Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3P8_LEIDO

TriTrypDb:

LdBPK_302510.1 , LdCL_300030800 , LDHU3_30.3380

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7X3P8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3P8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.485
CLV_NRD_NRD_1	149	151	PF00675	0.438
CLV_NRD_NRD_1	194	196	PF00675	0.643
CLV_NRD_NRD_1	34	36	PF00675	0.658
CLV_PCSK_KEX2_1	148	150	PF00082	0.462
CLV_PCSK_KEX2_1	194	196	PF00082	0.618
CLV_PCSK_KEX2_1	34	36	PF00082	0.662
CLV_PCSK_SKI1_1	186	190	PF00082	0.623
CLV_PCSK_SKI1_1	38	42	PF00082	0.336
DEG_APCC_DBOX_1	37	45	PF00400	0.336
DOC_CKS1_1	46	51	PF01111	0.279
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.489
DOC_MAPK_gen_1	146	155	PF00069	0.624
DOC_PP4_FxxP_1	46	49	PF00568	0.298
DOC_USP7_MATH_1	121	125	PF00917	0.395
DOC_USP7_MATH_1	5	9	PF00917	0.472
DOC_WW_Pin1_4	45	50	PF00397	0.311
DOC_WW_Pin1_4	54	59	PF00397	0.247
LIG_14-3-3_CanoR_1	35	41	PF00244	0.312
LIG_14-3-3_CanoR_1	75	83	PF00244	0.457
LIG_14-3-3_CterR_2	198	202	PF00244	0.464
LIG_BIR_II_1	1	5	PF00653	0.473
LIG_BIR_III_4	21	25	PF00653	0.447
LIG_BRCT_BRCA1_1	123	127	PF00533	0.304
LIG_BRCT_BRCA1_1	128	132	PF00533	0.249
LIG_BRCT_BRCA1_1	77	81	PF00533	0.440
LIG_deltaCOP1_diTrp_1	142	152	PF00928	0.620
LIG_FHA_1	115	121	PF00498	0.262
LIG_FHA_1	142	148	PF00498	0.692
LIG_FHA_2	16	22	PF00498	0.521
LIG_Integrin_RGD_1	23	25	PF01839	0.650
LIG_LIR_Gen_1	151	160	PF02991	0.633
LIG_LIR_Gen_1	79	90	PF02991	0.296
LIG_LIR_Nem_3	107	112	PF02991	0.391
LIG_LIR_Nem_3	151	155	PF02991	0.611
LIG_LIR_Nem_3	2	6	PF02991	0.452
LIG_LIR_Nem_3	25	30	PF02991	0.440
LIG_LIR_Nem_3	32	36	PF02991	0.395
LIG_LIR_Nem_3	78	83	PF02991	0.455
LIG_LIR_Nem_3	89	95	PF02991	0.300
LIG_LYPXL_S_1	132	136	PF13949	0.274
LIG_LYPXL_yS_3	133	136	PF13949	0.274
LIG_MLH1_MIPbox_1	77	81	PF16413	0.440
LIG_MYND_1	111	115	PF01753	0.399
LIG_Pex14_2	81	85	PF04695	0.274
LIG_SH2_CRK	187	191	PF00017	0.428
LIG_SH2_CRK	33	37	PF00017	0.478
LIG_SH2_GRB2like	82	85	PF00017	0.298
LIG_SH2_STAT5	112	115	PF00017	0.459
LIG_SH2_STAT5	3	6	PF00017	0.455
LIG_SH2_STAT5	82	85	PF00017	0.298
LIG_SH3_3	137	143	PF00018	0.560
LIG_SH3_3	163	169	PF00018	0.302
LIG_SH3_3	178	184	PF00018	0.274
LIG_SH3_3	52	58	PF00018	0.314
LIG_SH3_3	95	101	PF00018	0.498
LIG_TYR_ITIM	131	136	PF00017	0.391
MOD_CDK_SPxxK_3	54	61	PF00069	0.274
MOD_CK1_1	8	14	PF00069	0.489
MOD_GlcNHglycan	18	21	PF01048	0.641
MOD_GlcNHglycan	7	10	PF01048	0.638
MOD_GSK3_1	8	15	PF00069	0.491
MOD_NEK2_1	126	131	PF00069	0.283
MOD_NEK2_1	60	65	PF00069	0.680
MOD_NEK2_1	85	90	PF00069	0.298
MOD_PIKK_1	13	19	PF00454	0.462
MOD_PIKK_1	60	66	PF00454	0.637
MOD_PKA_2	11	17	PF00069	0.530
MOD_Plk_4	68	74	PF00069	0.628
MOD_ProDKin_1	45	51	PF00069	0.311
MOD_ProDKin_1	54	60	PF00069	0.247
MOD_SUMO_rev_2	63	71	PF00179	0.670
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.298
TRG_ENDOCYTIC_2	133	136	PF00928	0.316
TRG_ENDOCYTIC_2	187	190	PF00928	0.433
TRG_ENDOCYTIC_2	33	36	PF00928	0.443
TRG_ENDOCYTIC_2	82	85	PF00928	0.285
TRG_ENDOCYTIC_2	92	95	PF00928	0.257
TRG_ER_diArg_1	147	150	PF00400	0.689
TRG_ER_diArg_1	33	35	PF00400	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT69	Leptomonas seymouri	70%	98%
A0A0S4KH82	Bodo saltans	47%	100%
A0A1X0P1K1	Trypanosomatidae	54%	100%
A4HII4	Leishmania braziliensis	86%	100%
A4I5S7	Leishmania infantum	100%	100%
C9ZR46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
E9B123	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q742	Leishmania major	92%	100%