PhoLip_ATPase_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3X3_LEIDO

TriTrypDb:

LdBPK_303320.1 , LdCL_300038800 , LDHU3_30.4410

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X3X3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3X3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	95	97	PF00082	0.449
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.430
CLV_PCSK_PC7_1	91	97	PF00082	0.410
CLV_PCSK_SKI1_1	111	115	PF00082	0.400
CLV_PCSK_SKI1_1	2	6	PF00082	0.429
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DOC_CDC14_PxL_1	54	62	PF14671	0.496
DOC_MAPK_gen_1	25	35	PF00069	0.500
DOC_MAPK_MEF2A_6	111	120	PF00069	0.564
DOC_MAPK_MEF2A_6	72	81	PF00069	0.325
DOC_PP2B_LxvP_1	55	58	PF13499	0.509
DOC_SPAK_OSR1_1	96	100	PF12202	0.577
DOC_USP7_MATH_1	38	42	PF00917	0.300
LIG_14-3-3_CanoR_1	72	77	PF00244	0.399
LIG_APCC_ABBA_1	64	69	PF00400	0.393
LIG_BRCT_BRCA1_1	28	32	PF00533	0.522
LIG_BRCT_BRCA1_1	40	44	PF00533	0.300
LIG_eIF4E_1	30	36	PF01652	0.496
LIG_FHA_1	124	130	PF00498	0.528
LIG_LIR_Gen_1	27	38	PF02991	0.498
LIG_LIR_Gen_1	41	50	PF02991	0.276
LIG_LIR_Nem_3	142	147	PF02991	0.643
LIG_LIR_Nem_3	27	33	PF02991	0.499
LIG_LIR_Nem_3	41	45	PF02991	0.276
LIG_MYND_1	58	62	PF01753	0.416
LIG_NRBOX	50	56	PF00104	0.433
LIG_NRBOX	83	89	PF00104	0.379
LIG_PDZ_Class_1	160	165	PF00595	0.772
LIG_SH2_CRK	21	25	PF00017	0.529
LIG_SH2_CRK	30	34	PF00017	0.470
LIG_SH2_STAP1	145	149	PF00017	0.631
LIG_SH2_STAT5	149	152	PF00017	0.655
LIG_SH3_3	110	116	PF00018	0.520
LIG_SH3_3	53	59	PF00018	0.335
LIG_SH3_3	95	101	PF00018	0.599
LIG_SUMO_SIM_anti_2	83	89	PF11976	0.393
LIG_SUMO_SIM_par_1	77	83	PF11976	0.497
LIG_TYR_ITIM	19	24	PF00017	0.536
LIG_UBA3_1	87	95	PF00899	0.482
LIG_WRC_WIRS_1	39	44	PF05994	0.393
MOD_CK1_1	156	162	PF00069	0.595
MOD_CK1_1	46	52	PF00069	0.341
MOD_CK2_1	156	162	PF00069	0.650
MOD_GlcNHglycan	158	161	PF01048	0.507
MOD_GSK3_1	156	163	PF00069	0.597
MOD_GSK3_1	34	41	PF00069	0.525
MOD_NEK2_1	19	24	PF00069	0.522
MOD_PIKK_1	43	49	PF00454	0.393
MOD_PKA_2	90	96	PF00069	0.618
MOD_Plk_1	102	108	PF00069	0.551
MOD_Plk_1	26	32	PF00069	0.500
MOD_Plk_4	19	25	PF00069	0.571
MOD_Plk_4	38	44	PF00069	0.167
MOD_Plk_4	80	86	PF00069	0.393
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.411
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.493
TRG_ENDOCYTIC_2	144	147	PF00928	0.699
TRG_ENDOCYTIC_2	21	24	PF00928	0.515
TRG_ENDOCYTIC_2	30	33	PF00928	0.475
TRG_ER_diArg_1	138	141	PF00400	0.670
TRG_NLS_MonoExtN_4	91	98	PF00514	0.612
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2K3	Leptomonas seymouri	80%	100%
A0A1X0P2W0	Trypanosomatidae	49%	100%
A0A3R7N1L0	Trypanosoma rangeli	51%	100%
A4HIR6	Leishmania braziliensis	93%	100%
A4I611	Leishmania infantum	100%	100%
C9ZRD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	81%
E9B1A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6W2	Leishmania major	96%	100%