Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3T4_LEIDO

TriTrypDb:

LdBPK_303200.1 , LdCL_300037600 , LDHU3_30.4270

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.623
CLV_PCSK_KEX2_1	161	163	PF00082	0.470
CLV_PCSK_KEX2_1	289	291	PF00082	0.450
CLV_PCSK_KEX2_1	79	81	PF00082	0.684
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.470
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.496
CLV_PCSK_SKI1_1	276	280	PF00082	0.419
CLV_Separin_Metazoa	194	198	PF03568	0.481
DEG_APCC_DBOX_1	176	184	PF00400	0.552
DEG_Nend_UBRbox_1	1	4	PF02207	0.674
DOC_CKS1_1	38	43	PF01111	0.657
DOC_MAPK_gen_1	64	73	PF00069	0.527
DOC_PP1_RVXF_1	62	68	PF00149	0.580
DOC_USP7_MATH_1	109	113	PF00917	0.552
DOC_USP7_MATH_1	20	24	PF00917	0.553
DOC_USP7_UBL2_3	129	133	PF12436	0.573
DOC_USP7_UBL2_3	96	100	PF12436	0.483
DOC_WW_Pin1_4	269	274	PF00397	0.484
DOC_WW_Pin1_4	37	42	PF00397	0.638
LIG_14-3-3_CanoR_1	150	154	PF00244	0.522
LIG_14-3-3_CanoR_1	174	184	PF00244	0.411
LIG_14-3-3_CanoR_1	72	78	PF00244	0.649
LIG_14-3-3_CanoR_1	79	87	PF00244	0.589
LIG_Actin_WH2_2	82	97	PF00022	0.440
LIG_BRCT_BRCA1_1	311	315	PF00533	0.547
LIG_deltaCOP1_diTrp_1	83	91	PF00928	0.422
LIG_FHA_1	113	119	PF00498	0.495
LIG_FHA_1	135	141	PF00498	0.530
LIG_FHA_1	43	49	PF00498	0.523
LIG_FHA_2	174	180	PF00498	0.500
LIG_FHA_2	189	195	PF00498	0.470
LIG_FHA_2	223	229	PF00498	0.549
LIG_FHA_2	304	310	PF00498	0.549
LIG_LIR_Gen_1	142	153	PF02991	0.467
LIG_LIR_Gen_1	191	199	PF02991	0.438
LIG_LIR_Gen_1	44	53	PF02991	0.489
LIG_LIR_Gen_1	84	94	PF02991	0.406
LIG_LIR_Nem_3	142	148	PF02991	0.460
LIG_LIR_Nem_3	191	195	PF02991	0.422
LIG_LIR_Nem_3	253	258	PF02991	0.387
LIG_LIR_Nem_3	277	282	PF02991	0.494
LIG_LIR_Nem_3	44	49	PF02991	0.496
LIG_LIR_Nem_3	84	90	PF02991	0.416
LIG_PDZ_Class_2	310	315	PF00595	0.416
LIG_SH2_CRK	38	42	PF00017	0.549
LIG_SH2_CRK	55	59	PF00017	0.619
LIG_SH2_STAP1	209	213	PF00017	0.316
LIG_SH2_STAP1	248	252	PF00017	0.530
LIG_SH2_STAT5	257	260	PF00017	0.450
LIG_SH2_STAT5	55	58	PF00017	0.622
LIG_SH3_3	238	244	PF00018	0.382
LIG_TRAF2_1	191	194	PF00917	0.535
MOD_CDK_SPxxK_3	269	276	PF00069	0.476
MOD_CK1_1	107	113	PF00069	0.529
MOD_CK1_1	146	152	PF00069	0.549
MOD_CK1_1	178	184	PF00069	0.534
MOD_CK1_1	222	228	PF00069	0.515
MOD_CK1_1	303	309	PF00069	0.525
MOD_CK2_1	188	194	PF00069	0.545
MOD_CK2_1	222	228	PF00069	0.548
MOD_CK2_1	271	277	PF00069	0.473
MOD_GlcNHglycan	106	109	PF01048	0.463
MOD_GlcNHglycan	111	114	PF01048	0.496
MOD_GlcNHglycan	199	202	PF01048	0.370
MOD_GlcNHglycan	22	25	PF01048	0.606
MOD_GlcNHglycan	273	276	PF01048	0.521
MOD_GlcNHglycan	73	76	PF01048	0.582
MOD_GSK3_1	100	107	PF00069	0.463
MOD_GSK3_1	175	182	PF00069	0.412
MOD_NEK2_1	53	58	PF00069	0.498
MOD_NEK2_1	73	78	PF00069	0.629
MOD_PIKK_1	112	118	PF00454	0.502
MOD_PIKK_1	207	213	PF00454	0.502
MOD_PKA_1	79	85	PF00069	0.657
MOD_PKA_2	149	155	PF00069	0.532
MOD_PKA_2	173	179	PF00069	0.462
MOD_PKA_2	71	77	PF00069	0.565
MOD_PKA_2	79	85	PF00069	0.525
MOD_Plk_1	178	184	PF00069	0.507
MOD_Plk_1	300	306	PF00069	0.528
MOD_Plk_1	85	91	PF00069	0.418
MOD_Plk_4	149	155	PF00069	0.512
MOD_Plk_4	179	185	PF00069	0.396
MOD_ProDKin_1	269	275	PF00069	0.475
MOD_ProDKin_1	37	43	PF00069	0.641
MOD_SUMO_rev_2	61	65	PF00179	0.502
MOD_SUMO_rev_2	92	102	PF00179	0.442
TRG_DiLeu_BaEn_3	193	199	PF01217	0.523
TRG_DiLeu_BaLyEn_6	241	246	PF01217	0.359
TRG_ENDOCYTIC_2	55	58	PF00928	0.620
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I463	Leptomonas seymouri	72%	99%
A0A0S4JPV6	Bodo saltans	55%	98%
A0A1X0P1E1	Trypanosomatidae	63%	97%
A0A422P0S4	Trypanosoma rangeli	63%	97%
A4HIQ0	Leishmania braziliensis	91%	100%
A4I661	Leishmania infantum	100%	100%
C9ZRC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	97%
E9B190	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q6X4	Leishmania major	99%	100%
V5BMS9	Trypanosoma cruzi	64%	97%