WD domain, G-beta repeat, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3K9_LEIDO

TriTrypDb:

LdBPK_302160.1 , LdCL_300027100 , LDHU3_30.2920

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7X3K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3K9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	514	518	PF00656	0.412
CLV_C14_Caspase3-7	557	561	PF00656	0.446
CLV_NRD_NRD_1	254	256	PF00675	0.707
CLV_NRD_NRD_1	266	268	PF00675	0.762
CLV_NRD_NRD_1	421	423	PF00675	0.690
CLV_NRD_NRD_1	440	442	PF00675	0.545
CLV_NRD_NRD_1	452	454	PF00675	0.467
CLV_NRD_NRD_1	56	58	PF00675	0.433
CLV_NRD_NRD_1	635	637	PF00675	0.447
CLV_PCSK_FUR_1	264	268	PF00082	0.501
CLV_PCSK_KEX2_1	253	255	PF00082	0.678
CLV_PCSK_KEX2_1	266	268	PF00082	0.744
CLV_PCSK_KEX2_1	420	422	PF00082	0.677
CLV_PCSK_KEX2_1	442	444	PF00082	0.604
CLV_PCSK_KEX2_1	55	57	PF00082	0.444
CLV_PCSK_KEX2_1	635	637	PF00082	0.414
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.586
CLV_PCSK_SKI1_1	131	135	PF00082	0.438
CLV_PCSK_SKI1_1	412	416	PF00082	0.595
CLV_PCSK_SKI1_1	622	626	PF00082	0.364
CLV_PCSK_SKI1_1	66	70	PF00082	0.309
CLV_PCSK_SKI1_1	723	727	PF00082	0.491
CLV_PCSK_SKI1_1	760	764	PF00082	0.526
CLV_PCSK_SKI1_1	832	836	PF00082	0.524
DEG_APCC_DBOX_1	254	262	PF00400	0.527
DEG_APCC_DBOX_1	485	493	PF00400	0.521
DEG_COP1_1	769	779	PF00400	0.392
DEG_SPOP_SBC_1	12	16	PF00917	0.470
DEG_SPOP_SBC_1	649	653	PF00917	0.769
DOC_CKS1_1	320	325	PF01111	0.467
DOC_PP1_RVXF_1	527	534	PF00149	0.400
DOC_PP1_RVXF_1	64	71	PF00149	0.403
DOC_PP2B_PxIxI_1	784	790	PF00149	0.426
DOC_PP4_FxxP_1	320	323	PF00568	0.406
DOC_SPAK_OSR1_1	667	671	PF12202	0.441
DOC_USP7_MATH_1	11	15	PF00917	0.475
DOC_USP7_MATH_1	248	252	PF00917	0.631
DOC_USP7_MATH_1	272	276	PF00917	0.757
DOC_USP7_MATH_1	334	338	PF00917	0.633
DOC_USP7_MATH_1	425	429	PF00917	0.564
DOC_USP7_MATH_1	465	469	PF00917	0.629
DOC_USP7_MATH_1	494	498	PF00917	0.625
DOC_USP7_MATH_1	648	652	PF00917	0.751
DOC_USP7_MATH_1	791	795	PF00917	0.335
DOC_WW_Pin1_4	167	172	PF00397	0.622
DOC_WW_Pin1_4	25	30	PF00397	0.633
DOC_WW_Pin1_4	319	324	PF00397	0.557
DOC_WW_Pin1_4	580	585	PF00397	0.441
DOC_WW_Pin1_4	586	591	PF00397	0.441
LIG_14-3-3_CanoR_1	190	195	PF00244	0.409
LIG_14-3-3_CanoR_1	307	311	PF00244	0.503
LIG_14-3-3_CanoR_1	486	490	PF00244	0.597
LIG_14-3-3_CanoR_1	658	666	PF00244	0.563
LIG_14-3-3_CanoR_1	667	671	PF00244	0.505
LIG_BIR_III_4	38	42	PF00653	0.621
LIG_BRCT_BRCA1_1	13	17	PF00533	0.470
LIG_BRCT_BRCA1_1	27	31	PF00533	0.447
LIG_BRCT_BRCA1_1	613	617	PF00533	0.385
LIG_BRCT_BRCA1_1	88	92	PF00533	0.463
LIG_Clathr_ClatBox_1	133	137	PF01394	0.437
LIG_Clathr_ClatBox_1	20	24	PF01394	0.408
LIG_CSL_BTD_1	581	584	PF09270	0.426
LIG_CSL_BTD_1	827	830	PF09270	0.448
LIG_EH1_1	683	691	PF00400	0.302
LIG_eIF4E_1	619	625	PF01652	0.350
LIG_FHA_1	186	192	PF00498	0.478
LIG_FHA_1	213	219	PF00498	0.342
LIG_FHA_1	227	233	PF00498	0.341
LIG_FHA_1	307	313	PF00498	0.441
LIG_FHA_1	319	325	PF00498	0.398
LIG_FHA_1	334	340	PF00498	0.481
LIG_FHA_1	404	410	PF00498	0.585
LIG_FHA_1	467	473	PF00498	0.521
LIG_FHA_1	502	508	PF00498	0.467
LIG_FHA_1	716	722	PF00498	0.426
LIG_FHA_1	751	757	PF00498	0.426
LIG_FHA_2	281	287	PF00498	0.422
LIG_FHA_2	488	494	PF00498	0.563
LIG_FHA_2	49	55	PF00498	0.569
LIG_FHA_2	512	518	PF00498	0.406
LIG_FHA_2	555	561	PF00498	0.429
LIG_FHA_2	59	65	PF00498	0.521
LIG_Integrin_isoDGR_2	220	222	PF01839	0.356
LIG_Integrin_isoDGR_2	349	351	PF01839	0.534
LIG_LIR_Apic_2	317	323	PF02991	0.412
LIG_LIR_Gen_1	14	23	PF02991	0.477
LIG_LIR_Gen_1	28	39	PF02991	0.655
LIG_LIR_Gen_1	313	324	PF02991	0.470
LIG_LIR_Gen_1	477	484	PF02991	0.586
LIG_LIR_LC3C_4	204	208	PF02991	0.377
LIG_LIR_Nem_3	14	20	PF02991	0.450
LIG_LIR_Nem_3	313	319	PF02991	0.562
LIG_LIR_Nem_3	355	361	PF02991	0.432
LIG_LIR_Nem_3	365	369	PF02991	0.388
LIG_LIR_Nem_3	477	481	PF02991	0.601
LIG_LIR_Nem_3	614	620	PF02991	0.324
LIG_LIR_Nem_3	825	831	PF02991	0.366
LIG_NRBOX	619	625	PF00104	0.350
LIG_Pex14_1	88	92	PF04695	0.330
LIG_Pex14_2	474	478	PF04695	0.519
LIG_PTB_Apo_2	685	692	PF02174	0.295
LIG_SH2_CRK	316	320	PF00017	0.497
LIG_SH2_CRK	354	358	PF00017	0.484
LIG_SH2_GRB2like	354	357	PF00017	0.415
LIG_SH2_NCK_1	271	275	PF00017	0.643
LIG_SH2_NCK_1	354	358	PF00017	0.529
LIG_SH2_NCK_1	430	434	PF00017	0.634
LIG_SH2_NCK_1	732	736	PF00017	0.443
LIG_SH2_STAP1	316	320	PF00017	0.498
LIG_SH2_STAP1	354	358	PF00017	0.475
LIG_SH2_STAT5	316	319	PF00017	0.519
LIG_SH2_STAT5	354	357	PF00017	0.495
LIG_SH2_STAT5	363	366	PF00017	0.417
LIG_SH2_STAT5	430	433	PF00017	0.707
LIG_SH2_STAT5	619	622	PF00017	0.343
LIG_SH2_STAT5	822	825	PF00017	0.422
LIG_SH3_3	600	606	PF00018	0.531
LIG_SH3_3	827	833	PF00018	0.480
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.478
LIG_SUMO_SIM_anti_2	8	16	PF11976	0.382
LIG_SUMO_SIM_par_1	132	138	PF11976	0.396
LIG_SUMO_SIM_par_1	19	24	PF11976	0.396
LIG_SUMO_SIM_par_1	292	299	PF11976	0.463
LIG_SUMO_SIM_par_1	567	572	PF11976	0.420
LIG_SUMO_SIM_par_1	788	794	PF11976	0.316
LIG_SUMO_SIM_par_1	8	16	PF11976	0.384
LIG_TRAF2_1	278	281	PF00917	0.423
LIG_TRAF2_1	51	54	PF00917	0.499
LIG_UBA3_1	689	697	PF00899	0.324
LIG_WRC_WIRS_1	107	112	PF05994	0.446
MOD_CDK_SPxxK_3	580	587	PF00069	0.460
MOD_CK1_1	153	159	PF00069	0.538
MOD_CK1_1	212	218	PF00069	0.353
MOD_CK1_1	256	262	PF00069	0.694
MOD_CK1_1	27	33	PF00069	0.591
MOD_CK1_1	306	312	PF00069	0.447
MOD_CK1_1	314	320	PF00069	0.375
MOD_CK1_1	428	434	PF00069	0.683
MOD_CK1_1	5	11	PF00069	0.559
MOD_CK1_1	644	650	PF00069	0.753
MOD_CK1_1	651	657	PF00069	0.594
MOD_CK1_1	669	675	PF00069	0.431
MOD_CK1_1	72	78	PF00069	0.509
MOD_CK1_1	749	755	PF00069	0.368
MOD_CK1_1	821	827	PF00069	0.385
MOD_CK2_1	240	246	PF00069	0.497
MOD_CK2_1	41	47	PF00069	0.568
MOD_CK2_1	465	471	PF00069	0.564
MOD_CK2_1	48	54	PF00069	0.614
MOD_CK2_1	487	493	PF00069	0.554
MOD_CK2_1	649	655	PF00069	0.606
MOD_CK2_1	692	698	PF00069	0.462
MOD_GlcNHglycan	198	201	PF01048	0.603
MOD_GlcNHglycan	255	258	PF01048	0.764
MOD_GlcNHglycan	313	316	PF01048	0.558
MOD_GlcNHglycan	378	381	PF01048	0.729
MOD_GlcNHglycan	42	46	PF01048	0.726
MOD_GlcNHglycan	427	430	PF01048	0.597
MOD_GlcNHglycan	461	464	PF01048	0.644
MOD_GlcNHglycan	496	499	PF01048	0.588
MOD_GlcNHglycan	571	574	PF01048	0.448
MOD_GlcNHglycan	598	601	PF01048	0.680
MOD_GlcNHglycan	613	616	PF01048	0.449
MOD_GlcNHglycan	671	674	PF01048	0.433
MOD_GlcNHglycan	677	680	PF01048	0.365
MOD_GlcNHglycan	738	741	PF01048	0.580
MOD_GlcNHglycan	746	749	PF01048	0.417
MOD_GlcNHglycan	82	85	PF01048	0.543
MOD_GlcNHglycan	840	843	PF01048	0.403
MOD_GSK3_1	1	8	PF00069	0.500
MOD_GSK3_1	102	109	PF00069	0.622
MOD_GSK3_1	116	123	PF00069	0.327
MOD_GSK3_1	146	153	PF00069	0.424
MOD_GSK3_1	185	192	PF00069	0.544
MOD_GSK3_1	23	30	PF00069	0.567
MOD_GSK3_1	249	256	PF00069	0.662
MOD_GSK3_1	292	299	PF00069	0.350
MOD_GSK3_1	314	321	PF00069	0.422
MOD_GSK3_1	461	468	PF00069	0.713
MOD_GSK3_1	507	514	PF00069	0.379
MOD_GSK3_1	592	599	PF00069	0.618
MOD_GSK3_1	640	647	PF00069	0.673
MOD_GSK3_1	649	656	PF00069	0.602
MOD_GSK3_1	723	730	PF00069	0.519
MOD_GSK3_1	746	753	PF00069	0.526
MOD_GSK3_1	771	778	PF00069	0.515
