Stabilization of polarity axis, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Stabilization of polarity axis, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3N9_LEIDO

TriTrypDb:

LdBPK_302730.1 , LdCL_300032900 , LDHU3_30.3650

Length:

875

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3N9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3N9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051666	actin cortical patch localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.752
CLV_C14_Caspase3-7	392	396	PF00656	0.549
CLV_C14_Caspase3-7	754	758	PF00656	0.511
CLV_NRD_NRD_1	212	214	PF00675	0.486
CLV_NRD_NRD_1	259	261	PF00675	0.767
CLV_NRD_NRD_1	399	401	PF00675	0.576
CLV_NRD_NRD_1	52	54	PF00675	0.651
CLV_NRD_NRD_1	550	552	PF00675	0.346
CLV_NRD_NRD_1	578	580	PF00675	0.336
CLV_NRD_NRD_1	635	637	PF00675	0.578
CLV_NRD_NRD_1	811	813	PF00675	0.449
CLV_PCSK_KEX2_1	393	395	PF00082	0.472
CLV_PCSK_KEX2_1	399	401	PF00082	0.562
CLV_PCSK_KEX2_1	450	452	PF00082	0.489
CLV_PCSK_KEX2_1	52	54	PF00082	0.651
CLV_PCSK_KEX2_1	811	813	PF00082	0.449
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.528
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.489
CLV_PCSK_SKI1_1	13	17	PF00082	0.501
CLV_PCSK_SKI1_1	202	206	PF00082	0.529
CLV_PCSK_SKI1_1	381	385	PF00082	0.519
CLV_PCSK_SKI1_1	447	451	PF00082	0.496
CLV_PCSK_SKI1_1	544	548	PF00082	0.346
CLV_PCSK_SKI1_1	579	583	PF00082	0.335
CLV_PCSK_SKI1_1	683	687	PF00082	0.466
CLV_PCSK_SKI1_1	807	811	PF00082	0.446
DEG_APCC_DBOX_1	380	388	PF00400	0.547
DEG_APCC_DBOX_1	518	526	PF00400	0.513
DEG_COP1_1	56	65	PF00400	0.673
DEG_SCF_FBW7_2	243	249	PF00400	0.603
DEG_SPOP_SBC_1	144	148	PF00917	0.505
DOC_CKS1_1	243	248	PF01111	0.736
DOC_CYCLIN_RxL_1	680	688	PF00134	0.358
DOC_MAPK_gen_1	579	587	PF00069	0.520
DOC_MAPK_gen_1	702	710	PF00069	0.463
DOC_MAPK_gen_1	811	817	PF00069	0.467
DOC_MAPK_HePTP_8	17	29	PF00069	0.453
DOC_MAPK_MEF2A_6	20	29	PF00069	0.452
DOC_MAPK_MEF2A_6	579	587	PF00069	0.545
DOC_MAPK_MEF2A_6	60	67	PF00069	0.551
DOC_MAPK_MEF2A_6	702	710	PF00069	0.463
DOC_MAPK_MEF2A_6	766	774	PF00069	0.492
DOC_MAPK_RevD_3	536	552	PF00069	0.539
DOC_PP1_RVXF_1	379	386	PF00149	0.580
DOC_PP2B_LxvP_1	330	333	PF13499	0.751
DOC_PP4_FxxP_1	674	677	PF00568	0.594
DOC_USP7_MATH_1	144	148	PF00917	0.742
DOC_USP7_MATH_1	220	224	PF00917	0.689
DOC_USP7_MATH_1	228	232	PF00917	0.765
DOC_USP7_MATH_1	237	241	PF00917	0.777
DOC_USP7_MATH_1	264	268	PF00917	0.823
DOC_USP7_MATH_1	337	341	PF00917	0.837
DOC_USP7_MATH_1	35	39	PF00917	0.580
DOC_USP7_MATH_1	389	393	PF00917	0.481
DOC_USP7_MATH_1	583	587	PF00917	0.546
DOC_USP7_MATH_1	726	730	PF00917	0.591
DOC_USP7_MATH_1	739	743	PF00917	0.465
DOC_USP7_MATH_1	745	749	PF00917	0.502
DOC_USP7_MATH_1	854	858	PF00917	0.471
DOC_USP7_MATH_2	91	97	PF00917	0.565
DOC_WW_Pin1_4	242	247	PF00397	0.758
DOC_WW_Pin1_4	297	302	PF00397	0.691
DOC_WW_Pin1_4	506	511	PF00397	0.519
DOC_WW_Pin1_4	784	789	PF00397	0.645
DOC_WW_Pin1_4	826	831	PF00397	0.600
LIG_14-3-3_CanoR_1	124	129	PF00244	0.689
LIG_14-3-3_CanoR_1	202	208	PF00244	0.643
LIG_14-3-3_CanoR_1	519	523	PF00244	0.513
LIG_14-3-3_CanoR_1	741	750	PF00244	0.619
LIG_Actin_WH2_2	682	698	PF00022	0.487
LIG_BRCT_BRCA1_1	126	130	PF00533	0.679
LIG_Clathr_ClatBox_1	414	418	PF01394	0.439
LIG_eIF4E_1	520	526	PF01652	0.546
LIG_eIF4E_1	61	67	PF01652	0.519
LIG_FHA_1	10	16	PF00498	0.515
LIG_FHA_1	174	180	PF00498	0.376
LIG_FHA_1	182	188	PF00498	0.432
LIG_FHA_1	206	212	PF00498	0.663
LIG_FHA_1	358	364	PF00498	0.776
LIG_FHA_1	402	408	PF00498	0.517
LIG_FHA_1	472	478	PF00498	0.515
LIG_FHA_1	636	642	PF00498	0.713
LIG_FHA_1	651	657	PF00498	0.550
LIG_FHA_1	70	76	PF00498	0.628
LIG_FHA_1	714	720	PF00498	0.455
LIG_FHA_1	759	765	PF00498	0.537
LIG_FHA_2	257	263	PF00498	0.705
LIG_FHA_2	273	279	PF00498	0.724
LIG_FHA_2	627	633	PF00498	0.546
LIG_FHA_2	69	75	PF00498	0.624
LIG_FHA_2	80	86	PF00498	0.477
LIG_FHA_2	800	806	PF00498	0.504
LIG_LIR_Apic_2	413	419	PF02991	0.460
LIG_LIR_Gen_1	174	185	PF02991	0.521
LIG_LIR_Gen_1	198	207	PF02991	0.531
LIG_LIR_Gen_1	712	723	PF02991	0.463
LIG_LIR_Nem_3	174	180	PF02991	0.487
LIG_LIR_Nem_3	198	203	PF02991	0.520
LIG_LIR_Nem_3	418	424	PF02991	0.454
LIG_LIR_Nem_3	478	483	PF02991	0.537
LIG_LIR_Nem_3	514	520	PF02991	0.507
LIG_LIR_Nem_3	712	718	PF02991	0.406
LIG_NRBOX	533	539	PF00104	0.616
LIG_NRBOX	792	798	PF00104	0.467
LIG_Pex14_1	416	420	PF04695	0.458
LIG_PTB_Apo_2	602	609	PF02174	0.520
LIG_PTB_Apo_2	684	691	PF02174	0.422
LIG_PTB_Apo_2	729	736	PF02174	0.543
LIG_PTB_Phospho_1	684	690	PF10480	0.455
LIG_PTB_Phospho_1	729	735	PF10480	0.536
LIG_SH2_CRK	175	179	PF00017	0.453
LIG_SH2_CRK	453	457	PF00017	0.462
LIG_SH2_CRK	480	484	PF00017	0.552
LIG_SH2_CRK	682	686	PF00017	0.463
LIG_SH2_CRK	715	719	PF00017	0.450
LIG_SH2_GRB2like	492	495	PF00017	0.470
LIG_SH2_GRB2like	722	725	PF00017	0.508
LIG_SH2_NCK_1	182	186	PF00017	0.593
LIG_SH2_NCK_1	453	457	PF00017	0.462
LIG_SH2_NCK_1	493	497	PF00017	0.581
LIG_SH2_PTP2	584	587	PF00017	0.546
LIG_SH2_SRC	722	725	PF00017	0.508
LIG_SH2_STAP1	126	130	PF00017	0.664
LIG_SH2_STAP1	175	179	PF00017	0.468
LIG_SH2_STAP1	182	186	PF00017	0.598
LIG_SH2_STAP1	715	719	PF00017	0.450
LIG_SH2_STAP1	735	739	PF00017	0.448
LIG_SH2_STAT3	592	595	PF00017	0.483
LIG_SH2_STAT5	175	178	PF00017	0.576
LIG_SH2_STAT5	182	185	PF00017	0.621
LIG_SH2_STAT5	193	196	PF00017	0.366
LIG_SH2_STAT5	26	29	PF00017	0.583
LIG_SH2_STAT5	430	433	PF00017	0.456
LIG_SH2_STAT5	480	483	PF00017	0.532
LIG_SH2_STAT5	490	493	PF00017	0.426
LIG_SH2_STAT5	584	587	PF00017	0.546
LIG_SH2_STAT5	592	595	PF00017	0.546
LIG_SH2_STAT5	599	602	PF00017	0.546
