Intergrin_alpha_chain_protein_putative/GeneDB:Lmj F.31.0110

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FG-GAP repeat protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X408_LEIDO

TriTrypDb:

LdBPK_310120.1 , LdCL_310006100 , LDHU3_31.0150

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 2
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7X408

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X408

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	734	738	PF00656	0.398
CLV_C14_Caspase3-7	77	81	PF00656	0.273
CLV_NRD_NRD_1	181	183	PF00675	0.582
CLV_NRD_NRD_1	198	200	PF00675	0.682
CLV_PCSK_KEX2_1	146	148	PF00082	0.574
CLV_PCSK_KEX2_1	181	183	PF00082	0.564
CLV_PCSK_KEX2_1	197	199	PF00082	0.694
CLV_PCSK_KEX2_1	289	291	PF00082	0.652
CLV_PCSK_KEX2_1	682	684	PF00082	0.571
CLV_PCSK_KEX2_1	771	773	PF00082	0.408
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.574
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.652
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.558
CLV_PCSK_PC1ET2_1	771	773	PF00082	0.433
CLV_PCSK_SKI1_1	289	293	PF00082	0.742
CLV_PCSK_SKI1_1	305	309	PF00082	0.621
CLV_PCSK_SKI1_1	65	69	PF00082	0.467
DEG_APCC_DBOX_1	272	280	PF00400	0.425
DEG_APCC_DBOX_1	712	720	PF00400	0.353
DEG_Nend_Nbox_1	1	3	PF02207	0.649
DEG_ODPH_VHL_1	2	15	PF01847	0.501
DEG_SCF_FBW7_1	164	170	PF00400	0.498
DEG_SCF_FBW7_1	323	330	PF00400	0.391
DEG_SPOP_SBC_1	28	32	PF00917	0.452
DOC_CDC14_PxL_1	137	145	PF14671	0.394
DOC_CKS1_1	164	169	PF01111	0.511
DOC_CKS1_1	324	329	PF01111	0.289
DOC_CKS1_1	404	409	PF01111	0.384
DOC_CKS1_1	51	56	PF01111	0.274
DOC_CYCLIN_yCln2_LP_2	404	410	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.342
DOC_CYCLIN_yCln2_LP_2	755	761	PF00134	0.362
DOC_MAPK_DCC_7	752	762	PF00069	0.362
DOC_MAPK_DCC_7	98	108	PF00069	0.307
DOC_MAPK_gen_1	179	188	PF00069	0.395
DOC_MAPK_gen_1	302	312	PF00069	0.436
DOC_MAPK_gen_1	682	689	PF00069	0.299
DOC_MAPK_MEF2A_6	273	280	PF00069	0.468
DOC_MAPK_MEF2A_6	682	691	PF00069	0.328
DOC_MAPK_MEF2A_6	718	727	PF00069	0.293
DOC_MAPK_MEF2A_6	752	759	PF00069	0.396
DOC_MAPK_NFAT4_5	273	281	PF00069	0.447
DOC_MAPK_RevD_3	758	772	PF00069	0.413
DOC_PP1_RVXF_1	495	501	PF00149	0.373
DOC_PP2B_LxvP_1	138	141	PF13499	0.398
DOC_PP2B_LxvP_1	727	730	PF13499	0.341
DOC_PP2B_LxvP_1	755	758	PF13499	0.413
DOC_PP4_FxxP_1	702	705	PF00568	0.371
DOC_PP4_FxxP_1	92	95	PF00568	0.325
DOC_USP7_MATH_1	213	217	PF00917	0.416
DOC_USP7_MATH_1	272	276	PF00917	0.365
DOC_USP7_MATH_1	480	484	PF00917	0.318
DOC_USP7_MATH_1	630	634	PF00917	0.355
DOC_USP7_MATH_1	681	685	PF00917	0.449
DOC_WW_Pin1_4	163	168	PF00397	0.454
DOC_WW_Pin1_4	266	271	PF00397	0.431
DOC_WW_Pin1_4	323	328	PF00397	0.296
