Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3V1_LEIDO

TriTrypDb:

LdBPK_302670.1 , LdCL_300032300 , LDHU3_30.3570

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3S7X3V1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3V1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.399
CLV_C14_Caspase3-7	259	263	PF00656	0.435
CLV_C14_Caspase3-7	274	278	PF00656	0.635
CLV_MEL_PAP_1	196	202	PF00089	0.579
CLV_NRD_NRD_1	10	12	PF00675	0.712
CLV_NRD_NRD_1	292	294	PF00675	0.562
CLV_PCSK_KEX2_1	10	12	PF00082	0.710
CLV_PCSK_KEX2_1	292	294	PF00082	0.523
CLV_PCSK_KEX2_1	319	321	PF00082	0.455
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.455
CLV_PCSK_SKI1_1	186	190	PF00082	0.585
CLV_PCSK_SKI1_1	292	296	PF00082	0.562
DEG_APCC_DBOX_1	292	300	PF00400	0.330
DOC_AGCK_PIF_1	143	148	PF00069	0.319
DOC_ANK_TNKS_1	198	205	PF00023	0.375
DOC_CYCLIN_RxL_1	286	298	PF00134	0.429
DOC_MAPK_gen_1	172	181	PF00069	0.427
DOC_MAPK_gen_1	292	299	PF00069	0.290
DOC_MAPK_gen_1	319	325	PF00069	0.662
DOC_MAPK_MEF2A_6	172	181	PF00069	0.433
DOC_MAPK_MEF2A_6	292	301	PF00069	0.302
DOC_MAPK_MEF2A_6	337	346	PF00069	0.573
DOC_PP4_FxxP_1	165	168	PF00568	0.323
DOC_USP7_MATH_1	161	165	PF00917	0.364
DOC_USP7_MATH_1	264	268	PF00917	0.558
DOC_USP7_MATH_1	284	288	PF00917	0.517
DOC_USP7_MATH_1	307	311	PF00917	0.480
DOC_USP7_MATH_1	5	9	PF00917	0.628
DOC_WW_Pin1_4	138	143	PF00397	0.399
DOC_WW_Pin1_4	149	154	PF00397	0.285
DOC_WW_Pin1_4	173	178	PF00397	0.440
DOC_WW_Pin1_4	241	246	PF00397	0.393
DOC_WW_Pin1_4	285	290	PF00397	0.540
LIG_14-3-3_CanoR_1	100	107	PF00244	0.420
LIG_14-3-3_CanoR_1	134	143	PF00244	0.404
LIG_14-3-3_CanoR_1	144	149	PF00244	0.251
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_CtBP_PxDLS_1	82	86	PF00389	0.448
LIG_eIF4E_1	217	223	PF01652	0.440
LIG_FHA_1	174	180	PF00498	0.470
LIG_FHA_1	286	292	PF00498	0.496
LIG_FHA_1	336	342	PF00498	0.624
LIG_FHA_1	59	65	PF00498	0.435
LIG_FHA_1	96	102	PF00498	0.328
LIG_FHA_2	124	130	PF00498	0.353
LIG_IRF3_LxIS_1	291	298	PF10401	0.359
LIG_LIR_Apic_2	162	168	PF02991	0.340
LIG_LIR_Apic_2	58	63	PF02991	0.402
LIG_LIR_Gen_1	298	308	PF02991	0.431
LIG_LIR_Gen_1	355	363	PF02991	0.742
LIG_LIR_Nem_3	141	146	PF02991	0.375
LIG_LIR_Nem_3	182	188	PF02991	0.399
LIG_LIR_Nem_3	298	303	PF02991	0.387
LIG_LIR_Nem_3	355	360	PF02991	0.721
LIG_NRBOX	24	30	PF00104	0.572
LIG_NRBOX	290	296	PF00104	0.369
LIG_Pex14_2	145	149	PF04695	0.370
LIG_Pex14_2	233	237	PF04695	0.286
LIG_Pex14_2	52	56	PF04695	0.441
LIG_Pex3_1	291	302	PF04882	0.386
LIG_PTB_Apo_2	93	100	PF02174	0.394
LIG_PTB_Phospho_1	93	99	PF10480	0.389
LIG_SH2_CRK	235	239	PF00017	0.427
LIG_SH2_CRK	357	361	PF00017	0.779
LIG_SH2_CRK	60	64	PF00017	0.374
LIG_SH2_GRB2like	94	97	PF00017	0.392
LIG_SH2_SRC	94	97	PF00017	0.392
LIG_SH2_STAT3	247	250	PF00017	0.348
LIG_SH2_STAT5	184	187	PF00017	0.321
LIG_SH2_STAT5	235	238	PF00017	0.318
