Eukaryotic_translation_initiation_factor_3_subuni t_7-like_protein/GeneDB:LmjF.30.3040

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit d

Species:

Leishmania donovani

UniProt:

A0A3S7X3V2_LEIDO

TriTrypDb:

LdBPK_303080.1 , LdCL_300036400 , LDHU3_30.4090

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3V2

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.598
CLV_C14_Caspase3-7	378	382	PF00656	0.616
CLV_C14_Caspase3-7	53	57	PF00656	0.616
CLV_NRD_NRD_1	122	124	PF00675	0.395
CLV_NRD_NRD_1	125	127	PF00675	0.403
CLV_NRD_NRD_1	211	213	PF00675	0.429
CLV_NRD_NRD_1	325	327	PF00675	0.375
CLV_NRD_NRD_1	335	337	PF00675	0.297
CLV_NRD_NRD_1	385	387	PF00675	0.346
CLV_NRD_NRD_1	68	70	PF00675	0.429
CLV_PCSK_FUR_1	123	127	PF00082	0.416
CLV_PCSK_KEX2_1	122	124	PF00082	0.386
CLV_PCSK_KEX2_1	125	127	PF00082	0.390
CLV_PCSK_KEX2_1	335	337	PF00082	0.332
CLV_PCSK_KEX2_1	385	387	PF00082	0.409
CLV_PCSK_KEX2_1	68	70	PF00082	0.419
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.419
CLV_PCSK_SKI1_1	102	106	PF00082	0.346
CLV_PCSK_SKI1_1	126	130	PF00082	0.353
CLV_PCSK_SKI1_1	202	206	PF00082	0.370
CLV_PCSK_SKI1_1	421	425	PF00082	0.402
CLV_PCSK_SKI1_1	69	73	PF00082	0.360
DEG_APCC_DBOX_1	219	227	PF00400	0.629
DOC_CKS1_1	169	174	PF01111	0.629
DOC_CYCLIN_RxL_1	183	193	PF00134	0.629
DOC_MAPK_gen_1	407	416	PF00069	0.629
DOC_MAPK_gen_1	85	94	PF00069	0.663
DOC_PP1_RVXF_1	422	428	PF00149	0.532
DOC_PP1_RVXF_1	88	95	PF00149	0.616
DOC_PP4_FxxP_1	3	6	PF00568	0.544
DOC_USP7_MATH_1	306	310	PF00917	0.588
DOC_USP7_MATH_1	52	56	PF00917	0.616
DOC_USP7_MATH_2	30	36	PF00917	0.616
DOC_USP7_UBL2_3	110	114	PF12436	0.601
DOC_USP7_UBL2_3	494	498	PF12436	0.629
DOC_WW_Pin1_4	168	173	PF00397	0.621
DOC_WW_Pin1_4	319	324	PF00397	0.598
DOC_WW_Pin1_4	340	345	PF00397	0.629
DOC_WW_Pin1_4	452	457	PF00397	0.601
LIG_14-3-3_CanoR_1	125	135	PF00244	0.546
LIG_14-3-3_CanoR_1	156	164	PF00244	0.621
LIG_14-3-3_CanoR_1	202	211	PF00244	0.575
LIG_14-3-3_CanoR_1	239	243	PF00244	0.575
LIG_14-3-3_CanoR_1	290	295	PF00244	0.569
LIG_14-3-3_CanoR_1	307	314	PF00244	0.581
LIG_14-3-3_CanoR_1	330	335	PF00244	0.629
LIG_14-3-3_CanoR_1	410	417	PF00244	0.572
LIG_Actin_WH2_2	140	158	PF00022	0.627
LIG_Actin_WH2_2	197	214	PF00022	0.599
LIG_APCC_ABBA_1	478	483	PF00400	0.629
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_CaM_IQ_9	140	156	PF13499	0.629
LIG_Clathr_ClatBox_1	501	505	PF01394	0.707
LIG_FHA_1	169	175	PF00498	0.631
LIG_FHA_1	225	231	PF00498	0.554
LIG_FHA_2	175	181	PF00498	0.608
LIG_FHA_2	203	209	PF00498	0.547
LIG_FHA_2	427	433	PF00498	0.618
LIG_FHA_2	84	90	PF00498	0.609
LIG_LIR_Apic_2	15	19	PF02991	0.493
LIG_LIR_Apic_2	2	6	PF02991	0.425
LIG_LIR_Apic_2	7	12	PF02991	0.541
LIG_LIR_Gen_1	299	308	PF02991	0.601
LIG_LIR_Gen_1	345	355	PF02991	0.534
LIG_LIR_Gen_1	468	478	PF02991	0.629
LIG_LIR_Nem_3	299	305	PF02991	0.601
LIG_LIR_Nem_3	313	317	PF02991	0.625
