Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3G8_LEIDO

TriTrypDb:

LdBPK_302120.1 , LdCL_300026700 , LDHU3_30.2880

Length:

536

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3G8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.532
CLV_NRD_NRD_1	211	213	PF00675	0.488
CLV_NRD_NRD_1	278	280	PF00675	0.555
CLV_NRD_NRD_1	414	416	PF00675	0.549
CLV_NRD_NRD_1	422	424	PF00675	0.476
CLV_PCSK_KEX2_1	211	213	PF00082	0.424
CLV_PCSK_KEX2_1	278	280	PF00082	0.570
CLV_PCSK_KEX2_1	414	416	PF00082	0.549
CLV_PCSK_SKI1_1	127	131	PF00082	0.360
DEG_APCC_DBOX_1	325	333	PF00400	0.660
DEG_APCC_DBOX_1	80	88	PF00400	0.460
DOC_CKS1_1	304	309	PF01111	0.593
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.660
DOC_MAPK_MEF2A_6	81	90	PF00069	0.378
DOC_PP1_RVXF_1	125	131	PF00149	0.354
DOC_PP2B_PxIxI_1	454	460	PF00149	0.565
DOC_PP4_FxxP_1	347	350	PF00568	0.595
DOC_PP4_FxxP_1	80	83	PF00568	0.440
DOC_USP7_MATH_1	159	163	PF00917	0.749
DOC_USP7_MATH_1	264	268	PF00917	0.560
DOC_USP7_MATH_1	295	299	PF00917	0.605
DOC_USP7_MATH_1	316	320	PF00917	0.728
DOC_USP7_MATH_1	352	356	PF00917	0.629
DOC_USP7_MATH_1	427	431	PF00917	0.654
DOC_USP7_MATH_1	488	492	PF00917	0.620
DOC_USP7_UBL2_3	33	37	PF12436	0.533
DOC_WW_Pin1_4	157	162	PF00397	0.653
DOC_WW_Pin1_4	164	169	PF00397	0.593
DOC_WW_Pin1_4	181	186	PF00397	0.612
DOC_WW_Pin1_4	243	248	PF00397	0.697
DOC_WW_Pin1_4	26	31	PF00397	0.483
DOC_WW_Pin1_4	265	270	PF00397	0.676
DOC_WW_Pin1_4	271	276	PF00397	0.799
DOC_WW_Pin1_4	289	294	PF00397	0.518
DOC_WW_Pin1_4	303	308	PF00397	0.631
DOC_WW_Pin1_4	321	326	PF00397	0.603
DOC_WW_Pin1_4	327	332	PF00397	0.612
DOC_WW_Pin1_4	336	341	PF00397	0.616
DOC_WW_Pin1_4	353	358	PF00397	0.478
DOC_WW_Pin1_4	366	371	PF00397	0.681
DOC_WW_Pin1_4	423	428	PF00397	0.628
DOC_WW_Pin1_4	429	434	PF00397	0.590
DOC_WW_Pin1_4	90	95	PF00397	0.380
LIG_14-3-3_CanoR_1	175	180	PF00244	0.706
LIG_14-3-3_CanoR_1	195	204	PF00244	0.305
LIG_14-3-3_CanoR_1	233	238	PF00244	0.597
LIG_14-3-3_CanoR_1	364	370	PF00244	0.592
LIG_14-3-3_CanoR_1	440	450	PF00244	0.668
LIG_14-3-3_CanoR_1	470	478	PF00244	0.610
LIG_14-3-3_CanoR_1	63	68	PF00244	0.558
LIG_Actin_WH2_2	519	535	PF00022	0.542
LIG_BRCT_BRCA1_1	217	221	PF00533	0.461
LIG_BRCT_BRCA1_1	354	358	PF00533	0.659
LIG_BRCT_BRCA1_1	374	378	PF00533	0.609
LIG_BRCT_BRCA1_1	519	523	PF00533	0.553
LIG_deltaCOP1_diTrp_1	229	237	PF00928	0.495
LIG_deltaCOP1_diTrp_1	59	67	PF00928	0.522
LIG_EH1_1	447	455	PF00400	0.604
LIG_FHA_1	203	209	PF00498	0.500
LIG_FHA_1	304	310	PF00498	0.595
LIG_FHA_1	312	318	PF00498	0.595
LIG_FHA_1	390	396	PF00498	0.625
LIG_FHA_2	146	152	PF00498	0.472
LIG_FHA_2	7	13	PF00498	0.485
LIG_FHA_2	97	103	PF00498	0.391
LIG_GBD_Chelix_1	125	133	PF00786	0.349
LIG_LIR_Apic_2	102	106	PF02991	0.459
LIG_LIR_Apic_2	236	240	PF02991	0.600
LIG_LIR_Apic_2	306	311	PF02991	0.657
LIG_LIR_Apic_2	345	350	PF02991	0.600
LIG_LIR_Gen_1	115	122	PF02991	0.426
LIG_LIR_Gen_1	218	228	PF02991	0.394
LIG_LIR_Nem_3	115	119	PF02991	0.452
LIG_LIR_Nem_3	137	142	PF02991	0.376
LIG_LIR_Nem_3	218	224	PF02991	0.407
LIG_LIR_Nem_3	41	47	PF02991	0.419
LIG_LIR_Nem_3	520	526	PF02991	0.549
LIG_MYND_1	307	311	PF01753	0.591
LIG_NRBOX	16	22	PF00104	0.334
LIG_NRBOX	502	508	PF00104	0.504
LIG_PTAP_UEV_1	518	523	PF05743	0.552
LIG_SH2_CRK	139	143	PF00017	0.385
LIG_SH2_GRB2like	89	92	PF00017	0.384
LIG_SH2_NCK_1	55	59	PF00017	0.426
LIG_SH2_SRC	55	58	PF00017	0.398
LIG_SH2_SRC	89	92	PF00017	0.364
LIG_SH2_STAP1	391	395	PF00017	0.616
LIG_SH2_STAT5	214	217	PF00017	0.491
LIG_SH2_STAT5	308	311	PF00017	0.671
LIG_SH2_STAT5	391	394	PF00017	0.627
LIG_SH2_STAT5	89	92	PF00017	0.384
LIG_SH3_1	166	172	PF00018	0.588
LIG_SH3_3	155	161	PF00018	0.643
LIG_SH3_3	162	168	PF00018	0.595
LIG_SH3_3	182	188	PF00018	0.481
LIG_SH3_3	201	207	PF00018	0.316
LIG_SH3_3	328	334	PF00018	0.737
LIG_SH3_3	351	357	PF00018	0.660
LIG_SH3_3	516	522	PF00018	0.571
LIG_SUMO_SIM_par_1	313	319	PF11976	0.583
LIG_SUMO_SIM_par_1	93	99	PF11976	0.363
LIG_TRAF2_1	199	202	PF00917	0.422
LIG_TRAF2_1	54	57	PF00917	0.502
LIG_TRFH_1	347	351	PF08558	0.592
LIG_UBA3_1	506	514	PF00899	0.514
LIG_WW_3	172	176	PF00397	0.614
MOD_CDC14_SPxK_1	268	271	PF00782	0.625
MOD_CDK_SPK_2	321	326	PF00069	0.626
MOD_CDK_SPxK_1	265	271	PF00069	0.632
MOD_CDK_SPxxK_3	168	175	PF00069	0.625
MOD_CDK_SPxxK_3	26	33	PF00069	0.440
MOD_CDK_SPxxK_3	271	278	PF00069	0.619
MOD_CK1_1	145	151	PF00069	0.472
MOD_CK1_1	3	9	PF00069	0.605
MOD_CK1_1	303	309	PF00069	0.710
MOD_CK1_1	319	325	PF00069	0.600
MOD_CK1_1	336	342	PF00069	0.631
MOD_CK1_1	363	369	PF00069	0.734
MOD_CK1_1	428	434	PF00069	0.676
MOD_CK1_1	439	445	PF00069	0.661
MOD_CK1_1	487	493	PF00069	0.678
MOD_CK1_1	65	71	PF00069	0.591
MOD_CK2_1	196	202	PF00069	0.447
MOD_CK2_1	405	411	PF00069	0.558
MOD_CK2_1	51	57	PF00069	0.402
MOD_CK2_1	90	96	PF00069	0.375
MOD_Cter_Amidation	435	438	PF01082	0.688
MOD_GlcNHglycan	161	164	PF01048	0.622
MOD_GlcNHglycan	198	201	PF01048	0.494
MOD_GlcNHglycan	427	430	PF01048	0.646
MOD_GlcNHglycan	462	465	PF01048	0.672
MOD_GlcNHglycan	486	489	PF01048	0.668
MOD_GlcNHglycan	490	493	PF01048	0.590
MOD_GlcNHglycan	496	499	PF01048	0.458
MOD_GlcNHglycan	519	522	PF01048	0.579
MOD_GlcNHglycan	68	71	PF01048	0.561
MOD_GSK3_1	164	171	PF00069	0.659
MOD_GSK3_1	177	184	PF00069	0.611
MOD_GSK3_1	224	231	PF00069	0.535
MOD_GSK3_1	239	246	PF00069	0.527
MOD_GSK3_1	265	272	PF00069	0.636
MOD_GSK3_1	279	286	PF00069	0.563
MOD_GSK3_1	295	302	PF00069	0.603
MOD_GSK3_1	311	318	PF00069	0.594
MOD_GSK3_1	366	373	PF00069	0.586
MOD_GSK3_1	415	422	PF00069	0.608
MOD_GSK3_1	423	430	PF00069	0.520
MOD_GSK3_1	449	456	PF00069	0.636
MOD_GSK3_1	45	52	PF00069	0.483
MOD_GSK3_1	484	491	PF00069	0.737
MOD_GSK3_1	62	69	PF00069	0.391
MOD_N-GLC_1	175	180	PF02516	0.631
MOD_N-GLC_1	327	332	PF02516	0.636
MOD_N-GLC_1	90	95	PF02516	0.496
MOD_NEK2_1	228	233	PF00069	0.501
MOD_NEK2_1	299	304	PF00069	0.681
MOD_NEK2_1	315	320	PF00069	0.648
MOD_NEK2_1	378	383	PF00069	0.661
MOD_NEK2_1	419	424	PF00069	0.686
MOD_NEK2_1	49	54	PF00069	0.416
MOD_NEK2_1	526	531	PF00069	0.705
MOD_NEK2_2	45	50	PF00069	0.488
MOD_PIKK_1	239	245	PF00454	0.748
MOD_PIKK_1	285	291	PF00454	0.674
MOD_PK_1	287	293	PF00069	0.643
MOD_PKA_2	255	261	PF00069	0.619
MOD_PKA_2	363	369	PF00069	0.602
MOD_PKA_2	439	445	PF00069	0.632
MOD_PKA_2	49	55	PF00069	0.412
MOD_PKA_2	62	68	PF00069	0.479
MOD_Plk_1	108	114	PF00069	0.447
MOD_Plk_1	175	181	PF00069	0.646
MOD_Plk_1	224	230	PF00069	0.398
MOD_Plk_2-3	51	57	PF00069	0.428
MOD_Plk_2-3	96	102	PF00069	0.376
MOD_Plk_4	121	127	PF00069	0.362
MOD_Plk_4	233	239	PF00069	0.681
MOD_Plk_4	415	421	PF00069	0.597
MOD_Plk_4	449	455	PF00069	0.579
MOD_Plk_4	502	508	PF00069	0.527
MOD_ProDKin_1	157	163	PF00069	0.653
MOD_ProDKin_1	164	170	PF00069	0.594
MOD_ProDKin_1	181	187	PF00069	0.605
MOD_ProDKin_1	243	249	PF00069	0.700
MOD_ProDKin_1	26	32	PF00069	0.496
MOD_ProDKin_1	265	271	PF00069	0.677
MOD_ProDKin_1	289	295	PF00069	0.607
MOD_ProDKin_1	303	309	PF00069	0.630
MOD_ProDKin_1	321	327	PF00069	0.604
MOD_ProDKin_1	336	342	PF00069	0.728
MOD_ProDKin_1	353	359	PF00069	0.483
MOD_ProDKin_1	366	372	PF00069	0.681
MOD_ProDKin_1	423	429	PF00069	0.630
MOD_ProDKin_1	90	96	PF00069	0.375
TRG_DiLeu_BaEn_1	449	454	PF01217	0.607
TRG_DiLeu_BaEn_4	56	62	PF01217	0.439
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.397
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.355
TRG_DiLeu_BaLyEn_6	467	472	PF01217	0.567
TRG_ENDOCYTIC_2	139	142	PF00928	0.377
TRG_ER_diArg_1	277	279	PF00400	0.555
TRG_ER_diArg_1	413	415	PF00400	0.542
TRG_NLS_Bipartite_1	423	441	PF00514	0.681
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9W6	Leptomonas seymouri	48%	98%
A4HIE3	Leishmania braziliensis	78%	100%
A4I5P0	Leishmania infantum	100%	100%
E9B0Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q9NE60	Leishmania major	96%	100%