LeishMANIAdb
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CRAL/TRIO domain containing protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CRAL/TRIO domain containing protein, putative
Gene product:
CRAL/TRIO domain containing protein, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X454_LEIDO
TriTrypDb:
LdBPK_310320.1 * , LdCL_310008300 , LDHU3_31.0380
Length:
1139

Annotations

LeishMANIAdb annotations

Possible lipid transporter, contains a probable lipase domain found in other eukaryotes (A0A421H3N2_9STRA). Very highly expanded family for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
TermNameLevelCount
GO:0012505 endomembrane system 2 2
GO:0016020 membrane 2 20
GO:0044232 organelle membrane contact site 2 2
GO:0110165 cellular anatomical entity 1 20
GO:0140284 endoplasmic reticulum-endosome membrane contact site 3 2
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Expansion

Sequence features

A0A3S7X454
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X454

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 1124 1128 PF00656 0.381
CLV_C14_Caspase3-7 285 289 PF00656 0.410
CLV_C14_Caspase3-7 937 941 PF00656 0.351
CLV_NRD_NRD_1 1089 1091 PF00675 0.632
CLV_NRD_NRD_1 112 114 PF00675 0.463
CLV_NRD_NRD_1 419 421 PF00675 0.608
CLV_NRD_NRD_1 59 61 PF00675 0.536
CLV_NRD_NRD_1 593 595 PF00675 0.471
CLV_NRD_NRD_1 749 751 PF00675 0.365
CLV_NRD_NRD_1 81 83 PF00675 0.579
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I8N8 Leptomonas seymouri 66% 100%
A0A0N1PF84 Leptomonas seymouri 31% 100%
A0A0S4J3D4 Bodo saltans 31% 95%
A0A0S4KG02 Bodo saltans 35% 87%
A0A0S4KHN2 Bodo saltans 34% 94%
A0A1X0NJ96 Trypanosomatidae 40% 100%
A0A1X0NJE3 Trypanosomatidae 31% 100%
A0A3R7N104 Trypanosoma rangeli 38% 100%
A0A3S7X437 Leishmania donovani 31% 100%
A4HJ04 Leishmania braziliensis 76% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS