T-complex protein 11, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

T-complex protein 11, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X411_LEIDO

TriTrypDb:

LdBPK_303470.1 , LdCL_300040300

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X411

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X411

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.713
CLV_C14_Caspase3-7	742	746	PF00656	0.491
CLV_NRD_NRD_1	133	135	PF00675	0.545
CLV_NRD_NRD_1	169	171	PF00675	0.799
CLV_NRD_NRD_1	282	284	PF00675	0.561
CLV_NRD_NRD_1	316	318	PF00675	0.568
CLV_NRD_NRD_1	375	377	PF00675	0.722
CLV_NRD_NRD_1	401	403	PF00675	0.551
CLV_NRD_NRD_1	404	406	PF00675	0.526
CLV_NRD_NRD_1	606	608	PF00675	0.420
CLV_NRD_NRD_1	645	647	PF00675	0.415
CLV_NRD_NRD_1	711	713	PF00675	0.449
CLV_NRD_NRD_1	808	810	PF00675	0.475
CLV_NRD_NRD_1	92	94	PF00675	0.465
CLV_PCSK_FUR_1	402	406	PF00082	0.600
CLV_PCSK_KEX2_1	121	123	PF00082	0.657
CLV_PCSK_KEX2_1	133	135	PF00082	0.473
CLV_PCSK_KEX2_1	230	232	PF00082	0.594
CLV_PCSK_KEX2_1	292	294	PF00082	0.628
CLV_PCSK_KEX2_1	315	317	PF00082	0.581
CLV_PCSK_KEX2_1	374	376	PF00082	0.733
CLV_PCSK_KEX2_1	403	405	PF00082	0.535
CLV_PCSK_KEX2_1	463	465	PF00082	0.242
CLV_PCSK_KEX2_1	645	647	PF00082	0.413
CLV_PCSK_KEX2_1	711	713	PF00082	0.449
CLV_PCSK_KEX2_1	808	810	PF00082	0.363
CLV_PCSK_KEX2_1	91	93	PF00082	0.482
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.637
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.516
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.628
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.581
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.621
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.242
CLV_PCSK_SKI1_1	133	137	PF00082	0.551
CLV_PCSK_SKI1_1	189	193	PF00082	0.525
CLV_PCSK_SKI1_1	196	200	PF00082	0.541
CLV_PCSK_SKI1_1	227	231	PF00082	0.537
CLV_PCSK_SKI1_1	259	263	PF00082	0.627
CLV_PCSK_SKI1_1	292	296	PF00082	0.591
CLV_PCSK_SKI1_1	411	415	PF00082	0.486
CLV_PCSK_SKI1_1	463	467	PF00082	0.368
CLV_PCSK_SKI1_1	531	535	PF00082	0.470
CLV_PCSK_SKI1_1	624	628	PF00082	0.453
CLV_PCSK_SKI1_1	648	652	PF00082	0.385
CLV_PCSK_SKI1_1	712	716	PF00082	0.409
CLV_PCSK_SKI1_1	808	812	PF00082	0.365
CLV_PCSK_SKI1_1	843	847	PF00082	0.353
CLV_PCSK_SKI1_1	858	862	PF00082	0.294
DEG_APCC_DBOX_1	188	196	PF00400	0.520
DEG_APCC_DBOX_1	807	815	PF00400	0.459
DEG_APCC_DBOX_1	857	865	PF00400	0.449
DEG_APCC_DBOX_1	90	98	PF00400	0.461
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SCF_FBW7_1	52	58	PF00400	0.546
