Lorien protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Lorien protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3Z5_LEIDO

TriTrypDb:

LdBPK_303550.1 , LdCL_300041100 , LDHU3_30.4730

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3Z5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0019789	SUMO transferase activity	4	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0061665	SUMO ligase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	27	31	PF00656	0.742
CLV_C14_Caspase3-7	32	36	PF00656	0.802
CLV_NRD_NRD_1	113	115	PF00675	0.410
CLV_NRD_NRD_1	12	14	PF00675	0.781
CLV_NRD_NRD_1	233	235	PF00675	0.585
CLV_NRD_NRD_1	51	53	PF00675	0.515
CLV_PCSK_KEX2_1	113	115	PF00082	0.411
CLV_PCSK_KEX2_1	12	14	PF00082	0.771
CLV_PCSK_KEX2_1	16	18	PF00082	0.677
CLV_PCSK_KEX2_1	232	234	PF00082	0.573
CLV_PCSK_KEX2_1	51	53	PF00082	0.579
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.752
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.672
CLV_PCSK_PC7_1	12	18	PF00082	0.772
CLV_PCSK_SKI1_1	113	117	PF00082	0.367
CLV_PCSK_SKI1_1	13	17	PF00082	0.585
CLV_PCSK_SKI1_1	186	190	PF00082	0.477
CLV_PCSK_SKI1_1	345	349	PF00082	0.566
CLV_PCSK_SKI1_1	52	56	PF00082	0.476
CLV_PCSK_SKI1_1	68	72	PF00082	0.249
CLV_Separin_Metazoa	56	60	PF03568	0.521
DEG_APCC_DBOX_1	113	121	PF00400	0.394
DEG_APCC_DBOX_1	51	59	PF00400	0.533
DEG_APCC_DBOX_1	67	75	PF00400	0.267
DOC_CYCLIN_RxL_1	111	121	PF00134	0.530
DOC_CYCLIN_yClb5_NLxxxL_5	86	95	PF00134	0.550
DOC_MAPK_gen_1	113	120	PF00069	0.394
DOC_MAPK_gen_1	51	57	PF00069	0.529
DOC_MAPK_MEF2A_6	113	120	PF00069	0.394
DOC_MAPK_MEF2A_6	170	177	PF00069	0.459
DOC_MAPK_MEF2A_6	186	195	PF00069	0.241
DOC_PP2B_LxvP_1	116	119	PF13499	0.408
DOC_PP2B_LxvP_1	180	183	PF13499	0.335
DOC_PP2B_LxvP_1	95	98	PF13499	0.563
DOC_PP4_FxxP_1	63	66	PF00568	0.501
DOC_USP7_MATH_1	15	19	PF00917	0.737
DOC_USP7_MATH_1	242	246	PF00917	0.702
DOC_USP7_MATH_1	303	307	PF00917	0.568
DOC_USP7_MATH_1	325	329	PF00917	0.556
DOC_USP7_UBL2_3	348	352	PF12436	0.569
DOC_WW_Pin1_4	107	112	PF00397	0.594
DOC_WW_Pin1_4	147	152	PF00397	0.437
DOC_WW_Pin1_4	158	163	PF00397	0.438
DOC_WW_Pin1_4	175	180	PF00397	0.381
DOC_WW_Pin1_4	21	26	PF00397	0.727
DOC_WW_Pin1_4	238	243	PF00397	0.705
DOC_WW_Pin1_4	69	74	PF00397	0.379
LIG_14-3-3_CanoR_1	21	25	PF00244	0.767
LIG_14-3-3_CanoR_1	225	231	PF00244	0.564
LIG_Actin_WH2_2	332	350	PF00022	0.499
LIG_BIR_III_2	42	46	PF00653	0.633
LIG_FHA_1	172	178	PF00498	0.369
LIG_FHA_1	267	273	PF00498	0.508
LIG_FHA_1	359	365	PF00498	0.723
LIG_FHA_1	90	96	PF00498	0.498
LIG_FHA_2	132	138	PF00498	0.597