LIG_SH2_STAT5	61	64	PF00017	0.539
LIG_SH2_STAT5	715	718	PF00017	0.412
LIG_SH2_STAT5	722	725	PF00017	0.435
LIG_SH3_3	15	21	PF00018	0.604
LIG_SH3_3	279	285	PF00018	0.687
LIG_SH3_3	298	304	PF00018	0.522
LIG_SH3_3	406	412	PF00018	0.469
LIG_SH3_3	416	422	PF00018	0.463
LIG_SH3_3	504	510	PF00018	0.484
LIG_SH3_3	725	731	PF00018	0.643
LIG_SH3_3	96	102	PF00018	0.626
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.463
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.593
LIG_SUMO_SIM_anti_2	716	721	PF11976	0.566
LIG_SUMO_SIM_par_1	545	550	PF11976	0.514
LIG_TRAF2_1	188	191	PF00917	0.657
LIG_TRAF2_1	54	57	PF00917	0.615
LIG_TRAF2_1	71	74	PF00917	0.523
LIG_UBA3_1	536	545	PF00899	0.549
LIG_UBA3_1	546	552	PF00899	0.541
LIG_UBA3_1	618	625	PF00899	0.619
LIG_WRC_WIRS_1	735	740	PF05994	0.625
LIG_WW_1	23	26	PF00397	0.551
MOD_CDK_SPxxK_3	300	307	PF00069	0.672
MOD_CDK_SPxxK_3	784	791	PF00069	0.513
MOD_CK1_1	129	135	PF00069	0.705
MOD_CK1_1	242	248	PF00069	0.699
MOD_CK1_1	252	258	PF00069	0.758
MOD_CK1_1	300	306	PF00069	0.654
MOD_CK1_1	319	325	PF00069	0.824
MOD_CK1_1	38	44	PF00069	0.657
MOD_CK1_1	509	515	PF00069	0.499
MOD_CK1_1	521	527	PF00069	0.562
MOD_CK1_1	586	592	PF00069	0.507
MOD_CK1_1	626	632	PF00069	0.619
MOD_CK1_1	650	656	PF00069	0.741
MOD_CK1_1	868	874	PF00069	0.464
MOD_CK2_1	256	262	PF00069	0.638
MOD_CK2_1	319	325	PF00069	0.769
MOD_CK2_1	521	527	PF00069	0.619
MOD_CK2_1	626	632	PF00069	0.546
MOD_CK2_1	68	74	PF00069	0.622
MOD_CK2_1	79	85	PF00069	0.469
MOD_GlcNHglycan	131	134	PF01048	0.710
MOD_GlcNHglycan	147	150	PF01048	0.538
MOD_GlcNHglycan	222	225	PF01048	0.743
MOD_GlcNHglycan	230	233	PF01048	0.836
MOD_GlcNHglycan	234	237	PF01048	0.668
MOD_GlcNHglycan	266	269	PF01048	0.755
MOD_GlcNHglycan	295	298	PF01048	0.769
MOD_GlcNHglycan	325	329	PF01048	0.844
MOD_GlcNHglycan	339	342	PF01048	0.590
MOD_GlcNHglycan	37	40	PF01048	0.709
MOD_GlcNHglycan	438	442	PF01048	0.541
MOD_GlcNHglycan	484	487	PF01048	0.577
MOD_GlcNHglycan	643	646	PF01048	0.687
MOD_GlcNHglycan	649	652	PF01048	0.681
MOD_GlcNHglycan	743	746	PF01048	0.548
MOD_GlcNHglycan	830	833	PF01048	0.593
MOD_GlcNHglycan	867	870	PF01048	0.416
MOD_GSK3_1	118	125	PF00069	0.639
MOD_GSK3_1	129	136	PF00069	0.676
MOD_GSK3_1	228	235	PF00069	0.642
MOD_GSK3_1	245	252	PF00069	0.795
MOD_GSK3_1	264	271	PF00069	0.612
MOD_GSK3_1	293	300	PF00069	0.801
MOD_GSK3_1	314	321	PF00069	0.844
MOD_GSK3_1	332	339	PF00069	0.674
MOD_GSK3_1	341	348	PF00069	0.742
MOD_GSK3_1	37	44	PF00069	0.653
MOD_GSK3_1	373	380	PF00069	0.739
MOD_GSK3_1	389	396	PF00069	0.366
MOD_GSK3_1	471	478	PF00069	0.523
MOD_GSK3_1	521	528	PF00069	0.473
MOD_GSK3_1	635	642	PF00069	0.726
MOD_GSK3_1	69	76	PF00069	0.522
MOD_GSK3_1	741	748	PF00069	0.544
MOD_N-GLC_1	228	233	PF02516	0.750
MOD_N-GLC_1	256	261	PF02516	0.712
MOD_N-GLC_1	268	273	PF02516	0.657
