C2 NT-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3W0_LEIDO

TriTrypDb:

LdBPK_303250.1 , LdCL_300038100 , LDHU3_30.4340

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 14
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3W0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	4
GO:0003824	catalytic activity	1	4
GO:0016853	isomerase activity	2	4
GO:0016859	cis-trans isomerase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.582
CLV_C14_Caspase3-7	256	260	PF00656	0.578
CLV_NRD_NRD_1	232	234	PF00675	0.550
CLV_NRD_NRD_1	315	317	PF00675	0.483
CLV_NRD_NRD_1	482	484	PF00675	0.430
CLV_NRD_NRD_1	626	628	PF00675	0.516
CLV_PCSK_FUR_1	213	217	PF00082	0.484
CLV_PCSK_KEX2_1	215	217	PF00082	0.385
CLV_PCSK_KEX2_1	232	234	PF00082	0.550
CLV_PCSK_KEX2_1	315	317	PF00082	0.504
CLV_PCSK_KEX2_1	326	328	PF00082	0.513
CLV_PCSK_KEX2_1	363	365	PF00082	0.493
CLV_PCSK_KEX2_1	482	484	PF00082	0.430
CLV_PCSK_KEX2_1	626	628	PF00082	0.516
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.424
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.631
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.588
CLV_PCSK_SKI1_1	134	138	PF00082	0.406
CLV_PCSK_SKI1_1	245	249	PF00082	0.659
CLV_PCSK_SKI1_1	357	361	PF00082	0.459
CLV_PCSK_SKI1_1	363	367	PF00082	0.471
CLV_PCSK_SKI1_1	380	384	PF00082	0.506
CLV_PCSK_SKI1_1	396	400	PF00082	0.412
CLV_PCSK_SKI1_1	483	487	PF00082	0.447
CLV_PCSK_SKI1_1	541	545	PF00082	0.525
CLV_PCSK_SKI1_1	626	630	PF00082	0.584
CLV_PCSK_SKI1_1	766	770	PF00082	0.672
DEG_APCC_DBOX_1	314	322	PF00400	0.517
DEG_APCC_KENBOX_2	130	134	PF00400	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.443
DEG_SIAH_1	817	825	PF03145	0.478
DOC_CYCLIN_RxL_1	480	488	PF00134	0.508
DOC_CYCLIN_yClb3_PxF_3	741	747	PF00134	0.673
DOC_CYCLIN_yCln2_LP_2	3	9	PF00134	0.329
DOC_CYCLIN_yCln2_LP_2	743	749	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	768	774	PF00134	0.708
DOC_MAPK_gen_1	129	138	PF00069	0.532
DOC_MAPK_gen_1	245	255	PF00069	0.589
DOC_MAPK_gen_1	447	455	PF00069	0.432
DOC_MAPK_HePTP_8	212	224	PF00069	0.488
DOC_MAPK_MEF2A_6	191	200	PF00069	0.411
DOC_MAPK_MEF2A_6	215	224	PF00069	0.429
DOC_MAPK_MEF2A_6	449	457	PF00069	0.549
DOC_MAPK_NFAT4_5	452	460	PF00069	0.535
DOC_MAPK_RevD_3	220	234	PF00069	0.417
DOC_PP1_RVXF_1	850	856	PF00149	0.722
DOC_PP2B_LxvP_1	743	746	PF13499	0.682
DOC_PP2B_LxvP_1	800	803	PF13499	0.435
DOC_PP2B_LxvP_1	815	818	PF13499	0.591
DOC_PP4_FxxP_1	177	180	PF00568	0.511
DOC_USP7_MATH_1	118	122	PF00917	0.407
DOC_USP7_MATH_1	272	276	PF00917	0.763
DOC_USP7_MATH_1	694	698	PF00917	0.488
DOC_USP7_MATH_1	794	798	PF00917	0.635
DOC_USP7_MATH_1	811	815	PF00917	0.702
DOC_USP7_MATH_2	803	809	PF00917	0.477
DOC_WW_Pin1_4	263	268	PF00397	0.706
