Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3J4_LEIDO

TriTrypDb:

LdBPK_302320.1 , LdCL_300028700 , LDHU3_30.3140

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3J4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.506
CLV_NRD_NRD_1	175	177	PF00675	0.512
CLV_NRD_NRD_1	237	239	PF00675	0.416
CLV_NRD_NRD_1	240	242	PF00675	0.426
CLV_NRD_NRD_1	36	38	PF00675	0.608
CLV_NRD_NRD_1	372	374	PF00675	0.547
CLV_NRD_NRD_1	392	394	PF00675	0.278
CLV_NRD_NRD_1	455	457	PF00675	0.705
CLV_NRD_NRD_1	67	69	PF00675	0.483
CLV_PCSK_FUR_1	117	121	PF00082	0.530
CLV_PCSK_FUR_1	238	242	PF00082	0.498
CLV_PCSK_KEX2_1	117	119	PF00082	0.436
CLV_PCSK_KEX2_1	175	177	PF00082	0.512
CLV_PCSK_KEX2_1	237	239	PF00082	0.416
CLV_PCSK_KEX2_1	240	242	PF00082	0.426
CLV_PCSK_KEX2_1	250	252	PF00082	0.407
CLV_PCSK_KEX2_1	35	37	PF00082	0.589
CLV_PCSK_KEX2_1	372	374	PF00082	0.542
CLV_PCSK_KEX2_1	391	393	PF00082	0.362
CLV_PCSK_KEX2_1	67	69	PF00082	0.494
CLV_PCSK_KEX2_1	84	86	PF00082	0.496
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.426
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.572
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.315
CLV_PCSK_PC7_1	31	37	PF00082	0.628
CLV_PCSK_SKI1_1	119	123	PF00082	0.502
CLV_PCSK_SKI1_1	164	168	PF00082	0.429
CLV_PCSK_SKI1_1	250	254	PF00082	0.437
CLV_PCSK_SKI1_1	271	275	PF00082	0.448
CLV_PCSK_SKI1_1	31	35	PF00082	0.494
CLV_PCSK_SKI1_1	373	377	PF00082	0.561
CLV_PCSK_SKI1_1	400	404	PF00082	0.532
CLV_Separin_Metazoa	338	342	PF03568	0.501
DEG_SCF_FBW7_1	196	202	PF00400	0.582
DEG_SPOP_SBC_1	450	454	PF00917	0.520
DOC_CKS1_1	165	170	PF01111	0.491
DOC_CKS1_1	183	188	PF01111	0.312
DOC_CKS1_1	196	201	PF01111	0.480
DOC_CYCLIN_yClb5_NLxxxL_5	37	45	PF00134	0.570
DOC_MAPK_gen_1	175	183	PF00069	0.533
DOC_MAPK_gen_1	248	255	PF00069	0.449
DOC_MAPK_gen_1	35	43	PF00069	0.558
DOC_MAPK_MEF2A_6	164	172	PF00069	0.484
DOC_MAPK_MEF2A_6	36	45	PF00069	0.589
DOC_MAPK_MEF2A_6	405	412	PF00069	0.469
DOC_MAPK_NFAT4_5	405	413	PF00069	0.470
DOC_MAPK_RevD_3	21	36	PF00069	0.574
DOC_PP1_RVXF_1	407	413	PF00149	0.477
DOC_PP4_FxxP_1	448	451	PF00568	0.623
DOC_PP4_FxxP_1	78	81	PF00568	0.383
DOC_USP7_MATH_1	192	196	PF00917	0.519
DOC_USP7_MATH_1	451	455	PF00917	0.600
DOC_WW_Pin1_4	164	169	PF00397	0.491
DOC_WW_Pin1_4	182	187	PF00397	0.310
DOC_WW_Pin1_4	195	200	PF00397	0.473
LIG_14-3-3_CanoR_1	222	232	PF00244	0.552
LIG_14-3-3_CanoR_1	414	419	PF00244	0.479
LIG_14-3-3_CanoR_1	449	458	PF00244	0.648
LIG_Actin_WH2_2	69	86	PF00022	0.321
LIG_AP2alpha_1	144	148	PF02296	0.460
LIG_APCC_ABBA_1	145	150	PF00400	0.475
LIG_BRCT_BRCA1_1	102	106	PF00533	0.409
LIG_BRCT_BRCA1_1	148	152	PF00533	0.375
LIG_BRCT_BRCA1_1	429	433	PF00533	0.409
LIG_BRCT_BRCA1_1	49	53	PF00533	0.481
LIG_FHA_1	127	133	PF00498	0.403
LIG_FHA_1	165	171	PF00498	0.427
LIG_FHA_1	183	189	PF00498	0.341
LIG_FHA_1	196	202	PF00498	0.503
LIG_FHA_1	224	230	PF00498	0.480
LIG_FHA_1	351	357	PF00498	0.537
LIG_FHA_1	90	96	PF00498	0.584
LIG_FHA_2	185	191	PF00498	0.524
LIG_FHA_2	252	258	PF00498	0.449
LIG_FHA_2	279	285	PF00498	0.435
LIG_GBD_Chelix_1	395	403	PF00786	0.541
LIG_KLC1_Yacidic_2	319	324	PF13176	0.387
LIG_LIR_Apic_2	213	219	PF02991	0.555
LIG_LIR_Apic_2	445	451	PF02991	0.605
