Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3W4_LEIDO

TriTrypDb:

LdBPK_303180.1 , LdCL_300037400 , LDHU3_30.4250

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3W4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3W4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	154	156	PF00675	0.447
CLV_NRD_NRD_1	210	212	PF00675	0.485
CLV_PCSK_KEX2_1	154	156	PF00082	0.447
CLV_PCSK_KEX2_1	209	211	PF00082	0.484
CLV_PCSK_PC7_1	150	156	PF00082	0.436
CLV_PCSK_SKI1_1	119	123	PF00082	0.544
CLV_PCSK_SKI1_1	168	172	PF00082	0.516
DOC_PP2B_LxvP_1	37	40	PF13499	0.516
DOC_PP4_FxxP_1	141	144	PF00568	0.646
DOC_USP7_MATH_1	121	125	PF00917	0.475
DOC_USP7_MATH_1	177	181	PF00917	0.474
DOC_USP7_MATH_1	93	97	PF00917	0.592
DOC_WW_Pin1_4	171	176	PF00397	0.516
DOC_WW_Pin1_4	18	23	PF00397	0.572
DOC_WW_Pin1_4	67	72	PF00397	0.533
LIG_14-3-3_CanoR_1	133	141	PF00244	0.431
LIG_14-3-3_CanoR_1	92	102	PF00244	0.589
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	44	48	PF00533	0.655
LIG_FHA_2	68	74	PF00498	0.553
LIG_GBD_Chelix_1	181	189	PF00786	0.570
LIG_LIR_Gen_1	176	185	PF02991	0.480
LIG_LIR_Gen_1	27	37	PF02991	0.572
LIG_LIR_Nem_3	176	181	PF02991	0.476
LIG_LIR_Nem_3	27	33	PF02991	0.573
LIG_LYPXL_SIV_4	177	185	PF13949	0.479
LIG_PCNA_yPIPBox_3	106	114	PF02747	0.489
LIG_PDZ_Class_2	224	229	PF00595	0.460
LIG_Pex14_1	198	202	PF04695	0.528
LIG_SH2_STAP1	178	182	PF00017	0.478
LIG_SH2_STAT5	140	143	PF00017	0.508
LIG_SH2_STAT5	202	205	PF00017	0.516
LIG_SUMO_SIM_par_1	9	17	PF11976	0.584
LIG_TRFH_1	171	175	PF08558	0.521
LIG_UBA3_1	156	162	PF00899	0.425
MOD_CK1_1	101	107	PF00069	0.550
MOD_CK1_1	14	20	PF00069	0.596
MOD_CK1_1	205	211	PF00069	0.506
MOD_CK1_1	29	35	PF00069	0.591
MOD_CK1_1	64	70	PF00069	0.578
MOD_CK2_1	67	73	PF00069	0.622
MOD_GlcNHglycan	103	106	PF01048	0.543
MOD_GlcNHglycan	136	139	PF01048	0.500
MOD_GlcNHglycan	222	226	PF01048	0.460
MOD_GSK3_1	115	122	PF00069	0.582
MOD_GSK3_1	14	21	PF00069	0.613
MOD_GSK3_1	29	36	PF00069	0.625
MOD_GSK3_1	42	49	PF00069	0.578
MOD_N-GLC_1	17	22	PF02516	0.623
MOD_N-GLC_1	93	98	PF02516	0.588
MOD_NEK2_1	221	226	PF00069	0.480
MOD_NEK2_1	26	31	PF00069	0.592
MOD_PKA_2	115	121	PF00069	0.500
MOD_PKA_2	145	151	PF00069	0.463
MOD_PKA_2	98	104	PF00069	0.488
MOD_Plk_1	119	125	PF00069	0.550
MOD_Plk_1	26	32	PF00069	0.558
MOD_Plk_2-3	61	67	PF00069	0.559
MOD_Plk_4	177	183	PF00069	0.477
MOD_Plk_4	184	190	PF00069	0.497
MOD_Plk_4	98	104	PF00069	0.488
MOD_ProDKin_1	171	177	PF00069	0.508
MOD_ProDKin_1	18	24	PF00069	0.573
MOD_ProDKin_1	67	73	PF00069	0.529
MOD_SUMO_rev_2	112	121	PF00179	0.571
TRG_DiLeu_BaEn_4	3	9	PF01217	0.620
TRG_ENDOCYTIC_2	178	181	PF00928	0.476
TRG_ER_diArg_1	153	155	PF00400	0.435
TRG_ER_diArg_1	209	211	PF00400	0.484
TRG_ER_diArg_1	84	87	PF00400	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXB3	Leptomonas seymouri	72%	97%
A4HIP8	Leishmania braziliensis	77%	100%
A4I663	Leishmania infantum	100%	100%
E9B188	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6X6	Leishmania major	94%	100%