Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3S7X3H1_LEIDO

TriTrypDb:

LdBPK_302060.1 , LdCL_300025900 , LDHU3_30.2800

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3S7X3H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3H1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	247	251	PF00656	0.463
CLV_C14_Caspase3-7	317	321	PF00656	0.499
CLV_MEL_PAP_1	826	832	PF00089	0.643
CLV_NRD_NRD_1	137	139	PF00675	0.688
CLV_NRD_NRD_1	160	162	PF00675	0.704
CLV_NRD_NRD_1	282	284	PF00675	0.688
CLV_NRD_NRD_1	431	433	PF00675	0.627
CLV_NRD_NRD_1	840	842	PF00675	0.728
CLV_NRD_NRD_1	863	865	PF00675	0.630
CLV_NRD_NRD_1	932	934	PF00675	0.453
CLV_PCSK_KEX2_1	137	139	PF00082	0.688
CLV_PCSK_KEX2_1	160	162	PF00082	0.704
CLV_PCSK_KEX2_1	282	284	PF00082	0.749
CLV_PCSK_KEX2_1	431	433	PF00082	0.627
CLV_PCSK_KEX2_1	862	864	PF00082	0.637
CLV_PCSK_KEX2_1	905	907	PF00082	0.676
CLV_PCSK_KEX2_1	932	934	PF00082	0.453
CLV_PCSK_PC1ET2_1	905	907	PF00082	0.676
CLV_PCSK_SKI1_1	145	149	PF00082	0.632
CLV_PCSK_SKI1_1	184	188	PF00082	0.589
CLV_PCSK_SKI1_1	268	272	PF00082	0.597
CLV_PCSK_SKI1_1	393	397	PF00082	0.704
CLV_PCSK_SKI1_1	432	436	PF00082	0.632
CLV_PCSK_SKI1_1	782	786	PF00082	0.688
CLV_PCSK_SKI1_1	842	846	PF00082	0.647
CLV_PCSK_SKI1_1	864	868	PF00082	0.618
DEG_APCC_DBOX_1	861	869	PF00400	0.433
DEG_APCC_DBOX_1	932	940	PF00400	0.666
DEG_Nend_UBRbox_2	1	3	PF02207	0.462
DEG_SPOP_SBC_1	516	520	PF00917	0.483
DEG_SPOP_SBC_1	854	858	PF00917	0.521
DOC_CKS1_1	880	885	PF01111	0.433
DOC_CYCLIN_yCln2_LP_2	913	919	PF00134	0.328
DOC_MAPK_DCC_7	66	74	PF00069	0.481
DOC_MAPK_gen_1	285	295	PF00069	0.477
DOC_MAPK_gen_1	862	870	PF00069	0.408
DOC_MAPK_gen_1	905	912	PF00069	0.462
DOC_MAPK_gen_1	932	938	PF00069	0.616
DOC_MAPK_MEF2A_6	393	402	PF00069	0.380
DOC_MAPK_MEF2A_6	66	74	PF00069	0.430
DOC_MAPK_MEF2A_6	862	870	PF00069	0.478
DOC_MAPK_MEF2A_6	94	103	PF00069	0.427
DOC_PP1_RVXF_1	225	232	PF00149	0.391
DOC_PP1_SILK_1	400	405	PF00149	0.428
DOC_PP2B_LxvP_1	103	106	PF13499	0.522
DOC_PP2B_LxvP_1	67	70	PF13499	0.410
DOC_PP4_FxxP_1	30	33	PF00568	0.390
DOC_PP4_FxxP_1	34	37	PF00568	0.367
DOC_PP4_FxxP_1	851	854	PF00568	0.468
DOC_USP7_MATH_1	315	319	PF00917	0.624
DOC_USP7_MATH_1	377	381	PF00917	0.489
DOC_USP7_MATH_1	468	472	PF00917	0.450
DOC_USP7_MATH_1	517	521	PF00917	0.429
DOC_USP7_MATH_1	560	564	PF00917	0.524
DOC_USP7_MATH_1	585	589	PF00917	0.571
DOC_USP7_MATH_1	652	656	PF00917	0.534
