Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3S8_LEIDO

TriTrypDb:

LdBPK_303140.1 , LdCL_300037000 , LDHU3_30.4160

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3S8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.649
CLV_C14_Caspase3-7	512	516	PF00656	0.663
CLV_C14_Caspase3-7	665	669	PF00656	0.592
CLV_NRD_NRD_1	473	475	PF00675	0.529
CLV_NRD_NRD_1	654	656	PF00675	0.446
CLV_NRD_NRD_1	74	76	PF00675	0.660
CLV_PCSK_KEX2_1	473	475	PF00082	0.570
CLV_PCSK_KEX2_1	543	545	PF00082	0.469
CLV_PCSK_KEX2_1	654	656	PF00082	0.446
CLV_PCSK_KEX2_1	74	76	PF00082	0.645
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.469
CLV_PCSK_SKI1_1	147	151	PF00082	0.492
CLV_PCSK_SKI1_1	180	184	PF00082	0.397
CLV_PCSK_SKI1_1	339	343	PF00082	0.510
CLV_PCSK_SKI1_1	396	400	PF00082	0.397
CLV_PCSK_SKI1_1	445	449	PF00082	0.424
CLV_PCSK_SKI1_1	467	471	PF00082	0.518
CLV_PCSK_SKI1_1	61	65	PF00082	0.633
CLV_PCSK_SKI1_1	654	658	PF00082	0.474
CLV_PCSK_SKI1_1	75	79	PF00082	0.564
CLV_PCSK_SKI1_1	92	96	PF00082	0.407
DEG_APCC_DBOX_1	273	281	PF00400	0.524
DEG_APCC_DBOX_1	444	452	PF00400	0.521
DEG_APCC_DBOX_1	653	661	PF00400	0.476
DEG_APCC_KENBOX_2	423	427	PF00400	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.426
DEG_SPOP_SBC_1	121	125	PF00917	0.747
DEG_SPOP_SBC_1	126	130	PF00917	0.782
DEG_SPOP_SBC_1	19	23	PF00917	0.431
DEG_SPOP_SBC_1	364	368	PF00917	0.792
DEG_SPOP_SBC_1	558	562	PF00917	0.559
DOC_CKS1_1	330	335	PF01111	0.573
DOC_CYCLIN_RxL_1	467	481	PF00134	0.610
DOC_CYCLIN_RxL_1	652	663	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	499	505	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	682	688	PF00134	0.505
DOC_MAPK_DCC_7	274	282	PF00069	0.512
DOC_MAPK_gen_1	440	450	PF00069	0.526
DOC_MAPK_gen_1	543	551	PF00069	0.535
DOC_MAPK_gen_1	58	67	PF00069	0.595
DOC_MAPK_MEF2A_6	260	267	PF00069	0.462
DOC_MAPK_MEF2A_6	274	282	PF00069	0.333
DOC_MAPK_MEF2A_6	313	320	PF00069	0.461
DOC_MAPK_MEF2A_6	461	470	PF00069	0.649
DOC_MAPK_MEF2A_6	58	67	PF00069	0.393
DOC_PP2B_LxvP_1	581	584	PF13499	0.586
DOC_PP2B_LxvP_1	682	685	PF13499	0.548
DOC_USP7_MATH_1	122	126	PF00917	0.759
DOC_USP7_MATH_1	364	368	PF00917	0.735
DOC_USP7_MATH_1	505	509	PF00917	0.550
DOC_USP7_MATH_1	523	527	PF00917	0.469
DOC_USP7_MATH_1	627	631	PF00917	0.599
DOC_WW_Pin1_4	11	16	PF00397	0.420
DOC_WW_Pin1_4	312	317	PF00397	0.494
DOC_WW_Pin1_4	329	334	PF00397	0.421
DOC_WW_Pin1_4	351	356	PF00397	0.661
DOC_WW_Pin1_4	365	370	PF00397	0.694
DOC_WW_Pin1_4	488	493	PF00397	0.529
DOC_WW_Pin1_4	75	80	PF00397	0.545
LIG_14-3-3_CanoR_1	106	112	PF00244	0.519
LIG_14-3-3_CanoR_1	180	190	PF00244	0.505
LIG_14-3-3_CanoR_1	31	35	PF00244	0.421
LIG_14-3-3_CanoR_1	349	355	PF00244	0.717
LIG_14-3-3_CanoR_1	443	451	PF00244	0.551
LIG_14-3-3_CanoR_1	473	478	PF00244	0.491
LIG_14-3-3_CanoR_1	61	66	PF00244	0.600
LIG_14-3-3_CanoR_1	74	78	PF00244	0.335
LIG_Actin_WH2_2	231	248	PF00022	0.456
LIG_Actin_WH2_2	50	68	PF00022	0.382
LIG_APCC_ABBA_1	290	295	PF00400	0.437
LIG_Clathr_ClatBox_1	187	191	PF01394	0.510
LIG_Clathr_ClatBox_1	432	436	PF01394	0.386
LIG_CSL_BTD_1	254	257	PF09270	0.433
LIG_EH1_1	215	223	PF00400	0.538
LIG_eIF4E_1	216	222	PF01652	0.533
LIG_FHA_1	161	167	PF00498	0.458
LIG_FHA_1	182	188	PF00498	0.501
LIG_FHA_1	267	273	PF00498	0.522
LIG_FHA_1	294	300	PF00498	0.516
LIG_FHA_1	313	319	PF00498	0.366
LIG_FHA_1	478	484	PF00498	0.522
LIG_FHA_1	489	495	PF00498	0.522
LIG_FHA_1	526	532	PF00498	0.449
LIG_FHA_1	561	567	PF00498	0.384
LIG_FHA_1	572	578	PF00498	0.411
LIG_FHA_1	62	68	PF00498	0.698
LIG_FHA_1	674	680	PF00498	0.518
LIG_FHA_2	122	128	PF00498	0.748
LIG_FHA_2	130	136	PF00498	0.683
LIG_FHA_2	512	518	PF00498	0.712
LIG_GBD_Chelix_1	234	242	PF00786	0.475
LIG_IRF3_LxIS_1	202	208	PF10401	0.377
LIG_LIR_Gen_1	198	207	PF02991	0.522
LIG_LIR_Gen_1	301	311	PF02991	0.423
LIG_LIR_Gen_1	561	572	PF02991	0.413
LIG_LIR_Gen_1	78	87	PF02991	0.489
LIG_LIR_Nem_3	198	203	PF02991	0.378
LIG_LIR_Nem_3	210	216	PF02991	0.438
LIG_LIR_Nem_3	239	244	PF02991	0.347
LIG_LIR_Nem_3	301	306	PF02991	0.410
LIG_LIR_Nem_3	389	394	PF02991	0.495
LIG_LIR_Nem_3	4	8	PF02991	0.415
LIG_LIR_Nem_3	550	555	PF02991	0.422
LIG_LIR_Nem_3	561	567	PF02991	0.405
LIG_LIR_Nem_3	76	80	PF02991	0.490
LIG_LIR_Nem_3	99	104	PF02991	0.401
LIG_LYPXL_yS_3	275	278	PF13949	0.448
LIG_NRBOX	52	58	PF00104	0.350
LIG_NRBOX	528	534	PF00104	0.477
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.424
LIG_PCNA_yPIPBox_3	424	433	PF02747	0.538
LIG_SH2_CRK	459	463	PF00017	0.581
LIG_SH2_CRK	564	568	PF00017	0.487
LIG_SH2_CRK	80	84	PF00017	0.463
LIG_SH2_NCK_1	459	463	PF00017	0.581
LIG_SH2_NCK_1	555	559	PF00017	0.583
LIG_SH2_SRC	434	437	PF00017	0.456
LIG_SH2_SRC	7	10	PF00017	0.421
LIG_SH2_STAP1	294	298	PF00017	0.521
LIG_SH2_STAP1	564	568	PF00017	0.487
LIG_SH2_STAP1	571	575	PF00017	0.505
LIG_SH2_STAT5	244	247	PF00017	0.389
