Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X444_LEIDO

TriTrypDb:

LdBPK_310220.1 , LdCL_310007300 , LDHU3_31.0280

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X444

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X444

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	8	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	9	1
GO:0006397	mRNA processing	7	1
GO:0006399	tRNA metabolic process	7	1
GO:0008033	tRNA processing	8	1
GO:0008380	RNA splicing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0019205	nucleobase-containing compound kinase activity	5	12
GO:0051731	polynucleotide 5'-hydroxyl-kinase activity	5	12
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2
GO:0046404	polydeoxyribonucleotide 5'-hydroxyl-kinase activity	7	1
GO:0051733	polydeoxyribonucleotide kinase activity	6	1
GO:0051734	polynucleotide kinase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.575
CLV_NRD_NRD_1	474	476	PF00675	0.511
CLV_PCSK_KEX2_1	474	476	PF00082	0.471
CLV_PCSK_SKI1_1	101	105	PF00082	0.424
CLV_PCSK_SKI1_1	126	130	PF00082	0.403
CLV_PCSK_SKI1_1	17	21	PF00082	0.471
CLV_PCSK_SKI1_1	351	355	PF00082	0.497
CLV_PCSK_SKI1_1	399	403	PF00082	0.460
DOC_ANK_TNKS_1	317	324	PF00023	0.588
DOC_CKS1_1	163	168	PF01111	0.487
DOC_CKS1_1	379	384	PF01111	0.530
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.487
DOC_MAPK_FxFP_2	168	171	PF00069	0.340
DOC_MAPK_gen_1	230	238	PF00069	0.340
DOC_MAPK_gen_1	474	484	PF00069	0.399
DOC_MAPK_MEF2A_6	120	129	PF00069	0.525
DOC_PP1_RVXF_1	124	130	PF00149	0.427
DOC_PP2B_LxvP_1	80	83	PF13499	0.439
DOC_PP4_FxxP_1	168	171	PF00568	0.340
DOC_PP4_FxxP_1	379	382	PF00568	0.528
DOC_USP7_MATH_1	257	261	PF00917	0.695
DOC_USP7_MATH_1	263	267	PF00917	0.700
DOC_USP7_MATH_1	273	277	PF00917	0.638
DOC_USP7_MATH_1	409	413	PF00917	0.692
DOC_USP7_MATH_1	431	435	PF00917	0.469
DOC_USP7_MATH_1	64	68	PF00917	0.383
DOC_WW_Pin1_4	162	167	PF00397	0.487
DOC_WW_Pin1_4	189	194	PF00397	0.452
DOC_WW_Pin1_4	265	270	PF00397	0.673
DOC_WW_Pin1_4	378	383	PF00397	0.523
DOC_WW_Pin1_4	456	461	PF00397	0.537
DOC_WW_Pin1_4	488	493	PF00397	0.501
LIG_14-3-3_CanoR_1	17	23	PF00244	0.464
LIG_14-3-3_CanoR_1	399	404	PF00244	0.485
LIG_14-3-3_CanoR_1	466	472	PF00244	0.532
LIG_14-3-3_CanoR_1	494	498	PF00244	0.440
LIG_14-3-3_CanoR_1	89	99	PF00244	0.439
LIG_Clathr_ClatBox_1	390	394	PF01394	0.469
LIG_EH1_1	211	219	PF00400	0.452
LIG_FHA_1	190	196	PF00498	0.383
LIG_FHA_1	279	285	PF00498	0.528
LIG_FHA_1	381	387	PF00498	0.438
LIG_FHA_1	494	500	PF00498	0.464
LIG_FHA_1	50	56	PF00498	0.366
LIG_FHA_1	513	519	PF00498	0.342
LIG_FHA_1	75	81	PF00498	0.387
LIG_FHA_2	284	290	PF00498	0.430
LIG_FHA_2	435	441	PF00498	0.504
LIG_FHA_2	450	456	PF00498	0.328
LIG_LIR_Apic_2	165	171	PF02991	0.487
LIG_LIR_Apic_2	333	339	PF02991	0.580
LIG_LIR_Gen_1	12	19	PF02991	0.489
LIG_LIR_Gen_1	434	443	PF02991	0.523
LIG_LIR_Nem_3	12	16	PF02991	0.495
LIG_LIR_Nem_3	239	243	PF02991	0.367
LIG_LIR_Nem_3	434	438	PF02991	0.508
LIG_NRBOX	509	515	PF00104	0.475
LIG_Pex14_1	144	148	PF04695	0.452
LIG_Pex14_1	374	378	PF04695	0.383
LIG_SH2_CRK	154	158	PF00017	0.340
LIG_SH2_CRK	196	200	PF00017	0.417
LIG_SH2_NCK_1	196	200	PF00017	0.417
LIG_SH2_STAP1	91	95	PF00017	0.487
LIG_SH2_STAT5	141	144	PF00017	0.340
LIG_SH2_STAT5	377	380	PF00017	0.377
LIG_SH2_STAT5	8	11	PF00017	0.441
LIG_SH3_2	382	387	PF14604	0.555
LIG_SH3_3	201	207	PF00018	0.487
LIG_SH3_3	239	245	PF00018	0.494
LIG_SH3_3	361	367	PF00018	0.613
LIG_SH3_3	379	385	PF00018	0.455
LIG_SH3_3	53	59	PF00018	0.340
LIG_SH3_3	78	84	PF00018	0.344
LIG_SUMO_SIM_anti_2	356	363	PF11976	0.545
LIG_SUMO_SIM_anti_2	493	500	PF11976	0.424
LIG_SUMO_SIM_anti_2	77	82	PF11976	0.452
LIG_SUMO_SIM_par_1	155	160	PF11976	0.340
LIG_SUMO_SIM_par_1	389	394	PF11976	0.473
LIG_SUMO_SIM_par_1	445	452	PF11976	0.420
LIG_SUMO_SIM_par_1	495	500	PF11976	0.530
LIG_TYR_ITIM	152	157	PF00017	0.340
LIG_WRC_WIRS_1	10	15	PF05994	0.472
MOD_CDC14_SPxK_1	384	387	PF00782	0.552
MOD_CDK_SPxK_1	381	387	PF00069	0.547
MOD_CDK_SPxK_1	488	494	PF00069	0.502
MOD_CK1_1	21	27	PF00069	0.574
MOD_CK1_1	276	282	PF00069	0.635
MOD_CK1_1	28	34	PF00069	0.548
MOD_CK1_1	434	440	PF00069	0.492
MOD_CK1_1	451	457	PF00069	0.287
MOD_CK1_1	69	75	PF00069	0.452
MOD_CK2_1	105	111	PF00069	0.324
MOD_CK2_1	449	455	PF00069	0.395
MOD_CK2_1	467	473	PF00069	0.404
MOD_CK2_1	9	15	PF00069	0.478
MOD_CMANNOS	306	309	PF00535	0.501
MOD_GlcNHglycan	265	268	PF01048	0.720
MOD_GlcNHglycan	275	278	PF01048	0.734
MOD_GlcNHglycan	499	502	PF01048	0.556
MOD_GSK3_1	17	24	PF00069	0.523
MOD_GSK3_1	257	264	PF00069	0.670
MOD_GSK3_1	283	290	PF00069	0.546
MOD_GSK3_1	389	396	PF00069	0.430
MOD_GSK3_1	493	500	PF00069	0.448
MOD_GSK3_1	66	73	PF00069	0.397
MOD_GSK3_1	91	98	PF00069	0.359
MOD_N-GLC_1	189	194	PF02516	0.452
MOD_NEK2_1	22	27	PF00069	0.510
MOD_NEK2_1	287	292	PF00069	0.423
MOD_NEK2_1	360	365	PF00069	0.596
MOD_NEK2_1	393	398	PF00069	0.484
MOD_NEK2_1	486	491	PF00069	0.383
MOD_NEK2_1	497	502	PF00069	0.406
MOD_NEK2_1	71	76	PF00069	0.445
MOD_NEK2_1	95	100	PF00069	0.415
MOD_PIKK_1	22	28	PF00454	0.572
MOD_PIKK_1	276	282	PF00454	0.534
MOD_PIKK_1	393	399	PF00454	0.521
MOD_PK_1	66	72	PF00069	0.452
MOD_PKA_2	493	499	PF00069	0.449
MOD_PKB_1	475	483	PF00069	0.469
MOD_Plk_1	393	399	PF00069	0.429
MOD_Plk_4	137	143	PF00069	0.329
MOD_Plk_4	283	289	PF00069	0.465
MOD_Plk_4	302	308	PF00069	0.265
MOD_Plk_4	386	392	PF00069	0.420
MOD_Plk_4	410	416	PF00069	0.605
MOD_Plk_4	431	437	PF00069	0.384
MOD_Plk_4	477	483	PF00069	0.491
MOD_Plk_4	493	499	PF00069	0.333
MOD_Plk_4	66	72	PF00069	0.380
MOD_Plk_4	76	82	PF00069	0.293
MOD_Plk_4	95	101	PF00069	0.391
MOD_ProDKin_1	162	168	PF00069	0.487
MOD_ProDKin_1	189	195	PF00069	0.452
MOD_ProDKin_1	265	271	PF00069	0.678
MOD_ProDKin_1	378	384	PF00069	0.522
MOD_ProDKin_1	456	462	PF00069	0.537
MOD_ProDKin_1	488	494	PF00069	0.502
TRG_DiLeu_BaEn_1	493	498	PF01217	0.549
TRG_DiLeu_BaEn_4	186	192	PF01217	0.452
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.340
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.350
TRG_ENDOCYTIC_2	154	157	PF00928	0.352
TRG_ENDOCYTIC_2	196	199	PF00928	0.498
TRG_ER_diArg_1	112	115	PF00400	0.415
TRG_ER_diArg_1	230	233	PF00400	0.340
TRG_ER_diArg_1	371	374	PF00400	0.432
TRG_ER_diArg_1	474	477	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IA46	Leptomonas seymouri	76%	100%
A0A1X0NKV9	Trypanosomatidae	46%	100%
A0A422MZS5	Trypanosoma rangeli	46%	100%
A4HIZ6	Leishmania braziliensis	91%	100%
A4I6B3	Leishmania infantum	99%	100%
C9ZN71	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B1G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B1H1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q6P3	Leishmania major	95%	100%
V5BBI5	Trypanosoma cruzi	46%	100%