DOC_USP7_MATH_1	761	765	PF00917	0.593
DOC_WW_Pin1_4	17	22	PF00397	0.556
DOC_WW_Pin1_4	214	219	PF00397	0.460
DOC_WW_Pin1_4	320	325	PF00397	0.642
DOC_WW_Pin1_4	336	341	PF00397	0.460
DOC_WW_Pin1_4	352	357	PF00397	0.561
DOC_WW_Pin1_4	370	375	PF00397	0.436
DOC_WW_Pin1_4	583	588	PF00397	0.510
DOC_WW_Pin1_4	732	737	PF00397	0.580
DOC_WW_Pin1_4	828	833	PF00397	0.555
DOC_WW_Pin1_4	879	884	PF00397	0.443
DOC_WW_Pin1_4	912	917	PF00397	0.328
LIG_14-3-3_CanoR_1	114	120	PF00244	0.515
LIG_14-3-3_CanoR_1	137	146	PF00244	0.473
LIG_14-3-3_CanoR_1	254	260	PF00244	0.380
LIG_14-3-3_CanoR_1	262	267	PF00244	0.395
LIG_14-3-3_CanoR_1	288	294	PF00244	0.472
LIG_14-3-3_CanoR_1	393	402	PF00244	0.494
LIG_14-3-3_CanoR_1	431	435	PF00244	0.496
LIG_14-3-3_CanoR_1	457	464	PF00244	0.513
LIG_14-3-3_CanoR_1	743	749	PF00244	0.499
LIG_14-3-3_CanoR_1	750	755	PF00244	0.529
LIG_14-3-3_CanoR_1	762	771	PF00244	0.587
LIG_APCC_ABBA_1	187	192	PF00400	0.394
LIG_BIR_III_4	467	471	PF00653	0.449
LIG_BRCT_BRCA1_1	498	502	PF00533	0.502
LIG_BRCT_BRCA1_1	880	884	PF00533	0.361
LIG_BRCT_BRCA1_1	914	918	PF00533	0.328
LIG_Clathr_ClatBox_1	592	596	PF01394	0.460
LIG_FHA_1	123	129	PF00498	0.539
LIG_FHA_1	390	396	PF00498	0.449
LIG_FHA_1	443	449	PF00498	0.419
LIG_FHA_1	457	463	PF00498	0.525
LIG_FHA_1	481	487	PF00498	0.408
LIG_FHA_1	49	55	PF00498	0.392
LIG_FHA_1	549	555	PF00498	0.445
LIG_FHA_1	766	772	PF00498	0.571
LIG_FHA_1	855	861	PF00498	0.462
LIG_FHA_1	888	894	PF00498	0.408
LIG_FHA_1	923	929	PF00498	0.328
LIG_FHA_1	94	100	PF00498	0.457
LIG_FHA_2	315	321	PF00498	0.554
LIG_FHA_2	362	368	PF00498	0.546
LIG_FHA_2	392	398	PF00498	0.560
LIG_FHA_2	529	535	PF00498	0.513
LIG_FHA_2	578	584	PF00498	0.544
LIG_LIR_Gen_1	454	462	PF02991	0.372
LIG_LIR_Gen_1	499	508	PF02991	0.434
LIG_LIR_Gen_1	611	617	PF02991	0.451
LIG_LIR_LC3C_4	203	206	PF02991	0.484
LIG_LIR_Nem_3	24	30	PF02991	0.458
LIG_LIR_Nem_3	499	505	PF02991	0.438
LIG_LIR_Nem_3	565	571	PF02991	0.498
LIG_LIR_Nem_3	611	615	PF02991	0.449
LIG_LIR_Nem_3	874	880	PF02991	0.398
LIG_LIR_Nem_3	915	921	PF02991	0.431
LIG_MYND_3	188	192	PF01753	0.398
LIG_PCNA_yPIPBox_3	527	539	PF02747	0.437
LIG_Pex14_2	30	34	PF04695	0.392
LIG_Pex14_2	671	675	PF04695	0.529
LIG_Pex14_2	83	87	PF04695	0.513
LIG_Pex14_2	847	851	PF04695	0.454
LIG_SH2_CRK	257	261	PF00017	0.341
LIG_SH2_CRK	877	881	PF00017	0.393
LIG_SH2_SRC	496	499	PF00017	0.562
LIG_SH2_SRC	885	888	PF00017	0.359
