Protein yippee-like

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein yippee-like

Gene product:

zinc-binding protein (Yippee), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3Z2_LEIDO

TriTrypDb:

LdBPK_303520.1 , LdCL_300040800 , LDHU3_30.4680

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3Z2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.581
CLV_PCSK_KEX2_1	3	5	PF00082	0.578
CLV_PCSK_SKI1_1	102	106	PF00082	0.210
CLV_PCSK_SKI1_1	111	115	PF00082	0.201
CLV_PCSK_SKI1_1	119	123	PF00082	0.453
CLV_PCSK_SKI1_1	45	49	PF00082	0.285
CLV_PCSK_SKI1_1	73	77	PF00082	0.214
DOC_PP2B_LxvP_1	9	12	PF13499	0.556
DOC_PP4_FxxP_1	133	136	PF00568	0.523
DOC_USP7_MATH_1	10	14	PF00917	0.547
DOC_USP7_MATH_1	127	131	PF00917	0.567
LIG_14-3-3_CanoR_1	111	118	PF00244	0.475
LIG_14-3-3_CanoR_1	139	144	PF00244	0.461
LIG_Actin_WH2_2	105	121	PF00022	0.451
LIG_BRCT_BRCA1_1	129	133	PF00533	0.490
LIG_BRCT_BRCA1_1	35	39	PF00533	0.407
LIG_FHA_1	130	136	PF00498	0.568
LIG_LIR_Apic_2	130	136	PF02991	0.522
LIG_Pex14_1	86	90	PF04695	0.407
LIG_Pex14_2	19	23	PF04695	0.490
LIG_SH2_NCK_1	124	128	PF00017	0.536
LIG_SH2_STAP1	88	92	PF00017	0.424
LIG_SH2_STAT3	57	60	PF00017	0.490
LIG_SH2_STAT3	98	101	PF00017	0.490
LIG_SH2_STAT5	141	144	PF00017	0.463
LIG_SH2_STAT5	83	86	PF00017	0.447
MOD_CK2_1	10	16	PF00069	0.537
MOD_CK2_1	122	128	PF00069	0.620
MOD_CK2_1	47	53	PF00069	0.358
MOD_GlcNHglycan	12	15	PF01048	0.645
MOD_NEK2_1	122	127	PF00069	0.511
MOD_NEK2_1	47	52	PF00069	0.358
MOD_Plk_1	52	58	PF00069	0.358
MOD_Plk_4	52	58	PF00069	0.358
TRG_DiLeu_BaEn_1	61	66	PF01217	0.241
TRG_ER_diArg_1	2	4	PF00400	0.523
TRG_ER_diArg_1	39	42	PF00400	0.358
TRG_ER_diArg_1	5	8	PF00400	0.503
TRG_NES_CRM1_1	96	106	PF08389	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ4	Leptomonas seymouri	81%	100%
A0A1X0P1A1	Trypanosomatidae	58%	100%
A0A422NMC4	Trypanosoma rangeli	57%	100%
A4HIT5	Leishmania braziliensis	94%	100%
A4I637	Leishmania infantum	99%	100%
C9ZRF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	67%
E9B1C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O44440	Caenorhabditis elegans	36%	89%
P62699	Homo sapiens	40%	100%
P62700	Mus musculus	40%	100%
Q3ZBE7	Bos taurus	40%	100%
Q4Q6U2	Leishmania major	97%	100%
Q4R4Q6	Macaca fascicularis	41%	100%
Q5RDU7	Pongo abelii	40%	100%
Q65Z55	Chlorocebus aethiops	40%	100%
Q8S5M8	Oryza sativa subsp. japonica	41%	100%
Q9W2X7	Drosophila melanogaster	35%	100%
Q9XZF0	Drosophila melanogaster	40%	100%