DOC_WW_Pin1_4	61	66	PF00397	0.402
DOC_WW_Pin1_4	788	793	PF00397	0.593
DOC_WW_Pin1_4	845	850	PF00397	0.576
LIG_14-3-3_CanoR_1	442	448	PF00244	0.467
LIG_14-3-3_CanoR_1	454	458	PF00244	0.400
LIG_14-3-3_CanoR_1	564	570	PF00244	0.586
LIG_14-3-3_CanoR_1	626	635	PF00244	0.511
LIG_14-3-3_CanoR_1	730	734	PF00244	0.589
LIG_Actin_WH2_2	297	314	PF00022	0.575
LIG_Actin_WH2_2	439	456	PF00022	0.461
LIG_Actin_WH2_2	493	509	PF00022	0.492
LIG_AP2alpha_2	702	704	PF02296	0.538
LIG_BRCT_BRCA1_1	90	94	PF00533	0.285
LIG_EH1_1	343	351	PF00400	0.472
LIG_eIF4E_1	344	350	PF01652	0.491
LIG_EVH1_1	817	821	PF00568	0.518
LIG_FHA_1	117	123	PF00498	0.443
LIG_FHA_1	306	312	PF00498	0.510
LIG_FHA_1	332	338	PF00498	0.560
LIG_FHA_1	386	392	PF00498	0.452
LIG_FHA_1	438	444	PF00498	0.370
LIG_FHA_1	44	50	PF00498	0.434
LIG_FHA_1	454	460	PF00498	0.494
LIG_FHA_1	509	515	PF00498	0.510
LIG_FHA_1	58	64	PF00498	0.315
LIG_FHA_1	627	633	PF00498	0.515
LIG_FHA_1	763	769	PF00498	0.659
LIG_FHA_1	782	788	PF00498	0.587
LIG_FHA_1	8	14	PF00498	0.403
LIG_FHA_1	839	845	PF00498	0.755
LIG_FHA_2	24	30	PF00498	0.493
LIG_FHA_2	254	260	PF00498	0.629
LIG_FHA_2	312	318	PF00498	0.552
LIG_FHA_2	388	394	PF00498	0.480
LIG_FHA_2	458	464	PF00498	0.485
LIG_FHA_2	516	522	PF00498	0.451
LIG_FHA_2	649	655	PF00498	0.557
LIG_FHA_2	79	85	PF00498	0.459
LIG_LIR_Apic_2	732	737	PF02991	0.634
LIG_LIR_Apic_2	738	742	PF02991	0.640
LIG_LIR_Gen_1	292	300	PF02991	0.586
LIG_LIR_Gen_1	523	529	PF02991	0.553
LIG_LIR_Gen_1	666	675	PF02991	0.483
LIG_LIR_Gen_1	76	85	PF02991	0.332
LIG_LIR_Gen_1	8	17	PF02991	0.438
LIG_LIR_Nem_3	26	30	PF02991	0.341
LIG_LIR_Nem_3	292	297	PF02991	0.575
LIG_LIR_Nem_3	523	528	PF02991	0.554
LIG_LIR_Nem_3	666	671	PF02991	0.492
LIG_LIR_Nem_3	700	704	PF02991	0.661
LIG_LIR_Nem_3	76	82	PF02991	0.360
LIG_LIR_Nem_3	8	12	PF02991	0.436
LIG_LIR_Nem_3	87	92	PF02991	0.323
LIG_MYND_1	741	745	PF01753	0.662
LIG_NRBOX	162	168	PF00104	0.454
LIG_NRBOX	429	435	PF00104	0.366
LIG_PCNA_yPIPBox_3	685	693	PF02747	0.590
LIG_Pex14_1	90	94	PF04695	0.277
LIG_Rb_LxCxE_1	429	451	PF01857	0.314
LIG_SH2_CRK	30	34	PF00017	0.390
LIG_SH2_CRK	525	529	PF00017	0.435
LIG_SH2_CRK	668	672	PF00017	0.577
LIG_SH2_CRK	734	738	PF00017	0.636
LIG_SH2_CRK	739	743	PF00017	0.644
LIG_SH2_NCK_1	734	738	PF00017	0.634
LIG_SH2_PTP2	227	230	PF00017	0.445
LIG_SH2_SRC	227	230	PF00017	0.445
LIG_SH2_SRC	558	561	PF00017	0.419
LIG_SH2_STAP1	476	480	PF00017	0.421
LIG_SH2_STAP1	525	529	PF00017	0.470
LIG_SH2_STAT5	227	230	PF00017	0.390
LIG_SH2_STAT5	57	60	PF00017	0.401
LIG_SH2_STAT5	79	82	PF00017	0.351
LIG_SH2_STAT5	862	865	PF00017	0.728
LIG_SH3_1	739	745	PF00018	0.632
LIG_SH3_3	264	270	PF00018	0.728
LIG_SH3_3	739	745	PF00018	0.562
LIG_SH3_3	815	821	PF00018	0.609
LIG_SH3_3	850	856	PF00018	0.718
LIG_SUMO_SIM_par_1	269	275	PF11976	0.614
LIG_SUMO_SIM_par_1	455	461	PF11976	0.569
LIG_TRAF2_1	492	495	PF00917	0.423
LIG_TRAF2_1	655	658	PF00917	0.633
LIG_UBA3_1	207	215	PF00899	0.433
LIG_UBA3_1	469	475	PF00899	0.406
LIG_WRC_WIRS_1	17	22	PF05994	0.475
LIG_WRC_WIRS_1	79	84	PF05994	0.295
MOD_CDK_SPK_2	845	850	PF00069	0.742
MOD_CDK_SPxxK_3	845	852	PF00069	0.635
MOD_CK1_1	121	127	PF00069	0.466
MOD_CK1_1	153	159	PF00069	0.496
MOD_CK1_1	243	249	PF00069	0.631
MOD_CK1_1	287	293	PF00069	0.660
MOD_CK1_1	520	526	PF00069	0.545
MOD_CK1_1	634	640	PF00069	0.541
MOD_CK1_1	759	765	PF00069	0.742
MOD_CK1_1	833	839	PF00069	0.650
MOD_CK2_1	16	22	PF00069	0.436
MOD_CK2_1	162	168	PF00069	0.503
MOD_CK2_1	23	29	PF00069	0.491
MOD_CK2_1	243	249	PF00069	0.695
MOD_CK2_1	311	317	PF00069	0.594
MOD_CK2_1	387	393	PF00069	0.502
MOD_CK2_1	399	405	PF00069	0.409
MOD_CK2_1	457	463	PF00069	0.486
MOD_CK2_1	627	633	PF00069	0.579
MOD_CK2_1	648	654	PF00069	0.547
MOD_CK2_1	694	700	PF00069	0.568
MOD_CK2_1	708	714	PF00069	0.436
MOD_GlcNHglycan	245	248	PF01048	0.578
MOD_GlcNHglycan	274	277	PF01048	0.751
MOD_GlcNHglycan	281	284	PF01048	0.503
MOD_GlcNHglycan	286	289	PF01048	0.589
MOD_GlcNHglycan	331	334	PF01048	0.575
MOD_GlcNHglycan	400	404	PF01048	0.583
MOD_GlcNHglycan	696	699	PF01048	0.514
MOD_GlcNHglycan	710	713	PF01048	0.521
MOD_GlcNHglycan	758	761	PF01048	0.624
MOD_GlcNHglycan	796	799	PF01048	0.694
MOD_GlcNHglycan	865	868	PF01048	0.745
MOD_GSK3_1	150	157	PF00069	0.495
MOD_GSK3_1	16	23	PF00069	0.473
MOD_GSK3_1	175	182	PF00069	0.541
MOD_GSK3_1	236	243	PF00069	0.662
MOD_GSK3_1	259	266	PF00069	0.655
MOD_GSK3_1	329	336	PF00069	0.590
MOD_GSK3_1	437	444	PF00069	0.566
MOD_GSK3_1	453	460	PF00069	0.465
MOD_GSK3_1	57	64	PF00069	0.351
MOD_GSK3_1	627	634	PF00069	0.527
MOD_GSK3_1	778	785	PF00069	0.641
MOD_GSK3_1	84	91	PF00069	0.425
MOD_LATS_1	877	883	PF00433	0.577
MOD_N-GLC_1	42	47	PF02516	0.516
MOD_N-GLC_1	645	650	PF02516	0.629
MOD_N-GLC_2	223	225	PF02516	0.470
MOD_NEK2_1	20	25	PF00069	0.474
MOD_NEK2_1	253	258	PF00069	0.755
MOD_NEK2_1	284	289	PF00069	0.670
MOD_NEK2_1	305	310	PF00069	0.555
MOD_NEK2_1	311	316	PF00069	0.548
MOD_NEK2_1	37	42	PF00069	0.402
MOD_NEK2_1	384	389	PF00069	0.458
MOD_NEK2_1	399	404	PF00069	0.436
MOD_NEK2_1	413	418	PF00069	0.298
MOD_NEK2_1	437	442	PF00069	0.372
MOD_NEK2_1	453	458	PF00069	0.520
MOD_NEK2_1	485	490	PF00069	0.494
MOD_NEK2_1	506	511	PF00069	0.570
MOD_NEK2_1	635	640	PF00069	0.544
MOD_NEK2_1	780	785	PF00069	0.672
MOD_NEK2_1	863	868	PF00069	0.699
MOD_NEK2_2	78	83	PF00069	0.379
MOD_PIKK_1	238	244	PF00454	0.693
MOD_PIKK_1	305	311	PF00454	0.568
MOD_PIKK_1	331	337	PF00454	0.457
MOD_PIKK_1	413	419	PF00454	0.513
MOD_PIKK_1	508	514	PF00454	0.495
MOD_PIKK_1	648	654	PF00454	0.548
MOD_PIKK_1	681	687	PF00454	0.571
MOD_PIKK_1	830	836	PF00454	0.764
MOD_PKA_1	626	632	PF00069	0.636
MOD_PKA_2	311	317	PF00069	0.576
MOD_PKA_2	329	335	PF00069	0.592
MOD_PKA_2	441	447	PF00069	0.406
MOD_PKA_2	453	459	PF00069	0.497
MOD_PKA_2	563	569	PF00069	0.579
MOD_PKA_2	626	632	PF00069	0.564
MOD_PKA_2	729	735	PF00069	0.589
MOD_Plk_1	342	348	PF00069	0.431
MOD_Plk_1	42	48	PF00069	0.403
MOD_Plk_1	437	443	PF00069	0.574
MOD_Plk_1	520	526	PF00069	0.469
MOD_Plk_1	645	651	PF00069	0.520
MOD_Plk_1	7	13	PF00069	0.498
MOD_Plk_1	84	90	PF00069	0.483
MOD_Plk_2-3	168	174	PF00069	0.470
MOD_Plk_2-3	474	480	PF00069	0.495
MOD_Plk_4	118	124	PF00069	0.393
MOD_Plk_4	162	168	PF00069	0.531
MOD_Plk_4	729	735	PF00069	0.610
MOD_Plk_4	805	811	PF00069	0.480
MOD_ProDKin_1	263	269	PF00069	0.707
MOD_ProDKin_1	61	67	PF00069	0.401
MOD_ProDKin_1	788	794	PF00069	0.586
MOD_ProDKin_1	845	851	PF00069	0.574
MOD_SUMO_for_1	448	451	PF00179	0.411
MOD_SUMO_for_1	516	519	PF00179	0.557
MOD_SUMO_rev_2	126	136	PF00179	0.521
MOD_SUMO_rev_2	393	398	PF00179	0.432
TRG_DiLeu_BaEn_1	249	254	PF01217	0.575
TRG_DiLeu_BaEn_1	292	297	PF01217	0.556
TRG_DiLeu_BaEn_4	450	456	PF01217	0.549
TRG_DiLeu_BaEn_4	495	501	PF01217	0.405
TRG_DiLeu_BaLyEn_6	429	434	PF01217	0.460
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.403
TRG_DiLeu_BaLyEn_6	670	675	PF01217	0.564
TRG_ENDOCYTIC_2	227	230	PF00928	0.379
TRG_ENDOCYTIC_2	30	33	PF00928	0.391
TRG_ENDOCYTIC_2	525	528	PF00928	0.455
TRG_ENDOCYTIC_2	668	671	PF00928	0.582
TRG_ENDOCYTIC_2	749	752	PF00928	0.479
TRG_ENDOCYTIC_2	79	82	PF00928	0.293
TRG_ENDOCYTIC_2	89	92	PF00928	0.280
TRG_ER_diArg_1	231	233	PF00400	0.435
TRG_ER_diArg_1	626	628	PF00400	0.523
TRG_ER_diArg_1	849	852	PF00400	0.612
TRG_NES_CRM1_1	140	152	PF08389	0.449
TRG_NES_CRM1_1	495	508	PF08389	0.475
TRG_NLS_MonoExtC_3	355	361	PF00514	0.412
TRG_NLS_MonoExtN_4	213	219	PF00514	0.530
TRG_Pf-PMV_PEXEL_1	364	369	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	626	631	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	641	645	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	861	865	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD41	Leptomonas seymouri	64%	100%
A0A0S4JFL0	Bodo saltans	24%	71%
A0A1X0P1A9	Trypanosomatidae	37%	87%
A0A1X0P287	Trypanosomatidae	25%	78%
A0A422NMN4	Trypanosoma rangeli	23%	80%
A0A422P0Y3	Trypanosoma rangeli	38%	88%
A4HIQ9	Leishmania braziliensis	80%	100%
A4I604	Leishmania infantum	100%	100%
C9ZQI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	70%
C9ZRC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B195	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q6W9	Leishmania major	94%	100%
V5BCD0	Trypanosoma cruzi	22%	79%
V5BMS4	Trypanosoma cruzi	36%	93%