LIG_SH2_STAP1	168	172	PF00017	0.368
LIG_SH2_STAP1	257	261	PF00017	0.341
LIG_SH2_STAP1	568	572	PF00017	0.420
LIG_SH2_STAP1	908	912	PF00017	0.318
LIG_SH2_STAT3	207	210	PF00017	0.424
LIG_SH2_STAT3	908	911	PF00017	0.297
LIG_SH2_STAT5	158	161	PF00017	0.415
LIG_SH2_STAT5	257	260	PF00017	0.411
LIG_SH2_STAT5	264	267	PF00017	0.448
LIG_SH2_STAT5	29	32	PF00017	0.479
LIG_SH2_STAT5	571	574	PF00017	0.458
LIG_SH2_STAT5	612	615	PF00017	0.521
LIG_SH2_STAT5	885	888	PF00017	0.489
LIG_SH3_2	738	743	PF14604	0.494
LIG_SH3_3	350	356	PF00018	0.563
LIG_SH3_3	362	368	PF00018	0.486
LIG_SH3_3	371	377	PF00018	0.536
LIG_SH3_3	664	670	PF00018	0.494
LIG_SH3_3	730	736	PF00018	0.637
LIG_SH3_3	749	755	PF00018	0.498
LIG_SH3_3	863	869	PF00018	0.467
LIG_SH3_3	877	883	PF00018	0.338
LIG_SH3_CIN85_PxpxPR_1	354	359	PF14604	0.517
LIG_SUMO_SIM_anti_2	473	480	PF11976	0.437
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.408
LIG_SUMO_SIM_anti_2	518	526	PF11976	0.509
LIG_SUMO_SIM_anti_2	611	617	PF11976	0.513
LIG_SUMO_SIM_anti_2	823	828	PF11976	0.494
LIG_SUMO_SIM_par_1	146	152	PF11976	0.405
LIG_SUMO_SIM_par_1	36	42	PF11976	0.375
LIG_SUMO_SIM_par_1	459	465	PF11976	0.453
LIG_SUMO_SIM_par_1	588	596	PF11976	0.539
LIG_SUMO_SIM_par_1	772	778	PF11976	0.536
LIG_SUMO_SIM_par_1	823	828	PF11976	0.565
LIG_TRAF2_1	21	24	PF00917	0.553
LIG_TRAF2_1	436	439	PF00917	0.494
LIG_TRAF2_1	531	534	PF00917	0.510
LIG_TRAF2_1	755	758	PF00917	0.479
LIG_UBA3_1	259	268	PF00899	0.393
LIG_WW_3	339	343	PF00397	0.437
MOD_CDK_SPK_2	322	327	PF00069	0.549
MOD_CDK_SPK_2	370	375	PF00069	0.535
MOD_CDK_SPxK_1	336	342	PF00069	0.460
MOD_CDK_SPxxK_3	214	221	PF00069	0.457
MOD_CDK_SPxxK_3	320	327	PF00069	0.575
MOD_CDK_SPxxK_3	352	359	PF00069	0.516
MOD_CK1_1	214	220	PF00069	0.531
MOD_CK1_1	284	290	PF00069	0.474
MOD_CK1_1	3	9	PF00069	0.462
MOD_CK1_1	325	331	PF00069	0.544
MOD_CK1_1	451	457	PF00069	0.460
MOD_CK1_1	471	477	PF00069	0.361
MOD_CK1_1	520	526	PF00069	0.480
MOD_CK1_1	537	543	PF00069	0.361
MOD_CK1_1	588	594	PF00069	0.552
MOD_CK1_1	655	661	PF00069	0.649
MOD_CK1_1	753	759	PF00069	0.642
MOD_CK1_1	764	770	PF00069	0.553
MOD_CK1_1	92	98	PF00069	0.496
MOD_CK1_1	924	930	PF00069	0.343
MOD_CK2_1	370	376	PF00069	0.535
MOD_CK2_1	391	397	PF00069	0.454
MOD_CK2_1	486	492	PF00069	0.453
MOD_CK2_1	528	534	PF00069	0.515
MOD_CK2_1	560	566	PF00069	0.471
MOD_CK2_1	577	583	PF00069	0.405
MOD_CK2_1	655	661	PF00069	0.505
