DnaJ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X455_LEIDO

TriTrypDb:

LdBPK_310530.1 , LdCL_310010800 , LDHU3_31.0760

Length:

603

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A0A3S7X455

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X455

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	418	422	PF00656	0.621
CLV_NRD_NRD_1	225	227	PF00675	0.428
CLV_NRD_NRD_1	26	28	PF00675	0.471
CLV_NRD_NRD_1	304	306	PF00675	0.282
CLV_NRD_NRD_1	309	311	PF00675	0.258
CLV_NRD_NRD_1	408	410	PF00675	0.323
CLV_NRD_NRD_1	497	499	PF00675	0.425
CLV_PCSK_KEX2_1	26	28	PF00082	0.471
CLV_PCSK_KEX2_1	407	409	PF00082	0.307
CLV_PCSK_KEX2_1	468	470	PF00082	0.451
CLV_PCSK_KEX2_1	497	499	PF00082	0.456
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.463
CLV_PCSK_SKI1_1	108	112	PF00082	0.399
CLV_PCSK_SKI1_1	26	30	PF00082	0.512
CLV_PCSK_SKI1_1	310	314	PF00082	0.306
CLV_PCSK_SKI1_1	369	373	PF00082	0.457
CLV_PCSK_SKI1_1	411	415	PF00082	0.398
CLV_PCSK_SKI1_1	497	501	PF00082	0.501
CLV_PCSK_SKI1_1	531	535	PF00082	0.352
CLV_PCSK_SKI1_1	584	588	PF00082	0.399
DEG_APCC_DBOX_1	530	538	PF00400	0.612
DEG_COP1_1	354	363	PF00400	0.730
DEG_Nend_Nbox_1	1	3	PF02207	0.512
DEG_SCF_FBW7_1	243	250	PF00400	0.678
DEG_SPOP_SBC_1	592	596	PF00917	0.639
DOC_CYCLIN_yClb5_NLxxxL_5	414	420	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	380	386	PF00134	0.610
DOC_MAPK_gen_1	547	556	PF00069	0.549
DOC_PP1_RVXF_1	529	536	PF00149	0.588
DOC_USP7_MATH_1	247	251	PF00917	0.761
DOC_USP7_MATH_1	256	260	PF00917	0.801
DOC_USP7_MATH_1	299	303	PF00917	0.554
DOC_USP7_MATH_1	592	596	PF00917	0.709
DOC_USP7_UBL2_3	227	231	PF12436	0.644
DOC_WW_Pin1_4	243	248	PF00397	0.716
DOC_WW_Pin1_4	537	542	PF00397	0.637
DOC_WW_Pin1_4	587	592	PF00397	0.750
DOC_WW_Pin1_4	71	76	PF00397	0.768
DOC_WW_Pin1_4	81	86	PF00397	0.649
LIG_14-3-3_CanoR_1	346	350	PF00244	0.577
LIG_Actin_WH2_2	397	413	PF00022	0.556
LIG_APCC_ABBA_1	313	318	PF00400	0.467
LIG_Clathr_ClatBox_1	532	536	PF01394	0.602
LIG_deltaCOP1_diTrp_1	192	202	PF00928	0.577
LIG_deltaCOP1_diTrp_1	472	478	PF00928	0.650
LIG_FHA_1	592	598	PF00498	0.757
LIG_FHA_2	215	221	PF00498	0.594
LIG_FHA_2	244	250	PF00498	0.775
LIG_FHA_2	298	304	PF00498	0.482
LIG_FHA_2	588	594	PF00498	0.729
LIG_LIR_Gen_1	210	216	PF02991	0.619
LIG_LIR_Gen_1	327	337	PF02991	0.467
LIG_LIR_Gen_1	92	103	PF02991	0.709
LIG_LIR_Nem_3	163	168	PF02991	0.382
LIG_LIR_Nem_3	210	214	PF02991	0.584
LIG_LIR_Nem_3	327	333	PF02991	0.467
LIG_LIR_Nem_3	348	352	PF02991	0.519
LIG_LIR_Nem_3	92	98	PF02991	0.699
LIG_Pex14_2	2	6	PF04695	0.414
LIG_Pex14_2	386	390	PF04695	0.599
LIG_SH2_CRK	168	172	PF00017	0.400
LIG_SH2_CRK	290	294	PF00017	0.484
LIG_SH2_CRK	337	341	PF00017	0.508
LIG_SH2_STAP1	308	312	PF00017	0.540
LIG_SH2_STAP1	475	479	PF00017	0.671
LIG_SH2_STAT5	308	311	PF00017	0.538
LIG_SH2_STAT5	449	452	PF00017	0.559
LIG_SH3_1	65	71	PF00018	0.669
LIG_SH3_3	318	324	PF00018	0.546
LIG_SH3_3	54	60	PF00018	0.776
LIG_SH3_3	594	600	PF00018	0.641
LIG_SH3_3	65	71	PF00018	0.757
LIG_SUMO_SIM_anti_2	552	558	PF11976	0.622
LIG_TRAF2_1	32	35	PF00917	0.661
MOD_CDK_SPxxK_3	537	544	PF00069	0.635
MOD_CK1_1	183	189	PF00069	0.650
MOD_CK1_1	257	263	PF00069	0.788
MOD_CK1_1	297	303	PF00069	0.518
MOD_CK1_1	473	479	PF00069	0.571
MOD_CK1_1	481	487	PF00069	0.572
MOD_CK1_1	575	581	PF00069	0.701
MOD_CK1_1	595	601	PF00069	0.638
MOD_CK1_1	81	87	PF00069	0.766
MOD_CK2_1	186	192	PF00069	0.666
MOD_CK2_1	297	303	PF00069	0.493
MOD_CK2_1	422	428	PF00069	0.632
MOD_GlcNHglycan	182	185	PF01048	0.490
MOD_GlcNHglycan	249	252	PF01048	0.566
MOD_GlcNHglycan	255	259	PF01048	0.554
MOD_GlcNHglycan	423	427	PF01048	0.434
MOD_GlcNHglycan	428	431	PF01048	0.427
MOD_GlcNHglycan	480	483	PF01048	0.406
MOD_GlcNHglycan	62	65	PF01048	0.563
MOD_GlcNHglycan	80	83	PF01048	0.587
MOD_GSK3_1	22	29	PF00069	0.653
MOD_GSK3_1	234	241	PF00069	0.667
MOD_GSK3_1	243	250	PF00069	0.728
MOD_GSK3_1	256	263	PF00069	0.806
MOD_GSK3_1	294	301	PF00069	0.464
MOD_GSK3_1	338	345	PF00069	0.548
MOD_GSK3_1	422	429	PF00069	0.632
MOD_GSK3_1	470	477	PF00069	0.566
MOD_GSK3_1	587	594	PF00069	0.783
MOD_GSK3_1	97	104	PF00069	0.623
MOD_N-GLC_1	247	252	PF02516	0.574
MOD_N-GLC_1	324	329	PF02516	0.361
MOD_NEK2_1	101	106	PF00069	0.654
MOD_NEK2_1	2	7	PF00069	0.467
MOD_NEK2_1	462	467	PF00069	0.571
MOD_NEK2_1	535	540	PF00069	0.560
MOD_NEK2_2	324	329	PF00069	0.502
MOD_PKA_1	26	32	PF00069	0.685
MOD_PKA_2	26	32	PF00069	0.699
MOD_PKA_2	345	351	PF00069	0.560
MOD_Plk_1	324	330	PF00069	0.523
MOD_Plk_1	535	541	PF00069	0.549
MOD_Plk_1	552	558	PF00069	0.541
MOD_Plk_1	592	598	PF00069	0.640
MOD_Plk_1	96	102	PF00069	0.695
MOD_Plk_4	445	451	PF00069	0.547
MOD_Plk_4	470	476	PF00069	0.620
MOD_Plk_4	481	487	PF00069	0.652
MOD_Plk_4	552	558	PF00069	0.582
MOD_Plk_4	97	103	PF00069	0.628
MOD_ProDKin_1	243	249	PF00069	0.717
MOD_ProDKin_1	537	543	PF00069	0.638
MOD_ProDKin_1	587	593	PF00069	0.751
MOD_ProDKin_1	71	77	PF00069	0.757
MOD_ProDKin_1	81	87	PF00069	0.647
MOD_SUMO_rev_2	275	282	PF00179	0.715
TRG_ENDOCYTIC_2	168	171	PF00928	0.400
TRG_ENDOCYTIC_2	289	292	PF00928	0.460
TRG_ENDOCYTIC_2	337	340	PF00928	0.502
TRG_ENDOCYTIC_2	352	355	PF00928	0.519
TRG_ER_diArg_1	26	28	PF00400	0.690
TRG_ER_diArg_1	407	409	PF00400	0.521
TRG_NES_CRM1_1	378	391	PF08389	0.618
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBU7	Leptomonas seymouri	61%	99%
A0A0S4JJ62	Bodo saltans	31%	100%
A0A1X0NJF9	Trypanosomatidae	42%	100%
A0A1X0NZV2	Trypanosomatidae	42%	100%
A0A422NZZ9	Trypanosoma rangeli	40%	100%
A4HJ29	Leishmania braziliensis	79%	98%
A4I6K8	Leishmania infantum	100%	100%
C9ZN58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
C9ZWY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6L2	Leishmania major	93%	99%
V5BN17	Trypanosoma cruzi	39%	100%