Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin carboxyl-terminal hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X418_LEIDO

TriTrypDb:

LdBPK_310150.1 , LdCL_310006400 , LDHU3_31.0180

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X418

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X418

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0010498	proteasomal protein catabolic process	5	11
GO:0016579	protein deubiquitination	6	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0030163	protein catabolic process	4	11
GO:0036211	protein modification process	4	11
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0070646	protein modification by small protein removal	5	11
GO:0070647	protein modification by small protein conjugation or removal	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0009894	regulation of catabolic process	4	1
GO:0019222	regulation of metabolic process	3	1
GO:0030162	regulation of proteolysis	6	1
GO:0042176	regulation of protein catabolic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061136	regulation of proteasomal protein catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004843	cysteine-type deubiquitinase activity	5	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0019783	ubiquitin-like protein peptidase activity	4	11
GO:0101005	deubiquitinase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.480
CLV_NRD_NRD_1	343	345	PF00675	0.426
CLV_NRD_NRD_1	352	354	PF00675	0.438
CLV_PCSK_FUR_1	341	345	PF00082	0.491
CLV_PCSK_FUR_1	350	354	PF00082	0.479
CLV_PCSK_KEX2_1	343	345	PF00082	0.425
CLV_PCSK_KEX2_1	350	352	PF00082	0.432
CLV_PCSK_KEX2_1	428	430	PF00082	0.413
CLV_PCSK_PC1ET2_1	428	430	PF00082	0.390
CLV_PCSK_SKI1_1	129	133	PF00082	0.486
CLV_PCSK_SKI1_1	27	31	PF00082	0.430
CLV_PCSK_SKI1_1	305	309	PF00082	0.409
CLV_PCSK_SKI1_1	311	315	PF00082	0.397
DEG_APCC_KENBOX_2	9	13	PF00400	0.608
DEG_COP1_1	73	83	PF00400	0.752
DOC_MAPK_DCC_7	156	164	PF00069	0.456
DOC_MAPK_DCC_7	305	315	PF00069	0.415
DOC_MAPK_gen_1	229	237	PF00069	0.525
DOC_MAPK_gen_1	305	315	PF00069	0.415
DOC_MAPK_gen_1	31	38	PF00069	0.595
DOC_MAPK_gen_1	7	17	PF00069	0.560
DOC_MAPK_MEF2A_6	10	19	PF00069	0.550
DOC_MAPK_MEF2A_6	156	164	PF00069	0.486
DOC_PP1_RVXF_1	3	9	PF00149	0.413
DOC_PP1_RVXF_1	309	316	PF00149	0.398
DOC_PP4_FxxP_1	263	266	PF00568	0.525
DOC_USP7_MATH_1	100	104	PF00917	0.687
DOC_USP7_MATH_1	199	203	PF00917	0.460
DOC_USP7_MATH_1	420	424	PF00917	0.525
DOC_USP7_UBL2_3	27	31	PF12436	0.640
DOC_USP7_UBL2_3	330	334	PF12436	0.474
DOC_USP7_UBL2_3	406	410	PF12436	0.344
DOC_WW_Pin1_4	358	363	PF00397	0.548
DOC_WW_Pin1_4	450	455	PF00397	0.732
LIG_14-3-3_CanoR_1	262	266	PF00244	0.553
LIG_14-3-3_CanoR_1	296	300	PF00244	0.468
LIG_14-3-3_CanoR_1	352	362	PF00244	0.434
LIG_Actin_WH2_2	316	332	PF00022	0.489
LIG_Actin_WH2_2	415	433	PF00022	0.525
LIG_APCC_ABBAyCdc20_2	410	416	PF00400	0.344
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_FHA_1	110	116	PF00498	0.525
LIG_FHA_1	12	18	PF00498	0.587
LIG_FHA_1	164	170	PF00498	0.473
LIG_FHA_1	243	249	PF00498	0.495
LIG_FHA_1	319	325	PF00498	0.415
LIG_FHA_1	451	457	PF00498	0.717
LIG_FHA_1	65	71	PF00498	0.574
LIG_FHA_1	75	81	PF00498	0.675
LIG_FHA_2	172	178	PF00498	0.456
LIG_FHA_2	219	225	PF00498	0.476
LIG_Integrin_RGD_1	136	138	PF01839	0.525
LIG_Integrin_RGD_1	300	302	PF01839	0.480
LIG_LIR_Apic_2	260	266	PF02991	0.525
LIG_LIR_Gen_1	234	244	PF02991	0.432
LIG_LIR_Gen_1	288	297	PF02991	0.447
LIG_LIR_Nem_3	234	240	PF02991	0.413
LIG_LIR_Nem_3	288	292	PF02991	0.428
LIG_LIR_Nem_3	314	318	PF02991	0.402
LIG_LIR_Nem_3	379	385	PF02991	0.416
LIG_LIR_Nem_3	409	414	PF02991	0.429
LIG_MAD2	308	316	PF02301	0.413
LIG_NRBOX	192	198	PF00104	0.486
LIG_PDZ_Class_2	453	458	PF00595	0.673
LIG_Pex14_2	259	263	PF04695	0.525
LIG_PTB_Apo_2	108	115	PF02174	0.413
LIG_PTB_Apo_2	169	176	PF02174	0.456
LIG_PTB_Phospho_1	108	114	PF10480	0.413
LIG_SH2_GRB2like	114	117	PF00017	0.413
LIG_SH2_PTP2	289	292	PF00017	0.558
LIG_SH2_PTP2	440	443	PF00017	0.525
LIG_SH2_SRC	114	117	PF00017	0.525
LIG_SH2_STAP1	208	212	PF00017	0.525
LIG_SH2_STAP1	96	100	PF00017	0.757
LIG_SH2_STAT5	114	117	PF00017	0.450
LIG_SH2_STAT5	289	292	PF00017	0.426
LIG_SH2_STAT5	401	404	PF00017	0.413
LIG_SH2_STAT5	440	443	PF00017	0.413
LIG_SH2_STAT5	96	99	PF00017	0.849
LIG_SH3_3	220	226	PF00018	0.558
LIG_SH3_3	360	366	PF00018	0.521
LIG_SH3_3	451	457	PF00018	0.715
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.574
LIG_TRAF2_1	366	369	PF00917	0.513
LIG_TYR_ITIM	438	443	PF00017	0.525
LIG_UBA3_1	43	47	PF00899	0.574
MOD_CDK_SPxxK_3	358	365	PF00069	0.478
MOD_CK1_1	281	287	PF00069	0.451
MOD_CK1_1	73	79	PF00069	0.759
MOD_CK2_1	121	127	PF00069	0.496
MOD_CK2_1	171	177	PF00069	0.390
MOD_Cter_Amidation	404	407	PF01082	0.525
MOD_GlcNHglycan	116	119	PF01048	0.486
MOD_GlcNHglycan	379	382	PF01048	0.419
MOD_GlcNHglycan	394	397	PF01048	0.413
MOD_GlcNHglycan	57	60	PF01048	0.448
MOD_GlcNHglycan	72	75	PF01048	0.501
MOD_GSK3_1	164	171	PF00069	0.562
MOD_GSK3_1	238	245	PF00069	0.464
MOD_GSK3_1	318	325	PF00069	0.496
MOD_GSK3_1	70	77	PF00069	0.735
MOD_GSK3_1	90	97	PF00069	0.728
MOD_N-GLC_1	11	16	PF02516	0.447
MOD_N-GLC_1	242	247	PF02516	0.498
MOD_N-GLC_1	377	382	PF02516	0.401
MOD_N-GLC_1	90	95	PF02516	0.758
MOD_N-GLC_2	111	113	PF02516	0.413
MOD_NEK2_1	121	126	PF00069	0.504
MOD_NEK2_1	151	156	PF00069	0.491
MOD_NEK2_1	164	169	PF00069	0.400
MOD_NEK2_1	19	24	PF00069	0.568
MOD_NEK2_1	216	221	PF00069	0.436
MOD_NEK2_1	319	324	PF00069	0.481
MOD_PIKK_1	186	192	PF00454	0.456
MOD_PKA_2	261	267	PF00069	0.556
MOD_PKA_2	278	284	PF00069	0.328
MOD_PKA_2	295	301	PF00069	0.425
MOD_PKB_1	351	359	PF00069	0.499
MOD_Plk_1	11	17	PF00069	0.585
MOD_Plk_1	319	325	PF00069	0.514
MOD_Plk_1	53	59	PF00069	0.574
MOD_Plk_2-3	11	17	PF00069	0.663
MOD_Plk_2-3	247	253	PF00069	0.455
MOD_Plk_4	164	170	PF00069	0.461
MOD_Plk_4	199	205	PF00069	0.449
MOD_Plk_4	319	325	PF00069	0.480
MOD_Plk_4	64	70	PF00069	0.574
MOD_ProDKin_1	358	364	PF00069	0.548
MOD_ProDKin_1	450	456	PF00069	0.733
MOD_SUMO_for_1	376	379	PF00179	0.545
MOD_SUMO_rev_2	364	373	PF00179	0.480
MOD_SUMO_rev_2	423	430	PF00179	0.394
TRG_DiLeu_BaEn_1	39	44	PF01217	0.640
TRG_DiLeu_BaEn_2	179	185	PF01217	0.525
TRG_DiLeu_BaEn_4	369	375	PF01217	0.460
TRG_ENDOCYTIC_2	208	211	PF00928	0.525
TRG_ENDOCYTIC_2	289	292	PF00928	0.426
TRG_ENDOCYTIC_2	382	385	PF00928	0.413
TRG_ENDOCYTIC_2	440	443	PF00928	0.413
TRG_ER_diArg_1	350	353	PF00400	0.496
TRG_ER_diArg_1	444	447	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMH5	Leptomonas seymouri	81%	100%
A0A1X0NJ77	Trypanosomatidae	49%	97%
A0A3R7RDZ6	Trypanosoma rangeli	49%	98%
A4HIX8	Leishmania braziliensis	87%	100%
A5D9H7	Bos taurus	23%	100%
C9ZN32	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9AHK7	Leishmania infantum	100%	100%
E9B1G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O57429	Gallus gallus	24%	100%
O75317	Homo sapiens	23%	100%
P40826	Oryctolagus cuniculus	32%	93%
P43593	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	92%
P54578	Homo sapiens	33%	93%
P60051	Pan troglodytes	33%	93%
Q0IIF7	Bos taurus	33%	93%
Q17361	Caenorhabditis elegans	30%	94%
Q4Q6Q0	Leishmania major	95%	100%
Q4R6D3	Macaca fascicularis	22%	100%
Q84WC6	Arabidopsis thaliana	30%	96%
Q92353	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	98%
Q949Y0	Arabidopsis thaliana	31%	95%
Q9JMA1	Mus musculus	32%	93%
Q9UMW8	Homo sapiens	25%	100%
V5BIL0	Trypanosoma cruzi	51%	99%