LIG_LIR_Nem_3	333	337	PF02991	0.572
LIG_LIR_Nem_3	345	350	PF02991	0.489
LIG_LIR_Nem_3	395	399	PF02991	0.612
LIG_LIR_Nem_3	44	48	PF02991	0.558
LIG_LIR_Nem_3	468	474	PF02991	0.614
LIG_LYPXL_yS_3	221	224	PF13949	0.618
LIG_PTB_Apo_2	8	15	PF02174	0.557
LIG_SH2_CRK	169	173	PF00017	0.636
LIG_SH2_CRK	347	351	PF00017	0.544
LIG_SH2_GRB2like	9	12	PF00017	0.598
LIG_SH2_NCK_1	34	38	PF00017	0.616
LIG_SH2_NCK_1	454	458	PF00017	0.629
LIG_SH2_PTP2	9	12	PF00017	0.629
LIG_SH2_SRC	347	350	PF00017	0.598
LIG_SH2_SRC	9	12	PF00017	0.598
LIG_SH2_STAP1	195	199	PF00017	0.629
LIG_SH2_STAP1	302	306	PF00017	0.618
LIG_SH2_STAP1	347	351	PF00017	0.544
LIG_SH2_STAT5	199	202	PF00017	0.630
LIG_SH2_STAT5	337	340	PF00017	0.586
LIG_SH2_STAT5	9	12	PF00017	0.608
LIG_SH3_4	494	501	PF00018	0.629
LIG_SUMO_SIM_anti_2	227	235	PF11976	0.545
LIG_SUMO_SIM_anti_2	412	419	PF11976	0.629
LIG_SUMO_SIM_anti_2	499	510	PF11976	0.663
LIG_SUMO_SIM_par_1	221	229	PF11976	0.535
LIG_SUMO_SIM_par_1	232	238	PF11976	0.538
LIG_SUMO_SIM_par_1	447	453	PF11976	0.616
LIG_SUMO_SIM_par_1	499	515	PF11976	0.708
LIG_TRAF2_1	18	21	PF00917	0.624
LIG_TRAF2_1	429	432	PF00917	0.629
LIG_TYR_ITIM	249	254	PF00017	0.629
LIG_WW_1	172	175	PF00397	0.575
MOD_CDK_SPxK_1	340	346	PF00069	0.629
MOD_CDK_SPxxK_3	319	326	PF00069	0.629
MOD_CK1_1	322	328	PF00069	0.629
MOD_CK1_1	415	421	PF00069	0.627
MOD_CK1_1	450	456	PF00069	0.614
MOD_CK1_1	458	464	PF00069	0.615
MOD_CK2_1	174	180	PF00069	0.593
MOD_CK2_1	190	196	PF00069	0.508
MOD_CK2_1	260	266	PF00069	0.567
MOD_CK2_1	290	296	PF00069	0.615
MOD_CK2_1	426	432	PF00069	0.629
MOD_CK2_1	56	62	PF00069	0.619
MOD_CK2_1	83	89	PF00069	0.645
MOD_Cter_Amidation	108	111	PF01082	0.449
MOD_GlcNHglycan	137	140	PF01048	0.424
MOD_GlcNHglycan	157	160	PF01048	0.376
MOD_GSK3_1	131	138	PF00069	0.616
MOD_GSK3_1	306	313	PF00069	0.645
MOD_GSK3_1	375	382	PF00069	0.609
MOD_GSK3_1	483	490	PF00069	0.609
MOD_GSK3_1	52	59	PF00069	0.630
MOD_N-GLC_1	135	140	PF02516	0.429
MOD_N-GLC_1	319	324	PF02516	0.411
MOD_N-GLC_2	404	406	PF02516	0.429
MOD_NEK2_1	155	160	PF00069	0.621
MOD_NEK2_1	190	195	PF00069	0.577
MOD_NEK2_1	235	240	PF00069	0.537
MOD_OFUCOSY	304	310	PF10250	0.371
MOD_PIKK_1	458	464	PF00454	0.586
MOD_PKA_1	126	132	PF00069	0.631
MOD_PKA_2	155	161	PF00069	0.621
MOD_PKA_2	238	244	PF00069	0.614
MOD_PKA_2	278	284	PF00069	0.561
MOD_PKA_2	289	295	PF00069	0.498
MOD_PKA_2	306	312	PF00069	0.532
MOD_PKA_2	409	415	PF00069	0.624
MOD_Plk_1	135	141	PF00069	0.609
MOD_Plk_1	380	386	PF00069	0.629
MOD_Plk_1	88	94	PF00069	0.668
MOD_Plk_2-3	510	516	PF00069	0.814
MOD_Plk_2-3	56	62	PF00069	0.628
MOD_Plk_4	229	235	PF00069	0.610
MOD_Plk_4	392	398	PF00069	0.598
MOD_Plk_4	412	418	PF00069	0.423
MOD_Plk_4	487	493	PF00069	0.590
MOD_Plk_4	88	94	PF00069	0.616
MOD_ProDKin_1	168	174	PF00069	0.621
MOD_ProDKin_1	319	325	PF00069	0.598
MOD_ProDKin_1	340	346	PF00069	0.629
MOD_ProDKin_1	452	458	PF00069	0.601
MOD_SUMO_for_1	258	261	PF00179	0.629
