Zinc finger C-x8-C-x5-C-x3-H type (And similar), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3N7_LEIDO

TriTrypDb:

LdBPK_302790.1 , LdCL_300033500 , LDHU3_30.3720

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3S7X3N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3N7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	173	175	PF00675	0.726
CLV_NRD_NRD_1	227	229	PF00675	0.708
CLV_NRD_NRD_1	251	253	PF00675	0.699
CLV_PCSK_KEX2_1	173	175	PF00082	0.726
CLV_PCSK_KEX2_1	227	229	PF00082	0.715
CLV_PCSK_KEX2_1	251	253	PF00082	0.709
CLV_PCSK_SKI1_1	295	299	PF00082	0.656
DEG_SPOP_SBC_1	142	146	PF00917	0.667
DEG_SPOP_SBC_1	279	283	PF00917	0.542
DOC_ANK_TNKS_1	137	144	PF00023	0.625
DOC_MAPK_DCC_7	256	265	PF00069	0.576
DOC_PP1_RVXF_1	226	233	PF00149	0.672
DOC_USP7_MATH_1	150	154	PF00917	0.817
DOC_USP7_MATH_1	71	75	PF00917	0.552
DOC_WW_Pin1_4	256	261	PF00397	0.633
DOC_WW_Pin1_4	273	278	PF00397	0.639
DOC_WW_Pin1_4	95	100	PF00397	0.690
LIG_14-3-3_CanoR_1	133	142	PF00244	0.668
LIG_14-3-3_CanoR_1	15	24	PF00244	0.567
LIG_14-3-3_CanoR_1	191	199	PF00244	0.586
LIG_14-3-3_CanoR_1	227	231	PF00244	0.656
LIG_14-3-3_CanoR_1	308	312	PF00244	0.453
LIG_APCC_ABBA_1	210	215	PF00400	0.695
LIG_BIR_II_1	1	5	PF00653	0.628
LIG_BRCT_BRCA1_1	219	223	PF00533	0.726
LIG_BRCT_BRCA1_1	228	232	PF00533	0.631
LIG_FHA_1	11	17	PF00498	0.648
LIG_FHA_1	179	185	PF00498	0.634
LIG_FHA_1	279	285	PF00498	0.682
LIG_FHA_1	294	300	PF00498	0.406
LIG_FHA_2	100	106	PF00498	0.672
LIG_FHA_2	143	149	PF00498	0.780
LIG_FHA_2	21	27	PF00498	0.549
LIG_FHA_2	281	287	PF00498	0.553
LIG_FHA_2	3	9	PF00498	0.557
LIG_KLC1_Yacidic_2	211	215	PF13176	0.633
LIG_LIR_Apic_2	93	99	PF02991	0.569
LIG_LIR_Nem_3	23	27	PF02991	0.535
LIG_LIR_Nem_3	48	53	PF02991	0.434
LIG_MYND_1	162	166	PF01753	0.660
LIG_SH2_SRC	27	30	PF00017	0.494
LIG_SH2_STAT5	213	216	PF00017	0.634
LIG_SH2_STAT5	27	30	PF00017	0.558
LIG_SH3_1	186	192	PF00018	0.578
LIG_SH3_3	136	142	PF00018	0.703
LIG_SH3_3	186	192	PF00018	0.635
LIG_SH3_3	271	277	PF00018	0.734
LIG_SH3_3	98	104	PF00018	0.632
LIG_TRAF2_1	110	113	PF00917	0.678
MOD_CK1_1	128	134	PF00069	0.657
MOD_CK1_1	144	150	PF00069	0.543
MOD_CK1_1	176	182	PF00069	0.730
MOD_CK1_1	2	8	PF00069	0.559
MOD_CK1_1	234	240	PF00069	0.653
MOD_CK1_1	48	54	PF00069	0.430
MOD_CK2_1	142	148	PF00069	0.781
MOD_CK2_1	20	26	PF00069	0.560
MOD_CK2_1	280	286	PF00069	0.559
MOD_CK2_1	36	42	PF00069	0.335
MOD_CK2_1	77	83	PF00069	0.575
MOD_CK2_1	99	105	PF00069	0.714
MOD_Cter_Amidation	171	174	PF01082	0.691
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.635
MOD_GlcNHglycan	1	4	PF01048	0.632
MOD_GlcNHglycan	158	161	PF01048	0.695
MOD_GlcNHglycan	178	181	PF01048	0.675
MOD_GlcNHglycan	29	32	PF01048	0.632
MOD_GlcNHglycan	34	37	PF01048	0.572
MOD_GlcNHglycan	47	50	PF01048	0.328
MOD_GSK3_1	10	17	PF00069	0.656
MOD_GSK3_1	156	163	PF00069	0.728
MOD_GSK3_1	176	183	PF00069	0.626
MOD_GSK3_1	191	198	PF00069	0.595
MOD_GSK3_1	254	261	PF00069	0.772
MOD_GSK3_1	303	310	PF00069	0.335
MOD_GSK3_1	32	39	PF00069	0.480
MOD_GSK3_1	85	92	PF00069	0.576
MOD_GSK3_1	95	102	PF00069	0.682
MOD_N-GLC_1	237	242	PF02516	0.681
MOD_N-GLC_1	254	259	PF02516	0.507
MOD_N-GLC_1	88	93	PF02516	0.518
MOD_NEK2_1	178	183	PF00069	0.631
MOD_NEK2_1	20	25	PF00069	0.449
MOD_NEK2_1	303	308	PF00069	0.335
MOD_NEK2_1	85	90	PF00069	0.490
MOD_PKA_1	173	179	PF00069	0.673
MOD_PKA_2	14	20	PF00069	0.543
MOD_PKA_2	173	179	PF00069	0.651
MOD_PKA_2	226	232	PF00069	0.658
MOD_PKA_2	307	313	PF00069	0.453
MOD_ProDKin_1	256	262	PF00069	0.630
MOD_ProDKin_1	273	279	PF00069	0.634
MOD_ProDKin_1	95	101	PF00069	0.685
MOD_SUMO_rev_2	146	155	PF00179	0.707
MOD_SUMO_rev_2	170	179	PF00179	0.679
TRG_DiLeu_BaEn_1	42	47	PF01217	0.537
TRG_DiLeu_BaEn_2	285	291	PF01217	0.664
TRG_ER_diArg_1	132	135	PF00400	0.568
TRG_ER_diArg_1	251	253	PF00400	0.648
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD74	Leptomonas seymouri	33%	99%
A4HIL1	Leishmania braziliensis	67%	100%
A4I5V6	Leishmania infantum	99%	100%
E9B151	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q715	Leishmania major	90%	100%