Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (3 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3U4_LEIDO

TriTrypDb:

LdBPK_303310.1 , LdCL_300038700 , LDHU3_30.4400

Length:

411

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.368
CLV_C14_Caspase3-7	266	270	PF00656	0.623
CLV_C14_Caspase3-7	325	329	PF00656	0.552
CLV_NRD_NRD_1	318	320	PF00675	0.468
CLV_NRD_NRD_1	32	34	PF00675	0.352
CLV_NRD_NRD_1	352	354	PF00675	0.514
CLV_NRD_NRD_1	396	398	PF00675	0.487
CLV_PCSK_FUR_1	316	320	PF00082	0.606
CLV_PCSK_KEX2_1	318	320	PF00082	0.471
CLV_PCSK_KEX2_1	32	34	PF00082	0.374
CLV_PCSK_KEX2_1	352	354	PF00082	0.452
CLV_PCSK_SKI1_1	13	17	PF00082	0.429
CLV_PCSK_SKI1_1	162	166	PF00082	0.395
CLV_PCSK_SKI1_1	302	306	PF00082	0.455
CLV_PCSK_SKI1_1	36	40	PF00082	0.313
CLV_PCSK_SKI1_1	399	403	PF00082	0.565
CLV_PCSK_SKI1_1	404	408	PF00082	0.609
DEG_Nend_UBRbox_3	1	3	PF02207	0.619
DOC_CKS1_1	119	124	PF01111	0.384
DOC_CKS1_1	255	260	PF01111	0.394
DOC_MAPK_gen_1	32	41	PF00069	0.313
DOC_MAPK_HePTP_8	137	149	PF00069	0.337
DOC_MAPK_MEF2A_6	140	149	PF00069	0.448
DOC_USP7_MATH_1	128	132	PF00917	0.309
DOC_USP7_MATH_1	184	188	PF00917	0.376
DOC_USP7_MATH_1	263	267	PF00917	0.593
DOC_USP7_UBL2_3	306	310	PF12436	0.478
DOC_USP7_UBL2_3	404	408	PF12436	0.606
DOC_WW_Pin1_4	118	123	PF00397	0.399
DOC_WW_Pin1_4	188	193	PF00397	0.293
DOC_WW_Pin1_4	254	259	PF00397	0.425
DOC_WW_Pin1_4	85	90	PF00397	0.307
LIG_14-3-3_CanoR_1	140	147	PF00244	0.317
LIG_14-3-3_CanoR_1	378	382	PF00244	0.597
LIG_BIR_III_2	189	193	PF00653	0.454
LIG_BRCT_BRCA1_1	119	123	PF00533	0.387
LIG_BRCT_BRCA1_1	34	38	PF00533	0.427
LIG_FHA_1	189	195	PF00498	0.320
LIG_FHA_1	341	347	PF00498	0.521
LIG_FHA_1	63	69	PF00498	0.300
LIG_FHA_2	307	313	PF00498	0.472
LIG_FHA_2	378	384	PF00498	0.521
LIG_FHA_2	64	70	PF00498	0.374
LIG_Integrin_RGD_1	232	234	PF01839	0.461
LIG_LIR_Apic_2	253	258	PF02991	0.466
LIG_LIR_Gen_1	270	281	PF02991	0.367
LIG_LIR_Gen_1	35	45	PF02991	0.427
LIG_LIR_Nem_3	270	276	PF02991	0.367
LIG_LIR_Nem_3	35	41	PF02991	0.427
LIG_NRP_CendR_1	408	411	PF00754	0.677
LIG_PCNA_PIPBox_1	201	210	PF02747	0.415
LIG_PCNA_yPIPBox_3	198	208	PF02747	0.415
LIG_PTB_Apo_2	249	256	PF02174	0.469
LIG_PTB_Phospho_1	249	255	PF10480	0.537
LIG_SH2_CRK	255	259	PF00017	0.502
LIG_SH2_SRC	381	384	PF00017	0.508
LIG_SH2_STAP1	381	385	PF00017	0.545
LIG_SH2_STAT5	207	210	PF00017	0.291
LIG_SH2_STAT5	299	302	PF00017	0.452
LIG_SH2_STAT5	70	73	PF00017	0.341
LIG_SH2_STAT5	98	101	PF00017	0.311
LIG_TRAF2_1	309	312	PF00917	0.499
MOD_CK2_1	306	312	PF00069	0.454
MOD_CK2_1	324	330	PF00069	0.427
