Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3Y7_LEIDO

TriTrypDb:

LdBPK_303760.1 , LdCL_300043000 , LDHU3_30.5000

Length:

857

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X3Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3Y7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.743
CLV_C14_Caspase3-7	734	738	PF00656	0.351
CLV_C14_Caspase3-7	807	811	PF00656	0.287
CLV_MEL_PAP_1	567	573	PF00089	0.467
CLV_NRD_NRD_1	268	270	PF00675	0.527
CLV_NRD_NRD_1	324	326	PF00675	0.445
CLV_NRD_NRD_1	411	413	PF00675	0.377
CLV_NRD_NRD_1	460	462	PF00675	0.336
CLV_NRD_NRD_1	492	494	PF00675	0.386
CLV_NRD_NRD_1	530	532	PF00675	0.371
CLV_PCSK_KEX2_1	223	225	PF00082	0.317
CLV_PCSK_KEX2_1	239	241	PF00082	0.311
CLV_PCSK_KEX2_1	313	315	PF00082	0.353
CLV_PCSK_KEX2_1	323	325	PF00082	0.394
CLV_PCSK_KEX2_1	411	413	PF00082	0.395
CLV_PCSK_KEX2_1	462	464	PF00082	0.371
CLV_PCSK_KEX2_1	492	494	PF00082	0.387
CLV_PCSK_KEX2_1	530	532	PF00082	0.411
CLV_PCSK_KEX2_1	768	770	PF00082	0.541
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.317
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.311
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.353
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.371
CLV_PCSK_PC1ET2_1	768	770	PF00082	0.541
CLV_PCSK_PC7_1	235	241	PF00082	0.398
CLV_PCSK_SKI1_1	536	540	PF00082	0.326
CLV_PCSK_SKI1_1	544	548	PF00082	0.234
CLV_PCSK_SKI1_1	716	720	PF00082	0.535
CLV_PCSK_SKI1_1	724	728	PF00082	0.562
CLV_PCSK_SKI1_1	840	844	PF00082	0.443
DEG_APCC_DBOX_1	147	155	PF00400	0.475
DEG_Nend_UBRbox_3	1	3	PF02207	0.678
DOC_CDC14_PxL_1	254	262	PF14671	0.237
DOC_CKS1_1	143	148	PF01111	0.444
DOC_CKS1_1	571	576	PF01111	0.305
DOC_CYCLIN_RxL_1	499	507	PF00134	0.608
DOC_CYCLIN_RxL_1	834	845	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.676
DOC_CYCLIN_yCln2_LP_2	774	780	PF00134	0.325
DOC_MAPK_FxFP_2	14	17	PF00069	0.670
DOC_MAPK_gen_1	223	229	PF00069	0.509
DOC_MAPK_gen_1	269	276	PF00069	0.344
DOC_MAPK_gen_1	469	478	PF00069	0.612
DOC_MAPK_gen_1	768	776	PF00069	0.357
DOC_MAPK_JIP1_4	635	641	PF00069	0.326
DOC_MAPK_MEF2A_6	148	155	PF00069	0.547
DOC_MAPK_MEF2A_6	769	778	PF00069	0.328
DOC_MAPK_RevD_3	399	413	PF00069	0.384
DOC_MAPK_RevD_3	448	463	PF00069	0.284
DOC_PP2B_LxvP_1	177	180	PF13499	0.309
DOC_PP2B_LxvP_1	476	479	PF13499	0.673
DOC_PP2B_LxvP_1	774	777	PF13499	0.410
DOC_PP2B_PxIxI_1	705	711	PF00149	0.341
DOC_PP4_FxxP_1	14	17	PF00568	0.683
DOC_PP4_FxxP_1	571	574	PF00568	0.319
DOC_PP4_FxxP_1	781	784	PF00568	0.277
DOC_SPAK_OSR1_1	531	535	PF12202	0.602
DOC_USP7_MATH_1	10	14	PF00917	0.686
DOC_USP7_MATH_1	17	21	PF00917	0.663
DOC_USP7_MATH_1	392	396	PF00917	0.337
DOC_USP7_MATH_1	579	583	PF00917	0.391
