LeishMANIAdb
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3-hydroxy-3-methylglutaryl coenzyme A reductase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
3-hydroxy-3-methylglutaryl coenzyme A reductase
Gene product:
3-hydroxy-3-methylglutaryl-CoA reductase, putative
Species:
Leishmania donovani
UniProt:
A0A3S7X3U0_LEIDO
TriTrypDb:
LdBPK_303230.1 , LdCL_300037900 , LDHU3_30.4320
Length:
434

Annotations

Annotations by Jardim et al.

Sterol metabolism/biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A reductase HMGR

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005789 endoplasmic reticulum membrane 4 12
GO:0016020 membrane 2 12
GO:0031090 organelle membrane 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0005739 mitochondrion 5 1
GO:0005778 peroxisomal membrane 6 1
GO:0031903 microbody membrane 5 1
GO:0042579 microbody 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7X3U0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3U0

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006163 purine nucleotide metabolic process 5 12
GO:0006629 lipid metabolic process 3 12
GO:0006720 isoprenoid metabolic process 4 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006753 nucleoside phosphate metabolic process 4 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0008299 isoprenoid biosynthetic process 4 12
GO:0008610 lipid biosynthetic process 4 12
GO:0009058 biosynthetic process 2 12
GO:0009117 nucleotide metabolic process 5 12
GO:0009150 purine ribonucleotide metabolic process 6 12
GO:0009259 ribonucleotide metabolic process 5 12
GO:0009987 cellular process 1 12
GO:0015936 coenzyme A metabolic process 6 12
GO:0019637 organophosphate metabolic process 3 12
GO:0019693 ribose phosphate metabolic process 4 12
GO:0033865 nucleoside bisphosphate metabolic process 5 12
GO:0033875 ribonucleoside bisphosphate metabolic process 6 12
GO:0034032 purine nucleoside bisphosphate metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044255 cellular lipid metabolic process 3 12
GO:0044281 small molecule metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0055086 nucleobase-containing small molecule metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0072521 purine-containing compound metabolic process 4 12
GO:1901135 carbohydrate derivative metabolic process 3 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901576 organic substance biosynthetic process 3 12
GO:0006644 phospholipid metabolic process 4 1
GO:0006694 steroid biosynthetic process 5 1
GO:0006721 terpenoid metabolic process 5 1
GO:0008202 steroid metabolic process 4 1
GO:0008654 phospholipid biosynthetic process 5 1
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway 6 1
GO:0016114 terpenoid biosynthetic process 5 1
GO:0016125 sterol metabolic process 4 1
GO:0016126 sterol biosynthetic process 5 1
GO:0045337 farnesyl diphosphate biosynthetic process 6 1
GO:0045338 farnesyl diphosphate metabolic process 5 1
GO:0090407 organophosphate biosynthetic process 4 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
GO:1902767 isoprenoid biosynthetic process via mevalonate 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 12
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 19 23 PF00656 0.520
CLV_MEL_PAP_1 204 210 PF00089 0.288
CLV_NRD_NRD_1 2 4 PF00675 0.381
CLV_NRD_NRD_1 428 430 PF00675 0.402
CLV_NRD_NRD_1 54 56 PF00675 0.217
CLV_PCSK_KEX2_1 2 4 PF00082 0.397
CLV_PCSK_KEX2_1 274 276 PF00082 0.307
CLV_PCSK_KEX2_1 54 56 PF00082 0.225
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.307
CLV_PCSK_SKI1_1 180 184 PF00082 0.207