MOD_CK2_1	377	383	PF00069	0.523
MOD_CK2_1	63	69	PF00069	0.415
MOD_GlcNHglycan	157	160	PF01048	0.315
MOD_GlcNHglycan	223	226	PF01048	0.452
MOD_GlcNHglycan	269	272	PF01048	0.526
MOD_GlcNHglycan	408	411	PF01048	0.700
MOD_GSK3_1	110	117	PF00069	0.329
MOD_GSK3_1	118	125	PF00069	0.361
MOD_GSK3_1	184	191	PF00069	0.453
MOD_GSK3_1	263	270	PF00069	0.597
MOD_GSK3_1	294	301	PF00069	0.554
MOD_GSK3_1	402	409	PF00069	0.582
MOD_N-GLC_1	289	294	PF02516	0.422
MOD_N-GLC_1	347	352	PF02516	0.558
MOD_N-GLC_1	63	68	PF02516	0.319
MOD_N-GLC_1	79	84	PF02516	0.312
MOD_NEK2_1	402	407	PF00069	0.574
MOD_PIKK_1	115	121	PF00454	0.515
MOD_PKA_1	294	300	PF00069	0.489
MOD_PKA_1	32	38	PF00069	0.454
MOD_PKA_2	139	145	PF00069	0.454
MOD_PKA_2	155	161	PF00069	0.427
MOD_PKA_2	169	175	PF00069	0.294
MOD_PKA_2	263	269	PF00069	0.515
MOD_PKA_2	32	38	PF00069	0.423
MOD_PKA_2	377	383	PF00069	0.582
MOD_Plk_1	110	116	PF00069	0.320
MOD_Plk_1	402	408	PF00069	0.579
MOD_Plk_1	63	69	PF00069	0.319
MOD_Plk_4	52	58	PF00069	0.296
MOD_ProDKin_1	118	124	PF00069	0.394
MOD_ProDKin_1	188	194	PF00069	0.293
MOD_ProDKin_1	254	260	PF00069	0.422
MOD_ProDKin_1	85	91	PF00069	0.307
MOD_SUMO_rev_2	142	149	PF00179	0.384
TRG_DiLeu_BaEn_1	274	279	PF01217	0.384
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.294
TRG_ER_diArg_1	31	33	PF00400	0.369
TRG_ER_diArg_1	316	319	PF00400	0.451
TRG_ER_diArg_1	352	354	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVX1	Leptomonas seymouri	75%	100%
A0A0S4IZB7	Bodo saltans	24%	74%
A0A0S4J2H9	Bodo saltans	27%	72%
A0A0S4KFJ4	Bodo saltans	51%	100%
A0A1X0P1M7	Trypanosomatidae	52%	100%
A0A3R7KWY8	Trypanosoma rangeli	54%	100%
A4H9M0	Leishmania braziliensis	24%	100%
A4HIR5	Leishmania braziliensis	85%	100%
A4I610	Leishmania infantum	100%	100%
A6NK59	Homo sapiens	26%	70%
A6QPE7	Bos taurus	30%	100%
C9ZRD5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
D3J162	Medicago truncatula	27%	76%
E5RJM6	Homo sapiens	32%	100%
E9B1A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P0C927	Rattus norvegicus	25%	69%
Q1RHT6	Rickettsia bellii (strain RML369-C)	23%	67%
Q3KP44	Homo sapiens	28%	67%
Q3V096	Mus musculus	23%	78%
Q4JHE0	Oryza sativa subsp. japonica	22%	98%
Q4Q6W3	Leishmania major	97%	100%
Q4ULZ2	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	23%	100%
Q502M6	Danio rerio	26%	100%
Q63369	Rattus norvegicus	28%	79%
Q6AWW5	Arabidopsis thaliana	24%	78%
Q6P6B7	Homo sapiens	25%	100%
Q9J569	Fowlpox virus (strain NVSL)	27%	68%
Q9J5H9	Fowlpox virus (strain NVSL)	25%	71%
Q9J5I7	Fowlpox virus (strain NVSL)	22%	94%
V5BMS1	Trypanosoma cruzi	54%	100%