DOC_WW_Pin1_4	403	408	PF00397	0.310
DOC_WW_Pin1_4	449	454	PF00397	0.328
DOC_WW_Pin1_4	50	55	PF00397	0.272
DOC_WW_Pin1_4	620	625	PF00397	0.323
DOC_WW_Pin1_4	650	655	PF00397	0.334
DOC_WW_Pin1_4	677	682	PF00397	0.361
DOC_WW_Pin1_4	99	104	PF00397	0.287
LIG_14-3-3_CanoR_1	229	235	PF00244	0.426
LIG_14-3-3_CanoR_1	273	277	PF00244	0.475
LIG_14-3-3_CanoR_1	290	299	PF00244	0.387
LIG_14-3-3_CanoR_1	305	312	PF00244	0.414
LIG_14-3-3_CanoR_1	497	501	PF00244	0.374
LIG_14-3-3_CanoR_1	683	688	PF00244	0.402
LIG_14-3-3_CanoR_1	718	724	PF00244	0.307
LIG_14-3-3_CanoR_1	96	101	PF00244	0.349
LIG_APCC_ABBA_1	695	700	PF00400	0.268
LIG_APCC_ABBAyCdc20_2	694	700	PF00400	0.272
LIG_BRCT_BRCA1_1	308	312	PF00533	0.319
LIG_BRCT_BRCA1_1	344	348	PF00533	0.251
LIG_BRCT_BRCA1_1	424	428	PF00533	0.312
LIG_BRCT_BRCA1_1	652	656	PF00533	0.326
LIG_BRCT_BRCA1_1	739	743	PF00533	0.394
LIG_FHA_1	168	174	PF00498	0.479
LIG_FHA_1	189	195	PF00498	0.462
LIG_FHA_1	324	330	PF00498	0.287
LIG_FHA_1	370	376	PF00498	0.299
LIG_FHA_1	404	410	PF00498	0.366
LIG_FHA_1	461	467	PF00498	0.417
LIG_FHA_1	51	57	PF00498	0.301
LIG_FHA_1	514	520	PF00498	0.308
LIG_FHA_1	581	587	PF00498	0.325
LIG_FHA_1	633	639	PF00498	0.407
LIG_FHA_1	664	670	PF00498	0.338
LIG_FHA_1	684	690	PF00498	0.294
LIG_FHA_1	705	711	PF00498	0.364
LIG_FHA_1	734	740	PF00498	0.366
LIG_FHA_1	752	758	PF00498	0.215
LIG_FHA_2	170	176	PF00498	0.508
LIG_FHA_2	187	193	PF00498	0.364
LIG_FHA_2	290	296	PF00498	0.586
LIG_FHA_2	328	334	PF00498	0.379
LIG_FHA_2	452	458	PF00498	0.399
LIG_FHA_2	497	503	PF00498	0.272
LIG_FHA_2	656	662	PF00498	0.393
LIG_FHA_2	670	676	PF00498	0.234
LIG_FHA_2	81	87	PF00498	0.372
LIG_Integrin_isoDGR_2	568	570	PF01839	0.487
LIG_LIR_Apic_2	48	54	PF02991	0.295
LIG_LIR_Apic_2	700	705	PF02991	0.284
LIG_LIR_Apic_2	99	103	PF02991	0.297
LIG_LIR_Gen_1	383	392	PF02991	0.291
LIG_LIR_Gen_1	622	632	PF02991	0.337
LIG_LIR_Gen_1	71	79	PF02991	0.357
LIG_LIR_Gen_1	717	727	PF02991	0.300
LIG_LIR_LC3C_4	122	127	PF02991	0.280
LIG_LIR_LC3C_4	606	609	PF02991	0.275
LIG_LIR_Nem_3	32	38	PF02991	0.430
LIG_LIR_Nem_3	383	389	PF02991	0.292
LIG_LIR_Nem_3	440	445	PF02991	0.319
LIG_LIR_Nem_3	499	503	PF02991	0.274
LIG_LIR_Nem_3	533	537	PF02991	0.388
LIG_LIR_Nem_3	644	650	PF02991	0.309
LIG_LIR_Nem_3	653	659	PF02991	0.335
LIG_LIR_Nem_3	670	674	PF02991	0.233
LIG_LIR_Nem_3	71	75	PF02991	0.301
LIG_LIR_Nem_3	717	723	PF02991	0.309
LIG_LYPXL_yS_3	35	38	PF13949	0.321
LIG_MLH1_MIPbox_1	344	348	PF16413	0.251
LIG_NBox_RRM_1	13	23	PF00076	0.447
LIG_PDZ_Class_2	780	785	PF00595	0.635
LIG_Pex14_2	428	432	PF04695	0.359
LIG_Pex14_2	667	671	PF04695	0.325
LIG_Pex14_2	743	747	PF04695	0.286
LIG_SH2_CRK	100	104	PF00017	0.301
LIG_SH2_CRK	51	55	PF00017	0.369
LIG_SH2_CRK	720	724	PF00017	0.308
LIG_SH2_CRK	753	757	PF00017	0.362
LIG_SH2_GRB2like	556	559	PF00017	0.319
LIG_SH2_PTP2	647	650	PF00017	0.272
LIG_SH2_STAP1	556	560	PF00017	0.310
LIG_SH2_STAP1	685	689	PF00017	0.325
LIG_SH2_STAP1	753	757	PF00017	0.390
LIG_SH2_STAT3	617	620	PF00017	0.281
LIG_SH2_STAT5	137	140	PF00017	0.355
LIG_SH2_STAT5	346	349	PF00017	0.267
LIG_SH2_STAT5	572	575	PF00017	0.263
LIG_SH2_STAT5	617	620	PF00017	0.368
LIG_SH2_STAT5	625	628	PF00017	0.375
LIG_SH2_STAT5	647	650	PF00017	0.277
LIG_SH2_STAT5	685	688	PF00017	0.322
LIG_SH2_STAT5	753	756	PF00017	0.329
LIG_SH3_2	164	169	PF14604	0.405
LIG_SH3_2	678	683	PF14604	0.362
LIG_SH3_3	161	167	PF00018	0.419
LIG_SH3_3	529	535	PF00018	0.289
LIG_SH3_3	64	70	PF00018	0.318
LIG_SH3_3	675	681	PF00018	0.345
LIG_SH3_3	709	715	PF00018	0.336
LIG_SH3_3	85	91	PF00018	0.399
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.489
LIG_SUMO_SIM_anti_2	337	342	PF11976	0.298
LIG_SUMO_SIM_anti_2	559	564	PF11976	0.279
LIG_SUMO_SIM_par_1	115	122	PF11976	0.369
LIG_SUMO_SIM_par_1	582	588	PF11976	0.397
LIG_SUMO_SIM_par_1	684	690	PF11976	0.428
LIG_TYR_ITIM	751	756	PF00017	0.362
LIG_WRC_WIRS_1	656	661	PF05994	0.356
LIG_WRC_WIRS_1	69	74	PF05994	0.391
MOD_CDC14_SPxK_1	680	683	PF00782	0.360
MOD_CDK_SPK_2	50	55	PF00069	0.272
MOD_CDK_SPK_2	677	682	PF00069	0.345
MOD_CDK_SPxK_1	163	169	PF00069	0.393
MOD_CDK_SPxK_1	677	683	PF00069	0.354
MOD_CDK_SPxxK_3	266	273	PF00069	0.424
MOD_CDK_SPxxK_3	650	657	PF00069	0.337
MOD_CK1_1	266	272	PF00069	0.499
MOD_CK2_1	169	175	PF00069	0.482
MOD_CK2_1	186	192	PF00069	0.290
MOD_CK2_1	290	296	PF00069	0.462
MOD_DYRK1A_RPxSP_1	163	167	PF00069	0.482
MOD_DYRK1A_RPxSP_1	677	681	PF00069	0.356
MOD_GlcNHglycan	121	124	PF01048	0.414
MOD_GlcNHglycan	292	295	PF01048	0.592
MOD_GlcNHglycan	42	45	PF01048	0.537
MOD_GlcNHglycan	449	452	PF01048	0.530
MOD_GlcNHglycan	480	483	PF01048	0.554
MOD_GlcNHglycan	516	519	PF01048	0.502
MOD_GlcNHglycan	577	580	PF01048	0.532
MOD_GlcNHglycan	641	644	PF01048	0.583
MOD_GlcNHglycan	762	765	PF01048	0.337
MOD_GSK3_1	163	170	PF00069	0.511
MOD_GSK3_1	184	191	PF00069	0.439
MOD_GSK3_1	323	330	PF00069	0.381
MOD_GSK3_1	390	397	PF00069	0.333
MOD_GSK3_1	447	454	PF00069	0.300
MOD_GSK3_1	456	463	PF00069	0.328
MOD_GSK3_1	46	53	PF00069	0.287
MOD_GSK3_1	478	485	PF00069	0.323
MOD_GSK3_1	619	626	PF00069	0.320
MOD_GSK3_1	669	676	PF00069	0.296
MOD_GSK3_1	677	684	PF00069	0.352
MOD_GSK3_1	731	738	PF00069	0.311
MOD_LATS_1	94	100	PF00433	0.361
MOD_N-GLC_1	28	33	PF02516	0.611
MOD_N-GLC_1	395	400	PF02516	0.540
MOD_N-GLC_1	478	483	PF02516	0.597
MOD_NEK2_1	186	191	PF00069	0.437
MOD_NEK2_1	284	289	PF00069	0.459
MOD_NEK2_1	342	347	PF00069	0.252
MOD_NEK2_1	369	374	PF00069	0.302
