Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3V5_LEIDO

TriTrypDb:

LdBPK_303460.1 , LdCL_300040200 , LDHU3_30.4610

Length:

617

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0005875	microtubule associated complex	2	16
GO:0030286	dynein complex	3	16
GO:0032991	protein-containing complex	1	17
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:1902494	catalytic complex	2	16
GO:1990904	ribonucleoprotein complex	2	13
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3S7X3V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3V5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0009987	cellular process	1	16

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0008569	minus-end-directed microtubule motor activity	3	16
GO:0140657	ATP-dependent activity	1	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.610
CLV_NRD_NRD_1	289	291	PF00675	0.558
CLV_NRD_NRD_1	574	576	PF00675	0.420
CLV_PCSK_SKI1_1	15	19	PF00082	0.551
CLV_PCSK_SKI1_1	194	198	PF00082	0.303
CLV_PCSK_SKI1_1	220	224	PF00082	0.254
CLV_PCSK_SKI1_1	331	335	PF00082	0.392
CLV_PCSK_SKI1_1	589	593	PF00082	0.420
DEG_APCC_DBOX_1	367	375	PF00400	0.532
DOC_CYCLIN_RxL_1	214	226	PF00134	0.524
DOC_CYCLIN_RxL_1	589	601	PF00134	0.454
DOC_CYCLIN_yClb3_PxF_3	100	106	PF00134	0.509
DOC_MAPK_DCC_7	368	376	PF00069	0.531
DOC_MAPK_gen_1	150	158	PF00069	0.558
DOC_MAPK_gen_1	288	295	PF00069	0.583
DOC_MAPK_gen_1	575	583	PF00069	0.525
DOC_MAPK_MEF2A_6	368	376	PF00069	0.531
DOC_MAPK_MEF2A_6	66	73	PF00069	0.518
DOC_PP2B_LxvP_1	73	76	PF13499	0.495
DOC_PP4_FxxP_1	93	96	PF00568	0.648
DOC_SPAK_OSR1_1	353	357	PF12202	0.362
DOC_USP7_MATH_1	111	115	PF00917	0.531
DOC_USP7_MATH_1	192	196	PF00917	0.440
DOC_USP7_MATH_1	319	323	PF00917	0.707
DOC_USP7_UBL2_3	11	15	PF12436	0.362
DOC_USP7_UBL2_3	179	183	PF12436	0.457
DOC_USP7_UBL2_3	288	292	PF12436	0.719
LIG_14-3-3_CanoR_1	200	209	PF00244	0.529
LIG_14-3-3_CanoR_1	237	243	PF00244	0.454
LIG_14-3-3_CanoR_1	458	464	PF00244	0.365
LIG_APCC_ABBA_1	185	190	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	267	273	PF00400	0.637
LIG_BIR_II_1	1	5	PF00653	0.543
LIG_BRCT_BRCA1_1	388	392	PF00533	0.407
LIG_EVH1_1	99	103	PF00568	0.700
LIG_FHA_1	191	197	PF00498	0.480
LIG_FHA_1	400	406	PF00498	0.392
LIG_FHA_1	415	421	PF00498	0.412
LIG_FHA_1	448	454	PF00498	0.342
LIG_FHA_1	578	584	PF00498	0.402
LIG_FHA_1	590	596	PF00498	0.287
LIG_FHA_1	602	608	PF00498	0.309
LIG_FHA_2	16	22	PF00498	0.491
LIG_FHA_2	306	312	PF00498	0.581
LIG_FHA_2	322	328	PF00498	0.539
LIG_FHA_2	394	400	PF00498	0.328
LIG_FHA_2	489	495	PF00498	0.323
LIG_KLC1_Yacidic_2	154	159	PF13176	0.546
LIG_LIR_Apic_2	431	435	PF02991	0.361
LIG_LIR_Gen_1	3	13	PF02991	0.535