MOD_SUMO_rev_2	20	25	PF00179	0.571
MOD_SUMO_rev_2	415	423	PF00179	0.629
TRG_DiLeu_BaEn_1	229	234	PF01217	0.544
TRG_DiLeu_BaEn_1	354	359	PF01217	0.644
TRG_DiLeu_BaEn_2	195	201	PF01217	0.560
TRG_DiLeu_BaEn_4	20	26	PF01217	0.624
TRG_ENDOCYTIC_2	221	224	PF00928	0.618
TRG_ENDOCYTIC_2	251	254	PF00928	0.560
TRG_ENDOCYTIC_2	302	305	PF00928	0.632
TRG_ENDOCYTIC_2	347	350	PF00928	0.557
TRG_ER_diArg_1	122	125	PF00400	0.606
TRG_ER_diArg_1	334	336	PF00400	0.532
TRG_ER_diArg_1	384	386	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH4	Leptomonas seymouri	81%	100%
A0A0S4IWX5	Bodo saltans	31%	88%
A0A1X0P1D0	Trypanosomatidae	39%	100%
A0A3R7P1P7	Trypanosoma rangeli	39%	100%
A1C777	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	28%	91%
A1DI25	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	91%
A4HIN8	Leishmania braziliensis	94%	100%
A4I5Y5	Leishmania infantum	100%	100%
A4RFH6	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	25%	93%
A7SMR1	Nematostella vectensis	25%	94%
B0X6P7	Culex quinquefasciatus	23%	87%
B0XU47	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	91%
B3LY71	Drosophila ananassae	23%	95%
B3LZN3	Drosophila ananassae	24%	97%
B3P1F9	Drosophila erecta	24%	96%
B3P8G6	Drosophila erecta	23%	95%
B4GFS1	Drosophila persimilis	24%	97%
B4GP93	Drosophila persimilis	22%	98%
B4HFV9	Drosophila sechellia	22%	95%
B4HHG8	Drosophila sechellia	23%	97%
B4JTN0	Drosophila grimshawi	23%	94%
B4JUM0	Drosophila grimshawi	22%	95%
B4K892	Drosophila mojavensis	23%	94%
B4KDI2	Drosophila mojavensis	22%	96%
B4LYI3	Drosophila virilis	23%	94%
B4M5A7	Drosophila virilis	23%	96%
B4N8Z4	Drosophila willistoni	25%	97%
B4NLG2	Drosophila willistoni	23%	95%
B4PNN4	Drosophila yakuba	23%	96%
B4PNV2	Drosophila yakuba	22%	95%
B4QT07	Drosophila simulans	23%	96%
B4R222	Drosophila simulans	22%	95%
B5DY99	Drosophila pseudoobscura pseudoobscura	22%	94%
C9ZRB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	95%
E9B178	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
K7IM66	Nasonia vitripennis	24%	95%
O15371	Homo sapiens	24%	97%
O70194	Mus musculus	25%	97%
P0CN48	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	23%	97%
P0CN49	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	23%	97%
P30642	Caenorhabditis elegans	24%	93%
Q0ZB77	Bombyx mori	24%	97%
Q16UF8	Aedes aegypti	23%	86%
Q295S1	Drosophila pseudoobscura pseudoobscura	23%	97%
Q3T122	Bos taurus	24%	97%
Q4Q6Y6	Leishmania major	98%	100%
Q4R8R4	Macaca fascicularis	24%	97%
Q4X054	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	91%
Q554U9	Dictyostelium discoideum	24%	100%
Q5R925	Pongo abelii	24%	97%
Q6AYK8	Rattus norvegicus	25%	97%
Q6C1N1	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q6TH15	Danio rerio	25%	96%
Q7QBW3	Anopheles gambiae	24%	91%
Q9VCK0	Drosophila melanogaster	22%	95%
Q9VGC7	Drosophila melanogaster	23%	96%
V5B793	Trypanosoma cruzi	38%	100%