MOD_CK2_1	702	708	PF00069	0.557
MOD_Cter_Amidation	860	863	PF01082	0.705
MOD_Cter_Amidation	903	906	PF01082	0.665
MOD_GlcNHglycan	151	154	PF01048	0.596
MOD_GlcNHglycan	2	5	PF01048	0.753
MOD_GlcNHglycan	317	320	PF01048	0.825
MOD_GlcNHglycan	470	473	PF01048	0.552
MOD_GlcNHglycan	488	491	PF01048	0.683
MOD_GlcNHglycan	519	522	PF01048	0.664
MOD_GlcNHglycan	604	607	PF01048	0.682
MOD_GlcNHglycan	657	660	PF01048	0.837
MOD_GlcNHglycan	704	707	PF01048	0.759
MOD_GlcNHglycan	727	730	PF01048	0.700
MOD_GlcNHglycan	752	755	PF01048	0.732
MOD_GlcNHglycan	798	804	PF01048	0.733
MOD_GlcNHglycan	832	835	PF01048	0.652
MOD_GlcNHglycan	900	903	PF01048	0.687
MOD_GSK3_1	137	144	PF00069	0.401
MOD_GSK3_1	315	322	PF00069	0.591
MOD_GSK3_1	332	339	PF00069	0.438
MOD_GSK3_1	357	364	PF00069	0.611
MOD_GSK3_1	389	396	PF00069	0.553
MOD_GSK3_1	412	419	PF00069	0.413
MOD_GSK3_1	48	55	PF00069	0.389
MOD_GSK3_1	516	523	PF00069	0.448
MOD_GSK3_1	534	541	PF00069	0.454
MOD_GSK3_1	567	574	PF00069	0.524
MOD_GSK3_1	673	680	PF00069	0.445
MOD_GSK3_1	756	763	PF00069	0.520
MOD_GSK3_1	766	773	PF00069	0.525
MOD_GSK3_1	89	96	PF00069	0.455
MOD_N-GLC_1	115	120	PF02516	0.710
MOD_N-GLC_1	543	548	PF02516	0.575
MOD_N-GLC_1	655	660	PF02516	0.724
MOD_N-GLC_1	922	927	PF02516	0.431
MOD_N-GLC_2	418	420	PF02516	0.613
MOD_NEK2_1	122	127	PF00069	0.431
MOD_NEK2_1	128	133	PF00069	0.420
MOD_NEK2_1	148	153	PF00069	0.295
MOD_NEK2_1	191	196	PF00069	0.392
MOD_NEK2_1	209	214	PF00069	0.451
MOD_NEK2_1	308	313	PF00069	0.618
MOD_NEK2_1	332	337	PF00069	0.470
MOD_NEK2_1	391	396	PF00069	0.447
MOD_NEK2_1	398	403	PF00069	0.391
MOD_NEK2_1	416	421	PF00069	0.390
MOD_NEK2_1	448	453	PF00069	0.472
MOD_NEK2_1	486	491	PF00069	0.443
MOD_NEK2_1	515	520	PF00069	0.440
MOD_NEK2_1	538	543	PF00069	0.425
MOD_NEK2_1	643	648	PF00069	0.531
MOD_NEK2_1	677	682	PF00069	0.487
MOD_NEK2_1	921	926	PF00069	0.331
MOD_NEK2_2	377	382	PF00069	0.556
MOD_NEK2_2	673	678	PF00069	0.464
MOD_PIKK_1	268	274	PF00454	0.410
MOD_PIKK_1	528	534	PF00454	0.515
MOD_PIKK_1	643	649	PF00454	0.627
MOD_PIKK_1	775	781	PF00454	0.604
MOD_PKA_1	137	143	PF00069	0.475
MOD_PKA_2	137	143	PF00069	0.475
MOD_PKA_2	281	287	PF00069	0.494
MOD_PKA_2	430	436	PF00069	0.499
MOD_PKA_2	456	462	PF00069	0.488
MOD_PKA_2	602	608	PF00069	0.510
MOD_PKA_2	677	683	PF00069	0.416
MOD_PKA_2	742	748	PF00069	0.499
MOD_PKA_2	761	767	PF00069	0.528
MOD_Plk_1	101	107	PF00069	0.529
MOD_Plk_1	115	121	PF00069	0.384
