Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 31

Species:

Leishmania donovani

UniProt:

A0A3S7X3K3_LEIDO

TriTrypDb:

LdBPK_302410.1 , LdCL_300029600 , LDHU3_30.3260

Length:

273

Annotations

Annotations by Jardim et al.

Mitochondrial protein, outer mitochondrial membrane proteome 31 (POMP31) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3S7X3K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3K3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.362
CLV_PCSK_FUR_1	171	175	PF00082	0.370
CLV_PCSK_KEX2_1	161	163	PF00082	0.346
CLV_PCSK_KEX2_1	173	175	PF00082	0.276
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.301
CLV_PCSK_PC7_1	169	175	PF00082	0.427
CLV_PCSK_SKI1_1	173	177	PF00082	0.298
CLV_PCSK_SKI1_1	71	75	PF00082	0.351
CLV_PCSK_SKI1_1	99	103	PF00082	0.525
DEG_APCC_DBOX_1	98	106	PF00400	0.398
DEG_SPOP_SBC_1	9	13	PF00917	0.715
DEG_SPOP_SBC_1	93	97	PF00917	0.483
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.413
DOC_MAPK_gen_1	171	180	PF00069	0.477
DOC_MAPK_RevD_3	149	163	PF00069	0.330
DOC_PP2B_LxvP_1	85	88	PF13499	0.449
DOC_USP7_MATH_1	131	135	PF00917	0.364
DOC_USP7_MATH_1	187	191	PF00917	0.428
DOC_USP7_MATH_1	246	250	PF00917	0.798
DOC_USP7_MATH_1	9	13	PF00917	0.702
DOC_WW_Pin1_4	251	256	PF00397	0.762
DOC_WW_Pin1_4	94	99	PF00397	0.316
LIG_14-3-3_CanoR_1	108	116	PF00244	0.436
LIG_14-3-3_CanoR_1	186	196	PF00244	0.409
LIG_14-3-3_CanoR_1	222	226	PF00244	0.534
LIG_14-3-3_CanoR_1	261	268	PF00244	0.699
LIG_14-3-3_CanoR_1	71	77	PF00244	0.528
LIG_BIR_II_1	1	5	PF00653	0.748
LIG_BRCT_BRCA1_1	46	50	PF00533	0.604
LIG_deltaCOP1_diTrp_1	136	146	PF00928	0.366
LIG_FHA_1	12	18	PF00498	0.667
LIG_FHA_1	143	149	PF00498	0.413
LIG_FHA_1	170	176	PF00498	0.526
LIG_FHA_1	189	195	PF00498	0.208
LIG_FHA_1	215	221	PF00498	0.363
LIG_FHA_1	24	30	PF00498	0.473
LIG_FHA_1	243	249	PF00498	0.773
LIG_FHA_2	208	214	PF00498	0.376
LIG_GBD_Chelix_1	204	212	PF00786	0.398
LIG_LIR_Apic_2	145	149	PF02991	0.413
LIG_LIR_Apic_2	224	228	PF02991	0.605
LIG_LIR_Gen_1	107	116	PF02991	0.396
LIG_LIR_Gen_1	138	149	PF02991	0.346
LIG_LIR_Gen_1	190	197	PF02991	0.368
LIG_LIR_Nem_3	107	112	PF02991	0.403
LIG_LIR_Nem_3	122	127	PF02991	0.305
LIG_LIR_Nem_3	138	144	PF02991	0.312
LIG_Pex14_1	139	143	PF04695	0.358
LIG_RPA_C_Fungi	157	169	PF08784	0.546
LIG_SH2_STAP1	124	128	PF00017	0.395
LIG_SH2_STAP1	268	272	PF00017	0.749
LIG_SH2_STAT3	45	48	PF00017	0.542
LIG_SH2_STAT5	16	19	PF00017	0.618
LIG_SH2_STAT5	219	222	PF00017	0.379
LIG_SH2_STAT5	72	75	PF00017	0.432
LIG_SH2_STAT5	91	94	PF00017	0.190
LIG_SH3_3	191	197	PF00018	0.328
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.457
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.449
LIG_SUMO_SIM_par_1	110	117	PF11976	0.485
LIG_SUMO_SIM_par_1	207	213	PF11976	0.342
LIG_UBA3_1	152	157	PF00899	0.405
LIG_WRC_WIRS_1	189	194	PF05994	0.385
LIG_WW_3	254	258	PF00397	0.742
MOD_CDK_SPK_2	94	99	PF00069	0.385
MOD_CDK_SPxK_1	251	257	PF00069	0.745
MOD_CK1_1	190	196	PF00069	0.407
MOD_CK1_1	237	243	PF00069	0.643
MOD_CK1_1	260	266	PF00069	0.736
MOD_CK2_1	132	138	PF00069	0.512
MOD_CK2_1	19	25	PF00069	0.498
MOD_CK2_1	207	213	PF00069	0.388
MOD_CK2_1	62	68	PF00069	0.472
MOD_GlcNHglycan	1	4	PF01048	0.736
MOD_GlcNHglycan	166	169	PF01048	0.608
MOD_GSK3_1	119	126	PF00069	0.516
MOD_GSK3_1	147	154	PF00069	0.328
MOD_GSK3_1	19	26	PF00069	0.472
MOD_GSK3_1	230	237	PF00069	0.612
MOD_GSK3_1	238	245	PF00069	0.626
MOD_N-GLC_1	238	243	PF02516	0.744
MOD_NEK2_1	164	169	PF00069	0.598
MOD_NEK2_1	215	220	PF00069	0.363
MOD_NEK2_1	39	44	PF00069	0.439
MOD_NEK2_1	92	97	PF00069	0.410
MOD_PIKK_1	178	184	PF00454	0.398
MOD_PIKK_1	44	50	PF00454	0.507
MOD_PKA_2	107	113	PF00069	0.570
MOD_PKA_2	221	227	PF00069	0.416
MOD_PKA_2	260	266	PF00069	0.765
MOD_Plk_4	147	153	PF00069	0.385
MOD_Plk_4	207	213	PF00069	0.367
MOD_Plk_4	215	221	PF00069	0.363
MOD_Plk_4	39	45	PF00069	0.449
MOD_ProDKin_1	251	257	PF00069	0.715
MOD_ProDKin_1	94	100	PF00069	0.384
TRG_ENDOCYTIC_2	31	34	PF00928	0.460
TRG_ER_diArg_1	161	163	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK1	Leptomonas seymouri	71%	100%
A0A0S4ILA8	Bodo saltans	43%	100%
A0A1X0P1K3	Trypanosomatidae	50%	100%
A0A422NWC9	Trypanosoma rangeli	49%	100%
A4HIH1	Leishmania braziliensis	88%	100%
A4I5R8	Leishmania infantum	100%	100%
C9ZR37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	85%
E9B113	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4Q753	Leishmania major	96%	100%
V5AWV4	Trypanosoma cruzi	53%	100%