MOD_NEK2_1	390	395	PF00069	0.289
MOD_NEK2_1	40	45	PF00069	0.292
MOD_NEK2_1	421	426	PF00069	0.287
MOD_NEK2_1	513	518	PF00069	0.272
MOD_NEK2_1	574	579	PF00069	0.245
MOD_NEK2_1	607	612	PF00069	0.254
MOD_NEK2_1	619	624	PF00069	0.275
MOD_NEK2_1	641	646	PF00069	0.300
MOD_NEK2_1	719	724	PF00069	0.308
MOD_NEK2_1	735	740	PF00069	0.249
MOD_NEK2_1	760	765	PF00069	0.335
MOD_PIKK_1	29	35	PF00454	0.462
MOD_PIKK_1	70	76	PF00454	0.291
MOD_PK_1	198	204	PF00069	0.394
MOD_PKA_1	197	203	PF00069	0.489
MOD_PKA_1	289	295	PF00069	0.434
MOD_PKA_2	197	203	PF00069	0.458
MOD_PKA_2	228	234	PF00069	0.473
MOD_PKA_2	272	278	PF00069	0.438
MOD_PKA_2	289	295	PF00069	0.460
MOD_PKA_2	496	502	PF00069	0.347
MOD_PKA_2	523	529	PF00069	0.394
MOD_PKA_2	574	580	PF00069	0.334
MOD_Plk_1	184	190	PF00069	0.398
MOD_Plk_1	295	301	PF00069	0.448
MOD_Plk_1	414	420	PF00069	0.452
MOD_Plk_1	669	675	PF00069	0.327
MOD_Plk_1	687	693	PF00069	0.319
MOD_Plk_2-3	295	301	PF00069	0.372
MOD_Plk_2-3	414	420	PF00069	0.343
MOD_Plk_2-3	435	441	PF00069	0.255
MOD_Plk_2-3	496	502	PF00069	0.309
MOD_Plk_4	169	175	PF00069	0.523
MOD_Plk_4	198	204	PF00069	0.362
MOD_Plk_4	342	348	PF00069	0.251
MOD_Plk_4	46	52	PF00069	0.290
MOD_Plk_4	538	544	PF00069	0.322
MOD_Plk_4	589	595	PF00069	0.284
MOD_Plk_4	751	757	PF00069	0.349
MOD_ProDKin_1	163	169	PF00069	0.459
MOD_ProDKin_1	266	272	PF00069	0.426
MOD_ProDKin_1	323	329	PF00069	0.298
MOD_ProDKin_1	403	409	PF00069	0.308
MOD_ProDKin_1	449	455	PF00069	0.327
MOD_ProDKin_1	50	56	PF00069	0.271
MOD_ProDKin_1	620	626	PF00069	0.323
MOD_ProDKin_1	650	656	PF00069	0.334
MOD_ProDKin_1	677	683	PF00069	0.354
MOD_ProDKin_1	99	105	PF00069	0.293
MOD_SUMO_rev_2	227	235	PF00179	0.458
MOD_SUMO_rev_2	314	319	PF00179	0.351
MOD_SUMO_rev_2	470	475	PF00179	0.381
MOD_SUMO_rev_2	585	591	PF00179	0.372
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.380
TRG_ENDOCYTIC_2	137	140	PF00928	0.425
TRG_ENDOCYTIC_2	35	38	PF00928	0.396
TRG_ENDOCYTIC_2	625	628	PF00928	0.353
TRG_ENDOCYTIC_2	647	650	PF00928	0.272
TRG_ENDOCYTIC_2	720	723	PF00928	0.285
TRG_ENDOCYTIC_2	753	756	PF00928	0.362
TRG_ER_diArg_1	181	183	PF00400	0.386
TRG_ER_diArg_1	197	199	PF00400	0.524
TRG_ER_diArg_1	694	697	PF00400	0.353
TRG_NES_CRM1_1	717	733	PF08389	0.328
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U3	Leptomonas seymouri	67%	100%
A0A0S4JVN8	Bodo saltans	41%	90%
A0A1X0NSW9	Trypanosomatidae	47%	89%
A0A422NXM6	Trypanosoma rangeli	45%	92%
A4HIX5	Leishmania braziliensis	82%	100%
A4I6A4	Leishmania infantum	100%	100%
C9ZTY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9B1F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6Q3	Leishmania major	94%	100%
V5AJ13	Trypanosoma cruzi	44%	95%