LIG_SH2_STAT5	247	250	PF00017	0.395
LIG_SH2_STAT5	315	318	PF00017	0.689
LIG_SH2_STAT5	60	63	PF00017	0.363
LIG_SH2_STAT5	94	97	PF00017	0.392
LIG_SH3_1	174	180	PF00018	0.419
LIG_SH3_3	174	180	PF00018	0.389
LIG_SH3_3	185	191	PF00018	0.316
LIG_SH3_3	360	366	PF00018	0.721
LIG_SH3_3	38	44	PF00018	0.494
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.558
LIG_SUMO_SIM_anti_2	72	78	PF11976	0.313
LIG_SUMO_SIM_par_1	24	30	PF11976	0.566
LIG_SUMO_SIM_par_1	293	298	PF11976	0.421
LIG_WRC_WIRS_1	145	150	PF05994	0.313
MOD_CDK_SPxK_1	138	144	PF00069	0.394
MOD_CDK_SPxxK_3	285	292	PF00069	0.481
MOD_CK1_1	269	275	PF00069	0.587
MOD_CK1_1	278	284	PF00069	0.542
MOD_CK1_1	6	12	PF00069	0.527
MOD_CK2_1	123	129	PF00069	0.399
MOD_CK2_1	251	257	PF00069	0.425
MOD_Cter_Amidation	317	320	PF01082	0.465
MOD_GlcNHglycan	20	23	PF01048	0.603
MOD_GlcNHglycan	200	203	PF01048	0.635
MOD_GlcNHglycan	211	214	PF01048	0.619
MOD_GlcNHglycan	218	221	PF01048	0.593
MOD_GlcNHglycan	226	229	PF01048	0.609
MOD_GlcNHglycan	266	269	PF01048	0.722
MOD_GlcNHglycan	273	276	PF01048	0.829
MOD_GlcNHglycan	309	312	PF01048	0.447
MOD_GlcNHglycan	330	333	PF01048	0.420
MOD_GlcNHglycan	36	39	PF01048	0.685
MOD_GlcNHglycan	5	8	PF01048	0.692
MOD_GSK3_1	134	141	PF00069	0.483
MOD_GSK3_1	264	271	PF00069	0.513
MOD_GSK3_1	278	285	PF00069	0.549
MOD_GSK3_1	95	102	PF00069	0.420
MOD_N-GLC_1	269	274	PF02516	0.760
MOD_N-GLC_1	95	100	PF02516	0.511
MOD_NEK2_1	18	23	PF00069	0.509
MOD_NEK2_1	233	238	PF00069	0.345
MOD_NEK2_1	295	300	PF00069	0.367
MOD_NEK2_1	347	352	PF00069	0.693
MOD_PIKK_1	246	252	PF00454	0.400
MOD_PIKK_1	347	353	PF00454	0.727
MOD_PKA_2	198	204	PF00069	0.399
MOD_PKA_2	99	105	PF00069	0.409
MOD_Plk_1	161	167	PF00069	0.399
MOD_Plk_1	95	101	PF00069	0.306
MOD_Plk_2-3	203	209	PF00069	0.403
MOD_Plk_4	161	167	PF00069	0.371
MOD_Plk_4	179	185	PF00069	0.337
MOD_Plk_4	27	33	PF00069	0.545
MOD_ProDKin_1	138	144	PF00069	0.394
MOD_ProDKin_1	149	155	PF00069	0.285
MOD_ProDKin_1	173	179	PF00069	0.438
MOD_ProDKin_1	241	247	PF00069	0.384
MOD_ProDKin_1	285	291	PF00069	0.531
MOD_SUMO_rev_2	201	210	PF00179	0.468
MOD_SUMO_rev_2	272	281	PF00179	0.589
TRG_DiLeu_BaEn_1	72	77	PF01217	0.326
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.571
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.463
TRG_ENDOCYTIC_2	314	317	PF00928	0.629
TRG_ENDOCYTIC_2	357	360	PF00928	0.698
TRG_ER_diArg_1	10	13	PF00400	0.650
TRG_ER_diArg_1	133	136	PF00400	0.422
TRG_ER_diArg_1	291	293	PF00400	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT9	Leptomonas seymouri	47%	97%
A0A1X0P1M4	Trypanosomatidae	32%	94%
A0A422NM26	Trypanosoma rangeli	35%	96%
A4HIK0	Leishmania braziliensis	70%	100%
A4I5U4	Leishmania infantum	99%	100%
C9ZR64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B139	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q727	Leishmania major	92%	100%
V5DNY7	Trypanosoma cruzi	34%	88%