MOD_GSK3_1	818	825	PF00069	0.423
MOD_N-GLC_1	167	172	PF02516	0.650
MOD_N-GLC_1	212	217	PF02516	0.503
MOD_N-GLC_1	561	566	PF02516	0.453
MOD_NEK2_1	110	115	PF00069	0.498
MOD_NEK2_1	209	214	PF00069	0.512
MOD_NEK2_1	362	367	PF00069	0.482
MOD_NEK2_1	492	497	PF00069	0.548
MOD_NEK2_1	569	574	PF00069	0.375
MOD_NEK2_1	623	628	PF00069	0.428
MOD_NEK2_1	744	749	PF00069	0.420
MOD_NEK2_1	750	755	PF00069	0.337
MOD_NEK2_1	86	91	PF00069	0.536
MOD_PIKK_1	116	122	PF00454	0.555
MOD_PIKK_1	256	262	PF00454	0.614
MOD_PIKK_1	314	320	PF00454	0.574
MOD_PIKK_1	766	772	PF00454	0.507
MOD_PIKK_1	791	797	PF00454	0.429
MOD_PK_1	190	196	PF00069	0.289
MOD_PKA_1	253	259	PF00069	0.584
MOD_PKA_2	189	195	PF00069	0.427
MOD_PKA_2	253	259	PF00069	0.683
MOD_PKA_2	306	312	PF00069	0.494
MOD_PKA_2	485	491	PF00069	0.566
MOD_PKA_2	644	650	PF00069	0.541
MOD_PKA_2	666	672	PF00069	0.547
MOD_PKA_2	727	733	PF00069	0.550
MOD_Plk_1	110	116	PF00069	0.454
MOD_Plk_1	280	286	PF00069	0.480
MOD_Plk_1	5	11	PF00069	0.597
MOD_Plk_1	592	598	PF00069	0.477
MOD_Plk_1	72	78	PF00069	0.532
MOD_Plk_4	120	126	PF00069	0.515
MOD_Plk_4	13	19	PF00069	0.454
MOD_Plk_4	202	208	PF00069	0.521
MOD_Plk_4	27	33	PF00069	0.663
MOD_Plk_4	280	286	PF00069	0.519
MOD_Plk_4	334	340	PF00069	0.640
MOD_Plk_4	477	483	PF00069	0.559
MOD_Plk_4	5	11	PF00069	0.435
MOD_Plk_4	608	614	PF00069	0.353
MOD_Plk_4	705	711	PF00069	0.516
MOD_Plk_4	818	824	PF00069	0.424
MOD_ProDKin_1	167	173	PF00069	0.613
MOD_ProDKin_1	25	31	PF00069	0.638
MOD_ProDKin_1	319	325	PF00069	0.558
MOD_ProDKin_1	580	586	PF00069	0.452
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.407
TRG_ENDOCYTIC_2	305	308	PF00928	0.526
TRG_ENDOCYTIC_2	316	319	PF00928	0.328
TRG_ENDOCYTIC_2	354	357	PF00928	0.519
TRG_ER_diArg_1	253	255	PF00400	0.677
TRG_ER_diArg_1	420	422	PF00400	0.634
TRG_ER_diArg_1	55	57	PF00400	0.553
TRG_ER_diArg_1	634	636	PF00400	0.403
TRG_NLS_MonoExtC_3	441	446	PF00514	0.485
TRG_NLS_MonoExtN_4	441	447	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P916	Leptomonas seymouri	45%	91%
A0A1X0P1Y6	Trypanosomatidae	26%	100%
A0A3S5IQN0	Trypanosoma rangeli	26%	100%
A4HIE7	Leishmania braziliensis	74%	100%
A4I5P4	Leishmania infantum	100%	100%
C9ZR12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B0Y8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q778	Leishmania major	91%	100%
V5BC72	Trypanosoma cruzi	25%	96%