RF-1 domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3Z9_LEIDO

TriTrypDb:

LdBPK_303600.1 , LdCL_300041400 , LDHU3_30.4790

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3Z9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003747	translation release factor activity	5	3
GO:0005488	binding	1	3
GO:0008079	translation termination factor activity	4	3
GO:0008135	translation factor activity, RNA binding	3	3
GO:0045182	translation regulator activity	1	3
GO:0090079	translation regulator activity, nucleic acid binding	2	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	62	66	PF00656	0.596
CLV_NRD_NRD_1	137	139	PF00675	0.510
CLV_NRD_NRD_1	165	167	PF00675	0.379
CLV_NRD_NRD_1	2	4	PF00675	0.758
CLV_NRD_NRD_1	200	202	PF00675	0.507
CLV_NRD_NRD_1	221	223	PF00675	0.643
CLV_NRD_NRD_1	328	330	PF00675	0.490
CLV_NRD_NRD_1	37	39	PF00675	0.582
CLV_NRD_NRD_1	438	440	PF00675	0.697
CLV_NRD_NRD_1	88	90	PF00675	0.470
CLV_PCSK_FUR_1	194	198	PF00082	0.527
CLV_PCSK_FUR_1	89	93	PF00082	0.554
CLV_PCSK_KEX2_1	137	139	PF00082	0.510
CLV_PCSK_KEX2_1	165	167	PF00082	0.392
CLV_PCSK_KEX2_1	196	198	PF00082	0.489
CLV_PCSK_KEX2_1	199	201	PF00082	0.487
CLV_PCSK_KEX2_1	2	4	PF00082	0.758
CLV_PCSK_KEX2_1	221	223	PF00082	0.608
CLV_PCSK_KEX2_1	32	34	PF00082	0.584
CLV_PCSK_KEX2_1	328	330	PF00082	0.503
CLV_PCSK_KEX2_1	36	38	PF00082	0.568
CLV_PCSK_KEX2_1	438	440	PF00082	0.678
CLV_PCSK_KEX2_1	88	90	PF00082	0.475
CLV_PCSK_KEX2_1	91	93	PF00082	0.521
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.624
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.612
CLV_PCSK_PC7_1	194	200	PF00082	0.505
CLV_PCSK_PC7_1	33	39	PF00082	0.559
CLV_PCSK_SKI1_1	112	116	PF00082	0.423
CLV_PCSK_SKI1_1	169	173	PF00082	0.391
CLV_PCSK_SKI1_1	186	190	PF00082	0.428
CLV_PCSK_SKI1_1	272	276	PF00082	0.492
CLV_PCSK_SKI1_1	328	332	PF00082	0.495
CLV_PCSK_SKI1_1	355	359	PF00082	0.497
DEG_APCC_DBOX_1	75	83	PF00400	0.437
DEG_Nend_UBRbox_1	1	4	PF02207	0.662
DOC_MAPK_gen_1	100	109	PF00069	0.585
DOC_MAPK_gen_1	154	163	PF00069	0.452
DOC_MAPK_gen_1	165	176	PF00069	0.358
DOC_MAPK_gen_1	218	228	PF00069	0.594
DOC_MAPK_gen_1	438	447	PF00069	0.751
DOC_MAPK_gen_1	76	84	PF00069	0.494
DOC_MAPK_HePTP_8	151	163	PF00069	0.494
DOC_MAPK_MEF2A_6	154	163	PF00069	0.463
DOC_MAPK_MEF2A_6	169	176	PF00069	0.324
DOC_MAPK_MEF2A_6	383	391	PF00069	0.523
DOC_MAPK_NFAT4_5	169	177	PF00069	0.428
DOC_USP7_MATH_1	217	221	PF00917	0.501
DOC_USP7_MATH_1	234	238	PF00917	0.575
DOC_USP7_MATH_1	26	30	PF00917	0.704
DOC_USP7_MATH_1	274	278	PF00917	0.560
DOC_USP7_MATH_1	282	286	PF00917	0.629
DOC_USP7_MATH_1	316	320	PF00917	0.588
DOC_USP7_MATH_1	351	355	PF00917	0.639
DOC_USP7_MATH_1	374	378	PF00917	0.458
DOC_USP7_MATH_1	416	420	PF00917	0.665
DOC_USP7_MATH_1	8	12	PF00917	0.621
DOC_WW_Pin1_4	230	235	PF00397	0.565
DOC_WW_Pin1_4	396	401	PF00397	0.460
DOC_WW_Pin1_4	450	455	PF00397	0.717
LIG_14-3-3_CanoR_1	137	147	PF00244	0.494
LIG_14-3-3_CanoR_1	200	206	PF00244	0.528
LIG_14-3-3_CanoR_1	328	338	PF00244	0.488
LIG_14-3-3_CanoR_1	380	390	PF00244	0.503
LIG_14-3-3_CanoR_1	45	55	PF00244	0.557
LIG_14-3-3_CanoR_1	9	13	PF00244	0.626
LIG_Actin_WH2_2	330	345	PF00022	0.522
LIG_BRCT_BRCA1_1	105	109	PF00533	0.415
LIG_BRCT_BRCA1_1	9	13	PF00533	0.755
LIG_BRCT_BRCA1_2	105	111	PF00533	0.506
LIG_CSL_BTD_1	266	269	PF09270	0.523
LIG_FHA_1	139	145	PF00498	0.423
LIG_FHA_1	253	259	PF00498	0.452
LIG_FHA_1	442	448	PF00498	0.672
LIG_FHA_2	14	20	PF00498	0.716
LIG_FHA_2	284	290	PF00498	0.570
LIG_LIR_Apic_2	102	108	PF02991	0.583
LIG_LIR_Gen_1	332	342	PF02991	0.512
LIG_LIR_Nem_3	102	107	PF02991	0.583
LIG_LIR_Nem_3	156	161	PF02991	0.425
LIG_LIR_Nem_3	266	271	PF02991	0.445
LIG_LIR_Nem_3	332	337	PF02991	0.516
LIG_LIR_Nem_3	384	389	PF02991	0.436
LIG_Pex14_1	386	390	PF04695	0.487
LIG_Pex14_2	158	162	PF04695	0.430
LIG_Pex14_2	334	338	PF04695	0.377
LIG_REV1ctd_RIR_1	112	120	PF16727	0.431
LIG_REV1ctd_RIR_1	406	415	PF16727	0.435
LIG_RPA_C_Fungi	160	172	PF08784	0.473
LIG_RPA_C_Insects	160	175	PF08784	0.513
LIG_SH2_CRK	105	109	PF00017	0.500
LIG_SH2_CRK	390	394	PF00017	0.497
LIG_SH2_NCK_1	105	109	PF00017	0.535
LIG_SH2_SRC	303	306	PF00017	0.566
LIG_SH2_STAT5	113	116	PF00017	0.391
LIG_SH2_STAT5	207	210	PF00017	0.591
LIG_SH2_STAT5	297	300	PF00017	0.368
LIG_SH3_3	448	454	PF00018	0.648
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.426
LIG_TYR_ITSM	100	107	PF00017	0.600
LIG_UBA3_1	81	90	PF00899	0.568
MOD_CDK_SPxxK_3	396	403	PF00069	0.464
MOD_CK1_1	11	17	PF00069	0.722
MOD_CK1_1	449	455	PF00069	0.688
MOD_CK1_1	99	105	PF00069	0.575
MOD_CK2_1	389	395	PF00069	0.498
MOD_CK2_1	411	417	PF00069	0.571
MOD_GlcNHglycan	148	151	PF01048	0.473
MOD_GlcNHglycan	236	239	PF01048	0.568
MOD_GlcNHglycan	276	279	PF01048	0.555
MOD_GlcNHglycan	305	308	PF01048	0.565
MOD_GlcNHglycan	412	416	PF01048	0.344
MOD_GlcNHglycan	417	421	PF01048	0.461
MOD_GlcNHglycan	448	451	PF01048	0.718
