LeishMANIAdb
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Serine/threonine-protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein kinase, putative
Gene product:
serine/threonine-protein kinase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X404_LEIDO
TriTrypDb:
LdBPK_303640.1 * , LdCL_300041800 , LDHU3_30.4840
Length:
749

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3S7X404
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X404

Function

Biological processes
TermNameLevelCount
GO:0000245 spliceosomal complex assembly 7 1
GO:0006468 protein phosphorylation 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0007165 signal transduction 2 1
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 1
GO:0016310 phosphorylation 5 12
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Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004672 protein kinase activity 3 12
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016301 kinase activity 4 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 12
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 371 375 PF00656 0.787
CLV_C14_Caspase3-7 587 591 PF00656 0.728
CLV_C14_Caspase3-7 695 699 PF00656 0.720
CLV_NRD_NRD_1 143 145 PF00675 0.473
CLV_NRD_NRD_1 25 27 PF00675 0.705
CLV_NRD_NRD_1 338 340 PF00675 0.523
CLV_NRD_NRD_1 348 350 PF00675 0.529
CLV_PCSK_KEX2_1 25 27 PF00082 0.660
CLV_PCSK_KEX2_1 269 271 PF00082 0.165
CLV_PCSK_KEX2_1 337 339 PF00082 0.544
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1I1H8 Leptomonas seymouri 81% 100%
A0A0S4JMD1 Bodo saltans 55% 97%
A0A1X0P1B0 Trypanosomatidae 60% 100%
A0A3R7KF70 Trypanosoma rangeli 58% 100%
A4HIU4 Leishmania braziliensis 84% 100%
A4I649 Leishmania infantum 99% 100%
C9ZRG9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9B1D2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q6T0 Leishmania major 95% 100%
V5B752 Trypanosoma cruzi 63% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS