Triose-phosphate Transporter family, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triose-phosphate Transporter family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3R1_LEIDO

TriTrypDb:

LdBPK_302680.1 , LdCL_300032400 , LDHU3_30.3580

Length:

325

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3S7X3R1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3R1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015291	secondary active transmembrane transporter activity	4	2
GO:0015297	antiporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022804	active transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.317
CLV_PCSK_KEX2_1	119	121	PF00082	0.246
CLV_PCSK_KEX2_1	25	27	PF00082	0.477
CLV_PCSK_KEX2_1	70	72	PF00082	0.274
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.277
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.477
CLV_PCSK_SKI1_1	26	30	PF00082	0.473
CLV_PCSK_SKI1_1	60	64	PF00082	0.283
CLV_PCSK_SKI1_1	70	74	PF00082	0.268
DEG_APCC_DBOX_1	119	127	PF00400	0.483
DEG_MDM2_SWIB_1	214	222	PF02201	0.260
DOC_CKS1_1	104	109	PF01111	0.303
DOC_CKS1_1	185	190	PF01111	0.246
DOC_CKS1_1	61	66	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	104	110	PF00134	0.312
DOC_MAPK_gen_1	119	129	PF00069	0.470
DOC_MAPK_gen_1	272	279	PF00069	0.371
DOC_MAPK_gen_1	314	322	PF00069	0.599
DOC_MAPK_MEF2A_6	102	111	PF00069	0.334
DOC_MAPK_MEF2A_6	272	281	PF00069	0.297
DOC_WW_Pin1_4	103	108	PF00397	0.295
DOC_WW_Pin1_4	184	189	PF00397	0.398
DOC_WW_Pin1_4	239	244	PF00397	0.444
DOC_WW_Pin1_4	291	296	PF00397	0.568
DOC_WW_Pin1_4	307	312	PF00397	0.703
DOC_WW_Pin1_4	60	65	PF00397	0.528
LIG_14-3-3_CanoR_1	307	311	PF00244	0.737
LIG_APCC_ABBAyCdc20_2	25	31	PF00400	0.260
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	222	226	PF00533	0.316
LIG_BRCT_BRCA1_1	254	258	PF00533	0.397
LIG_BRCT_BRCA1_1	4	8	PF00533	0.412
LIG_BRCT_BRCA1_1	75	79	PF00533	0.258
LIG_deltaCOP1_diTrp_1	145	155	PF00928	0.227
LIG_EH1_1	97	105	PF00400	0.412
LIG_eIF4E_1	251	257	PF01652	0.296
LIG_FHA_1	1	7	PF00498	0.501
LIG_FHA_1	104	110	PF00498	0.294
LIG_FHA_1	13	19	PF00498	0.426
LIG_FHA_1	168	174	PF00498	0.513
LIG_FHA_1	217	223	PF00498	0.333
LIG_FHA_1	239	245	PF00498	0.450
LIG_FHA_1	252	258	PF00498	0.295
LIG_FHA_1	45	51	PF00498	0.397
LIG_FHA_1	90	96	PF00498	0.295
LIG_GBD_Chelix_1	248	256	PF00786	0.371
LIG_IRF3_LxIS_1	69	76	PF10401	0.443
LIG_LIR_Gen_1	151	160	PF02991	0.250
LIG_LIR_Gen_1	216	226	PF02991	0.326
LIG_LIR_Gen_1	233	243	PF02991	0.277
LIG_LIR_Gen_1	261	270	PF02991	0.360
LIG_LIR_Gen_1	288	297	PF02991	0.464
LIG_LIR_Gen_1	35	43	PF02991	0.292
LIG_LIR_Gen_1	5	14	PF02991	0.376
LIG_LIR_Gen_1	96	104	PF02991	0.355
LIG_LIR_Nem_3	151	156	PF02991	0.286
LIG_LIR_Nem_3	211	217	PF02991	0.295
LIG_LIR_Nem_3	233	238	PF02991	0.312
LIG_LIR_Nem_3	261	265	PF02991	0.341
LIG_LIR_Nem_3	288	292	PF02991	0.464
LIG_LIR_Nem_3	35	39	PF02991	0.305
LIG_LIR_Nem_3	5	11	PF02991	0.337
LIG_LIR_Nem_3	76	82	PF02991	0.260
LIG_LIR_Nem_3	96	101	PF02991	0.435
LIG_NRBOX	122	128	PF00104	0.509
LIG_NRBOX	6	12	PF00104	0.412
LIG_PCNA_PIPBox_1	149	158	PF02747	0.246
LIG_PDZ_Class_2	320	325	PF00595	0.710
LIG_Pex14_2	214	218	PF04695	0.267
LIG_Pex14_2	228	232	PF04695	0.360
LIG_Pex14_2	258	262	PF04695	0.298
LIG_Pex14_2	45	49	PF04695	0.242
LIG_PTB_Apo_2	158	165	PF02174	0.296
LIG_PTB_Apo_2	21	28	PF02174	0.246
LIG_PTB_Phospho_1	158	164	PF10480	0.296
LIG_SH2_CRK	98	102	PF00017	0.338
LIG_SH2_NCK_1	289	293	PF00017	0.350
LIG_SH2_STAP1	210	214	PF00017	0.299
LIG_SH2_STAT5	164	167	PF00017	0.281
LIG_SH2_STAT5	251	254	PF00017	0.285
LIG_SH2_STAT5	82	85	PF00017	0.281
LIG_SH3_3	194	200	PF00018	0.359
LIG_SH3_3	294	300	PF00018	0.655
LIG_SUMO_SIM_anti_2	124	131	PF11976	0.284
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.281
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.407
LIG_SUMO_SIM_anti_2	37	44	PF11976	0.336
LIG_SUMO_SIM_par_1	106	113	PF11976	0.321
LIG_SUMO_SIM_par_1	218	223	PF11976	0.376
MOD_CDK_SPK_2	60	65	PF00069	0.528
MOD_CDK_SPxK_1	60	66	PF00069	0.427
MOD_CDK_SPxxK_3	291	298	PF00069	0.479
MOD_CDK_SPxxK_3	307	314	PF00069	0.524
MOD_CK1_1	162	168	PF00069	0.316
MOD_CK1_1	2	8	PF00069	0.483
MOD_CK1_1	242	248	PF00069	0.444
MOD_CK1_1	306	312	PF00069	0.690
MOD_CK1_1	89	95	PF00069	0.314
MOD_CK2_1	287	293	PF00069	0.425
MOD_Cter_Amidation	117	120	PF01082	0.328
MOD_GlcNHglycan	189	192	PF01048	0.258
MOD_GlcNHglycan	265	268	PF01048	0.505
MOD_GSK3_1	121	128	PF00069	0.490
MOD_GSK3_1	2	9	PF00069	0.444
MOD_GSK3_1	216	223	PF00069	0.298
MOD_GSK3_1	238	245	PF00069	0.440
MOD_GSK3_1	287	294	PF00069	0.315
MOD_GSK3_1	303	310	PF00069	0.639
MOD_GSK3_1	34	41	PF00069	0.260
MOD_GSK3_1	89	96	PF00069	0.300
MOD_N-GLC_1	12	17	PF02516	0.371
MOD_N-GLC_1	230	235	PF02516	0.309
MOD_N-GLC_1	86	91	PF02516	0.295
MOD_NEK2_1	12	17	PF00069	0.407
MOD_NEK2_1	252	257	PF00069	0.322
MOD_NEK2_1	34	39	PF00069	0.254
MOD_NEK2_1	45	50	PF00069	0.299
MOD_NEK2_1	6	11	PF00069	0.331
MOD_NEK2_1	91	96	PF00069	0.232
MOD_NEK2_2	210	215	PF00069	0.333
MOD_PK_1	65	71	PF00069	0.461
MOD_PKA_1	65	71	PF00069	0.477
MOD_PKA_2	303	309	PF00069	0.608
MOD_Plk_1	210	216	PF00069	0.259
MOD_Plk_1	230	236	PF00069	0.276
MOD_Plk_1	34	40	PF00069	0.227
MOD_Plk_1	86	92	PF00069	0.293
MOD_Plk_4	122	128	PF00069	0.450
MOD_Plk_4	136	142	PF00069	0.291
MOD_Plk_4	148	154	PF00069	0.292
MOD_Plk_4	159	165	PF00069	0.316
MOD_Plk_4	2	8	PF00069	0.437
MOD_Plk_4	213	219	PF00069	0.264
MOD_Plk_4	252	258	PF00069	0.278
MOD_Plk_4	277	283	PF00069	0.247
MOD_Plk_4	298	304	PF00069	0.658
MOD_Plk_4	35	41	PF00069	0.254
MOD_Plk_4	45	51	PF00069	0.293
MOD_Plk_4	86	92	PF00069	0.316
MOD_Plk_4	93	99	PF00069	0.251
MOD_ProDKin_1	103	109	PF00069	0.295
MOD_ProDKin_1	184	190	PF00069	0.398
MOD_ProDKin_1	239	245	PF00069	0.444
MOD_ProDKin_1	291	297	PF00069	0.578
MOD_ProDKin_1	307	313	PF00069	0.702
MOD_ProDKin_1	60	66	PF00069	0.528
TRG_ENDOCYTIC_2	289	292	PF00928	0.409
TRG_ENDOCYTIC_2	82	85	PF00928	0.299
TRG_ENDOCYTIC_2	98	101	PF00928	0.288
TRG_ER_diArg_1	69	71	PF00400	0.515
TRG_PTS2	1	34	PF00400	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N6	Leptomonas seymouri	39%	100%
A0A0N1PAW1	Leptomonas seymouri	70%	100%
A0A0S4IKX4	Bodo saltans	37%	100%
A0A0S4JRZ1	Bodo saltans	36%	100%
A0A1X0P276	Trypanosomatidae	65%	100%
A0A1X0P5Z4	Trypanosomatidae	41%	100%
A0A3R7NGZ9	Trypanosoma rangeli	63%	100%
A0A3S7WVL9	Leishmania donovani	38%	100%
A0A422NUS0	Trypanosoma rangeli	40%	100%
A4HAA0	Leishmania braziliensis	34%	100%
A4HYI0	Leishmania infantum	38%	100%
A4I5U5	Leishmania infantum	100%	100%
A4IFK2	Bos taurus	34%	100%
A6QM03	Bos taurus	28%	89%
C9ZR66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ASA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B140	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
F4IHS9	Arabidopsis thaliana	30%	95%
P49131	Flaveria pringlei	24%	80%
P49133	Zea mays	24%	79%
Q1JQ66	Danio rerio	35%	100%
Q3E6T0	Arabidopsis thaliana	24%	93%
Q4Q726	Leishmania major	93%	100%
Q4QD58	Leishmania major	36%	100%
Q550W6	Dictyostelium discoideum	23%	88%
Q5RKL7	Rattus norvegicus	25%	93%
Q5XF09	Arabidopsis thaliana	27%	100%
Q6DBP3	Arabidopsis thaliana	26%	100%
Q6PGC7	Mus musculus	34%	100%
Q7Z769	Homo sapiens	35%	100%
Q8GUJ1	Arabidopsis thaliana	33%	92%
Q8RWW7	Arabidopsis thaliana	30%	96%
Q8RXL8	Arabidopsis thaliana	32%	91%
Q9C521	Arabidopsis thaliana	25%	97%
Q9FDZ5	Arabidopsis thaliana	29%	97%
Q9FG70	Arabidopsis thaliana	27%	82%
Q9FIH5	Arabidopsis thaliana	29%	93%
Q9FTT3	Oryza sativa subsp. japonica	24%	78%
Q9FYE5	Arabidopsis thaliana	26%	100%
Q9LDH3	Arabidopsis thaliana	25%	90%
Q9LFN3	Arabidopsis thaliana	27%	93%
Q9LNH5	Arabidopsis thaliana	27%	89%
Q9LPU2	Arabidopsis thaliana	28%	93%
Q9LRP2	Arabidopsis thaliana	27%	87%
Q9LU76	Arabidopsis thaliana	27%	83%
Q9NQQ7	Homo sapiens	25%	89%
Q9SFE9	Arabidopsis thaliana	28%	95%
Q9SKJ7	Arabidopsis thaliana	24%	94%
Q9SRE4	Arabidopsis thaliana	29%	94%
Q9SS40	Arabidopsis thaliana	25%	92%
Q9SUV2	Arabidopsis thaliana	26%	93%
Q9SZ96	Arabidopsis thaliana	32%	97%
V5BMW3	Trypanosoma cruzi	61%	100%
V5D4Q6	Trypanosoma cruzi	42%	100%