LeishMANIAdb
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Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ankyrin repeats (3 copies)/Ankyrin repeats (Many copies)/Ankyrin repeat, putative
Gene product:
Ankyrin repeats (3 copies), putative
Species:
Leishmania donovani
UniProt:
A0A3S7X3U4_LEIDO
TriTrypDb:
LdBPK_303310.1 , LdCL_300038700 , LDHU3_30.4400
Length:
411

Annotations

LeishMANIAdb annotations

An expanding group of Kinetoplastid proteins. Some members of this group have a hydrophobic C-terminal segment that might help membrane attachment

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
TermNameLevelCount
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1
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Expansion

Sequence features

A0A3S7X3U4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3U4

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 183 187 PF00656 0.368
CLV_C14_Caspase3-7 266 270 PF00656 0.623
CLV_C14_Caspase3-7 325 329 PF00656 0.552
CLV_NRD_NRD_1 318 320 PF00675 0.468
CLV_NRD_NRD_1 32 34 PF00675 0.352
CLV_NRD_NRD_1 352 354 PF00675 0.514
CLV_NRD_NRD_1 396 398 PF00675 0.487
CLV_PCSK_FUR_1 316 320 PF00082 0.606
CLV_PCSK_KEX2_1 318 320 PF00082 0.471
CLV_PCSK_KEX2_1 32 34 PF00082 0.374
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1HVX1 Leptomonas seymouri 75% 100%
A0A0S4IZB7 Bodo saltans 24% 74%
A0A0S4J2H9 Bodo saltans 27% 72%
A0A0S4KFJ4 Bodo saltans 51% 100%
A0A1X0P1M7 Trypanosomatidae 52% 100%
A0A3R7KWY8 Trypanosoma rangeli 54% 100%
A4H9M0 Leishmania braziliensis 24% 100%
A4HIR5 Leishmania braziliensis 85% 100%
A4I610 Leishmania infantum 100% 100%
A6NK59 Homo sapiens 26% 70%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS