Serine/threonine-protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X404_LEIDO

TriTrypDb:

LdBPK_303640.1 , LdCL_300041800 , LDHU3_30.4840

Length:

749

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X404

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X404

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0000245	spliceosomal complex assembly	7	1
GO:0007165	signal transduction	2	1
GO:0016043	cellular component organization	3	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035556	intracellular signal transduction	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0050684	regulation of mRNA processing	7	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065007	biological regulation	1	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903311	regulation of mRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004674	protein serine/threonine kinase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	371	375	PF00656	0.787
CLV_C14_Caspase3-7	587	591	PF00656	0.728
CLV_C14_Caspase3-7	695	699	PF00656	0.720
CLV_NRD_NRD_1	143	145	PF00675	0.473
CLV_NRD_NRD_1	25	27	PF00675	0.705
CLV_NRD_NRD_1	338	340	PF00675	0.523
CLV_NRD_NRD_1	348	350	PF00675	0.529
CLV_PCSK_KEX2_1	25	27	PF00082	0.660
CLV_PCSK_KEX2_1	269	271	PF00082	0.165
CLV_PCSK_KEX2_1	337	339	PF00082	0.544
CLV_PCSK_KEX2_1	609	611	PF00082	0.781
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.672
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.165
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.799
CLV_PCSK_SKI1_1	162	166	PF00082	0.363
CLV_PCSK_SKI1_1	26	30	PF00082	0.724
CLV_PCSK_SKI1_1	273	277	PF00082	0.342
CLV_PCSK_SKI1_1	330	334	PF00082	0.556
CLV_PCSK_SKI1_1	343	347	PF00082	0.488
CLV_PCSK_SKI1_1	350	354	PF00082	0.615
CLV_PCSK_SKI1_1	407	411	PF00082	0.328
CLV_PCSK_SKI1_1	500	504	PF00082	0.347
CLV_PCSK_SKI1_1	523	527	PF00082	0.410
CLV_PCSK_SKI1_1	641	645	PF00082	0.490
CLV_PCSK_SKI1_1	9	13	PF00082	0.780
DEG_APCC_DBOX_1	272	280	PF00400	0.344
DEG_SCF_FBW7_1	298	305	PF00400	0.413
DOC_ANK_TNKS_1	107	114	PF00023	0.811
DOC_CKS1_1	299	304	PF01111	0.413
DOC_CKS1_1	429	434	PF01111	0.319
DOC_MAPK_gen_1	183	191	PF00069	0.388
DOC_MAPK_gen_1	269	279	PF00069	0.322
DOC_MAPK_gen_1	416	425	PF00069	0.325
DOC_MAPK_HePTP_8	267	279	PF00069	0.165
DOC_MAPK_HePTP_8	413	425	PF00069	0.328
DOC_MAPK_MEF2A_6	270	279	PF00069	0.312
