Protoglobin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X442_LEIDO

TriTrypDb:

LdBPK_310190.1 , LdCL_310006900 , LDHU3_31.0230

Length:

157

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X442

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X442

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	33	35	PF00082	0.431
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.431
CLV_PCSK_SKI1_1	30	34	PF00082	0.403
DEG_Nend_UBRbox_2	1	3	PF02207	0.524
LIG_14-3-3_CanoR_1	127	135	PF00244	0.477
LIG_14-3-3_CanoR_1	138	147	PF00244	0.439
LIG_14-3-3_CanoR_1	23	31	PF00244	0.412
LIG_14-3-3_CanoR_1	90	94	PF00244	0.436
LIG_eIF4E_1	129	135	PF01652	0.478
LIG_eIF4E_1	7	13	PF01652	0.335
LIG_FHA_1	123	129	PF00498	0.323
LIG_FHA_1	139	145	PF00498	0.373
LIG_FHA_1	33	39	PF00498	0.419
LIG_FHA_1	60	66	PF00498	0.515
LIG_FHA_1	90	96	PF00498	0.539
LIG_FHA_2	44	50	PF00498	0.501
LIG_FHA_2	75	81	PF00498	0.512
LIG_FHA_2	9	15	PF00498	0.295
LIG_GBD_Chelix_1	96	104	PF00786	0.260
LIG_LIR_Gen_1	14	21	PF02991	0.491
LIG_LIR_Gen_1	22	32	PF02991	0.439
LIG_LIR_Nem_3	14	19	PF02991	0.376
LIG_LIR_Nem_3	22	27	PF02991	0.311
LIG_LIR_Nem_3	77	82	PF02991	0.525
LIG_LIR_Nem_3	92	96	PF02991	0.459
LIG_NRBOX	146	152	PF00104	0.370
LIG_PCNA_PIPBox_1	1	10	PF02747	0.495
LIG_SH2_SRC	7	10	PF00017	0.347
LIG_SH2_SRC	72	75	PF00017	0.413
LIG_SH2_STAP1	129	133	PF00017	0.458
LIG_SH2_STAT5	16	19	PF00017	0.361
LIG_SH2_STAT5	7	10	PF00017	0.324
LIG_TRAF2_1	53	56	PF00917	0.287
LIG_UBA3_1	100	107	PF00899	0.281
LIG_UBA3_1	27	33	PF00899	0.409
LIG_Vh1_VBS_1	133	151	PF01044	0.377
MOD_CK1_1	22	28	PF00069	0.548
MOD_CK1_1	83	89	PF00069	0.475
MOD_CK2_1	43	49	PF00069	0.571
MOD_GlcNHglycan	24	27	PF01048	0.507
MOD_GlcNHglycan	51	54	PF01048	0.522
MOD_GSK3_1	39	46	PF00069	0.476
MOD_LATS_1	136	142	PF00433	0.469
MOD_NEK2_1	8	13	PF00069	0.363
MOD_PIKK_1	32	38	PF00454	0.361
MOD_PIKK_1	80	86	PF00454	0.501
MOD_PKA_2	137	143	PF00069	0.465
MOD_PKA_2	22	28	PF00069	0.544
MOD_PKA_2	89	95	PF00069	0.391
MOD_Plk_1	42	48	PF00069	0.576
MOD_Plk_2-3	43	49	PF00069	0.547
MOD_Plk_2-3	74	80	PF00069	0.402
MOD_Plk_4	74	80	PF00069	0.398
MOD_Plk_4	8	14	PF00069	0.377
TRG_DiLeu_BaEn_4	55	61	PF01217	0.281
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.468
TRG_ENDOCYTIC_2	16	19	PF00928	0.335
TRG_Pf-PMV_PEXEL_1	94	99	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH9	Leptomonas seymouri	62%	100%
A0A1X0NJ16	Trypanosomatidae	36%	97%
A0A3R7MDS1	Trypanosoma rangeli	44%	96%
A4HIZ3	Leishmania braziliensis	75%	100%
A4I6B0	Leishmania infantum	98%	100%
C9ZN37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9B1G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q6P6	Leishmania major	89%	100%
V5BDZ3	Trypanosoma cruzi	41%	96%