Serine/threonine phosphatase, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine phosphatase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3U9_LEIDO

TriTrypDb:

LdBPK_303330.1 , LdCL_300038900 , LDHU3_30.4420

Length:

371

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 9
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3S7X3U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3U9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016787	hydrolase activity	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.269
CLV_NRD_NRD_1	31	33	PF00675	0.253
CLV_PCSK_KEX2_1	31	33	PF00082	0.250
CLV_PCSK_SKI1_1	136	140	PF00082	0.281
CLV_PCSK_SKI1_1	154	158	PF00082	0.166
CLV_PCSK_SKI1_1	224	228	PF00082	0.450
DEG_APCC_DBOX_1	356	364	PF00400	0.497
DOC_MAPK_gen_1	6	13	PF00069	0.330
DOC_MAPK_MEF2A_6	6	13	PF00069	0.295
DOC_MAPK_NFAT4_5	6	14	PF00069	0.327
DOC_USP7_MATH_1	308	312	PF00917	0.382
DOC_USP7_MATH_1	350	354	PF00917	0.651
DOC_USP7_UBL2_3	120	124	PF12436	0.460
DOC_USP7_UBL2_3	236	240	PF12436	0.280
DOC_WW_Pin1_4	197	202	PF00397	0.266
LIG_BIR_II_1	1	5	PF00653	0.311
LIG_FHA_1	189	195	PF00498	0.355
LIG_FHA_1	295	301	PF00498	0.311
LIG_FHA_2	208	214	PF00498	0.319
LIG_Integrin_RGD_1	116	118	PF01839	0.311
LIG_LIR_Gen_1	330	339	PF02991	0.397
LIG_LIR_Nem_3	118	122	PF02991	0.449
LIG_LIR_Nem_3	239	245	PF02991	0.277
LIG_LIR_Nem_3	330	334	PF02991	0.397
LIG_LIR_Nem_3	365	371	PF02991	0.649
LIG_NRBOX	8	14	PF00104	0.275
LIG_PCNA_PIPBox_1	320	329	PF02747	0.300
LIG_SH2_STAP1	43	47	PF00017	0.526
LIG_SH2_STAT5	149	152	PF00017	0.439
LIG_SH2_STAT5	327	330	PF00017	0.306
LIG_SH2_STAT5	348	351	PF00017	0.645
LIG_SH3_3	214	220	PF00018	0.244
LIG_SH3_3	251	257	PF00018	0.311
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.481
LIG_SUMO_SIM_anti_2	332	338	PF11976	0.402
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.465
LIG_SUMO_SIM_anti_2	8	14	PF11976	0.281
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.465
LIG_SUMO_SIM_par_1	219	225	PF11976	0.253
LIG_SUMO_SIM_par_1	269	274	PF11976	0.274
LIG_SUMO_SIM_par_1	32	38	PF11976	0.462
LIG_UBA3_1	176	182	PF00899	0.343
LIG_WRC_WIRS_1	328	333	PF05994	0.288
MOD_CDK_SPxxK_3	197	204	PF00069	0.391
MOD_CK1_1	141	147	PF00069	0.318
MOD_CK1_1	170	176	PF00069	0.298
MOD_CK1_1	188	194	PF00069	0.326
MOD_CK1_1	306	312	PF00069	0.621
MOD_CK2_1	178	184	PF00069	0.319
MOD_GlcNHglycan	129	132	PF01048	0.329
MOD_GlcNHglycan	13	16	PF01048	0.383
MOD_GlcNHglycan	26	29	PF01048	0.368
MOD_GlcNHglycan	312	315	PF01048	0.652
MOD_GlcNHglycan	331	334	PF01048	0.176
MOD_GlcNHglycan	352	355	PF01048	0.521
MOD_GSK3_1	123	130	PF00069	0.318
MOD_GSK3_1	302	309	PF00069	0.608
MOD_GSK3_1	7	14	PF00069	0.399
MOD_N-GLC_1	141	146	PF02516	0.331
MOD_N-GLC_1	195	200	PF02516	0.339
MOD_NEK2_1	11	16	PF00069	0.334
MOD_NEK2_1	127	132	PF00069	0.307
MOD_NEK2_1	176	181	PF00069	0.357
MOD_NEK2_1	195	200	PF00069	0.166
MOD_NEK2_1	222	227	PF00069	0.339
MOD_NEK2_1	275	280	PF00069	0.353
MOD_NEK2_1	302	307	PF00069	0.444
MOD_NEK2_1	319	324	PF00069	0.637
MOD_Plk_1	294	300	PF00069	0.414
MOD_Plk_1	43	49	PF00069	0.325
MOD_Plk_4	244	250	PF00069	0.283
MOD_Plk_4	338	344	PF00069	0.324
MOD_Plk_4	45	51	PF00069	0.325
MOD_Plk_4	7	13	PF00069	0.306
MOD_ProDKin_1	197	203	PF00069	0.327
MOD_SUMO_rev_2	235	243	PF00179	0.393
TRG_DiLeu_BaEn_1	29	34	PF01217	0.416
TRG_DiLeu_BaEn_1	65	70	PF01217	0.423
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.609
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.450
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.394
TRG_ENDOCYTIC_2	119	122	PF00928	0.325
TRG_ENDOCYTIC_2	159	162	PF00928	0.425
TRG_ENDOCYTIC_2	326	329	PF00928	0.471
TRG_ENDOCYTIC_2	348	351	PF00928	0.604
TRG_ENDOCYTIC_2	368	371	PF00928	0.549
TRG_ER_diArg_1	150	153	PF00400	0.310
TRG_ER_diArg_1	31	33	PF00400	0.305
TRG_NES_CRM1_1	66	82	PF08389	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V2	Leptomonas seymouri	75%	99%
A0A0N1P9R1	Leptomonas seymouri	26%	100%
A0A0S4JBT9	Bodo saltans	33%	95%
A0A0S4JMN0	Bodo saltans	29%	92%
A0A0S4KJG1	Bodo saltans	52%	100%
A0A1X0NU01	Trypanosomatidae	24%	99%
A0A1X0NZX7	Trypanosomatidae	30%	83%
A0A1X0P2G6	Trypanosomatidae	65%	100%
A0A3Q8IBB4	Leishmania donovani	28%	100%
A0A3Q8IIK0	Leishmania donovani	27%	100%
A0A3R7NTC0	Trypanosoma rangeli	64%	100%
A0A3S5IRW3	Trypanosoma rangeli	27%	90%
A4HCJ2	Leishmania braziliensis	28%	100%
A4HH45	Leishmania braziliensis	29%	100%
A4HIR7	Leishmania braziliensis	81%	100%
A4I008	Leishmania infantum	28%	100%
A4I498	Leishmania infantum	27%	100%
A4I612	Leishmania infantum	99%	100%
C9ZQ86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
C9ZRD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	84%
E9ADP5	Leishmania major	28%	100%
E9AM35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B1A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O74480	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q4Q6W1	Leishmania major	93%	100%
Q4QBJ8	Leishmania major	27%	100%
Q944L7	Arabidopsis thaliana	27%	95%
V5ARZ9	Trypanosoma cruzi	25%	99%
V5BPY7	Trypanosoma cruzi	30%	85%
V5BX32	Trypanosoma cruzi	64%	100%