DEG_SPOP_SBC_1	359	363	PF00917	0.798
DOC_CKS1_1	332	337	PF01111	0.777
DOC_CKS1_1	52	57	PF01111	0.620
DOC_CYCLIN_RxL_1	186	193	PF00134	0.532
DOC_CYCLIN_RxL_1	460	470	PF00134	0.313
DOC_MAPK_DCC_7	820	830	PF00069	0.417
DOC_MAPK_DCC_7	858	866	PF00069	0.571
DOC_MAPK_gen_1	121	129	PF00069	0.726
DOC_MAPK_gen_1	463	471	PF00069	0.417
DOC_MAPK_gen_1	607	615	PF00069	0.470
DOC_MAPK_gen_1	645	653	PF00069	0.385
DOC_MAPK_gen_1	88	97	PF00069	0.455
DOC_MAPK_MEF2A_6	858	866	PF00069	0.571
DOC_MAPK_RevD_3	697	712	PF00069	0.417
DOC_PP1_RVXF_1	622	629	PF00149	0.449
DOC_PP1_RVXF_1	680	687	PF00149	0.344
DOC_PP1_RVXF_1	807	814	PF00149	0.344
DOC_PP2B_LxvP_1	53	56	PF13499	0.630
DOC_PP2B_LxvP_1	603	606	PF13499	0.475
DOC_USP7_MATH_1	234	238	PF00917	0.697
DOC_USP7_MATH_1	323	327	PF00917	0.599
DOC_USP7_MATH_1	359	363	PF00917	0.757
DOC_USP7_MATH_1	367	371	PF00917	0.725
DOC_USP7_MATH_1	537	541	PF00917	0.458
DOC_USP7_MATH_1	636	640	PF00917	0.366
DOC_USP7_MATH_1	704	708	PF00917	0.477
DOC_USP7_MATH_1	717	721	PF00917	0.389
DOC_WW_Pin1_4	162	167	PF00397	0.775
DOC_WW_Pin1_4	171	176	PF00397	0.802
DOC_WW_Pin1_4	201	206	PF00397	0.585
DOC_WW_Pin1_4	240	245	PF00397	0.795
DOC_WW_Pin1_4	324	329	PF00397	0.689
DOC_WW_Pin1_4	331	336	PF00397	0.726
DOC_WW_Pin1_4	360	365	PF00397	0.746
DOC_WW_Pin1_4	455	460	PF00397	0.385
DOC_WW_Pin1_4	51	56	PF00397	0.574
DOC_WW_Pin1_4	525	530	PF00397	0.449
DOC_WW_Pin1_4	547	552	PF00397	0.385
LIG_14-3-3_CanoR_1	133	138	PF00244	0.563
LIG_14-3-3_CanoR_1	26	36	PF00244	0.636
LIG_14-3-3_CanoR_1	272	276	PF00244	0.586
LIG_14-3-3_CanoR_1	293	299	PF00244	0.537
LIG_14-3-3_CanoR_1	304	311	PF00244	0.500
LIG_14-3-3_CanoR_1	538	546	PF00244	0.443
LIG_14-3-3_CanoR_1	607	616	PF00244	0.377
LIG_14-3-3_CanoR_1	663	668	PF00244	0.359
LIG_14-3-3_CanoR_1	724	734	PF00244	0.437
LIG_14-3-3_CanoR_1	820	828	PF00244	0.398
LIG_Actin_WH2_2	644	662	PF00022	0.354
LIG_Actin_WH2_2	731	746	PF00022	0.389
LIG_Actin_WH2_2	90	105	PF00022	0.410
LIG_BIR_III_4	6	10	PF00653	0.683
LIG_BRCT_BRCA1_1	611	615	PF00533	0.344
LIG_Clathr_ClatBox_1	698	702	PF01394	0.413
LIG_EVH1_2	674	678	PF00568	0.449
LIG_FHA_1	139	145	PF00498	0.505
LIG_FHA_1	163	169	PF00498	0.787
LIG_FHA_1	293	299	PF00498	0.569
LIG_FHA_1	325	331	PF00498	0.706
LIG_FHA_1	353	359	PF00498	0.796
LIG_FHA_1	548	554	PF00498	0.449
LIG_FHA_1	608	614	PF00498	0.353
LIG_FHA_1	653	659	PF00498	0.451
LIG_FHA_1	694	700	PF00498	0.395
LIG_FHA_1	820	826	PF00498	0.370
LIG_FHA_1	830	836	PF00498	0.277
LIG_FHA_1	867	873	PF00498	0.693
LIG_FHA_2	1	7	PF00498	0.735