CLV_PCSK_SKI1_1 240 244 PF00082 0.251
CLV_PCSK_SKI1_1 3 7 PF00082 0.437
CLV_PCSK_SKI1_1 33 37 PF00082 0.322
CLV_PCSK_SKI1_1 373 377 PF00082 0.279
DEG_APCC_DBOX_1 372 380 PF00400 0.410
DEG_Nend_UBRbox_1 1 4 PF02207 0.663
DOC_ANK_TNKS_1 274 281 PF00023 0.423
DOC_CYCLIN_yCln2_LP_2 103 109 PF00134 0.469
DOC_MAPK_MEF2A_6 344 353 PF00069 0.413
DOC_PP1_RVXF_1 30 37 PF00149 0.493
DOC_PP2B_LxvP_1 353 356 PF13499 0.507
DOC_PP2B_PxIxI_1 355 361 PF00149 0.402
DOC_SPAK_OSR1_1 175 179 PF12202 0.451
DOC_USP7_MATH_1 182 186 PF00917 0.402
DOC_USP7_UBL2_3 223 227 PF12436 0.402
DOC_USP7_UBL2_3 426 430 PF12436 0.242
LIG_14-3-3_CanoR_1 2 6 PF00244 0.598
LIG_14-3-3_CanoR_1 240 245 PF00244 0.451
LIG_14-3-3_CanoR_1 263 268 PF00244 0.402
LIG_Actin_WH2_2 270 285 PF00022 0.402
LIG_BIR_III_4 214 218 PF00653 0.402
LIG_BRCT_BRCA1_1 244 248 PF00533 0.488
LIG_FHA_1 142 148 PF00498 0.413
LIG_FHA_1 293 299 PF00498 0.488
LIG_FHA_1 67 73 PF00498 0.507
LIG_FHA_2 323 329 PF00498 0.402
LIG_FHA_2 338 344 PF00498 0.402
LIG_LIR_Gen_1 16 25 PF02991 0.527
LIG_LIR_Gen_1 173 183 PF02991 0.421
LIG_LIR_Gen_1 81 86 PF02991 0.386
LIG_LIR_Nem_3 173 179 PF02991 0.405
LIG_LIR_Nem_3 186 192 PF02991 0.379
LIG_LIR_Nem_3 81 85 PF02991 0.411
LIG_PCNA_yPIPBox_3 372 386 PF02747 0.488
LIG_SH2_PTP2 96 99 PF00017 0.413
LIG_SH2_SRC 96 99 PF00017 0.413
LIG_SH2_STAP1 47 51 PF00017 0.522
LIG_SH2_STAT5 322 325 PF00017 0.488
LIG_SH2_STAT5 96 99 PF00017 0.402
LIG_SH3_3 111 117 PF00018 0.413
LIG_SH3_3 94 100 PF00018 0.413
LIG_SUMO_SIM_anti_2 163 170 PF11976 0.507
LIG_SUMO_SIM_anti_2 408 413 PF11976 0.254
LIG_SUMO_SIM_par_1 105 110 PF11976 0.462
LIG_SUMO_SIM_par_1 155 161 PF11976 0.450
LIG_SUMO_SIM_par_1 240 245 PF11976 0.413
LIG_SUMO_SIM_par_1 347 354 PF11976 0.393
LIG_TYR_ITIM 94 99 PF00017 0.402
LIG_UBA3_1 192 196 PF00899 0.479
LIG_WRC_WIRS_1 159 164 PF05994 0.488
MOD_CK1_1 16 22 PF00069 0.501
MOD_CK1_1 209 215 PF00069 0.488
MOD_CK1_1 288 294 PF00069 0.442
MOD_CK1_1 410 416 PF00069 0.231
MOD_CK2_1 158 164 PF00069 0.402
MOD_CK2_1 381 387 PF00069 0.427
MOD_GlcNHglycan 127 130 PF01048 0.251
MOD_GlcNHglycan 138 141 PF01048 0.124
MOD_GlcNHglycan 208 211 PF01048 0.264
MOD_GlcNHglycan 244 247 PF01048 0.200
MOD_GlcNHglycan 254 257 PF01048 0.202
MOD_GlcNHglycan 300 303 PF01048 0.202
MOD_GlcNHglycan 334 337 PF01048 0.288
MOD_GlcNHglycan 412 415 PF01048 0.262
MOD_GlcNHglycan 421 424 PF01048 0.433
MOD_GlcNHglycan 9 12 PF01048 0.380
MOD_GSK3_1 288 295 PF00069 0.474
MOD_GSK3_1 334 341 PF00069 0.402
MOD_GSK3_1 364 371 PF00069 0.474
MOD_GSK3_1 62 69 PF00069 0.497
MOD_N-GLC_1 136 141 PF02516 0.288
MOD_N-GLC_1 292 297 PF02516 0.288
MOD_N-GLC_2 247 249 PF02516 0.202
MOD_NEK2_1 1 6 PF00069 0.585
MOD_NEK2_1 125 130 PF00069 0.392
MOD_NEK2_1 183 188 PF00069 0.402
MOD_NEK2_1 206 211 PF00069 0.406
MOD_NEK2_1 242 247 PF00069 0.413
MOD_NEK2_1 292 297 PF00069 0.423
MOD_NEK2_1 298 303 PF00069 0.385
MOD_NEK2_1 349 354 PF00069 0.409
MOD_NEK2_1 7 12 PF00069 0.530
MOD_PIKK_1 368 374 PF00454 0.488
MOD_PK_1 191 197 PF00069 0.488
MOD_PK_1 263 269 PF00069 0.426
MOD_PKA_1 252 258 PF00069 0.402
MOD_PKA_2 1 7 PF00069 0.614
MOD_PKA_2 206 212 PF00069 0.418
MOD_PKA_2 298 304 PF00069 0.488
MOD_Plk_1 407 413 PF00069 0.254
MOD_Plk_1 80 86 PF00069 0.451
MOD_Plk_2-3 158 164 PF00069 0.413
MOD_Plk_4 263 269 PF00069 0.396
MOD_Plk_4 285 291 PF00069 0.419
MOD_Plk_4 407 413 PF00069 0.254
MOD_Plk_4 81 87 PF00069 0.451
MOD_SUMO_rev_2 24 34 PF00179 0.568
MOD_SUMO_rev_2 245 255 PF00179 0.392
TRG_DiLeu_BaLyEn_6 103 108 PF01217 0.507
TRG_ENDOCYTIC_2 96 99 PF00928 0.393
TRG_ER_diArg_1 1 3 PF00400 0.603
TRG_ER_diArg_1 53 55 PF00400 0.418

