TPH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3P7_LEIDO

TriTrypDb:

LdBPK_302840.1 , LdCL_300034000 , LDHU3_30.3770

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3P7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.587
CLV_C14_Caspase3-7	755	759	PF00656	0.560
CLV_NRD_NRD_1	14	16	PF00675	0.619
CLV_NRD_NRD_1	267	269	PF00675	0.460
CLV_NRD_NRD_1	277	279	PF00675	0.466
CLV_NRD_NRD_1	322	324	PF00675	0.431
CLV_NRD_NRD_1	330	332	PF00675	0.442
CLV_NRD_NRD_1	385	387	PF00675	0.479
CLV_NRD_NRD_1	412	414	PF00675	0.498
CLV_NRD_NRD_1	447	449	PF00675	0.542
CLV_NRD_NRD_1	455	457	PF00675	0.610
CLV_NRD_NRD_1	586	588	PF00675	0.436
CLV_NRD_NRD_1	607	609	PF00675	0.537
CLV_NRD_NRD_1	617	619	PF00675	0.404
CLV_NRD_NRD_1	735	737	PF00675	0.488
CLV_PCSK_FUR_1	264	268	PF00082	0.586
CLV_PCSK_FUR_1	320	324	PF00082	0.464
CLV_PCSK_FUR_1	328	332	PF00082	0.445
CLV_PCSK_FUR_1	383	387	PF00082	0.441
CLV_PCSK_KEX2_1	144	146	PF00082	0.531
CLV_PCSK_KEX2_1	187	189	PF00082	0.512
CLV_PCSK_KEX2_1	264	266	PF00082	0.475
CLV_PCSK_KEX2_1	267	269	PF00082	0.453
CLV_PCSK_KEX2_1	277	279	PF00082	0.453
CLV_PCSK_KEX2_1	322	324	PF00082	0.447
CLV_PCSK_KEX2_1	330	332	PF00082	0.417
CLV_PCSK_KEX2_1	385	387	PF00082	0.441
CLV_PCSK_KEX2_1	412	414	PF00082	0.498
CLV_PCSK_KEX2_1	447	449	PF00082	0.544
CLV_PCSK_KEX2_1	470	472	PF00082	0.531
CLV_PCSK_KEX2_1	586	588	PF00082	0.433
CLV_PCSK_KEX2_1	607	609	PF00082	0.480
CLV_PCSK_KEX2_1	700	702	PF00082	0.438
CLV_PCSK_KEX2_1	735	737	PF00082	0.499
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.531
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.505
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.531
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.414
CLV_PCSK_SKI1_1	127	131	PF00082	0.513
CLV_PCSK_SKI1_1	164	168	PF00082	0.493
CLV_PCSK_SKI1_1	297	301	PF00082	0.448
CLV_PCSK_SKI1_1	314	318	PF00082	0.410
CLV_PCSK_SKI1_1	342	346	PF00082	0.523
CLV_PCSK_SKI1_1	350	354	PF00082	0.417
CLV_PCSK_SKI1_1	366	370	PF00082	0.349
CLV_PCSK_SKI1_1	412	416	PF00082	0.563
CLV_PCSK_SKI1_1	608	612	PF00082	0.409
CLV_PCSK_SKI1_1	618	622	PF00082	0.393
CLV_PCSK_SKI1_1	710	714	PF00082	0.432
CLV_PCSK_SKI1_1	725	729	PF00082	0.414
CLV_PCSK_SKI1_1	791	795	PF00082	0.470
DEG_APCC_DBOX_1	439	447	PF00400	0.541
DEG_APCC_DBOX_1	607	615	PF00400	0.468
DEG_APCC_DBOX_1	790	798	PF00400	0.482
DEG_SPOP_SBC_1	75	79	PF00917	0.601
DOC_CDC14_PxL_1	4	12	PF14671	0.589
DOC_CYCLIN_RxL_1	615	622	PF00134	0.505
DOC_MAPK_FxFP_2	18	21	PF00069	0.451
DOC_PP4_FxxP_1	104	107	PF00568	0.595
DOC_PP4_FxxP_1	18	21	PF00568	0.529
DOC_USP7_MATH_1	107	111	PF00917	0.725
DOC_USP7_MATH_1	217	221	PF00917	0.656
DOC_USP7_MATH_1	42	46	PF00917	0.814
DOC_USP7_MATH_1	54	58	PF00917	0.593
DOC_USP7_MATH_1	574	578	PF00917	0.456
DOC_USP7_MATH_1	651	655	PF00917	0.644
DOC_USP7_MATH_1	670	674	PF00917	0.326
DOC_USP7_MATH_1	741	745	PF00917	0.522
