S-adenosylmethionine decarboxylase proenzyme-like, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

S-adenosylmethionine decarboxylase proenzyme- like, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3S7_LEIDO

TriTrypDb:

LdBPK_303160.1 , LdCL_300037200 , LDHU3_30.4220

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

A0A3S7X3S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3S7

Function

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Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	23
GO:0006595	polyamine metabolic process	6	23
GO:0006596	polyamine biosynthetic process	7	23
GO:0006597	spermine biosynthetic process	8	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0008152	metabolic process	1	23
GO:0008215	spermine metabolic process	7	23
GO:0008216	spermidine metabolic process	7	23
GO:0008295	spermidine biosynthetic process	8	23
GO:0009058	biosynthetic process	2	23

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0004014	adenosylmethionine decarboxylase activity	5	22
GO:0016829	lyase activity	2	23
GO:0016830	carbon-carbon lyase activity	3	22
GO:0016831	carboxy-lyase activity	4	22

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.511
CLV_C14_Caspase3-7	55	59	PF00656	0.588
CLV_NRD_NRD_1	111	113	PF00675	0.439
CLV_NRD_NRD_1	169	171	PF00675	0.498
CLV_NRD_NRD_1	262	264	PF00675	0.540
CLV_PCSK_KEX2_1	20	22	PF00082	0.330
CLV_PCSK_KEX2_1	262	264	PF00082	0.540
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.336
CLV_PCSK_SKI1_1	113	117	PF00082	0.501
CLV_PCSK_SKI1_1	137	141	PF00082	0.371

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z0	Leptomonas seymouri	23%	76%
A0A0N1PCH0	Leptomonas seymouri	73%	94%
A0A0S4JHX8	Bodo saltans	26%	78%
A0A0S4JRG8	Bodo saltans	38%	90%
A0A1X0P1C0	Trypanosomatidae	41%	91%
A0A1X0P1E2	Trypanosomatidae	24%	81%
A0A3Q8IEH8	Leishmania donovani	25%	100%
A0A422P0Q5	Trypanosoma rangeli	42%	91%
A0A422P0V0	Trypanosoma rangeli	26%	80%
A4HIP5	Leishmania braziliensis	23%	100%

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