MOD_N-GLC_1	434	439	PF02516	0.632
MOD_N-GLC_1	623	628	PF02516	0.393
MOD_N-GLC_1	647	652	PF02516	0.770
MOD_N-GLC_1	68	73	PF02516	0.522
MOD_N-GLC_1	9	14	PF02516	0.451
MOD_N-GLC_1	93	98	PF02516	0.556
MOD_NEK2_1	122	127	PF00069	0.678
MOD_NEK2_1	195	200	PF00069	0.584
MOD_NEK2_1	203	208	PF00069	0.542
MOD_NEK2_1	256	261	PF00069	0.756
MOD_NEK2_1	272	277	PF00069	0.653
MOD_NEK2_1	324	329	PF00069	0.740
MOD_NEK2_1	498	503	PF00069	0.517
MOD_NEK2_1	525	530	PF00069	0.496
MOD_NEK2_1	547	552	PF00069	0.508
MOD_NEK2_1	641	646	PF00069	0.647
MOD_NEK2_1	685	690	PF00069	0.568
MOD_NEK2_1	713	718	PF00069	0.446
MOD_NEK2_1	734	739	PF00069	0.514
MOD_NEK2_1	750	755	PF00069	0.490
MOD_NEK2_1	799	804	PF00069	0.488
MOD_NEK2_1	825	830	PF00069	0.498
MOD_NEK2_2	268	273	PF00069	0.758
MOD_PIKK_1	314	320	PF00454	0.773
MOD_PIKK_1	43	49	PF00454	0.731
MOD_PK_1	124	130	PF00069	0.659
MOD_PKA_1	213	219	PF00069	0.504
MOD_PKA_1	393	399	PF00069	0.565
MOD_PKA_1	636	642	PF00069	0.632
MOD_PKA_2	106	112	PF00069	0.492
MOD_PKA_2	35	41	PF00069	0.660
MOD_PKA_2	393	399	PF00069	0.565
MOD_PKA_2	518	524	PF00069	0.513
MOD_PKA_2	635	641	PF00069	0.719
MOD_Plk_1	118	124	PF00069	0.628
MOD_Plk_1	173	179	PF00069	0.392
MOD_Plk_1	268	274	PF00069	0.755
MOD_Plk_1	437	443	PF00069	0.525
MOD_Plk_1	623	629	PF00069	0.580
MOD_Plk_1	73	79	PF00069	0.546
MOD_Plk_1	93	99	PF00069	0.442
MOD_Plk_2-3	135	141	PF00069	0.592
MOD_Plk_4	173	179	PF00069	0.392
MOD_Plk_4	206	212	PF00069	0.565
MOD_Plk_4	239	245	PF00069	0.737
MOD_Plk_4	410	416	PF00069	0.460
MOD_Plk_4	521	527	PF00069	0.546
MOD_Plk_4	623	629	PF00069	0.619
MOD_Plk_4	685	691	PF00069	0.574
MOD_Plk_4	713	719	PF00069	0.411
MOD_Plk_4	751	757	PF00069	0.491
MOD_ProDKin_1	242	248	PF00069	0.759
MOD_ProDKin_1	297	303	PF00069	0.689
MOD_ProDKin_1	506	512	PF00069	0.521
MOD_ProDKin_1	784	790	PF00069	0.639
MOD_ProDKin_1	826	832	PF00069	0.604
MOD_SUMO_for_1	116	119	PF00179	0.619
MOD_SUMO_rev_2	617	627	PF00179	0.619
MOD_SUMO_rev_2	846	854	PF00179	0.482
TRG_DiLeu_BaEn_1	543	548	PF01217	0.546
TRG_DiLeu_BaEn_1	768	773	PF01217	0.466
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.543
TRG_ENDOCYTIC_2	175	178	PF00928	0.475
TRG_ENDOCYTIC_2	26	29	PF00928	0.508
TRG_ENDOCYTIC_2	453	456	PF00928	0.479
TRG_ENDOCYTIC_2	480	483	PF00928	0.498
TRG_ENDOCYTIC_2	584	587	PF00928	0.546
TRG_ENDOCYTIC_2	682	685	PF00928	0.465
TRG_ENDOCYTIC_2	715	718	PF00928	0.448
TRG_ENDOCYTIC_2	735	738	PF00928	0.522
TRG_ER_diArg_1	52	54	PF00400	0.651
TRG_ER_diArg_1	705	708	PF00400	0.397
TRG_ER_diArg_1	810	812	PF00400	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P522	Leptomonas seymouri	58%	87%
A4HIK5	Leishmania braziliensis	74%	100%
A4I5V0	Leishmania infantum	100%	100%
E9B145	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q721	Leishmania major	91%	100%