LIG_FHA_2	272	278	PF00498	0.582
LIG_FHA_2	305	311	PF00498	0.538
LIG_FHA_2	343	349	PF00498	0.725
LIG_FHA_2	425	431	PF00498	0.644
LIG_FHA_2	442	448	PF00498	0.441
LIG_FHA_2	468	474	PF00498	0.281
LIG_FHA_2	639	645	PF00498	0.328
LIG_FHA_2	663	669	PF00498	0.449
LIG_FHA_2	689	695	PF00498	0.385
LIG_FHA_2	740	746	PF00498	0.475
LIG_FHA_2	777	783	PF00498	0.334
LIG_FHA_2	794	800	PF00498	0.475
LIG_LIR_Apic_2	331	335	PF02991	0.739
LIG_LIR_Gen_1	309	318	PF02991	0.580
LIG_LIR_Gen_1	491	500	PF02991	0.423
LIG_LIR_Gen_1	668	678	PF02991	0.415
LIG_LIR_Gen_1	800	811	PF02991	0.352
LIG_LIR_Nem_3	220	225	PF02991	0.401
LIG_LIR_Nem_3	309	314	PF02991	0.569
LIG_LIR_Nem_3	491	495	PF02991	0.353
LIG_LIR_Nem_3	497	501	PF02991	0.302
LIG_LIR_Nem_3	668	673	PF02991	0.316
LIG_LIR_Nem_3	800	806	PF02991	0.352
LIG_MYND_1	379	383	PF01753	0.606
LIG_MYND_1	482	486	PF01753	0.398
LIG_NRBOX	464	470	PF00104	0.449
LIG_NRBOX	696	702	PF00104	0.344
LIG_Pex14_2	142	146	PF04695	0.519
LIG_Pex14_2	561	565	PF04695	0.364
LIG_Pex14_2	615	619	PF04695	0.475
LIG_SH2_CRK	299	303	PF00017	0.521
LIG_SH2_CRK	332	336	PF00017	0.736
LIG_SH2_NCK_1	332	336	PF00017	0.736
LIG_SH2_STAP1	225	229	PF00017	0.511
LIG_SH2_STAP1	419	423	PF00017	0.449
LIG_SH2_STAT3	225	228	PF00017	0.554
LIG_SH2_STAT5	113	116	PF00017	0.692
LIG_SH2_STAT5	147	150	PF00017	0.507
LIG_SH2_STAT5	210	213	PF00017	0.549
LIG_SH2_STAT5	386	389	PF00017	0.586
LIG_SH2_STAT5	408	411	PF00017	0.509
LIG_SH2_STAT5	594	597	PF00017	0.376
LIG_SH2_STAT5	679	682	PF00017	0.363
LIG_SH2_STAT5	803	806	PF00017	0.348
LIG_SH3_1	376	382	PF00018	0.638
LIG_SH3_1	429	435	PF00018	0.708
LIG_SH3_3	11	17	PF00018	0.679
LIG_SH3_3	376	382	PF00018	0.587
LIG_SH3_3	389	395	PF00018	0.580
LIG_SH3_3	429	435	PF00018	0.679
LIG_SH3_3	49	55	PF00018	0.565
LIG_SH3_3	628	634	PF00018	0.398
LIG_SH3_3	668	674	PF00018	0.455
LIG_SH3_3	849	855	PF00018	0.381
LIG_SUMO_SIM_anti_2	655	661	PF11976	0.449
LIG_SUMO_SIM_anti_2	696	702	PF11976	0.347
LIG_SUMO_SIM_anti_2	728	734	PF11976	0.376
LIG_SUMO_SIM_par_1	467	474	PF11976	0.439
LIG_SUMO_SIM_par_1	696	702	PF11976	0.346
LIG_SUMO_SIM_par_1	730	737	PF11976	0.340
LIG_TRAF2_1	641	644	PF00917	0.396
LIG_TRAF2_1	691	694	PF00917	0.344
LIG_TYR_ITIM	297	302	PF00017	0.514
LIG_UBA3_1	104	111	PF00899	0.519
LIG_WRC_WIRS_1	803	808	PF05994	0.364
LIG_WW_3	480	484	PF00397	0.437
MOD_CDC14_SPxK_1	528	531	PF00782	0.449
MOD_CDK_SPK_2	240	245	PF00069	0.706
MOD_CDK_SPK_2	324	329	PF00069	0.689
MOD_CDK_SPxK_1	525	531	PF00069	0.449
MOD_CDK_SPxxK_3	171	178	PF00069	0.671
