
DOC_CYCLIN_RxL_1	233	245	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	322	328	PF00134	0.506
DOC_MAPK_FxFP_2	81	84	PF00069	0.609
DOC_MAPK_gen_1	357	365	PF00069	0.689
DOC_MAPK_MEF2A_6	485	494	PF00069	0.489
DOC_MAPK_RevD_3	723	737	PF00069	0.564
DOC_PP1_RVXF_1	236	243	PF00149	0.489
DOC_PP4_FxxP_1	443	446	PF00568	0.508
DOC_PP4_FxxP_1	81	84	PF00568	0.609
DOC_SPAK_OSR1_1	238	242	PF12202	0.592
DOC_USP7_MATH_1	157	161	PF00917	0.592
DOC_USP7_MATH_1	206	210	PF00917	0.650
DOC_USP7_MATH_1	257	261	PF00917	0.636
DOC_USP7_MATH_1	262	266	PF00917	0.620
DOC_USP7_MATH_1	379	383	PF00917	0.621
DOC_USP7_MATH_1	417	421	PF00917	0.614
DOC_USP7_MATH_1	468	472	PF00917	0.545
DOC_USP7_MATH_1	512	516	PF00917	0.576
DOC_USP7_MATH_1	532	536	PF00917	0.295
DOC_USP7_MATH_1	579	583	PF00917	0.648
DOC_USP7_MATH_1	678	682	PF00917	0.724
DOC_USP7_MATH_1	710	714	PF00917	0.430
DOC_USP7_MATH_1	778	782	PF00917	0.686
DOC_USP7_UBL2_3	152	156	PF12436	0.623
DOC_USP7_UBL2_3	411	415	PF12436	0.635
DOC_WW_Pin1_4	102	107	PF00397	0.613
DOC_WW_Pin1_4	170	175	PF00397	0.713
DOC_WW_Pin1_4	202	207	PF00397	0.751
DOC_WW_Pin1_4	265	270	PF00397	0.597
DOC_WW_Pin1_4	572	577	PF00397	0.712
DOC_WW_Pin1_4	679	684	PF00397	0.661
DOC_WW_Pin1_4	725	730	PF00397	0.615
DOC_WW_Pin1_4	795	800	PF00397	0.525
LIG_14-3-3_CanoR_1	277	283	PF00244	0.599
LIG_14-3-3_CanoR_1	298	304	PF00244	0.702
LIG_14-3-3_CanoR_1	362	366	PF00244	0.753
LIG_14-3-3_CanoR_1	380	385	PF00244	0.572
LIG_14-3-3_CanoR_1	389	393	PF00244	0.634
LIG_14-3-3_CanoR_1	401	406	PF00244	0.751
LIG_14-3-3_CanoR_1	536	542	PF00244	0.406
LIG_14-3-3_CanoR_1	588	593	PF00244	0.526
LIG_14-3-3_CanoR_1	622	628	PF00244	0.387
LIG_14-3-3_CanoR_1	690	695	PF00244	0.561
LIG_14-3-3_CanoR_1	711	715	PF00244	0.420
LIG_14-3-3_CanoR_1	79	84	PF00244	0.607
LIG_14-3-3_CanoR_1	807	813	PF00244	0.538
LIG_APCC_ABBA_1	727	732	PF00400	0.629
LIG_BIR_III_4	2	6	PF00653	0.582
LIG_BRCT_BRCA1_1	712	716	PF00533	0.442
LIG_BRCT_BRCA1_1	763	767	PF00533	0.561
LIG_deltaCOP1_diTrp_1	213	220	PF00928	0.504
LIG_deltaCOP1_diTrp_1	74	83	PF00928	0.512
LIG_FHA_1	10	16	PF00498	0.476
LIG_FHA_1	133	139	PF00498	0.532
LIG_FHA_1	171	177	PF00498	0.637
LIG_FHA_1	317	323	PF00498	0.685
LIG_FHA_1	335	341	PF00498	0.657
LIG_FHA_1	536	542	PF00498	0.569
LIG_FHA_2	106	112	PF00498	0.581
LIG_FHA_2	138	144	PF00498	0.565
LIG_FHA_2	298	304	PF00498	0.777
LIG_FHA_2	325	331	PF00498	0.581