MOD_Plk_1	191	197	PF00069	0.400
MOD_Plk_1	377	383	PF00069	0.467
MOD_Plk_1	412	418	PF00069	0.395
MOD_Plk_1	543	549	PF00069	0.376
MOD_Plk_1	57	63	PF00069	0.435
MOD_Plk_1	588	594	PF00069	0.469
MOD_Plk_1	673	679	PF00069	0.504
MOD_Plk_1	820	826	PF00069	0.554
MOD_Plk_1	922	928	PF00069	0.431
MOD_Plk_2-3	480	486	PF00069	0.422
MOD_Plk_2-3	713	719	PF00069	0.580
MOD_Plk_4	117	123	PF00069	0.431
MOD_Plk_4	128	134	PF00069	0.417
MOD_Plk_4	138	144	PF00069	0.395
MOD_Plk_4	255	261	PF00069	0.379
MOD_Plk_4	262	268	PF00069	0.400
MOD_Plk_4	398	404	PF00069	0.414
MOD_Plk_4	448	454	PF00069	0.462
MOD_Plk_4	520	526	PF00069	0.485
MOD_Plk_4	534	540	PF00069	0.397
MOD_Plk_4	549	555	PF00069	0.366
MOD_Plk_4	567	573	PF00069	0.328
MOD_Plk_4	588	594	PF00069	0.469
MOD_Plk_4	820	826	PF00069	0.536
MOD_Plk_4	889	895	PF00069	0.428
MOD_Plk_4	924	930	PF00069	0.340
MOD_ProDKin_1	17	23	PF00069	0.555
MOD_ProDKin_1	214	220	PF00069	0.458
MOD_ProDKin_1	320	326	PF00069	0.638
MOD_ProDKin_1	336	342	PF00069	0.461
MOD_ProDKin_1	352	358	PF00069	0.558
MOD_ProDKin_1	370	376	PF00069	0.436
MOD_ProDKin_1	583	589	PF00069	0.509
MOD_ProDKin_1	732	738	PF00069	0.579
MOD_ProDKin_1	828	834	PF00069	0.554
MOD_ProDKin_1	879	885	PF00069	0.440
MOD_ProDKin_1	912	918	PF00069	0.328
MOD_SUMO_for_1	232	235	PF00179	0.385
TRG_DiLeu_BaEn_1	192	197	PF01217	0.400
TRG_DiLeu_BaEn_1	439	444	PF01217	0.405
TRG_DiLeu_BaEn_1	482	487	PF01217	0.404
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.364
TRG_DiLeu_LyEn_5	192	197	PF01217	0.400
TRG_ENDOCYTIC_2	257	260	PF00928	0.411
TRG_ENDOCYTIC_2	264	267	PF00928	0.448
TRG_ENDOCYTIC_2	455	458	PF00928	0.385
TRG_ENDOCYTIC_2	612	615	PF00928	0.503
TRG_ENDOCYTIC_2	877	880	PF00928	0.426
TRG_ER_diArg_1	136	138	PF00400	0.491
TRG_ER_diArg_1	159	161	PF00400	0.512
TRG_ER_diArg_1	193	196	PF00400	0.400
TRG_ER_diArg_1	282	285	PF00400	0.506
TRG_ER_diArg_1	296	299	PF00400	0.437
TRG_ER_diArg_1	326	329	PF00400	0.559
TRG_ER_diArg_1	572	575	PF00400	0.432
TRG_ER_diArg_1	862	864	PF00400	0.437
TRG_ER_diArg_1	932	934	PF00400	0.611
TRG_NES_CRM1_1	590	604	PF08389	0.531
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.704
TRG_Pf-PMV_PEXEL_1	555	559	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N8	Leptomonas seymouri	46%	81%
A4HID7	Leishmania braziliensis	76%	100%
A4I5N4	Leishmania infantum	100%	100%
E9B0X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q788	Leishmania major	88%	100%