LIG_FHA_2	98	104	PF00498	0.642
LIG_LIR_Apic_2	127	133	PF02991	0.463
LIG_LIR_Apic_2	61	66	PF02991	0.499
LIG_LIR_Gen_1	72	83	PF02991	0.481
LIG_LIR_Nem_3	203	208	PF02991	0.412
LIG_LIR_Nem_3	72	78	PF02991	0.326
LIG_MAD2	348	356	PF02301	0.614
LIG_PCNA_yPIPBox_3	310	324	PF02747	0.468
LIG_SH2_GRB2like	146	149	PF00017	0.426
LIG_SH2_STAT5	146	149	PF00017	0.534
LIG_SH2_STAT5	278	281	PF00017	0.550
LIG_SH2_STAT5	337	340	PF00017	0.539
LIG_SH3_2	343	348	PF14604	0.400
LIG_SH3_3	149	155	PF00018	0.419
LIG_SH3_3	340	346	PF00018	0.407
LIG_SH3_3	67	73	PF00018	0.421
LIG_SUMO_SIM_anti_2	360	369	PF11976	0.727
LIG_SUMO_SIM_par_1	173	178	PF11976	0.443
LIG_SUMO_SIM_par_1	360	369	PF11976	0.637
LIG_TRAF2_1	36	39	PF00917	0.694
LIG_TRFH_1	69	73	PF08558	0.389
MOD_CDC14_SPxK_1	110	113	PF00782	0.556
MOD_CDC14_SPxK_1	161	164	PF00782	0.600
MOD_CDK_SPxK_1	107	113	PF00069	0.575
MOD_CDK_SPxK_1	158	164	PF00069	0.589
MOD_CDK_SPxxK_3	107	114	PF00069	0.568
MOD_CK1_1	19	25	PF00069	0.706
MOD_CK1_1	241	247	PF00069	0.707
MOD_CK1_1	89	95	PF00069	0.518
MOD_CK2_1	131	137	PF00069	0.570
MOD_CK2_1	242	248	PF00069	0.708
MOD_CK2_1	357	363	PF00069	0.656
MOD_CK2_1	97	103	PF00069	0.625
MOD_DYRK1A_RPxSP_1	21	25	PF00069	0.589
MOD_GlcNHglycan	18	21	PF01048	0.731
MOD_GlcNHglycan	195	198	PF01048	0.569
MOD_GlcNHglycan	26	29	PF01048	0.729
MOD_GlcNHglycan	305	308	PF01048	0.368
MOD_GSK3_1	120	127	PF00069	0.403
MOD_GSK3_1	15	22	PF00069	0.725
MOD_GSK3_1	171	178	PF00069	0.467
MOD_GSK3_1	238	245	PF00069	0.719
MOD_GSK3_1	86	93	PF00069	0.443
MOD_N-GLC_1	147	152	PF02516	0.458
MOD_N-GLC_1	89	94	PF02516	0.499
MOD_NEK2_1	141	146	PF00069	0.499
MOD_NEK2_1	91	96	PF00069	0.524
MOD_PIKK_1	325	331	PF00454	0.425
MOD_PKA_1	16	22	PF00069	0.779
MOD_PKA_2	16	22	PF00069	0.750
MOD_Plk_1	255	261	PF00069	0.566
MOD_Plk_4	141	147	PF00069	0.491
MOD_ProDKin_1	107	113	PF00069	0.584
MOD_ProDKin_1	147	153	PF00069	0.445
MOD_ProDKin_1	158	164	PF00069	0.437
MOD_ProDKin_1	175	181	PF00069	0.377
MOD_ProDKin_1	21	27	PF00069	0.727
MOD_ProDKin_1	238	244	PF00069	0.705
MOD_ProDKin_1	69	75	PF00069	0.381
MOD_SUMO_for_1	309	312	PF00179	0.507
TRG_ENDOCYTIC_2	75	78	PF00928	0.399
TRG_ER_diArg_1	113	115	PF00400	0.411
TRG_ER_diArg_1	12	14	PF00400	0.580
TRG_NES_CRM1_1	203	216	PF08389	0.500
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JLR1	Bodo saltans	38%	66%
A0A1X0P185	Trypanosomatidae	47%	67%
A0A3R7KHL3	Trypanosoma rangeli	47%	72%
C9ZRF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	70%
E9B1C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6T7	Leishmania major	92%	100%
V5BSC2	Trypanosoma cruzi	48%	72%