DOC_USP7_MATH_1	75	79	PF00917	0.644
DOC_USP7_UBL2_3	58	62	PF12436	0.648
DOC_USP7_UBL2_3	696	700	PF12436	0.467
DOC_WW_Pin1_4	117	122	PF00397	0.676
DOC_WW_Pin1_4	8	13	PF00397	0.666
LIG_14-3-3_CanoR_1	145	151	PF00244	0.581
LIG_14-3-3_CanoR_1	15	21	PF00244	0.695
LIG_14-3-3_CanoR_1	272	277	PF00244	0.552
LIG_14-3-3_CanoR_1	525	529	PF00244	0.522
LIG_14-3-3_CanoR_1	586	590	PF00244	0.404
LIG_14-3-3_CanoR_1	689	695	PF00244	0.471
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_FHA_1	335	341	PF00498	0.343
LIG_FHA_1	427	433	PF00498	0.528
LIG_FHA_1	663	669	PF00498	0.540
LIG_FHA_2	147	153	PF00498	0.511
LIG_FHA_2	28	34	PF00498	0.623
LIG_FHA_2	333	339	PF00498	0.386
LIG_FHA_2	365	371	PF00498	0.461
LIG_FHA_2	504	510	PF00498	0.526
LIG_FHA_2	586	592	PF00498	0.539
LIG_LIR_Apic_2	102	107	PF02991	0.739
LIG_LIR_Apic_2	26	32	PF02991	0.603
LIG_LIR_Gen_1	298	308	PF02991	0.449
LIG_LIR_Gen_1	622	633	PF02991	0.396
LIG_LIR_Gen_1	729	738	PF02991	0.497
LIG_LIR_Nem_3	19	23	PF02991	0.552
LIG_LIR_Nem_3	298	303	PF02991	0.450
LIG_LIR_Nem_3	362	368	PF02991	0.467
LIG_LIR_Nem_3	622	628	PF02991	0.394
LIG_LIR_Nem_3	729	734	PF02991	0.488
LIG_MYND_1	8	12	PF01753	0.665
LIG_PCNA_yPIPBox_3	534	547	PF02747	0.431
LIG_SH2_CRK	147	151	PF00017	0.524
LIG_SH2_CRK	596	600	PF00017	0.537
LIG_SH2_NCK_1	147	151	PF00017	0.576
LIG_SH2_SRC	113	116	PF00017	0.656
LIG_SH2_STAP1	100	104	PF00017	0.617
LIG_SH2_STAP1	25	29	PF00017	0.679
LIG_SH2_STAT3	439	442	PF00017	0.481
LIG_SH2_STAT5	113	116	PF00017	0.684
LIG_SH2_STAT5	29	32	PF00017	0.598
LIG_SH3_3	69	75	PF00018	0.666
LIG_SH3_5	21	25	PF00018	0.443
LIG_TRAF2_1	149	152	PF00917	0.549
LIG_TRAF2_1	279	282	PF00917	0.556
LIG_TRAF2_1	35	38	PF00917	0.641
LIG_TRAF2_1	416	419	PF00917	0.519
LIG_TRAF2_1	506	509	PF00917	0.565
LIG_TRAF2_1	552	555	PF00917	0.413
LIG_TRAF2_1	673	676	PF00917	0.412
LIG_TRAF2_1	743	746	PF00917	0.532
LIG_WRC_WIRS_1	365	370	PF05994	0.462
LIG_WRC_WIRS_1	575	580	PF05994	0.462
MOD_CDK_SPxxK_3	8	15	PF00069	0.666
MOD_CK1_1	11	17	PF00069	0.615
MOD_CK1_1	116	122	PF00069	0.607
MOD_CK1_1	43	49	PF00069	0.749
MOD_CK1_1	576	582	PF00069	0.423
MOD_CK1_1	684	690	PF00069	0.490
MOD_CK1_1	77	83	PF00069	0.603
MOD_CK2_1	146	152	PF00069	0.573
MOD_CK2_1	255	261	PF00069	0.581
MOD_CK2_1	27	33	PF00069	0.618
MOD_CK2_1	332	338	PF00069	0.381
MOD_CK2_1	364	370	PF00069	0.460
MOD_CK2_1	495	501	PF00069	0.544
MOD_CK2_1	503	509	PF00069	0.507
MOD_CK2_1	585	591	PF00069	0.472
MOD_CK2_1	670	676	PF00069	0.532
MOD_CK2_1	726	732	PF00069	0.579
MOD_CK2_1	740	746	PF00069	0.398
MOD_GlcNHglycan	219	222	PF01048	0.601
MOD_GlcNHglycan	433	438	PF01048	0.470
MOD_GlcNHglycan	84	87	PF01048	0.640
MOD_GSK3_1	113	120	PF00069	0.679
MOD_GSK3_1	227	234	PF00069	0.758
MOD_GSK3_1	40	47	PF00069	0.698
MOD_GSK3_1	503	510	PF00069	0.559
MOD_GSK3_1	6	13	PF00069	0.611
MOD_GSK3_1	684	691	PF00069	0.490
MOD_GSK3_1	77	84	PF00069	0.585
MOD_LATS_1	270	276	PF00433	0.550