LIG_FHA_2	362	368	PF00498	0.670
LIG_FHA_2	565	571	PF00498	0.728
LIG_FHA_2	669	675	PF00498	0.658
LIG_IRF3_LxIS_1	133	139	PF10401	0.392
LIG_LIR_Gen_1	18	28	PF02991	0.484
LIG_LIR_Gen_1	317	328	PF02991	0.635
LIG_LIR_Gen_1	525	533	PF02991	0.386
LIG_LIR_Gen_1	728	738	PF02991	0.452
LIG_LIR_Gen_1	743	752	PF02991	0.475
LIG_LIR_Gen_1	801	810	PF02991	0.573
LIG_LIR_Nem_3	18	24	PF02991	0.481
LIG_LIR_Nem_3	219	223	PF02991	0.685
LIG_LIR_Nem_3	27	33	PF02991	0.320
LIG_LIR_Nem_3	317	323	PF02991	0.766
LIG_LIR_Nem_3	518	523	PF02991	0.421
LIG_LIR_Nem_3	525	531	PF02991	0.351
LIG_LIR_Nem_3	614	618	PF02991	0.559
LIG_LIR_Nem_3	728	733	PF02991	0.465
LIG_LIR_Nem_3	743	748	PF02991	0.456
LIG_LIR_Nem_3	75	81	PF02991	0.545
LIG_LIR_Nem_3	801	806	PF02991	0.523
LIG_Pex14_1	744	748	PF04695	0.455
LIG_SH2_CRK	320	324	PF00017	0.641
LIG_SH2_CRK	37	41	PF00017	0.516
LIG_SH2_CRK	615	619	PF00017	0.500
LIG_SH2_CRK	625	629	PF00017	0.329
LIG_SH2_GRB2like	37	40	PF00017	0.457
LIG_SH2_NCK_1	320	324	PF00017	0.641
LIG_SH2_NCK_1	625	629	PF00017	0.436
LIG_SH2_PTP2	21	24	PF00017	0.475
LIG_SH2_SRC	21	24	PF00017	0.523
LIG_SH2_SRC	37	40	PF00017	0.505
LIG_SH2_STAP1	413	417	PF00017	0.576
LIG_SH2_STAP1	436	440	PF00017	0.492
LIG_SH2_STAT5	21	24	PF00017	0.523
LIG_SH2_STAT5	227	230	PF00017	0.517
LIG_SH2_STAT5	275	278	PF00017	0.523
LIG_SH2_STAT5	594	597	PF00017	0.588
LIG_SH3_3	19	25	PF00018	0.579
LIG_SH3_3	225	231	PF00018	0.565
LIG_SH3_3	400	406	PF00018	0.692
LIG_SH3_3	526	532	PF00018	0.393
LIG_SH3_3	553	559	PF00018	0.724
LIG_SH3_3	81	87	PF00018	0.612
LIG_SUMO_SIM_par_1	134	140	PF11976	0.517
LIG_SUMO_SIM_par_1	336	341	PF11976	0.561
LIG_SUMO_SIM_par_1	367	375	PF11976	0.502
LIG_SxIP_EBH_1	715	724	PF03271	0.553
LIG_TRAF2_1	656	659	PF00917	0.567
LIG_TRAF2_2	656	661	PF00917	0.568
LIG_TYR_ITIM	19	24	PF00017	0.482
LIG_TYR_ITIM	318	323	PF00017	0.644
LIG_UBA3_1	365	373	PF00899	0.509
LIG_UBA3_1	516	522	PF00899	0.392
LIG_WRC_WIRS_1	800	805	PF05994	0.564
MOD_CDK_SPK_2	170	175	PF00069	0.587
MOD_CK1_1	229	235	PF00069	0.623
MOD_CK1_1	265	271	PF00069	0.584
MOD_CK1_1	305	311	PF00069	0.744
MOD_CK1_1	371	377	PF00069	0.596
MOD_CK1_1	404	410	PF00069	0.714
MOD_CK1_1	48	54	PF00069	0.714
MOD_CK1_1	506	512	PF00069	0.684
MOD_CK1_1	515	521	PF00069	0.519
MOD_CK1_1	535	541	PF00069	0.284
MOD_CK1_1	561	567	PF00069	0.639
MOD_CK1_1	626	632	PF00069	0.497
MOD_CK1_1	681	687	PF00069	0.606
MOD_CK1_1	717	723	PF00069	0.476
MOD_CK1_1	773	779	PF00069	0.670
MOD_CK1_1	82	88	PF00069	0.555
MOD_CK2_1	105	111	PF00069	0.567
MOD_CK2_1	297	303	PF00069	0.780
MOD_CK2_1	324	330	PF00069	0.677
MOD_CK2_1	361	367	PF00069	0.653
MOD_CK2_1	564	570	PF00069	0.642
MOD_CK2_1	574	580	PF00069	0.706
MOD_CK2_1	581	587	PF00069	0.647
MOD_CK2_1	778	784	PF00069	0.525
MOD_CK2_1	795	801	PF00069	0.504
MOD_CMANNOS	449	452	PF00535	0.523
MOD_GlcNHglycan	159	163	PF01048	0.709
MOD_GlcNHglycan	168	171	PF01048	0.695
MOD_GlcNHglycan	208	211	PF01048	0.675
MOD_GlcNHglycan	228	231	PF01048	0.480
MOD_GlcNHglycan	244	247	PF01048	0.464
MOD_GlcNHglycan	259	262	PF01048	0.725
MOD_GlcNHglycan	278	281	PF01048	0.412
MOD_GlcNHglycan	306	310	PF01048	0.610
MOD_GlcNHglycan	385	388	PF01048	0.654
MOD_GlcNHglycan	394	397	PF01048	0.602
MOD_GlcNHglycan	403	406	PF01048	0.516
MOD_GlcNHglycan	419	422	PF01048	0.625
MOD_GlcNHglycan	47	50	PF01048	0.678
MOD_GlcNHglycan	486	489	PF01048	0.506
MOD_GlcNHglycan	505	508	PF01048	0.556
MOD_GlcNHglycan	510	513	PF01048	0.671
MOD_GlcNHglycan	544	547	PF01048	0.403
MOD_GlcNHglycan	577	580	PF01048	0.616
MOD_GlcNHglycan	581	584	PF01048	0.525
MOD_GlcNHglycan	59	62	PF01048	0.584
MOD_GlcNHglycan	628	631	PF01048	0.426
MOD_GlcNHglycan	661	665	PF01048	0.570
MOD_GlcNHglycan	756	759	PF01048	0.609
MOD_GlcNHglycan	763	766	PF01048	0.526
MOD_GlcNHglycan	772	775	PF01048	0.513
MOD_GlcNHglycan	779	783	PF01048	0.553
MOD_GlcNHglycan	8	12	PF01048	0.589
MOD_GSK3_1	132	139	PF00069	0.482
MOD_GSK3_1	166	173	PF00069	0.673
MOD_GSK3_1	202	209	PF00069	0.616
MOD_GSK3_1	334	341	PF00069	0.596
MOD_GSK3_1	368	375	PF00069	0.595
MOD_GSK3_1	379	386	PF00069	0.561
MOD_GSK3_1	388	395	PF00069	0.561
MOD_GSK3_1	401	408	PF00069	0.624
MOD_GSK3_1	44	51	PF00069	0.515
MOD_GSK3_1	462	469	PF00069	0.705
MOD_GSK3_1	508	515	PF00069	0.624
MOD_GSK3_1	531	538	PF00069	0.474
MOD_GSK3_1	571	578	PF00069	0.715
MOD_GSK3_1	626	633	PF00069	0.387
MOD_GSK3_1	710	717	PF00069	0.446
MOD_GSK3_1	773	780	PF00069	0.605
MOD_GSK3_1	795	802	PF00069	0.525
MOD_LATS_1	399	405	PF00433	0.551
MOD_N-GLC_1	542	547	PF02516	0.419
MOD_N-GLC_1	572	577	PF02516	0.664
MOD_N-GLC_1	659	664	PF02516	0.753
MOD_N-GLC_1	668	673	PF02516	0.706
MOD_N-GLC_1	761	766	PF02516	0.563
MOD_N-GLC_1	91	96	PF02516	0.730
MOD_N-GLC_2	699	701	PF02516	0.388
MOD_NEK2_1	136	141	PF00069	0.432
MOD_NEK2_1	314	319	PF00069	0.580
MOD_NEK2_1	484	489	PF00069	0.599