LIG_LIR_Gen_1	307	316	PF02991	0.620
LIG_LIR_Gen_1	360	366	PF02991	0.368
LIG_LIR_Gen_1	523	532	PF02991	0.323
LIG_LIR_LC3C_4	67	72	PF02991	0.562
LIG_LIR_Nem_3	3	8	PF02991	0.545
LIG_LIR_Nem_3	360	365	PF02991	0.369
LIG_LIR_Nem_3	523	529	PF02991	0.444
LIG_MYND_1	100	104	PF01753	0.699
LIG_Pex14_1	384	388	PF04695	0.326
LIG_Pex14_2	388	392	PF04695	0.456
LIG_PTB_Apo_2	422	429	PF02174	0.427
LIG_SH2_CRK	432	436	PF00017	0.504
LIG_SH2_CRK	5	9	PF00017	0.543
LIG_SH2_GRB2like	432	435	PF00017	0.385
LIG_SH2_NCK_1	408	412	PF00017	0.493
LIG_SH2_NCK_1	432	436	PF00017	0.400
LIG_SH2_NCK_1	5	9	PF00017	0.381
LIG_SH2_PTP2	362	365	PF00017	0.358
LIG_SH2_SRC	432	435	PF00017	0.350
LIG_SH2_STAP1	119	123	PF00017	0.512
LIG_SH2_STAT3	188	191	PF00017	0.457
LIG_SH2_STAT5	157	160	PF00017	0.457
LIG_SH2_STAT5	188	191	PF00017	0.457
LIG_SH2_STAT5	348	351	PF00017	0.445
LIG_SH2_STAT5	362	365	PF00017	0.310
LIG_SH2_STAT5	5	8	PF00017	0.464
LIG_SH2_STAT5	560	563	PF00017	0.330
LIG_SH2_STAT5	570	573	PF00017	0.340
LIG_SH3_3	226	232	PF00018	0.446
LIG_SH3_3	568	574	PF00018	0.276
LIG_SH3_3	97	103	PF00018	0.721
LIG_SUMO_SIM_anti_2	195	200	PF11976	0.457
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.514
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.434
LIG_SUMO_SIM_par_1	341	347	PF11976	0.512
LIG_SUMO_SIM_par_1	362	367	PF11976	0.358
LIG_SUMO_SIM_par_1	416	422	PF11976	0.497
LIG_TRAF2_1	411	414	PF00917	0.550
LIG_TYR_ITSM	1	8	PF00017	0.396
LIG_WRC_WIRS_1	420	425	PF05994	0.430
LIG_WW_2	100	103	PF00397	0.713
MOD_CK1_1	277	283	PF00069	0.749
MOD_CK1_1	322	328	PF00069	0.695
MOD_CK1_1	336	342	PF00069	0.562
MOD_CK1_1	387	393	PF00069	0.486
MOD_CK1_1	419	425	PF00069	0.406
MOD_CK1_1	562	568	PF00069	0.414
MOD_CK1_1	64	70	PF00069	0.601
MOD_CK2_1	15	21	PF00069	0.503
MOD_CK2_1	305	311	PF00069	0.593
MOD_CK2_1	393	399	PF00069	0.330
MOD_GlcNHglycan	114	117	PF01048	0.550
MOD_GlcNHglycan	262	265	PF01048	0.687
MOD_GlcNHglycan	311	315	PF01048	0.576
MOD_GlcNHglycan	321	324	PF01048	0.571
MOD_GlcNHglycan	35	38	PF01048	0.474
MOD_GlcNHglycan	359	362	PF01048	0.469
MOD_GlcNHglycan	439	442	PF01048	0.388
MOD_GlcNHglycan	443	446	PF01048	0.342
MOD_GlcNHglycan	447	450	PF01048	0.397
MOD_GlcNHglycan	561	564	PF01048	0.325
MOD_GSK3_1	190	197	PF00069	0.464
MOD_GSK3_1	437	444	PF00069	0.347
MOD_GSK3_1	484	491	PF00069	0.392
MOD_GSK3_1	597	604	PF00069	0.508
MOD_N-GLC_1	106	111	PF02516	0.585
MOD_N-GLC_1	112	117	PF02516	0.459
MOD_N-GLC_1	406	411	PF02516	0.438
MOD_N-GLC_1	459	464	PF02516	0.449
MOD_N-GLC_1	64	69	PF02516	0.581
MOD_N-GLC_2	496	498	PF02516	0.523
MOD_NEK2_1	106	111	PF00069	0.674
MOD_NEK2_1	142	147	PF00069	0.561
MOD_NEK2_1	236	241	PF00069	0.454
MOD_NEK2_1	260	265	PF00069	0.528
MOD_NEK2_1	304	309	PF00069	0.564
MOD_NEK2_1	310	315	PF00069	0.576
MOD_NEK2_1	392	397	PF00069	0.470
MOD_NEK2_1	428	433	PF00069	0.356
MOD_NEK2_1	447	452	PF00069	0.361
MOD_NEK2_1	473	478	PF00069	0.422
MOD_NEK2_1	492	497	PF00069	0.207
MOD_NEK2_1	539	544	PF00069	0.384
MOD_NEK2_1	577	582	PF00069	0.486
MOD_NEK2_1	597	602	PF00069	0.365
MOD_NEK2_2	119	124	PF00069	0.486
MOD_NEK2_2	238	243	PF00069	0.457
MOD_PIKK_1	387	393	PF00454	0.477
MOD_PIKK_1	473	479	PF00454	0.411
MOD_PIKK_1	540	546	PF00454	0.355
MOD_PIKK_1	64	70	PF00454	0.532
MOD_PKA_2	166	172	PF00069	0.527
MOD_PKA_2	236	242	PF00069	0.465
MOD_PKA_2	293	299	PF00069	0.622
MOD_PKA_2	466	472	PF00069	0.407
MOD_Plk_1	106	112	PF00069	0.599
MOD_Plk_1	119	125	PF00069	0.455
MOD_Plk_1	304	310	PF00069	0.569
MOD_Plk_1	384	390	PF00069	0.366
MOD_Plk_1	406	412	PF00069	0.368
MOD_Plk_1	413	419	PF00069	0.403
MOD_Plk_1	459	465	PF00069	0.477
MOD_Plk_1	577	583	PF00069	0.518
MOD_Plk_1	64	70	PF00069	0.613
MOD_Plk_2-3	305	311	PF00069	0.593
MOD_Plk_2-3	82	88	PF00069	0.666
MOD_Plk_4	305	311	PF00069	0.589
MOD_Plk_4	344	350	PF00069	0.460
MOD_Plk_4	400	406	PF00069	0.375
MOD_Plk_4	459	465	PF00069	0.398
MOD_Plk_4	488	494	PF00069	0.319
MOD_Plk_4	565	571	PF00069	0.403
MOD_Plk_4	598	604	PF00069	0.395
MOD_SUMO_for_1	151	154	PF00179	0.526
MOD_SUMO_for_1	282	285	PF00179	0.737
MOD_SUMO_for_1	77	80	PF00179	0.666
TRG_DiLeu_BaEn_2	304	310	PF01217	0.528
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.409
TRG_ENDOCYTIC_2	362	365	PF00928	0.342
TRG_ENDOCYTIC_2	5	8	PF00928	0.546
TRG_ER_diArg_1	242	245	PF00400	0.595
TRG_NES_CRM1_1	546	558	PF08389	0.444
TRG_NLS_MonoExtC_3	289	294	PF00514	0.583
TRG_NLS_MonoExtN_4	288	295	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.246
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	593	598	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S6	Leptomonas seymouri	84%	100%
A0A0N1PCL0	Leptomonas seymouri	27%	70%
A0A0S4J7X8	Bodo saltans	28%	83%
A0A0S4JKZ2	Bodo saltans	49%	93%
A0A1X0P1Y1	Trypanosomatidae	51%	99%
A0A1X0P3P9	Trypanosomatidae	27%	80%
A0A3R7KEX8	Trypanosoma rangeli	27%	82%
A0A3S7X707	Leishmania donovani	27%	71%
A0A422NMN1	Trypanosoma rangeli	51%	100%
A4HIS9	Leishmania braziliensis	89%	100%
A4HLS7	Leishmania braziliensis	27%	71%
A4I631	Leishmania infantum	100%	100%
A4I986	Leishmania infantum	27%	71%
C9ZRE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	99%
D0A6A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	80%
E9B1B6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9B453	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	71%
Q4Q6U8	Leishmania major	98%	100%
Q9GRN2	Leishmania major	27%	71%
V5DNT3	Trypanosoma cruzi	52%	100%
V5DQD1	Trypanosoma cruzi	28%	82%