DOC_USP7_MATH_1	94	98	PF00917	0.637
DOC_WW_Pin1_4	108	113	PF00397	0.670
DOC_WW_Pin1_4	142	147	PF00397	0.442
DOC_WW_Pin1_4	382	387	PF00397	0.413
DOC_WW_Pin1_4	485	490	PF00397	0.592
DOC_WW_Pin1_4	570	575	PF00397	0.406
DOC_WW_Pin1_4	584	589	PF00397	0.389
DOC_WW_Pin1_4	702	707	PF00397	0.292
LIG_14-3-3_CanoR_1	217	223	PF00244	0.500
LIG_14-3-3_CanoR_1	269	274	PF00244	0.353
LIG_14-3-3_CanoR_1	411	419	PF00244	0.524
LIG_14-3-3_CanoR_1	473	477	PF00244	0.662
LIG_14-3-3_CanoR_1	570	574	PF00244	0.346
LIG_14-3-3_CanoR_1	681	686	PF00244	0.289
LIG_14-3-3_CanoR_1	724	730	PF00244	0.369
LIG_14-3-3_CanoR_1	769	777	PF00244	0.367
LIG_14-3-3_CanoR_1	803	809	PF00244	0.307
LIG_14-3-3_CanoR_1	834	839	PF00244	0.293
LIG_Actin_WH2_2	208	225	PF00022	0.383
LIG_APCC_ABBA_1	683	688	PF00400	0.345
LIG_BRCT_BRCA1_1	143	147	PF00533	0.496
LIG_BRCT_BRCA1_1	359	363	PF00533	0.349
LIG_CSL_BTD_1	728	731	PF09270	0.377
LIG_EH1_1	246	254	PF00400	0.329
LIG_eIF4E_1	156	162	PF01652	0.267
LIG_eIF4E_1	247	253	PF01652	0.409
LIG_eIF4E_1	419	425	PF01652	0.272
LIG_FHA_1	150	156	PF00498	0.375
LIG_FHA_1	162	168	PF00498	0.279
LIG_FHA_1	287	293	PF00498	0.341
LIG_FHA_1	35	41	PF00498	0.785
LIG_FHA_1	383	389	PF00498	0.446
LIG_FHA_1	442	448	PF00498	0.378
LIG_FHA_1	473	479	PF00498	0.656
LIG_FHA_1	585	591	PF00498	0.351
LIG_FHA_1	751	757	PF00498	0.382
LIG_FHA_1	784	790	PF00498	0.341
LIG_FHA_2	342	348	PF00498	0.498
LIG_FHA_2	466	472	PF00498	0.548
LIG_FHA_2	486	492	PF00498	0.511
LIG_FHA_2	49	55	PF00498	0.700
LIG_FHA_2	732	738	PF00498	0.341
LIG_FHA_2	843	849	PF00498	0.312
LIG_GBD_Chelix_1	205	213	PF00786	0.335
LIG_GBD_Chelix_1	425	433	PF00786	0.335
LIG_Integrin_RGD_1	224	226	PF01839	0.297
LIG_LIR_Apic_2	125	129	PF02991	0.727
LIG_LIR_Apic_2	13	17	PF02991	0.669
LIG_LIR_Apic_2	728	732	PF02991	0.383
LIG_LIR_Gen_1	130	139	PF02991	0.512
LIG_LIR_Gen_1	170	179	PF02991	0.279
LIG_LIR_Gen_1	191	200	PF02991	0.283
LIG_LIR_Gen_1	202	211	PF02991	0.224
LIG_LIR_Gen_1	289	297	PF02991	0.311
LIG_LIR_Gen_1	355	365	PF02991	0.467
LIG_LIR_Gen_1	405	410	PF02991	0.405
LIG_LIR_Gen_1	418	427	PF02991	0.252
LIG_LIR_Gen_1	662	671	PF02991	0.276
LIG_LIR_Gen_1	786	793	PF02991	0.400
LIG_LIR_Gen_1	804	812	PF02991	0.348
LIG_LIR_LC3C_4	289	293	PF02991	0.363
LIG_LIR_Nem_3	120	126	PF02991	0.654
LIG_LIR_Nem_3	130	134	PF02991	0.471
LIG_LIR_Nem_3	144	150	PF02991	0.494
LIG_LIR_Nem_3	170	174	PF02991	0.270
LIG_LIR_Nem_3	191	197	PF02991	0.255
LIG_LIR_Nem_3	202	206	PF02991	0.255
LIG_LIR_Nem_3	289	293	PF02991	0.311
LIG_LIR_Nem_3	355	361	PF02991	0.521
LIG_LIR_Nem_3	387	393	PF02991	0.289
LIG_LIR_Nem_3	405	409	PF02991	0.202
LIG_LIR_Nem_3	414	419	PF02991	0.422
LIG_LIR_Nem_3	66	70	PF02991	0.711
LIG_LIR_Nem_3	660	664	PF02991	0.267