MOD_GlcNHglycan	61	64	PF01048	0.608
MOD_GSK3_1	153	160	PF00069	0.400
MOD_GSK3_1	230	237	PF00069	0.586
MOD_GSK3_1	259	266	PF00069	0.548
MOD_GSK3_1	441	448	PF00069	0.754
MOD_GSK3_1	449	456	PF00069	0.721
MOD_GSK3_1	7	14	PF00069	0.700
MOD_GSK3_1	91	98	PF00069	0.645
MOD_GSK3_1	99	106	PF00069	0.590
MOD_N-GLC_1	374	379	PF02516	0.568
MOD_NEK2_1	13	18	PF00069	0.615
MOD_NEK2_1	381	386	PF00069	0.369
MOD_NEK2_2	8	13	PF00069	0.711
MOD_PIKK_1	238	244	PF00454	0.589
MOD_PIKK_1	46	52	PF00454	0.577
MOD_PK_1	103	109	PF00069	0.568
MOD_PKA_1	32	38	PF00069	0.568
MOD_PKA_1	439	445	PF00069	0.546
MOD_PKA_1	59	65	PF00069	0.609
MOD_PKA_1	91	97	PF00069	0.652
MOD_PKA_2	217	223	PF00069	0.568
MOD_PKA_2	32	38	PF00069	0.571
MOD_PKA_2	46	52	PF00069	0.467
MOD_PKA_2	8	14	PF00069	0.688
MOD_PKA_2	91	97	PF00069	0.591
MOD_PKB_1	199	207	PF00069	0.565
MOD_Plk_1	121	127	PF00069	0.476
MOD_Plk_1	351	357	PF00069	0.591
MOD_Plk_4	157	163	PF00069	0.419
MOD_Plk_4	263	269	PF00069	0.541
MOD_Plk_4	8	14	PF00069	0.722
MOD_ProDKin_1	230	236	PF00069	0.567
MOD_ProDKin_1	396	402	PF00069	0.456
MOD_ProDKin_1	450	456	PF00069	0.721
MOD_SUMO_for_1	409	412	PF00179	0.535
MOD_SUMO_rev_2	106	114	PF00179	0.481
MOD_SUMO_rev_2	117	125	PF00179	0.376
MOD_SUMO_rev_2	62	69	PF00179	0.558
TRG_DiLeu_BaEn_4	121	127	PF01217	0.607
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.462
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.542
TRG_ENDOCYTIC_2	104	107	PF00928	0.484
TRG_ENDOCYTIC_2	39	42	PF00928	0.686
TRG_ENDOCYTIC_2	390	393	PF00928	0.489
TRG_ENDOCYTIC_2	70	73	PF00928	0.517
TRG_ER_diArg_1	1	3	PF00400	0.713
TRG_ER_diArg_1	137	139	PF00400	0.526
TRG_ER_diArg_1	196	199	PF00400	0.500
TRG_ER_diArg_1	200	203	PF00400	0.508
TRG_ER_diArg_1	327	329	PF00400	0.504
TRG_ER_diArg_1	340	343	PF00400	0.339
TRG_ER_diArg_1	36	38	PF00400	0.581
TRG_ER_diArg_1	368	371	PF00400	0.419
TRG_ER_diArg_1	437	439	PF00400	0.661
TRG_NLS_MonoCore_2	88	93	PF00514	0.598
TRG_NLS_MonoExtC_3	89	95	PF00514	0.622
TRG_NLS_MonoExtN_4	88	94	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ29	Leptomonas seymouri	61%	98%
A0A0S4JPR1	Bodo saltans	33%	84%
A0A1X0P2E4	Trypanosomatidae	39%	97%
A0A3R7MQL4	Trypanosoma rangeli	45%	95%
A4HIU0	Leishmania braziliensis	80%	100%
A4I645	Leishmania infantum	100%	100%
C9ZRG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	97%
E9B1C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6T4	Leishmania major	93%	100%
V5BX14	Trypanosoma cruzi	41%	94%