Dynein regulatory complex subunit 7

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF773), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X403_LEIDO

TriTrypDb:

LdBPK_303670.1 , LdCL_300042100 , LDHU3_30.4890

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X403

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X403

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.572
CLV_C14_Caspase3-7	187	191	PF00656	0.374
CLV_NRD_NRD_1	19	21	PF00675	0.463
CLV_NRD_NRD_1	25	27	PF00675	0.469
CLV_NRD_NRD_1	287	289	PF00675	0.399
CLV_NRD_NRD_1	375	377	PF00675	0.545
CLV_NRD_NRD_1	85	87	PF00675	0.325
CLV_PCSK_KEX2_1	287	289	PF00082	0.464
CLV_PCSK_KEX2_1	375	377	PF00082	0.515
CLV_PCSK_KEX2_1	84	86	PF00082	0.286
CLV_PCSK_SKI1_1	133	137	PF00082	0.324
CLV_PCSK_SKI1_1	21	25	PF00082	0.462
CLV_PCSK_SKI1_1	287	291	PF00082	0.465
CLV_PCSK_SKI1_1	375	379	PF00082	0.469
CLV_PCSK_SKI1_1	55	59	PF00082	0.356
CLV_PCSK_SKI1_1	86	90	PF00082	0.255
DEG_APCC_DBOX_1	75	83	PF00400	0.446
DOC_CDC14_PxL_1	36	44	PF14671	0.470
DOC_MAPK_FxFP_2	158	161	PF00069	0.482
DOC_MAPK_gen_1	314	324	PF00069	0.569
DOC_PP4_FxxP_1	158	161	PF00568	0.482
DOC_USP7_MATH_1	307	311	PF00917	0.548
DOC_USP7_MATH_2	230	236	PF00917	0.572
DOC_USP7_UBL2_3	55	59	PF12436	0.531
LIG_14-3-3_CanoR_1	165	174	PF00244	0.543
LIG_14-3-3_CanoR_1	20	24	PF00244	0.534
LIG_14-3-3_CanoR_1	288	298	PF00244	0.417
LIG_14-3-3_CanoR_1	328	336	PF00244	0.506
LIG_14-3-3_CanoR_1	356	361	PF00244	0.438
LIG_14-3-3_CanoR_1	84	89	PF00244	0.557
LIG_AP2alpha_2	154	156	PF02296	0.572
LIG_BIR_III_4	183	187	PF00653	0.572
LIG_FHA_1	237	243	PF00498	0.476
LIG_FHA_1	271	277	PF00498	0.594
LIG_FHA_1	281	287	PF00498	0.467
LIG_FHA_2	222	228	PF00498	0.552
LIG_FHA_2	279	285	PF00498	0.531
LIG_FHA_2	364	370	PF00498	0.561
LIG_GBD_Chelix_1	379	387	PF00786	0.478
LIG_LIR_Gen_1	137	147	PF02991	0.536
LIG_LIR_Gen_1	31	40	PF02991	0.493
LIG_LIR_Nem_3	137	142	PF02991	0.547
LIG_LIR_Nem_3	208	212	PF02991	0.550
LIG_LIR_Nem_3	31	35	PF02991	0.480
LIG_PDZ_Class_2	383	388	PF00595	0.540
LIG_Pex14_2	156	160	PF04695	0.481
LIG_SH2_CRK	139	143	PF00017	0.531
LIG_SH2_CRK	32	36	PF00017	0.522
LIG_SH2_CRK	48	52	PF00017	0.427
LIG_SH2_GRB2like	138	141	PF00017	0.572
LIG_SH2_NCK_1	48	52	PF00017	0.450
LIG_SH2_SRC	172	175	PF00017	0.572
LIG_SH2_SRC	48	51	PF00017	0.440
LIG_SUMO_SIM_par_1	376	382	PF11976	0.480
LIG_TRAF2_1	123	126	PF00917	0.572
MOD_CK1_1	179	185	PF00069	0.572
MOD_CK1_1	22	28	PF00069	0.609
MOD_CK2_1	165	171	PF00069	0.572
MOD_CK2_1	221	227	PF00069	0.482
MOD_CK2_1	256	262	PF00069	0.520
MOD_CK2_1	278	284	PF00069	0.533
MOD_CK2_1	289	295	PF00069	0.444
MOD_CK2_1	363	369	PF00069	0.559
MOD_GlcNHglycan	249	252	PF01048	0.565
MOD_GlcNHglycan	291	294	PF01048	0.556
MOD_GSK3_1	232	239	PF00069	0.481
MOD_GSK3_1	352	359	PF00069	0.565
MOD_N-GLC_1	326	331	PF02516	0.593
MOD_NEK2_1	143	148	PF00069	0.518
MOD_NEK2_1	289	294	PF00069	0.556
MOD_NEK2_1	301	306	PF00069	0.453
MOD_PIKK_1	74	80	PF00454	0.572
MOD_PKA_1	84	90	PF00069	0.375
MOD_PKA_2	19	25	PF00069	0.534
MOD_PKA_2	270	276	PF00069	0.534
MOD_PKA_2	307	313	PF00069	0.498
MOD_PKA_2	327	333	PF00069	0.283
MOD_PKA_2	84	90	PF00069	0.375
MOD_Plk_1	232	238	PF00069	0.580
MOD_Plk_2-3	278	284	PF00069	0.501
MOD_Plk_4	19	25	PF00069	0.570
MOD_Plk_4	307	313	PF00069	0.552
MOD_SUMO_rev_2	14	23	PF00179	0.496
TRG_DiLeu_BaEn_1	31	36	PF01217	0.481
TRG_ENDOCYTIC_2	10	13	PF00928	0.423
TRG_ENDOCYTIC_2	139	142	PF00928	0.500
TRG_ENDOCYTIC_2	32	35	PF00928	0.511
TRG_ER_diArg_1	129	132	PF00400	0.582
TRG_ER_diArg_1	286	288	PF00400	0.551
TRG_ER_diArg_1	305	308	PF00400	0.490
TRG_ER_diArg_1	375	377	PF00400	0.515
TRG_ER_diArg_1	84	86	PF00400	0.529
TRG_NLS_MonoExtC_3	25	31	PF00514	0.478
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA07	Leptomonas seymouri	58%	100%
A0A0S4JRC2	Bodo saltans	27%	92%
A0A1X0P1A0	Trypanosomatidae	32%	94%
A0A3R7KHJ9	Trypanosoma rangeli	33%	100%
A4I652	Leishmania infantum	98%	100%
C9ZRH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
E9B1D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q6S7	Leishmania major	90%	100%
V5BMP1	Trypanosoma cruzi	32%	94%