LIG_LIR_Nem_3	668	674	PF02991	0.277
LIG_LIR_Nem_3	684	689	PF02991	0.263
LIG_LIR_Nem_3	74	79	PF02991	0.621
LIG_LIR_Nem_3	804	809	PF02991	0.378
LIG_LIR_Nem_3	85	91	PF02991	0.601
LIG_NRBOX	150	156	PF00104	0.314
LIG_PCNA_PIPBox_1	213	222	PF02747	0.527
LIG_Pex14_2	195	199	PF04695	0.289
LIG_Pex14_2	628	632	PF04695	0.273
LIG_Pex14_2	725	729	PF04695	0.342
LIG_PTB_Apo_2	75	82	PF02174	0.619
LIG_PTB_Phospho_1	75	81	PF10480	0.621
LIG_SH2_CRK	126	130	PF00017	0.614
LIG_SH2_CRK	178	182	PF00017	0.366
LIG_SH2_CRK	280	284	PF00017	0.270
LIG_SH2_CRK	358	362	PF00017	0.482
LIG_SH2_CRK	419	423	PF00017	0.344
LIG_SH2_CRK	671	675	PF00017	0.255
LIG_SH2_GRB2like	280	283	PF00017	0.340
LIG_SH2_GRB2like	76	79	PF00017	0.637
LIG_SH2_GRB2like	788	791	PF00017	0.265
LIG_SH2_NCK_1	126	130	PF00017	0.614
LIG_SH2_NCK_1	280	284	PF00017	0.338
LIG_SH2_NCK_1	91	95	PF00017	0.724
LIG_SH2_PTP2	664	667	PF00017	0.362
LIG_SH2_SRC	121	124	PF00017	0.654
LIG_SH2_SRC	126	129	PF00017	0.551
LIG_SH2_SRC	178	181	PF00017	0.282
LIG_SH2_SRC	280	283	PF00017	0.340
LIG_SH2_SRC	65	68	PF00017	0.719
LIG_SH2_SRC	664	667	PF00017	0.351
LIG_SH2_SRC	71	74	PF00017	0.626
LIG_SH2_SRC	808	811	PF00017	0.283
LIG_SH2_STAP1	169	173	PF00017	0.367
LIG_SH2_STAP1	200	204	PF00017	0.215
LIG_SH2_STAP1	27	31	PF00017	0.776
LIG_SH2_STAP1	280	284	PF00017	0.307
LIG_SH2_STAP1	35	39	PF00017	0.724
LIG_SH2_STAP1	419	423	PF00017	0.363
LIG_SH2_STAP1	480	484	PF00017	0.724
LIG_SH2_STAP1	648	652	PF00017	0.341
LIG_SH2_STAP1	766	770	PF00017	0.288
LIG_SH2_STAT3	275	278	PF00017	0.344
LIG_SH2_STAT3	374	377	PF00017	0.350
LIG_SH2_STAT3	480	483	PF00017	0.608
LIG_SH2_STAT3	79	82	PF00017	0.691
LIG_SH2_STAT5	150	153	PF00017	0.285
LIG_SH2_STAT5	156	159	PF00017	0.271
LIG_SH2_STAT5	169	172	PF00017	0.301
LIG_SH2_STAT5	194	197	PF00017	0.390
LIG_SH2_STAT5	244	247	PF00017	0.290
LIG_SH2_STAT5	275	278	PF00017	0.332
LIG_SH2_STAT5	296	299	PF00017	0.303
LIG_SH2_STAT5	35	38	PF00017	0.752
LIG_SH2_STAT5	382	385	PF00017	0.391
LIG_SH2_STAT5	402	405	PF00017	0.273
LIG_SH2_STAT5	480	483	PF00017	0.726
LIG_SH2_STAT5	497	500	PF00017	0.556
LIG_SH2_STAT5	618	621	PF00017	0.251
LIG_SH2_STAT5	648	651	PF00017	0.416
LIG_SH2_STAT5	664	667	PF00017	0.231
LIG_SH2_STAT5	742	745	PF00017	0.306
LIG_SH2_STAT5	788	791	PF00017	0.339
LIG_SH2_STAT5	808	811	PF00017	0.251
LIG_SH2_STAT5	841	844	PF00017	0.374
LIG_SH2_STAT5	91	94	PF00017	0.748
LIG_SH3_3	177	183	PF00018	0.385
LIG_SH3_3	252	258	PF00018	0.404
LIG_SH3_3	37	43	PF00018	0.724
LIG_SH3_3	385	391	PF00018	0.297
LIG_SH3_3	585	591	PF00018	0.386
LIG_SH3_3	641	647	PF00018	0.388
LIG_SUMO_SIM_anti_2	289	295	PF11976	0.428
LIG_SUMO_SIM_anti_2	405	411	PF11976	0.495
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.275
LIG_SUMO_SIM_anti_2	444	450	PF11976	0.314
LIG_SUMO_SIM_anti_2	572	579	PF11976	0.298
LIG_SUMO_SIM_anti_2	609	614	PF11976	0.234
LIG_SUMO_SIM_anti_2	751	760	PF11976	0.321
LIG_SUMO_SIM_par_1	672	678	PF11976	0.352
LIG_SUMO_SIM_par_1	751	760	PF11976	0.291
LIG_TRAF2_1	488	491	PF00917	0.650
LIG_TYR_ITIM	245	250	PF00017	0.326
LIG_TYR_ITIM	356	361	PF00017	0.594
LIG_UBA3_1	505	510	PF00899	0.609
LIG_Vh1_VBS_1	198	216	PF01044	0.292
LIG_WRC_WIRS_1	139	144	PF05994	0.537
LIG_WRC_WIRS_1	189	194	PF05994	0.363
LIG_WRC_WIRS_1	200	205	PF05994	0.253
LIG_WW_1	128	131	PF00397	0.583
MOD_CDK_SPxK_1	142	148	PF00069	0.440
MOD_CDK_SPxxK_3	485	492	PF00069	0.594
MOD_CK1_1	188	194	PF00069	0.365
MOD_CK1_1	233	239	PF00069	0.537
MOD_CK1_1	309	315	PF00069	0.657
MOD_CK1_1	380	386	PF00069	0.394
MOD_CK1_1	405	411	PF00069	0.424
MOD_CK1_1	634	640	PF00069	0.387
MOD_CK1_1	749	755	PF00069	0.396
MOD_CK1_1	804	810	PF00069	0.352
MOD_CK2_1	341	347	PF00069	0.497
MOD_CK2_1	465	471	PF00069	0.550
MOD_CK2_1	48	54	PF00069	0.722
MOD_CK2_1	485	491	PF00069	0.508
MOD_CMANNOS	298	301	PF00535	0.345
MOD_GlcNHglycan	308	311	PF01048	0.352
MOD_GlcNHglycan	748	751	PF01048	0.672
MOD_GlcNHglycan	770	773	PF01048	0.484
MOD_GlcNHglycan	799	802	PF01048	0.516
MOD_GlcNHglycan	96	99	PF01048	0.528
MOD_GSK3_1	106	113	PF00069	0.650
MOD_GSK3_1	138	145	PF00069	0.557
MOD_GSK3_1	23	30	PF00069	0.750
MOD_GSK3_1	34	41	PF00069	0.737
MOD_GSK3_1	357	364	PF00069	0.469
MOD_GSK3_1	378	385	PF00069	0.367
MOD_GSK3_1	411	418	PF00069	0.608
MOD_GSK3_1	627	634	PF00069	0.370
MOD_GSK3_1	677	684	PF00069	0.259
MOD_GSK3_1	746	753	PF00069	0.440
MOD_GSK3_1	797	804	PF00069	0.286
MOD_N-GLC_1	10	15	PF02516	0.506
MOD_N-GLC_1	167	172	PF02516	0.307
MOD_N-GLC_1	17	22	PF02516	0.540
MOD_N-GLC_1	185	190	PF02516	0.562
MOD_N-GLC_1	54	59	PF02516	0.554
MOD_N-GLC_1	579	584	PF02516	0.582
MOD_N-GLC_1	657	662	PF02516	0.551
MOD_N-GLC_1	746	751	PF02516	0.541
MOD_N-GLC_1	794	799	PF02516	0.576
MOD_N-GLC_1	825	830	PF02516	0.608
MOD_N-GLC_2	830	832	PF02516	0.539
MOD_NEK2_1	161	166	PF00069	0.281
MOD_NEK2_1	167	172	PF00069	0.327
MOD_NEK2_1	199	204	PF00069	0.277
MOD_NEK2_1	286	291	PF00069	0.349
MOD_NEK2_1	357	362	PF00069	0.481
MOD_NEK2_1	431	436	PF00069	0.345
MOD_NEK2_1	472	477	PF00069	0.645
MOD_NEK2_1	532	537	PF00069	0.607
MOD_NEK2_1	561	566	PF00069	0.445
MOD_NEK2_1	578	583	PF00069	0.317
MOD_NEK2_1	616	621	PF00069	0.262
MOD_NEK2_1	725	730	PF00069	0.333
MOD_NEK2_1	791	796	PF00069	0.393
MOD_NEK2_1	842	847	PF00069	0.371
MOD_NEK2_2	10	15	PF00069	0.652
MOD_NEK2_2	369	374	PF00069	0.384
MOD_PIKK_1	411	417	PF00454	0.496
MOD_PIKK_1	48	54	PF00454	0.755
MOD_PIKK_1	794	800	PF00454	0.332
MOD_PKA_1	269	275	PF00069	0.348
MOD_PKA_1	411	417	PF00069	0.570
MOD_PKA_1	768	774	PF00069	0.373
MOD_PKA_2	411	417	PF00069	0.496
MOD_PKA_2	472	478	PF00069	0.709
MOD_PKA_2	569	575	PF00069	0.386
MOD_PKA_2	768	774	PF00069	0.359
MOD_PKA_2	833	839	PF00069	0.281
MOD_Plk_1	167	173	PF00069	0.305
MOD_Plk_1	185	191	PF00069	0.299
MOD_Plk_1	23	29	PF00069	0.702
MOD_Plk_1	579	585	PF00069	0.413
MOD_Plk_1	657	663	PF00069	0.347
MOD_Plk_2-3	122	128	PF00069	0.642
MOD_Plk_2-3	23	29	PF00069	0.790
MOD_Plk_4	10	16	PF00069	0.690
MOD_Plk_4	138	144	PF00069	0.513
MOD_Plk_4	149	155	PF00069	0.283
MOD_Plk_4	199	205	PF00069	0.341
MOD_Plk_4	269	275	PF00069	0.349
MOD_Plk_4	286	292	PF00069	0.289
MOD_Plk_4	341	347	PF00069	0.516
MOD_Plk_4	352	358	PF00069	0.508
MOD_Plk_4	384	390	PF00069	0.266
MOD_Plk_4	402	408	PF00069	0.252
MOD_Plk_4	418	424	PF00069	0.229
MOD_Plk_4	493	499	PF00069	0.625
MOD_Plk_4	627	633	PF00069	0.327
MOD_Plk_4	634	640	PF00069	0.281
MOD_Plk_4	681	687	PF00069	0.287
MOD_Plk_4	71	77	PF00069	0.710
MOD_Plk_4	725	731	PF00069	0.352
MOD_Plk_4	738	744	PF00069	0.273
MOD_Plk_4	834	840	PF00069	0.348
MOD_ProDKin_1	108	114	PF00069	0.668
MOD_ProDKin_1	142	148	PF00069	0.440
MOD_ProDKin_1	382	388	PF00069	0.414
MOD_ProDKin_1	485	491	PF00069	0.594
MOD_ProDKin_1	570	576	PF00069	0.401
MOD_ProDKin_1	584	590	PF00069	0.388
MOD_ProDKin_1	702	708	PF00069	0.288
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.335
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.387
TRG_ENDOCYTIC_2	131	134	PF00928	0.543
TRG_ENDOCYTIC_2	150	153	PF00928	0.170
TRG_ENDOCYTIC_2	194	197	PF00928	0.425
TRG_ENDOCYTIC_2	200	203	PF00928	0.440
TRG_ENDOCYTIC_2	247	250	PF00928	0.288
TRG_ENDOCYTIC_2	280	283	PF00928	0.270
TRG_ENDOCYTIC_2	296	299	PF00928	0.229
TRG_ENDOCYTIC_2	358	361	PF00928	0.504
TRG_ENDOCYTIC_2	419	422	PF00928	0.246
TRG_ENDOCYTIC_2	664	667	PF00928	0.271
TRG_ENDOCYTIC_2	671	674	PF00928	0.254
TRG_ENDOCYTIC_2	788	791	PF00928	0.281
TRG_ER_diArg_1	322	325	PF00400	0.651
TRG_ER_diArg_1	410	412	PF00400	0.591
TRG_ER_diArg_1	492	494	PF00400	0.628
TRG_ER_diArg_1	530	532	PF00400	0.611
TRG_ER_diArg_1	722	725	PF00400	0.353
TRG_NLS_MonoCore_2	460	465	PF00514	0.602
TRG_NLS_MonoExtN_4	461	466	PF00514	0.644
TRG_Pf-PMV_PEXEL_1	502	507	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	840	844	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB4	Leptomonas seymouri	70%	100%
A0A1X0P1U6	Trypanosomatidae	49%	100%
A0A422NAB6	Trypanosoma rangeli	45%	100%
A4HIV7	Leishmania braziliensis	79%	100%
A4I5Z7	Leishmania infantum	100%	100%
C9ZRI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B1E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6R8	Leishmania major	92%	100%
V5BX06	Trypanosoma cruzi	45%	100%