MOD_CDK_SPxxK_3	240	247	PF00069	0.752
MOD_CK1_1	150	156	PF00069	0.652
MOD_CK1_1	169	175	PF00069	0.637
MOD_CK1_1	177	183	PF00069	0.628
MOD_CK1_1	217	223	PF00069	0.411
MOD_CK1_1	243	249	PF00069	0.813
MOD_CK1_1	57	63	PF00069	0.647
MOD_CK1_1	629	635	PF00069	0.472
MOD_CK1_1	865	871	PF00069	0.651
MOD_CK2_1	234	240	PF00069	0.684
MOD_CK2_1	271	277	PF00069	0.595
MOD_CK2_1	29	35	PF00069	0.545
MOD_CK2_1	304	310	PF00069	0.558
MOD_CK2_1	342	348	PF00069	0.659
MOD_CK2_1	441	447	PF00069	0.413
MOD_CK2_1	467	473	PF00069	0.450
MOD_CK2_1	638	644	PF00069	0.360
MOD_CK2_1	688	694	PF00069	0.385
MOD_CK2_1	778	784	PF00069	0.292
MOD_CK2_1	793	799	PF00069	0.437
MOD_CK2_1	853	859	PF00069	0.439
MOD_GlcNHglycan	115	118	PF01048	0.651
MOD_GlcNHglycan	171	174	PF01048	0.756
MOD_GlcNHglycan	179	182	PF01048	0.594
MOD_GlcNHglycan	219	222	PF01048	0.467
MOD_GlcNHglycan	236	239	PF01048	0.731
MOD_GlcNHglycan	35	39	PF01048	0.509
MOD_GlcNHglycan	369	372	PF01048	0.692
MOD_GlcNHglycan	539	542	PF01048	0.464
MOD_GlcNHglycan	599	602	PF01048	0.463
MOD_GlcNHglycan	660	663	PF01048	0.321
MOD_GlcNHglycan	719	722	PF01048	0.458
MOD_GSK3_1	113	120	PF00069	0.474
MOD_GSK3_1	147	154	PF00069	0.518
MOD_GSK3_1	162	169	PF00069	0.631
MOD_GSK3_1	177	184	PF00069	0.532
MOD_GSK3_1	210	217	PF00069	0.510
MOD_GSK3_1	236	243	PF00069	0.733
MOD_GSK3_1	246	253	PF00069	0.782
MOD_GSK3_1	266	273	PF00069	0.420
MOD_GSK3_1	300	307	PF00069	0.529
MOD_GSK3_1	450	457	PF00069	0.451
MOD_GSK3_1	51	58	PF00069	0.550
MOD_GSK3_1	64	71	PF00069	0.479
MOD_GSK3_1	658	665	PF00069	0.383
MOD_GSK3_1	739	746	PF00069	0.315
MOD_GSK3_1	776	783	PF00069	0.443
MOD_GSK3_1	784	791	PF00069	0.421
MOD_GSK3_1	862	869	PF00069	0.554
MOD_N-GLC_1	342	347	PF02516	0.654
MOD_N-GLC_1	455	460	PF02516	0.413
MOD_N-GLC_1	510	515	PF02516	0.423
MOD_N-GLC_1	583	588	PF02516	0.475
MOD_NEK2_1	214	219	PF00069	0.413
MOD_NEK2_1	223	228	PF00069	0.436
MOD_NEK2_1	358	363	PF00069	0.799
MOD_NEK2_1	626	631	PF00069	0.475
MOD_NEK2_1	658	663	PF00069	0.339
MOD_NEK2_1	743	748	PF00069	0.334
MOD_NEK2_1	750	755	PF00069	0.330
MOD_NEK2_1	866	871	PF00069	0.665
MOD_PIKK_1	128	134	PF00454	0.691
MOD_PIKK_1	147	153	PF00454	0.607
MOD_PIKK_1	250	256	PF00454	0.741
MOD_PIKK_1	441	447	PF00454	0.487
MOD_PIKK_1	725	731	PF00454	0.463
MOD_PIKK_1	750	756	PF00454	0.421
MOD_PK_1	93	99	PF00069	0.507
MOD_PKA_1	133	139	PF00069	0.528
MOD_PKA_1	292	298	PF00069	0.571
MOD_PKA_1	607	613	PF00069	0.242
MOD_PKA_2	133	139	PF00069	0.528
MOD_PKA_2	169	175	PF00069	0.717
MOD_PKA_2	177	183	PF00069	0.530
MOD_PKA_2	246	252	PF00069	0.649