MOD_N-GLC_1	303	308	PF02516	0.404
MOD_N-GLC_1	495	500	PF02516	0.546
MOD_NEK2_1	146	151	PF00069	0.526
MOD_NEK2_1	303	308	PF00069	0.404
MOD_NEK2_1	426	431	PF00069	0.593
MOD_NEK2_1	503	508	PF00069	0.513
MOD_NEK2_1	511	516	PF00069	0.490
MOD_NEK2_1	573	578	PF00069	0.461
MOD_PIKK_1	210	216	PF00454	0.608
MOD_PIKK_1	741	747	PF00454	0.586
MOD_PK_1	681	687	PF00069	0.536
MOD_PKA_1	82	88	PF00069	0.639
MOD_PKA_2	202	208	PF00069	0.518
MOD_PKA_2	390	396	PF00069	0.544
MOD_PKA_2	524	530	PF00069	0.523
MOD_PKA_2	54	60	PF00069	0.733
MOD_PKA_2	585	591	PF00069	0.443
MOD_PKA_2	688	694	PF00069	0.534
MOD_Plk_1	303	309	PF00069	0.404
MOD_Plk_1	32	38	PF00069	0.491
MOD_Plk_1	495	501	PF00069	0.601
MOD_Plk_1	651	657	PF00069	0.544
MOD_Plk_2-3	585	591	PF00069	0.404
MOD_Plk_4	303	309	PF00069	0.427
MOD_Plk_4	524	530	PF00069	0.596
MOD_Plk_4	651	657	PF00069	0.544
MOD_ProDKin_1	117	123	PF00069	0.681
MOD_ProDKin_1	8	14	PF00069	0.665
MOD_SUMO_for_1	166	169	PF00179	0.554
MOD_SUMO_for_1	316	319	PF00179	0.439
MOD_SUMO_for_1	414	417	PF00179	0.717
MOD_SUMO_for_1	569	572	PF00179	0.448
MOD_SUMO_for_1	680	683	PF00179	0.443
MOD_SUMO_for_1	695	698	PF00179	0.457
MOD_SUMO_rev_2	138	146	PF00179	0.515
MOD_SUMO_rev_2	346	354	PF00179	0.504
MOD_SUMO_rev_2	359	365	PF00179	0.402
MOD_SUMO_rev_2	544	552	PF00179	0.443
MOD_SUMO_rev_2	613	621	PF00179	0.400
MOD_SUMO_rev_2	673	680	PF00179	0.531
MOD_SUMO_rev_2	697	702	PF00179	0.422
MOD_SUMO_rev_2	718	727	PF00179	0.461
TRG_AP2beta_CARGO_1	362	372	PF09066	0.479
TRG_DiLeu_BaEn_1	311	316	PF01217	0.409
TRG_DiLeu_BaEn_1	723	728	PF01217	0.436
TRG_DiLeu_LyEn_5	311	316	PF01217	0.409
TRG_ENDOCYTIC_2	147	150	PF00928	0.575
TRG_ENDOCYTIC_2	568	571	PF00928	0.357
TRG_ENDOCYTIC_2	596	599	PF00928	0.419
TRG_ER_diArg_1	179	182	PF00400	0.628
TRG_ER_diArg_1	264	267	PF00400	0.473
TRG_ER_diArg_1	276	278	PF00400	0.461
TRG_ER_diArg_1	321	323	PF00400	0.483
TRG_ER_diArg_1	383	386	PF00400	0.538
TRG_ER_diArg_1	446	448	PF00400	0.562
TRG_ER_diArg_1	561	564	PF00400	0.395
TRG_ER_diArg_1	607	609	PF00400	0.480
TRG_ER_diArg_1	671	674	PF00400	0.529
TRG_ER_diArg_1	734	736	PF00400	0.494
TRG_ER_diArg_1	747	750	PF00400	0.668
TRG_NLS_Bipartite_1	50	65	PF00514	0.673
TRG_NLS_MonoCore_2	57	62	PF00514	0.719
TRG_NLS_MonoExtC_3	57	62	PF00514	0.674
TRG_NLS_MonoExtN_4	48	54	PF00514	0.620
TRG_NLS_MonoExtN_4	55	62	PF00514	0.618
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	314	318	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	520	524	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC64	Leptomonas seymouri	71%	100%
A0A1X0P1G0	Trypanosomatidae	42%	98%
A0A3R7M5L7	Trypanosoma rangeli	45%	100%
A4HIL6	Leishmania braziliensis	85%	100%
A4I5W1	Leishmania infantum	99%	100%
C9ZR81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B156	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q710	Leishmania major	94%	100%