Calmodulin-related protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

calmodulin-related protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3V3_LEIDO

TriTrypDb:

LdBPK_303410.1 , LdCL_300039700 , LDHU3_30.4510

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7X3V3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3V3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.340
CLV_C14_Caspase3-7	338	342	PF00656	0.444
CLV_C14_Caspase3-7	440	444	PF00656	0.582
CLV_C14_Caspase3-7	9	13	PF00656	0.683
CLV_NRD_NRD_1	421	423	PF00675	0.755
CLV_NRD_NRD_1	500	502	PF00675	0.580
CLV_NRD_NRD_1	546	548	PF00675	0.654
CLV_NRD_NRD_1	698	700	PF00675	0.589
CLV_NRD_NRD_1	701	703	PF00675	0.599
CLV_PCSK_FUR_1	699	703	PF00082	0.581
CLV_PCSK_KEX2_1	421	423	PF00082	0.755
CLV_PCSK_KEX2_1	5	7	PF00082	0.704
CLV_PCSK_KEX2_1	546	548	PF00082	0.654
CLV_PCSK_KEX2_1	635	637	PF00082	0.628
CLV_PCSK_KEX2_1	698	700	PF00082	0.589
CLV_PCSK_KEX2_1	701	703	PF00082	0.599
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.704
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.663
CLV_PCSK_SKI1_1	220	224	PF00082	0.614
CLV_PCSK_SKI1_1	231	235	PF00082	0.291
CLV_PCSK_SKI1_1	294	298	PF00082	0.506
CLV_PCSK_SKI1_1	332	336	PF00082	0.408
CLV_PCSK_SKI1_1	355	359	PF00082	0.475
CLV_PCSK_SKI1_1	709	713	PF00082	0.582
DEG_APCC_DBOX_1	293	301	PF00400	0.558
DEG_APCC_DBOX_1	349	357	PF00400	0.485
DOC_ANK_TNKS_1	398	405	PF00023	0.595
DOC_CYCLIN_RxL_1	355	363	PF00134	0.555
DOC_MAPK_gen_1	281	289	PF00069	0.347
DOC_MAPK_gen_1	546	554	PF00069	0.708
DOC_MAPK_gen_1	701	712	PF00069	0.612
DOC_MAPK_gen_1	83	91	PF00069	0.458
DOC_MAPK_MEF2A_6	170	177	PF00069	0.444
DOC_MAPK_MEF2A_6	298	307	PF00069	0.588
DOC_PP1_RVXF_1	356	362	PF00149	0.586
DOC_PP1_RVXF_1	707	713	PF00149	0.592
DOC_PP4_FxxP_1	497	500	PF00568	0.569
DOC_USP7_MATH_1	128	132	PF00917	0.455
DOC_USP7_MATH_1	257	261	PF00917	0.408
DOC_USP7_MATH_1	532	536	PF00917	0.708
DOC_USP7_MATH_1	548	552	PF00917	0.534
DOC_USP7_MATH_1	562	566	PF00917	0.530
DOC_USP7_MATH_1	571	575	PF00917	0.589
DOC_USP7_MATH_1	624	628	PF00917	0.670
DOC_WW_Pin1_4	540	545	PF00397	0.701
DOC_WW_Pin1_4	575	580	PF00397	0.703
DOC_WW_Pin1_4	620	625	PF00397	0.750
DOC_WW_Pin1_4	689	694	PF00397	0.639
LIG_14-3-3_CanoR_1	120	126	PF00244	0.512
LIG_14-3-3_CanoR_1	220	229	PF00244	0.669
LIG_14-3-3_CanoR_1	391	395	PF00244	0.519
LIG_14-3-3_CanoR_1	422	431	PF00244	0.711
LIG_14-3-3_CanoR_1	437	446	PF00244	0.578
LIG_14-3-3_CanoR_1	539	544	PF00244	0.773
LIG_14-3-3_CanoR_1	547	553	PF00244	0.617
LIG_14-3-3_CanoR_1	598	607	PF00244	0.638
LIG_14-3-3_CanoR_1	636	641	PF00244	0.652
LIG_14-3-3_CanoR_1	705	712	PF00244	0.553
LIG_14-3-3_CanoR_1	88	98	PF00244	0.495
LIG_Actin_WH2_2	19	37	PF00022	0.503
LIG_AP2alpha_1	361	365	PF02296	0.454
LIG_APCC_ABBA_1	334	339	PF00400	0.444
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_2	363	367	PF00653	0.580
LIG_BIR_III_4	256	260	PF00653	0.429
LIG_BRCT_BRCA1_1	44	48	PF00533	0.485
LIG_FHA_1	153	159	PF00498	0.361
LIG_FHA_1	288	294	PF00498	0.437
LIG_FHA_1	376	382	PF00498	0.537
LIG_FHA_1	652	658	PF00498	0.545
LIG_FHA_1	90	96	PF00498	0.498
LIG_FHA_2	120	126	PF00498	0.500
LIG_FHA_2	136	142	PF00498	0.344
LIG_FHA_2	158	164	PF00498	0.369
LIG_FHA_2	205	211	PF00498	0.590
LIG_FHA_2	221	227	PF00498	0.418
LIG_FHA_2	260	266	PF00498	0.391
LIG_FHA_2	286	292	PF00498	0.344
LIG_FHA_2	438	444	PF00498	0.547
LIG_FHA_2	465	471	PF00498	0.617
LIG_KLC1_Yacidic_2	477	481	PF13176	0.526
LIG_LIR_Apic_2	155	159	PF02991	0.432
LIG_LIR_Apic_2	207	211	PF02991	0.648
LIG_LIR_Apic_2	72	76	PF02991	0.453
LIG_LIR_Gen_1	131	137	PF02991	0.485
LIG_LIR_Gen_1	232	238	PF02991	0.356
LIG_LIR_Gen_1	242	251	PF02991	0.325
LIG_LIR_Gen_1	36	44	PF02991	0.344
LIG_LIR_Gen_1	714	723	PF02991	0.447
LIG_LIR_Nem_3	131	136	PF02991	0.344
LIG_LIR_Nem_3	160	164	PF02991	0.369
LIG_LIR_Nem_3	166	172	PF02991	0.336
LIG_LIR_Nem_3	232	237	PF02991	0.356
LIG_LIR_Nem_3	242	247	PF02991	0.325
LIG_LIR_Nem_3	248	254	PF02991	0.302
LIG_LIR_Nem_3	65	70	PF02991	0.478
LIG_LIR_Nem_3	662	666	PF02991	0.489
LIG_LIR_Nem_3	675	680	PF02991	0.537
LIG_LIR_Nem_3	697	703	PF02991	0.552
LIG_LIR_Nem_3	714	718	PF02991	0.307
LIG_MAD2	358	366	PF02301	0.605
LIG_PCNA_TLS_4	391	398	PF02747	0.450
LIG_PCNA_yPIPBox_3	281	293	PF02747	0.408
LIG_Pex14_2	292	296	PF04695	0.344
LIG_Pex14_2	361	365	PF04695	0.454
LIG_Pex14_2	397	401	PF04695	0.471
LIG_Pex14_2	711	715	PF04695	0.579
LIG_Pex14_2	94	98	PF04695	0.432
LIG_SH2_CRK	251	255	PF00017	0.272
LIG_SH2_SRC	208	211	PF00017	0.609
LIG_SH2_STAT5	156	159	PF00017	0.474
LIG_SH2_STAT5	208	211	PF00017	0.652
LIG_SH2_STAT5	479	482	PF00017	0.588
LIG_SH2_STAT5	671	674	PF00017	0.471
LIG_SH2_STAT5	73	76	PF00017	0.443
LIG_SH3_1	156	162	PF00018	0.408
LIG_SH3_3	156	162	PF00018	0.423
LIG_SH3_3	404	410	PF00018	0.642
LIG_SH3_3	477	483	PF00018	0.606
LIG_SH3_3	556	562	PF00018	0.751
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.325
LIG_SUMO_SIM_par_1	186	192	PF11976	0.485
LIG_SUMO_SIM_par_1	636	642	PF11976	0.587
LIG_TRAF2_1	122	125	PF00917	0.518
LIG_TRAF2_1	196	199	PF00917	0.344