DOC_MAPK_MEF2A_6	416	425	PF00069	0.328
DOC_PP1_RVXF_1	163	170	PF00149	0.328
DOC_PP4_FxxP_1	30	33	PF00568	0.746
DOC_PP4_FxxP_1	313	316	PF00568	0.550
DOC_PP4_FxxP_1	531	534	PF00568	0.328
DOC_USP7_MATH_1	302	306	PF00917	0.517
DOC_USP7_MATH_1	33	37	PF00917	0.712
DOC_USP7_MATH_1	468	472	PF00917	0.449
DOC_USP7_MATH_1	608	612	PF00917	0.796
DOC_USP7_MATH_1	618	622	PF00917	0.671
DOC_USP7_UBL2_3	12	16	PF12436	0.686
DOC_USP7_UBL2_3	23	27	PF12436	0.730
DOC_USP7_UBL2_3	330	334	PF12436	0.563
DOC_USP7_UBL2_3	342	346	PF12436	0.530
DOC_USP7_UBL2_3	5	9	PF12436	0.707
DOC_USP7_UBL2_3	519	523	PF12436	0.342
DOC_USP7_UBL2_3	67	71	PF12436	0.588
DOC_WW_Pin1_4	298	303	PF00397	0.344
DOC_WW_Pin1_4	428	433	PF00397	0.331
DOC_WW_Pin1_4	542	547	PF00397	0.459
LIG_14-3-3_CanoR_1	321	329	PF00244	0.698
LIG_14-3-3_CanoR_1	349	353	PF00244	0.711
LIG_14-3-3_CanoR_1	671	680	PF00244	0.684
LIG_APCC_ABBA_1	244	249	PF00400	0.344
LIG_BRCT_BRCA1_1	620	624	PF00533	0.700
LIG_Clathr_ClatBox_1	276	280	PF01394	0.344
LIG_CtBP_PxDLS_1	478	482	PF00389	0.344
LIG_deltaCOP1_diTrp_1	383	391	PF00928	0.632
LIG_deltaCOP1_diTrp_1	434	443	PF00928	0.328
LIG_EH1_1	303	311	PF00400	0.495
LIG_eIF4E_1	203	209	PF01652	0.328
LIG_FHA_1	172	178	PF00498	0.328
LIG_FHA_1	32	38	PF00498	0.630
LIG_FHA_1	408	414	PF00498	0.328
LIG_FHA_1	675	681	PF00498	0.655
LIG_FHA_2	126	132	PF00498	0.698
LIG_FHA_2	133	139	PF00498	0.420
LIG_FHA_2	323	329	PF00498	0.683
LIG_FHA_2	380	386	PF00498	0.610
LIG_FHA_2	429	435	PF00498	0.328
LIG_FHA_2	587	593	PF00498	0.754
LIG_FHA_2	634	640	PF00498	0.561
LIG_FHA_2	642	648	PF00498	0.474
LIG_FHA_2	734	740	PF00498	0.803
LIG_Integrin_RGD_1	363	365	PF01839	0.816
LIG_LIR_Apic_2	415	421	PF02991	0.328
LIG_LIR_Apic_2	427	432	PF02991	0.328
LIG_LIR_Apic_2	530	534	PF02991	0.344
LIG_LIR_Gen_1	184	191	PF02991	0.329
LIG_LIR_Gen_1	200	209	PF02991	0.286
LIG_LIR_Gen_1	389	399	PF02991	0.413
LIG_LIR_Nem_3	159	164	PF02991	0.334
LIG_LIR_Nem_3	200	206	PF02991	0.354
LIG_LIR_Nem_3	259	263	PF02991	0.346
LIG_LIR_Nem_3	389	394	PF02991	0.538
LIG_LIR_Nem_3	405	409	PF02991	0.225
LIG_LIR_Nem_3	485	491	PF02991	0.427
LIG_LIR_Nem_3	504	510	PF02991	0.256
LIG_LIR_Nem_3	554	559	PF02991	0.448
LIG_LIR_Nem_3	561	567	PF02991	0.490
LIG_MAD2	716	724	PF02301	0.610
LIG_MYND_3	533	537	PF01753	0.319
LIG_Pex14_2	172	176	PF04695	0.314
LIG_PTB_Apo_2	155	162	PF02174	0.473
LIG_PTB_Apo_2	631	638	PF02174	0.576
LIG_PTB_Phospho_1	155	161	PF10480	0.477
LIG_PTB_Phospho_1	631	637	PF10480	0.581
LIG_Rb_pABgroove_1	238	246	PF01858	0.474
LIG_SH2_CRK	161	165	PF00017	0.392
LIG_SH2_CRK	260	264	PF00017	0.328
LIG_SH2_CRK	341	345	PF00017	0.511
LIG_SH2_CRK	429	433	PF00017	0.319
LIG_SH2_CRK	564	568	PF00017	0.596
LIG_SH2_GRB2like	492	495	PF00017	0.406
LIG_SH2_NCK_1	198	202	PF00017	0.344
LIG_SH2_NCK_1	598	602	PF00017	0.754
LIG_SH2_SRC	203	206	PF00017	0.328
LIG_SH2_STAP1	132	136	PF00017	0.616
LIG_SH2_STAP1	198	202	PF00017	0.354
LIG_SH2_STAT5	171	174	PF00017	0.328
LIG_SH2_STAT5	229	232	PF00017	0.363
LIG_SH2_STAT5	637	640	PF00017	0.570
LIG_SUMO_SIM_anti_2	284	291	PF11976	0.344
LIG_SUMO_SIM_anti_2	305	311	PF11976	0.540
LIG_SUMO_SIM_anti_2	463	472	PF11976	0.328
LIG_SUMO_SIM_par_1	249	256	PF11976	0.328
LIG_SUMO_SIM_par_1	430	437	PF11976	0.319
LIG_TRAF2_1	345	348	PF00917	0.632
LIG_TRAF2_1	582	585	PF00917	0.729
LIG_TRAF2_1	737	740	PF00917	0.734
LIG_TYR_ITIM	505	510	PF00017	0.449
LIG_UBA3_1	306	311	PF00899	0.466
MOD_CDK_SPK_2	298	303	PF00069	0.344
MOD_CK1_1	194	200	PF00069	0.449
MOD_CK1_1	305	311	PF00069	0.537
MOD_CK1_1	35	41	PF00069	0.670
MOD_CK1_1	377	383	PF00069	0.745
MOD_CK1_1	402	408	PF00069	0.328
MOD_CK1_1	591	597	PF00069	0.718
MOD_CK1_1	600	606	PF00069	0.768
MOD_CK1_1	674	680	PF00069	0.624
MOD_CK2_1	106	112	PF00069	0.764
MOD_CK2_1	132	138	PF00069	0.599
MOD_CK2_1	194	200	PF00069	0.449
MOD_CK2_1	250	256	PF00069	0.346
MOD_CK2_1	379	385	PF00069	0.647
MOD_CK2_1	458	464	PF00069	0.328
MOD_CK2_1	571	577	PF00069	0.651
MOD_CK2_1	579	585	PF00069	0.711
MOD_CK2_1	633	639	PF00069	0.579
MOD_CK2_1	733	739	PF00069	0.803
MOD_CMANNOS	176	179	PF00535	0.328
MOD_Cter_Amidation	68	71	PF01082	0.621
MOD_GlcNHglycan	193	196	PF01048	0.328
MOD_GlcNHglycan	571	576	PF01048	0.692
MOD_GlcNHglycan	577	582	PF01048	0.720
MOD_GlcNHglycan	599	602	PF01048	0.734
MOD_GSK3_1	102	109	PF00069	0.771
MOD_GSK3_1	12	19	PF00069	0.777
MOD_GSK3_1	298	305	PF00069	0.413
MOD_GSK3_1	31	38	PF00069	0.699
MOD_GSK3_1	328	335	PF00069	0.574
MOD_GSK3_1	588	595	PF00069	0.736
MOD_GSK3_1	596	603	PF00069	0.730
MOD_GSK3_1	604	611	PF00069	0.714
MOD_GSK3_1	674	681	PF00069	0.631
MOD_GSK3_1	704	711	PF00069	0.767
MOD_N-GLC_1	235	240	PF02516	0.384
MOD_N-GLC_1	633	638	PF02516	0.573
MOD_N-GLC_2	220	222	PF02516	0.436
MOD_N-GLC_2	401	403	PF02516	0.328
MOD_NEK2_1	1	6	PF00069	0.777
MOD_NEK2_1	230	235	PF00069	0.344
