LeishMANIAdb
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MORN_repeat-containing_protein_1/GeneDB:LmjF.30.3 310

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MORN_repeat-containing_protein_1/GeneDB:LmjF.30.3 310
Gene product:
MORN repeat-containing protein 1
Species:
Leishmania donovani
UniProt:
A0A3S7X3U7_LEIDO
TriTrypDb:
LdBPK_303360.1 , LdCL_300039200 , LDHU3_30.4460
Length:
358

Annotations

Annotations by Jardim et al.

Drug resistance proteins, MORN repeat-containing 1 (MORN1) | | length=358 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 38
NetGPI no yes: 0, no: 40
Cellular components
Term Name Level Count
GO:0005929 cilium 4 2
GO:0031514 motile cilium 5 2
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 4
GO:0120025 plasma membrane bounded cell projection 3 2
GO:0005737 cytoplasm 2 1
GO:0005815 microtubule organizing center 2 1
GO:0005816 spindle pole body 3 1
GO:0036064 ciliary basal body 3 1
GO:0044732 mitotic spindle pole body 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X3U7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3U7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006897 endocytosis 5 1
GO:0016192 vesicle-mediated transport 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0006793 phosphorus metabolic process 3 1
GO:0006796 phosphate-containing compound metabolic process 4 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016310 phosphorylation 5 1
GO:0044237 cellular metabolic process 2 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016301 kinase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.267
CLV_C14_Caspase3-7 333 337 PF00656 0.333
CLV_C14_Caspase3-7 42 46 PF00656 0.395
CLV_C14_Caspase3-7 88 92 PF00656 0.356
CLV_C14_Caspase3-7 98 102 PF00656 0.266
CLV_NRD_NRD_1 292 294 PF00675 0.323
CLV_PCSK_KEX2_1 126 128 PF00082 0.292
CLV_PCSK_KEX2_1 292 294 PF00082 0.330
CLV_PCSK_KEX2_1 34 36 PF00082 0.328
CLV_PCSK_PC1ET2_1 126 128 PF00082 0.296
CLV_PCSK_PC1ET2_1 34 36 PF00082 0.310
CLV_PCSK_SKI1_1 273 277 PF00082 0.435
CLV_PCSK_SKI1_1 321 325 PF00082 0.429
DOC_ANK_TNKS_1 291 298 PF00023 0.390
DOC_MAPK_gen_1 315 324 PF00069 0.429
DOC_PP2B_LxvP_1 299 302 PF13499 0.296
DOC_USP7_MATH_1 138 142 PF00917 0.456
DOC_USP7_MATH_1 302 306 PF00917 0.319
DOC_USP7_MATH_1 44 48 PF00917 0.330
DOC_USP7_UBL2_3 126 130 PF12436 0.282
DOC_USP7_UBL2_3 177 181 PF12436 0.366
DOC_USP7_UBL2_3 57 61 PF12436 0.337
LIG_BRCT_BRCA1_1 142 146 PF00533 0.326
LIG_deltaCOP1_diTrp_1 75 78 PF00928 0.330
LIG_FHA_1 2 8 PF00498 0.441
LIG_FHA_1 225 231 PF00498 0.441
LIG_FHA_2 331 337 PF00498 0.313
LIG_FHA_2 40 46 PF00498 0.356
LIG_Integrin_isoDGR_2 82 84 PF01839 0.312
LIG_LIR_Apic_2 132 138 PF02991 0.361
LIG_LIR_Apic_2 183 187 PF02991 0.349
LIG_LIR_Nem_3 213 218 PF02991 0.352
LIG_LIR_Nem_3 75 81 PF02991 0.296
LIG_Pex14_1 158 162 PF04695 0.343
LIG_Pex14_2 146 150 PF04695 0.228
LIG_Pex14_2 330 334 PF04695 0.312
LIG_PTB_Phospho_1 352 358 PF10480 0.493
LIG_SH2_CRK 204 208 PF00017 0.307
LIG_SH2_GRB2like 112 115 PF00017 0.275
LIG_SH2_GRB2like 209 212 PF00017 0.276
LIG_SH2_GRB2like 255 258 PF00017 0.296
LIG_SH2_GRB2like 278 281 PF00017 0.296
LIG_SH2_PTP2 184 187 PF00017 0.307
LIG_SH2_SRC 163 166 PF00017 0.296
LIG_SH2_SRC 209 212 PF00017 0.306
LIG_SH2_SRC 278 281 PF00017 0.312
LIG_SH2_SRC 43 46 PF00017 0.315
LIG_SH2_SRC 89 92 PF00017 0.431
LIG_SH2_STAT5 184 187 PF00017 0.319
LIG_SH2_STAT5 209 212 PF00017 0.288
LIG_SH2_STAT5 232 235 PF00017 0.354
LIG_SH2_STAT5 238 241 PF00017 0.342
LIG_SH2_STAT5 3 6 PF00017 0.390
LIG_SH2_STAT5 346 349 PF00017 0.489
LIG_SH2_STAT5 41 44 PF00017 0.348
LIG_SH2_STAT5 72 75 PF00017 0.377
MOD_CK2_1 138 144 PF00069 0.424
MOD_CK2_1 302 308 PF00069 0.296
MOD_Cter_Amidation 244 247 PF01082 0.296
MOD_Cter_Amidation 313 316 PF01082 0.291
MOD_Cter_Amidation 32 35 PF01082 0.312
MOD_GlcNHglycan 268 271 PF01048 0.323
MOD_GlcNHglycan 67 70 PF01048 0.334
MOD_GSK3_1 224 231 PF00069 0.362
MOD_GSK3_1 249 256 PF00069 0.377
MOD_GSK3_1 70 77 PF00069 0.371
MOD_N-GLC_1 266 271 PF02516 0.335
MOD_N-GLC_2 280 282 PF02516 0.296
MOD_NEK2_1 253 258 PF00069 0.294
MOD_NEK2_1 330 335 PF00069 0.356
MOD_NEK2_2 60 65 PF00069 0.330
MOD_PKA_2 236 242 PF00069 0.459
MOD_PKA_2 249 255 PF00069 0.351
MOD_PKA_2 70 76 PF00069 0.388
MOD_PKA_2 83 89 PF00069 0.393
MOD_Plk_1 74 80 PF00069 0.340
MOD_Plk_2-3 303 309 PF00069 0.302
MOD_Plk_4 180 186 PF00069 0.299
MOD_Plk_4 205 211 PF00069 0.371
MOD_Plk_4 228 234 PF00069 0.382
MOD_SUMO_rev_2 170 178 PF00179 0.348
MOD_SUMO_rev_2 216 224 PF00179 0.390
MOD_SUMO_rev_2 50 58 PF00179 0.297
TRG_DiLeu_BaEn_1 296 301 PF01217 0.432
TRG_ENDOCYTIC_2 204 207 PF00928 0.334
TRG_ER_diArg_1 319 322 PF00400 0.408