LIG_TRAF2_1	27	30	PF00917	0.513
LIG_TRAF2_1	393	396	PF00917	0.624
LIG_TRAF2_1	50	53	PF00917	0.485
LIG_TRAF2_1	69	72	PF00917	0.426
LIG_TRFH_1	687	691	PF08558	0.621
LIG_WRC_WIRS_1	293	298	PF05994	0.589
LIG_WRC_WIRS_1	398	403	PF05994	0.555
LIG_WRC_WIRS_1	643	648	PF05994	0.594
MOD_CDC14_SPxK_1	543	546	PF00782	0.573
MOD_CDK_SPK_2	575	580	PF00069	0.740
MOD_CDK_SPxK_1	540	546	PF00069	0.582
MOD_CDK_SPxxK_3	540	547	PF00069	0.695
MOD_CK1_1	279	285	PF00069	0.485
MOD_CK1_1	375	381	PF00069	0.514
MOD_CK1_1	424	430	PF00069	0.722
MOD_CK1_1	439	445	PF00069	0.546
MOD_CK1_1	540	546	PF00069	0.780
MOD_CK1_1	565	571	PF00069	0.798
MOD_CK1_1	575	581	PF00069	0.682
MOD_CK1_1	599	605	PF00069	0.751
MOD_CK1_1	704	710	PF00069	0.579
MOD_CK2_1	119	125	PF00069	0.505
MOD_CK2_1	186	192	PF00069	0.378
MOD_CK2_1	193	199	PF00069	0.298
MOD_CK2_1	204	210	PF00069	0.615
MOD_CK2_1	220	226	PF00069	0.432
MOD_CK2_1	257	263	PF00069	0.458
MOD_CK2_1	390	396	PF00069	0.554
MOD_CK2_1	397	403	PF00069	0.574
MOD_CK2_1	464	470	PF00069	0.625
MOD_CK2_1	47	53	PF00069	0.444
MOD_CK2_1	552	558	PF00069	0.795
MOD_CK2_1	628	634	PF00069	0.742
MOD_CK2_1	636	642	PF00069	0.585
MOD_CK2_1	689	695	PF00069	0.559
MOD_CK2_1	87	93	PF00069	0.447
MOD_GlcNHglycan	123	129	PF01048	0.602
MOD_GlcNHglycan	178	181	PF01048	0.332
MOD_GlcNHglycan	259	262	PF01048	0.373
MOD_GlcNHglycan	283	286	PF01048	0.444
MOD_GlcNHglycan	326	329	PF01048	0.534
MOD_GlcNHglycan	403	407	PF01048	0.625
MOD_GlcNHglycan	417	420	PF01048	0.643
MOD_GlcNHglycan	472	475	PF01048	0.520
MOD_GlcNHglycan	508	511	PF01048	0.573
MOD_GlcNHglycan	534	537	PF01048	0.746
MOD_GlcNHglycan	554	557	PF01048	0.502
MOD_GlcNHglycan	564	567	PF01048	0.747
MOD_GSK3_1	124	131	PF00069	0.531
MOD_GSK3_1	18	25	PF00069	0.555
MOD_GSK3_1	259	266	PF00069	0.391
MOD_GSK3_1	275	282	PF00069	0.303
MOD_GSK3_1	371	378	PF00069	0.496
MOD_GSK3_1	431	438	PF00069	0.693
MOD_GSK3_1	538	545	PF00069	0.723
MOD_GSK3_1	548	555	PF00069	0.671
MOD_GSK3_1	561	568	PF00069	0.791
MOD_GSK3_1	571	578	PF00069	0.796
MOD_GSK3_1	596	603	PF00069	0.733
MOD_GSK3_1	605	612	PF00069	0.692
MOD_GSK3_1	620	627	PF00069	0.662
MOD_GSK3_1	647	654	PF00069	0.556
MOD_N-GLC_2	111	113	PF02516	0.545
MOD_NEK2_1	1	6	PF00069	0.664
MOD_NEK2_1	193	198	PF00069	0.337
MOD_NEK2_1	292	297	PF00069	0.583
MOD_NEK2_1	34	39	PF00069	0.485
MOD_NEK2_1	372	377	PF00069	0.514
MOD_NEK2_1	397	402	PF00069	0.576
MOD_NEK2_1	431	436	PF00069	0.711
MOD_NEK2_1	506	511	PF00069	0.578
MOD_NEK2_1	538	543	PF00069	0.737
MOD_NEK2_1	573	578	PF00069	0.802
MOD_NEK2_1	607	612	PF00069	0.656
MOD_NEK2_2	588	593	PF00069	0.499
MOD_PIKK_1	209	215	PF00454	0.686
MOD_PIKK_1	263	269	PF00454	0.351
MOD_PIKK_1	573	579	PF00454	0.799
MOD_PIKK_1	596	602	PF00454	0.741
MOD_PIKK_1	609	615	PF00454	0.621
MOD_PK_1	636	642	PF00069	0.591
MOD_PKA_1	421	427	PF00069	0.782
MOD_PKA_1	701	707	PF00069	0.599
MOD_PKA_2	119	125	PF00069	0.513
MOD_PKA_2	276	282	PF00069	0.429
MOD_PKA_2	34	40	PF00069	0.466
MOD_PKA_2	390	396	PF00069	0.565
MOD_PKA_2	42	48	PF00069	0.414
MOD_PKA_2	421	427	PF00069	0.782
MOD_PKA_2	436	442	PF00069	0.637
MOD_PKA_2	525	531	PF00069	0.729
MOD_PKA_2	538	544	PF00069	0.566
MOD_PKA_2	548	554	PF00069	0.585
MOD_PKA_2	673	679	PF00069	0.560
MOD_PKA_2	701	707	PF00069	0.596
MOD_PKA_2	87	93	PF00069	0.504
MOD_PKB_1	699	707	PF00069	0.594
MOD_Plk_1	124	130	PF00069	0.599
MOD_Plk_1	225	231	PF00069	0.444
MOD_Plk_1	263	269	PF00069	0.344
MOD_Plk_1	588	594	PF00069	0.565
MOD_Plk_1	648	654	PF00069	0.577
MOD_Plk_2-3	339	345	PF00069	0.444
MOD_Plk_2-3	87	93	PF00069	0.491
MOD_Plk_4	171	177	PF00069	0.444
MOD_Plk_4	18	24	PF00069	0.578
MOD_Plk_4	204	210	PF00069	0.643
MOD_Plk_4	225	231	PF00069	0.451
MOD_Plk_4	34	40	PF00069	0.442
MOD_Plk_4	372	378	PF00069	0.505
MOD_Plk_4	548	554	PF00069	0.743
MOD_Plk_4	624	630	PF00069	0.707
MOD_Plk_4	648	654	PF00069	0.566
MOD_ProDKin_1	540	546	PF00069	0.698
MOD_ProDKin_1	575	581	PF00069	0.704
MOD_ProDKin_1	620	626	PF00069	0.751
MOD_ProDKin_1	689	695	PF00069	0.634
TRG_DiLeu_BaEn_1	329	334	PF01217	0.560
TRG_DiLeu_BaEn_1	714	719	PF01217	0.527
TRG_DiLeu_BaEn_4	124	130	PF01217	0.499
TRG_DiLeu_BaEn_4	29	35	PF01217	0.479
TRG_ENDOCYTIC_2	251	254	PF00928	0.328
TRG_ENDOCYTIC_2	663	666	PF00928	0.593
TRG_ENDOCYTIC_2	681	684	PF00928	0.397
TRG_ENDOCYTIC_2	703	706	PF00928	0.535
TRG_ER_diArg_1	313	316	PF00400	0.547
TRG_ER_diArg_1	420	422	PF00400	0.746
TRG_ER_diArg_1	546	549	PF00400	0.655
TRG_ER_diArg_1	698	700	PF00400	0.589
TRG_ER_diArg_1	701	703	PF00400	0.595
TRG_ER_diArg_1	722	725	PF00400	0.498
TRG_NES_CRM1_1	267	280	PF08389	0.444
TRG_NES_CRM1_1	469	482	PF08389	0.622
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	24	29	PF00026	0.622
TRG_PTS1	722	725	PF00515	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB40	Leptomonas seymouri	57%	100%
A0A1X0P1B1	Trypanosomatidae	41%	100%
A0A3R7R5F4	Trypanosoma rangeli	40%	100%
A4HIS4	Leishmania braziliensis	72%	100%
A4I620	Leishmania infantum	100%	100%
E9B1B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q6V3	Leishmania major	95%	100%
V5BMR3	Trypanosoma cruzi	41%	100%