MOD_NEK2_1	571	576	PF00069	0.774
MOD_NEK2_1	595	600	PF00069	0.458
MOD_NEK2_1	702	707	PF00069	0.421
MOD_NEK2_1	738	743	PF00069	0.442
MOD_NEK2_1	91	96	PF00069	0.718
MOD_NEK2_2	537	542	PF00069	0.495
MOD_PIKK_1	372	378	PF00454	0.658
MOD_PIKK_1	595	601	PF00454	0.480
MOD_PIKK_1	717	723	PF00454	0.466
MOD_PKA_1	151	157	PF00069	0.472
MOD_PKA_1	411	417	PF00069	0.630
MOD_PKA_2	276	282	PF00069	0.473
MOD_PKA_2	297	303	PF00069	0.672
MOD_PKA_2	361	367	PF00069	0.741
MOD_PKA_2	379	385	PF00069	0.585
MOD_PKA_2	388	394	PF00069	0.594
MOD_PKA_2	484	490	PF00069	0.515
MOD_PKA_2	535	541	PF00069	0.462
MOD_PKA_2	689	695	PF00069	0.590
MOD_PKA_2	710	716	PF00069	0.427
MOD_PKB_1	688	696	PF00069	0.521
MOD_PKB_1	77	85	PF00069	0.538
MOD_Plk_1	338	344	PF00069	0.599
MOD_Plk_1	436	442	PF00069	0.595
MOD_Plk_1	630	636	PF00069	0.461
MOD_Plk_1	738	744	PF00069	0.453
MOD_Plk_1	91	97	PF00069	0.732
MOD_Plk_2-3	302	308	PF00069	0.552
MOD_Plk_4	132	138	PF00069	0.512
MOD_Plk_4	361	367	PF00069	0.658
MOD_Plk_4	380	386	PF00069	0.662
MOD_Plk_4	388	394	PF00069	0.729
MOD_Plk_4	512	518	PF00069	0.548
MOD_Plk_4	524	530	PF00069	0.400
MOD_Plk_4	581	587	PF00069	0.629
MOD_Plk_4	623	629	PF00069	0.423
MOD_Plk_4	740	746	PF00069	0.618
MOD_ProDKin_1	102	108	PF00069	0.599
MOD_ProDKin_1	170	176	PF00069	0.713
MOD_ProDKin_1	202	208	PF00069	0.750
MOD_ProDKin_1	265	271	PF00069	0.597
MOD_ProDKin_1	572	578	PF00069	0.710
MOD_ProDKin_1	679	685	PF00069	0.660
MOD_ProDKin_1	725	731	PF00069	0.618
MOD_ProDKin_1	795	801	PF00069	0.520
MOD_SUMO_for_1	150	153	PF00179	0.443
MOD_SUMO_for_1	174	177	PF00179	0.609
MOD_SUMO_rev_2	251	258	PF00179	0.667
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.699
TRG_ENDOCYTIC_2	21	24	PF00928	0.624
TRG_ENDOCYTIC_2	320	323	PF00928	0.642
TRG_ENDOCYTIC_2	37	40	PF00928	0.299
TRG_ENDOCYTIC_2	615	618	PF00928	0.464
TRG_ENDOCYTIC_2	625	628	PF00928	0.365
TRG_ER_diArg_1	147	149	PF00400	0.456
TRG_ER_diArg_1	482	485	PF00400	0.551
TRG_ER_diArg_1	622	624	PF00400	0.528
TRG_NLS_MonoExtN_4	645	651	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T0	Leptomonas seymouri	46%	99%
A0A1X0NK18	Trypanosomatidae	27%	100%
A0A3R7NKJ0	Trypanosoma rangeli	28%	100%
A4HJ41	Leishmania braziliensis	74%	100%
A4I6F6	Leishmania infantum	100%	100%
C9ZN74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B1L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q6K1	Leishmania major	89%	100%