LIG_LIR_Gen_1	142	152	PF02991	0.360
LIG_LIR_Gen_1	333	344	PF02991	0.461
LIG_LIR_Gen_1	430	439	PF02991	0.403
LIG_LIR_Nem_3	127	133	PF02991	0.407
LIG_LIR_Nem_3	142	147	PF02991	0.322
LIG_LIR_Nem_3	149	155	PF02991	0.477
LIG_LIR_Nem_3	333	339	PF02991	0.473
LIG_LIR_Nem_3	430	436	PF02991	0.404
LIG_Pex14_2	144	148	PF04695	0.403
LIG_Pex14_2	412	416	PF04695	0.520
LIG_REV1ctd_RIR_1	104	114	PF16727	0.385
LIG_SH2_CRK	130	134	PF00017	0.383
LIG_SH2_SRC	136	139	PF00017	0.461
LIG_SH2_SRC	207	210	PF00017	0.487
LIG_SH2_SRC	79	82	PF00017	0.491
LIG_SH2_STAP1	136	140	PF00017	0.500
LIG_SH2_STAT5	207	210	PF00017	0.448
LIG_SH2_STAT5	322	325	PF00017	0.384
LIG_SH2_STAT5	437	440	PF00017	0.488
LIG_SH3_3	2	8	PF00018	0.520
LIG_SH3_3	420	426	PF00018	0.449
LIG_SUMO_SIM_par_1	251	257	PF11976	0.454
LIG_TRAF2_1	358	361	PF00917	0.487
MOD_CK1_1	139	145	PF00069	0.501
MOD_CK1_1	195	201	PF00069	0.586
MOD_CK2_1	278	284	PF00069	0.503
MOD_Cter_Amidation	248	251	PF01082	0.481
MOD_GlcNHglycan	257	261	PF01048	0.398
MOD_GlcNHglycan	294	297	PF01048	0.529
MOD_GlcNHglycan	429	432	PF01048	0.553
MOD_GSK3_1	122	129	PF00069	0.574
MOD_GSK3_1	184	191	PF00069	0.431
MOD_GSK3_1	195	202	PF00069	0.468
MOD_GSK3_1	294	301	PF00069	0.416
MOD_GSK3_1	425	432	PF00069	0.482
MOD_GSK3_1	457	464	PF00069	0.665
MOD_LATS_1	326	332	PF00433	0.532
MOD_LATS_1	455	461	PF00433	0.550
MOD_N-GLC_1	292	297	PF02516	0.477
MOD_NEK2_1	188	193	PF00069	0.464
MOD_NEK2_1	329	334	PF00069	0.533
MOD_NEK2_1	339	344	PF00069	0.454
MOD_NEK2_1	89	94	PF00069	0.512
MOD_NEK2_1	9	14	PF00069	0.476
MOD_PIKK_1	122	128	PF00454	0.589
MOD_PIKK_1	25	31	PF00454	0.537
MOD_PIKK_1	431	437	PF00454	0.392
MOD_PK_1	414	420	PF00069	0.521
MOD_PKA_2	192	198	PF00069	0.546
MOD_PKA_2	236	242	PF00069	0.475
MOD_Plk_1	278	284	PF00069	0.477
MOD_Plk_1	69	75	PF00069	0.551
MOD_Plk_2-3	184	190	PF00069	0.526
MOD_Plk_2-3	279	285	PF00069	0.496
MOD_Plk_4	139	145	PF00069	0.356
MOD_Plk_4	192	198	PF00069	0.435
MOD_Plk_4	251	257	PF00069	0.480
MOD_Plk_4	271	277	PF00069	0.212
MOD_Plk_4	294	300	PF00069	0.449
MOD_Plk_4	350	356	PF00069	0.407
MOD_Plk_4	69	75	PF00069	0.485
MOD_ProDKin_1	164	170	PF00069	0.492
MOD_ProDKin_1	182	188	PF00069	0.311
MOD_ProDKin_1	195	201	PF00069	0.475
MOD_SUMO_rev_2	380	384	PF00179	0.605
TRG_DiLeu_BaEn_1	227	232	PF01217	0.474
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.506
TRG_DiLeu_BaLyEn_6	420	425	PF01217	0.554
TRG_ENDOCYTIC_2	130	133	PF00928	0.383
TRG_ER_diArg_1	117	120	PF00400	0.476
TRG_ER_diArg_1	237	240	PF00400	0.410
TRG_ER_diArg_1	312	315	PF00400	0.539
TRG_ER_diArg_1	35	37	PF00400	0.628
TRG_ER_diArg_1	371	373	PF00400	0.551
TRG_ER_diArg_1	392	394	PF00400	0.616
TRG_ER_diArg_1	66	68	PF00400	0.507
TRG_NLS_Bipartite_1	373	395	PF00514	0.535
TRG_NLS_MonoExtC_3	455	461	PF00514	0.550
TRG_NLS_MonoExtN_4	389	395	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P922	Leptomonas seymouri	72%	100%
A0A1X0P2C1	Trypanosomatidae	48%	100%
A0A422NW63	Trypanosoma rangeli	48%	100%
A4HIG3	Leishmania braziliensis	87%	100%
A4I5Q9	Leishmania infantum	100%	100%
C9ZR28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B104	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q762	Leishmania major	94%	100%
V5BGV8	Trypanosoma cruzi	45%	100%