LIG_SH2_STAT5	322	325	PF00017	0.514
LIG_SH2_STAT5	412	415	PF00017	0.434
LIG_SH2_STAT5	434	437	PF00017	0.448
LIG_SH2_STAT5	7	10	PF00017	0.421
LIG_SH3_1	142	148	PF00018	0.452
LIG_SH3_2	276	281	PF14604	0.504
LIG_SH3_3	142	148	PF00018	0.581
LIG_SH3_3	273	279	PF00018	0.532
LIG_SH3_3	366	372	PF00018	0.640
LIG_SH3_3	452	458	PF00018	0.588
LIG_SH3_3	499	505	PF00018	0.555
LIG_SH3_3	688	694	PF00018	0.617
LIG_SH3_4	147	154	PF00018	0.519
LIG_SUMO_SIM_anti_2	14	24	PF11976	0.427
LIG_SUMO_SIM_anti_2	163	168	PF11976	0.528
LIG_SUMO_SIM_anti_2	261	270	PF11976	0.554
LIG_SUMO_SIM_anti_2	528	533	PF11976	0.509
LIG_SUMO_SIM_par_1	203	208	PF11976	0.419
LIG_TRAF2_1	378	381	PF00917	0.657
LIG_TRFH_1	275	279	PF08558	0.512
LIG_TYR_ITIM	242	247	PF00017	0.379
LIG_TYR_ITIM	3	8	PF00017	0.418
LIG_TYR_ITIM	320	325	PF00017	0.407
LIG_TYR_ITSM	76	83	PF00017	0.571
LIG_UBA3_1	166	175	PF00899	0.414
MOD_CDC14_SPxK_1	354	357	PF00782	0.689
MOD_CDK_SPxK_1	351	357	PF00069	0.667
MOD_CK1_1	125	131	PF00069	0.740
MOD_CK1_1	23	29	PF00069	0.436
MOD_CK1_1	351	357	PF00069	0.670
MOD_CK1_1	367	373	PF00069	0.686
MOD_CK1_1	386	392	PF00069	0.330
MOD_CK1_1	476	482	PF00069	0.560
MOD_CK1_1	508	514	PF00069	0.682
MOD_CK1_1	662	668	PF00069	0.564
MOD_CK2_1	121	127	PF00069	0.768
MOD_CK2_1	511	517	PF00069	0.700
MOD_Cter_Amidation	72	75	PF01082	0.644
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.558
MOD_GlcNHglycan	124	127	PF01048	0.711
MOD_GlcNHglycan	129	132	PF01048	0.742
MOD_GlcNHglycan	325	328	PF01048	0.433
MOD_GlcNHglycan	334	337	PF01048	0.427
MOD_GlcNHglycan	445	448	PF01048	0.546
MOD_GlcNHglycan	511	514	PF01048	0.673
MOD_GlcNHglycan	540	543	PF01048	0.457
MOD_GSK3_1	116	123	PF00069	0.612
MOD_GSK3_1	125	132	PF00069	0.701
MOD_GSK3_1	19	26	PF00069	0.432
MOD_GSK3_1	205	212	PF00069	0.414
MOD_GSK3_1	328	335	PF00069	0.539
MOD_GSK3_1	363	370	PF00069	0.730
MOD_GSK3_1	372	379	PF00069	0.711
MOD_GSK3_1	382	389	PF00069	0.381
MOD_GSK3_1	408	415	PF00069	0.565
MOD_GSK3_1	469	476	PF00069	0.524
MOD_GSK3_1	505	512	PF00069	0.599
MOD_GSK3_1	554	561	PF00069	0.521
MOD_GSK3_1	61	68	PF00069	0.671
MOD_GSK3_1	659	666	PF00069	0.526
MOD_N-GLC_1	135	140	PF02516	0.785
MOD_N-GLC_1	328	333	PF02516	0.580
MOD_N-GLC_1	663	668	PF02516	0.593
MOD_NEK2_1	1	6	PF00069	0.418
MOD_NEK2_1	107	112	PF00069	0.577
MOD_NEK2_1	18	23	PF00069	0.413
MOD_NEK2_1	181	186	PF00069	0.475
MOD_NEK2_1	205	210	PF00069	0.393
MOD_NEK2_1	224	229	PF00069	0.533
MOD_NEK2_1	323	328	PF00069	0.411
MOD_NEK2_1	39	44	PF00069	0.413
MOD_NEK2_1	469	474	PF00069	0.537
MOD_NEK2_1	538	543	PF00069	0.449
MOD_NEK2_1	65	70	PF00069	0.679
MOD_NEK2_1	659	664	PF00069	0.489
MOD_PIKK_1	116	122	PF00454	0.596
MOD_PIKK_1	147	153	PF00454	0.510
MOD_PIKK_1	181	187	PF00454	0.480
MOD_PIKK_1	21	27	PF00454	0.433
MOD_PIKK_1	376	382	PF00454	0.591
MOD_PIKK_1	44	50	PF00454	0.400
MOD_PIKK_1	66	72	PF00454	0.713
MOD_PK_1	193	199	PF00069	0.523
MOD_PKA_1	473	479	PF00069	0.493
MOD_PKA_2	30	36	PF00069	0.415
MOD_PKA_2	348	354	PF00069	0.622
MOD_PKA_2	473	479	PF00069	0.536
MOD_PKA_2	65	71	PF00069	0.621
MOD_PKA_2	660	666	PF00069	0.491
MOD_PKA_2	73	79	PF00069	0.582
MOD_PKB_1	347	355	PF00069	0.700
MOD_Plk_1	386	392	PF00069	0.426
MOD_Plk_1	622	628	PF00069	0.514
MOD_Plk_1	663	669	PF00069	0.595
MOD_Plk_4	160	166	PF00069	0.493
MOD_Plk_4	236	242	PF00069	0.371
MOD_Plk_4	285	291	PF00069	0.390
MOD_Plk_4	314	320	PF00069	0.464
MOD_Plk_4	473	479	PF00069	0.501
MOD_Plk_4	547	553	PF00069	0.392
MOD_ProDKin_1	11	17	PF00069	0.421
MOD_ProDKin_1	312	318	PF00069	0.488
MOD_ProDKin_1	329	335	PF00069	0.424
MOD_ProDKin_1	351	357	PF00069	0.666
MOD_ProDKin_1	365	371	PF00069	0.695
MOD_ProDKin_1	488	494	PF00069	0.524
MOD_ProDKin_1	75	81	PF00069	0.540
TRG_DiLeu_BaEn_1	217	222	PF01217	0.526
TRG_DiLeu_BaEn_1	301	306	PF01217	0.391
TRG_DiLeu_BaEn_2	176	182	PF01217	0.402
TRG_DiLeu_BaEn_3	261	267	PF01217	0.459
TRG_DiLeu_BaEn_4	546	552	PF01217	0.483
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.427
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.521
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.437
TRG_ENDOCYTIC_2	244	247	PF00928	0.389
TRG_ENDOCYTIC_2	275	278	PF00928	0.432
TRG_ENDOCYTIC_2	322	325	PF00928	0.389
TRG_ENDOCYTIC_2	5	8	PF00928	0.419
TRG_ENDOCYTIC_2	564	567	PF00928	0.482
TRG_ENDOCYTIC_2	80	83	PF00928	0.443
TRG_ER_diArg_1	473	475	PF00400	0.570
TRG_ER_diArg_1	653	655	PF00400	0.441
TRG_NES_CRM1_1	198	211	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D3	Leptomonas seymouri	66%	100%
A0A1X0P1N4	Trypanosomatidae	40%	100%
A0A422P0R1	Trypanosoma rangeli	39%	100%
A4HIP4	Leishmania braziliensis	85%	100%
A4I5Z1	Leishmania infantum	100%	100%
C9ZRB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B184	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q6Y0	Leishmania major	95%	100%
V5BSF5	Trypanosoma cruzi	39%	100%