MOD_PKA_2	27	33	PF00069	0.621
MOD_PKA_2	271	277	PF00069	0.607
MOD_PKA_2	292	298	PF00069	0.519
MOD_PKA_2	300	306	PF00069	0.428
MOD_PKA_2	537	543	PF00069	0.418
MOD_PKA_2	662	668	PF00069	0.395
MOD_PKA_2	788	794	PF00069	0.447
MOD_PKA_2	819	825	PF00069	0.398
MOD_PKB_1	91	99	PF00069	0.568
MOD_Plk_1	531	537	PF00069	0.389
MOD_Plk_1	583	589	PF00069	0.470
MOD_Plk_1	693	699	PF00069	0.364
MOD_Plk_1	767	773	PF00069	0.418
MOD_Plk_2-3	236	242	PF00069	0.662
MOD_Plk_4	138	144	PF00069	0.539
MOD_Plk_4	210	216	PF00069	0.526
MOD_Plk_4	271	277	PF00069	0.588
MOD_Plk_4	467	473	PF00069	0.412
MOD_Plk_4	531	537	PF00069	0.398
MOD_Plk_4	693	699	PF00069	0.357
MOD_Plk_4	704	710	PF00069	0.304
MOD_Plk_4	743	749	PF00069	0.326
MOD_ProDKin_1	162	168	PF00069	0.775
MOD_ProDKin_1	171	177	PF00069	0.800
MOD_ProDKin_1	201	207	PF00069	0.584
MOD_ProDKin_1	240	246	PF00069	0.799
MOD_ProDKin_1	324	330	PF00069	0.691
MOD_ProDKin_1	331	337	PF00069	0.728
MOD_ProDKin_1	360	366	PF00069	0.746
MOD_ProDKin_1	455	461	PF00069	0.385
MOD_ProDKin_1	51	57	PF00069	0.572
MOD_ProDKin_1	525	531	PF00069	0.449
MOD_ProDKin_1	547	553	PF00069	0.385
MOD_SUMO_for_1	229	232	PF00179	0.593
MOD_SUMO_rev_2	193	200	PF00179	0.570
MOD_SUMO_rev_2	285	294	PF00179	0.641
MOD_SUMO_rev_2	406	415	PF00179	0.584
TRG_DiLeu_BaEn_1	694	699	PF01217	0.344
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.447
TRG_ENDOCYTIC_2	299	302	PF00928	0.514
TRG_ENDOCYTIC_2	419	422	PF00928	0.480
TRG_ENDOCYTIC_2	803	806	PF00928	0.320
TRG_ENDOCYTIC_2	857	860	PF00928	0.330
TRG_ER_diArg_1	133	135	PF00400	0.583
TRG_ER_diArg_1	26	29	PF00400	0.671
TRG_ER_diArg_1	316	318	PF00400	0.623
TRG_ER_diArg_1	373	376	PF00400	0.677
TRG_ER_diArg_1	402	405	PF00400	0.570
TRG_ER_diArg_1	482	485	PF00400	0.347
TRG_ER_diArg_1	486	489	PF00400	0.344
TRG_ER_diArg_1	645	648	PF00400	0.449
TRG_ER_diArg_1	808	810	PF00400	0.475
TRG_ER_diArg_1	91	93	PF00400	0.539
TRG_NES_CRM1_1	39	51	PF08389	0.591
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	569	573	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	724	729	PF00026	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ54	Leptomonas seymouri	63%	100%
A0A0S4JLJ6	Bodo saltans	30%	91%
A0A1X0P1B7	Trypanosomatidae	38%	100%
A0A422NMF0	Trypanosoma rangeli	38%	100%
A4HIT0	Leishmania braziliensis	85%	100%
A4I632	Leishmania infantum	99%	100%
C9ZRF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B1B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6U7	Leishmania major	94%	100%
V5B765	Trypanosoma cruzi	37%	100%