MOD_NEK2_1	332	337	PF00069	0.522
MOD_NEK2_1	399	404	PF00069	0.317
MOD_NEK2_1	633	638	PF00069	0.573
MOD_NEK2_1	82	87	PF00069	0.687
MOD_PIKK_1	332	338	PF00454	0.538
MOD_PIKK_1	592	598	PF00454	0.721
MOD_PIKK_1	705	711	PF00454	0.795
MOD_PKA_1	16	22	PF00069	0.797
MOD_PKA_2	348	354	PF00069	0.710
MOD_PKA_2	41	47	PF00069	0.677
MOD_Plk_1	633	639	PF00069	0.545
MOD_Plk_2-3	586	592	PF00069	0.828
MOD_Plk_2-3	734	740	PF00069	0.790
MOD_Plk_4	171	177	PF00069	0.328
MOD_Plk_4	250	256	PF00069	0.328
MOD_Plk_4	302	308	PF00069	0.512
MOD_Plk_4	348	354	PF00069	0.698
MOD_Plk_4	647	653	PF00069	0.606
MOD_ProDKin_1	298	304	PF00069	0.344
MOD_ProDKin_1	428	434	PF00069	0.331
MOD_ProDKin_1	542	548	PF00069	0.459
MOD_SUMO_for_1	292	295	PF00179	0.328
MOD_SUMO_for_1	345	348	PF00179	0.603
MOD_SUMO_rev_2	199	209	PF00179	0.347
MOD_SUMO_rev_2	286	294	PF00179	0.344
MOD_SUMO_rev_2	326	332	PF00179	0.581
MOD_SUMO_rev_2	347	352	PF00179	0.702
MOD_SUMO_rev_2	355	362	PF00179	0.655
MOD_SUMO_rev_2	55	63	PF00179	0.715
TRG_DiLeu_BaEn_1	348	353	PF01217	0.665
TRG_DiLeu_BaEn_1	668	673	PF01217	0.494
TRG_DiLeu_BaEn_1	675	680	PF01217	0.580
TRG_DiLeu_BaEn_2	526	532	PF01217	0.344
TRG_DiLeu_BaEn_4	628	634	PF01217	0.585
TRG_DiLeu_BaEn_4	675	681	PF01217	0.691
TRG_DiLeu_LyEn_5	668	673	PF01217	0.536
TRG_ENDOCYTIC_2	148	151	PF00928	0.402
TRG_ENDOCYTIC_2	161	164	PF00928	0.314
TRG_ENDOCYTIC_2	186	189	PF00928	0.357
TRG_ENDOCYTIC_2	203	206	PF00928	0.241
TRG_ENDOCYTIC_2	260	263	PF00928	0.328
TRG_ENDOCYTIC_2	341	344	PF00928	0.512
TRG_ENDOCYTIC_2	406	409	PF00928	0.332
TRG_ENDOCYTIC_2	507	510	PF00928	0.449
TRG_ENDOCYTIC_2	564	567	PF00928	0.535
TRG_ER_diArg_1	337	339	PF00400	0.582
TRG_NLS_Bipartite_1	16	30	PF00514	0.746
TRG_NLS_MonoExtC_3	24	29	PF00514	0.730
TRG_NLS_MonoExtC_3	521	526	PF00514	0.385
TRG_NLS_MonoExtC_3	66	71	PF00514	0.720
TRG_NLS_MonoExtN_4	23	30	PF00514	0.741
TRG_NLS_MonoExtN_4	519	526	PF00514	0.385
TRG_NLS_MonoExtN_4	65	71	PF00514	0.768
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H8	Leptomonas seymouri	81%	100%
A0A0S4JMD1	Bodo saltans	55%	97%
A0A1X0P1B0	Trypanosomatidae	60%	100%
A0A3R7KF70	Trypanosoma rangeli	58%	100%
A4HIU4	Leishmania braziliensis	84%	100%
A4I649	Leishmania infantum	99%	100%
C9ZRG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B1D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6T0	Leishmania major	95%	100%
V5B752	Trypanosoma cruzi	63%	100%