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0A1C3I2 Panax ginseng 54% 76%
A0A0A1C930 Panax ginseng 53% 73%
A0A0N1HYY3 Leptomonas seymouri 84% 100%
A0A0S4JI16 Bodo saltans 67% 100%
A0A1X0P1N0 Trypanosomatidae 64% 100%
A0A3S5ISH8 Trypanosoma rangeli 63% 100%
A2X8W3 Oryza sativa subsp. indica 56% 81%
A4HIQ3 Leishmania braziliensis 93% 100%
A4I602 Leishmania infantum 100% 100%
B0R6J9 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 46% 100%
C8VN86 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 50% 100%
C9ZRC5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9B193 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O08424 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 42% 100%
O24594 Zea mays 54% 75%
O26662 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 43% 100%
O59469 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 46% 100%
O64966 Gossypium hirsutum 54% 74%
O64967 Gossypium hirsutum 55% 69%
P14891 Arabidopsis thaliana 53% 73%
P29057 Hevea brasiliensis 54% 75%
P34135 Dictyostelium discoideum 50% 79%
P34136 Dictyostelium discoideum 52% 83%
P43256 Arabidopsis thaliana 53% 77%
P48020 Solanum tuberosum 52% 73%
P48021 Camptotheca acuminata 54% 73%
P48022 Solanum lycopersicum 52% 72%
Q00583 Hevea brasiliensis 52% 74%
Q01559 Nicotiana sylvestris 52% 72%
Q03163 Catharanthus roseus 53% 72%
Q0DY59 Oryza sativa subsp. japonica 56% 82%
Q41437 Solanum tuberosum 51% 73%
Q41438 Solanum tuberosum 51% 76%
Q58116 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 40% 100%
Q59468 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) 44% 100%
Q9V1R3 Pyrococcus abyssi (strain GE5 / Orsay) 44% 100%
Q9XEL8 Capsicum annuum 52% 72%
Q9XHL5 Oryza sativa subsp. japonica 55% 77%
Q9Y0F3 Leishmania major 97% 100%
Q9YAS4 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 51% 100%
U5JCC6 Panax ginseng 53% 74%
V5B780 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS