UV excision repair protein RAD23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UV excision repair RAD23-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7X3W6_LEIDO

TriTrypDb:

LdBPK_303350.1 , LdCL_300039100 , LDHU3_30.4440

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	11
GO:0005829	cytosol	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7X3W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3W6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006289	nucleotide-excision repair	6	12
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	12
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12
GO:0030163	protein catabolic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044265	obsolete cellular macromolecule catabolic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051603	proteolysis involved in protein catabolic process	5	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	11
GO:0031593	polyubiquitin modification-dependent protein binding	4	11
GO:0032182	ubiquitin-like protein binding	3	11
GO:0043130	ubiquitin binding	4	11
GO:0097159	organic cyclic compound binding	2	12
GO:0140030	modification-dependent protein binding	3	11
GO:1901363	heterocyclic compound binding	2	12
GO:0044877	protein-containing complex binding	2	1
GO:0070628	proteasome binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	69	71	PF00675	0.294
CLV_PCSK_KEX2_1	27	29	PF00082	0.362
CLV_PCSK_KEX2_1	71	73	PF00082	0.276
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.362
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.276
CLV_PCSK_SKI1_1	190	194	PF00082	0.424
CLV_PCSK_SKI1_1	2	6	PF00082	0.307
CLV_PCSK_SKI1_1	262	266	PF00082	0.319
CLV_PCSK_SKI1_1	27	31	PF00082	0.311
DEG_APCC_DBOX_1	261	269	PF00400	0.338
DEG_Nend_UBRbox_1	1	4	PF02207	0.419
DEG_SCF_FBW7_1	107	113	PF00400	0.538
DEG_SPOP_SBC_1	111	115	PF00917	0.697
DEG_SPOP_SBC_1	142	146	PF00917	0.752
DOC_CKS1_1	107	112	PF01111	0.574
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.661
DOC_CYCLIN_yCln2_LP_2	294	300	PF00134	0.537
DOC_MAPK_MEF2A_6	182	189	PF00069	0.304
DOC_MAPK_MEF2A_6	305	313	PF00069	0.529
DOC_MAPK_NFAT4_5	182	190	PF00069	0.451
DOC_PP1_RVXF_1	38	44	PF00149	0.556
DOC_PP2B_LxvP_1	221	224	PF13499	0.505
DOC_USP7_MATH_1	117	121	PF00917	0.603
DOC_USP7_MATH_1	136	140	PF00917	0.691
DOC_USP7_MATH_1	141	145	PF00917	0.671
DOC_USP7_MATH_1	147	151	PF00917	0.629
DOC_USP7_MATH_1	153	157	PF00917	0.525
DOC_USP7_MATH_1	228	232	PF00917	0.627
DOC_USP7_MATH_1	233	237	PF00917	0.618
DOC_USP7_MATH_1	330	334	PF00917	0.714
DOC_USP7_MATH_1	342	346	PF00917	0.700
DOC_USP7_MATH_1	92	96	PF00917	0.706
DOC_USP7_MATH_1	97	101	PF00917	0.689
DOC_USP7_UBL2_3	2	6	PF12436	0.389
DOC_WW_Pin1_4	106	111	PF00397	0.674
DOC_WW_Pin1_4	113	118	PF00397	0.603
DOC_WW_Pin1_4	143	148	PF00397	0.729
DOC_WW_Pin1_4	213	218	PF00397	0.421
DOC_WW_Pin1_4	244	249	PF00397	0.668
DOC_WW_Pin1_4	99	104	PF00397	0.731
LIG_BRCT_BRCA1_1	175	179	PF00533	0.412
LIG_BRCT_BRCA1_1	396	400	PF00533	0.486
LIG_FHA_1	107	113	PF00498	0.577
LIG_FHA_1	161	167	PF00498	0.515
LIG_FHA_1	18	24	PF00498	0.497
LIG_FHA_1	280	286	PF00498	0.514
LIG_FHA_1	413	419	PF00498	0.618
LIG_FHA_2	20	26	PF00498	0.458
LIG_FHA_2	356	362	PF00498	0.588
LIG_LIR_Gen_1	216	226	PF02991	0.484
LIG_LIR_Gen_1	308	314	PF02991	0.457
LIG_LIR_Nem_3	201	207	PF02991	0.507
LIG_LIR_Nem_3	216	221	PF02991	0.594
LIG_LIR_Nem_3	308	313	PF02991	0.465
LIG_PTAP_UEV_1	137	142	PF05743	0.522
LIG_SH2_NCK_1	300	304	PF00017	0.537
LIG_SH2_NCK_1	34	38	PF00017	0.512
LIG_SH2_SRC	34	37	PF00017	0.537
LIG_SH2_STAT5	202	205	PF00017	0.502
LIG_SH2_STAT5	385	388	PF00017	0.482
LIG_SH3_1	72	78	PF00018	0.676
LIG_SH3_3	121	127	PF00018	0.705
LIG_SH3_3	135	141	PF00018	0.534
LIG_SH3_3	323	329	PF00018	0.713
LIG_SH3_3	72	78	PF00018	0.629
LIG_Sin3_3	335	342	PF02671	0.525
LIG_UBA3_1	4	11	PF00899	0.492
MOD_CK1_1	120	126	PF00069	0.743
MOD_CK1_1	156	162	PF00069	0.590
MOD_CK1_1	231	237	PF00069	0.680
MOD_CK1_1	99	105	PF00069	0.684
MOD_CK2_1	252	258	PF00069	0.682
MOD_CK2_1	350	356	PF00069	0.600
MOD_Cter_Amidation	68	71	PF01082	0.263
MOD_GlcNHglycan	119	122	PF01048	0.733
MOD_GlcNHglycan	133	136	PF01048	0.692
MOD_GlcNHglycan	138	141	PF01048	0.570
MOD_GlcNHglycan	149	152	PF01048	0.645
MOD_GlcNHglycan	155	158	PF01048	0.514
MOD_GlcNHglycan	218	221	PF01048	0.602
MOD_GlcNHglycan	233	236	PF01048	0.676
MOD_GlcNHglycan	316	319	PF01048	0.484
MOD_GlcNHglycan	321	324	PF01048	0.664
MOD_GlcNHglycan	352	355	PF01048	0.622
MOD_GlcNHglycan	377	382	PF01048	0.551
MOD_GlcNHglycan	93	97	PF01048	0.669
MOD_GlcNHglycan	99	102	PF01048	0.619
MOD_GSK3_1	106	113	PF00069	0.636
MOD_GSK3_1	116	123	PF00069	0.668
MOD_GSK3_1	143	150	PF00069	0.591
MOD_GSK3_1	156	163	PF00069	0.541
MOD_GSK3_1	252	259	PF00069	0.604
MOD_GSK3_1	92	99	PF00069	0.687
MOD_N-GLC_1	61	66	PF02516	0.301
MOD_NEK2_1	112	117	PF00069	0.736
MOD_NEK2_1	314	319	PF00069	0.460
MOD_NEK2_1	48	53	PF00069	0.512
MOD_PIKK_1	385	391	PF00454	0.560
MOD_PIKK_1	412	418	PF00454	0.648
MOD_Plk_1	342	348	PF00069	0.575
MOD_Plk_1	360	366	PF00069	0.496
MOD_Plk_1	377	383	PF00069	0.455
MOD_Plk_1	48	54	PF00069	0.527
MOD_Plk_1	61	67	PF00069	0.497
MOD_Plk_4	19	25	PF00069	0.530
MOD_Plk_4	309	315	PF00069	0.559
MOD_Plk_4	343	349	PF00069	0.687
MOD_Plk_4	394	400	PF00069	0.498
MOD_Plk_4	61	67	PF00069	0.483
MOD_ProDKin_1	106	112	PF00069	0.676
MOD_ProDKin_1	113	119	PF00069	0.605
MOD_ProDKin_1	143	149	PF00069	0.729
MOD_ProDKin_1	213	219	PF00069	0.425
MOD_ProDKin_1	244	250	PF00069	0.670
MOD_ProDKin_1	99	105	PF00069	0.733
MOD_SUMO_for_1	86	89	PF00179	0.639
MOD_SUMO_rev_2	21	29	PF00179	0.505
TRG_DiLeu_BaEn_2	342	348	PF01217	0.691
TRG_DiLeu_BaLyEn_6	25	30	PF01217	0.473
TRG_ENDOCYTIC_2	300	303	PF00928	0.517
TRG_NLS_MonoCore_2	69	74	PF00514	0.512
TRG_NLS_MonoExtC_3	70	75	PF00514	0.670
TRG_NLS_MonoExtN_4	70	75	PF00514	0.669
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	275	280	PF00026	0.276
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC65	Leptomonas seymouri	60%	98%
A0A0S4KFK0	Bodo saltans	35%	100%
A0A1X0P199	Trypanosomatidae	34%	100%
A0A3R7KQ25	Trypanosoma rangeli	33%	100%
A3KMV2	Bos taurus	26%	100%
A4HIR8	Leishmania braziliensis	77%	100%
A4I614	Leishmania infantum	100%	100%
C9ZRD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B1A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O74803	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
P32628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P54725	Homo sapiens	27%	100%
P54726	Mus musculus	26%	100%
P54727	Homo sapiens	28%	100%
P54728	Mus musculus	27%	100%
Q29RK4	Bos taurus	25%	100%
Q40742	Oryza sativa subsp. japonica	27%	100%
Q4KMA2	Rattus norvegicus	27%	100%
Q4Q6V9	Leishmania major	91%	100%
Q84L30	Arabidopsis thaliana	28%	100%
Q84L31	Arabidopsis thaliana	27%	100%
Q84L32	Arabidopsis thaliana	27%	100%
Q84L33	Arabidopsis thaliana	27%	100%
V5B773	Trypanosoma cruzi	36%	100%