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IIK8 Leptomonas seymouri 95% 100%
A0A0N1PBP4 Leptomonas seymouri 28% 100%
A0A0S4IT41 Bodo saltans 25% 100%
A0A0S4J443 Bodo saltans 27% 81%
A0A0S4JES9 Bodo saltans 27% 71%
A0A0S4JF26 Bodo saltans 30% 100%
A0A0S4JFV2 Bodo saltans 29% 82%
A0A0S4KIY0 Bodo saltans 81% 100%
A0A0S4KKM9 Bodo saltans 28% 67%
A0A1X0NTG8 Trypanosomatidae 36% 82%
A0A1X0P1A5 Trypanosomatidae 78% 100%
A0A1X0P3N0 Trypanosomatidae 25% 100%
A0A3R7M394 Trypanosoma rangeli 27% 100%
A0A3R7NAK8 Trypanosoma rangeli 37% 87%
A0A3S7WVR3 Leishmania donovani 31% 81%
A0A3S7WXA1 Leishmania donovani 36% 68%
A0A3S7XBA2 Leishmania donovani 28% 100%
A0A422P0W0 Trypanosoma rangeli 78% 100%
A4H3Q9 Leishmania braziliensis 29% 100%
A4HCH7 Leishmania braziliensis 37% 100%
A4HIR9 Leishmania braziliensis 96% 100%
A4HPP6 Leishmania braziliensis 28% 100%
A4HYK3 Leishmania infantum 31% 81%
A4HZZ9 Leishmania infantum 36% 68%
A4I615 Leishmania infantum 100% 100%
A4ID18 Leishmania infantum 27% 100%
C9ZRE1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 100%
C9ZSQ2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 82%
D0A8G8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9ATG0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AVX2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1A6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q4Q137 Leishmania major 28% 100%
Q4Q6V8 Leishmania major 99% 100%
Q4QBK7 Leishmania major 36% 100%
Q4QD31 Leishmania major 30% 81%
V5AUB0 Trypanosoma cruzi 30% 100%
V5B9Q7 Trypanosoma cruzi 29% 69%
V5BX28 Trypanosoma cruzi 76% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS