NFACT-R_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF814), putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3G6_LEIDO

TriTrypDb:

LdBPK_302080.1 , LdCL_300026100 , LDHU3_30.2820

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.452
CLV_NRD_NRD_1	143	145	PF00675	0.573
CLV_NRD_NRD_1	155	157	PF00675	0.456
CLV_PCSK_KEX2_1	115	117	PF00082	0.452
CLV_PCSK_KEX2_1	155	157	PF00082	0.513
CLV_PCSK_KEX2_1	177	179	PF00082	0.613
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.613
CLV_PCSK_PC7_1	173	179	PF00082	0.581
CLV_PCSK_SKI1_1	125	129	PF00082	0.617
DEG_APCC_DBOX_1	124	132	PF00400	0.646
DEG_APCC_KENBOX_2	73	77	PF00400	0.377
DOC_CKS1_1	89	94	PF01111	0.234
DOC_MAPK_gen_1	135	143	PF00069	0.509
DOC_MAPK_gen_1	97	104	PF00069	0.305
DOC_PP4_FxxP_1	30	33	PF00568	0.377
DOC_USP7_UBL2_3	129	133	PF12436	0.596
DOC_WW_Pin1_4	59	64	PF00397	0.249
DOC_WW_Pin1_4	88	93	PF00397	0.234
LIG_Actin_WH2_2	82	99	PF00022	0.305
LIG_APCC_ABBA_1	182	187	PF00400	0.474
LIG_eIF4E_1	22	28	PF01652	0.234
LIG_FHA_1	196	202	PF00498	0.671
LIG_FHA_1	60	66	PF00498	0.330
LIG_FHA_2	132	138	PF00498	0.560
LIG_LIR_Nem_3	140	146	PF02991	0.515
LIG_LIR_Nem_3	34	40	PF02991	0.234
LIG_LIR_Nem_3	91	96	PF02991	0.241
LIG_SH2_CRK	117	121	PF00017	0.617
LIG_SH2_GRB2like	22	25	PF00017	0.234
LIG_SH2_PTP2	49	52	PF00017	0.293
LIG_SH2_STAT5	4	7	PF00017	0.249
LIG_SH2_STAT5	49	52	PF00017	0.234
LIG_SH2_STAT5	90	93	PF00017	0.234
LIG_SH3_3	47	53	PF00018	0.265
LIG_SH3_3	86	92	PF00018	0.234
LIG_TYR_ITIM	2	7	PF00017	0.249
LIG_UBA3_1	127	133	PF00899	0.505
MOD_CK1_1	9	15	PF00069	0.285
MOD_CK2_1	131	137	PF00069	0.588
MOD_GlcNHglycan	44	47	PF01048	0.234
MOD_GSK3_1	119	126	PF00069	0.599
MOD_GSK3_1	5	12	PF00069	0.352
MOD_N-GLC_1	123	128	PF02516	0.446
MOD_NEK2_1	131	136	PF00069	0.497
MOD_NEK2_1	3	8	PF00069	0.324
MOD_PK_1	74	80	PF00069	0.234
MOD_Plk_1	123	129	PF00069	0.614
MOD_Plk_1	131	137	PF00069	0.576
MOD_Plk_1	74	80	PF00069	0.343
MOD_Plk_4	9	15	PF00069	0.275
MOD_ProDKin_1	59	65	PF00069	0.249
MOD_ProDKin_1	88	94	PF00069	0.234
TRG_AP2beta_CARGO_1	140	150	PF09066	0.568
TRG_DiLeu_BaEn_1	23	28	PF01217	0.234
TRG_DiLeu_BaEn_1	68	73	PF01217	0.310
TRG_ENDOCYTIC_2	117	120	PF00928	0.466
TRG_ENDOCYTIC_2	185	188	PF00928	0.499
TRG_ENDOCYTIC_2	4	7	PF00928	0.249
TRG_ENDOCYTIC_2	49	52	PF00928	0.234
TRG_ER_diArg_1	114	116	PF00400	0.467
TRG_NLS_Bipartite_1	144	160	PF00514	0.667
TRG_NLS_MonoExtC_3	155	161	PF00514	0.580
TRG_NLS_MonoExtN_4	155	160	PF00514	0.582
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME9	Leptomonas seymouri	85%	100%
A0A0S4JLK1	Bodo saltans	70%	100%
A0A1X0P1Z6	Trypanosomatidae	65%	100%
A0A422P3G2	Trypanosoma rangeli	65%	100%
A4HID9	Leishmania braziliensis	91%	100%
A4I5N6	Leishmania infantum	100%	100%
C9ZR05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9B0Y0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P40206	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q3SZX8	Bos taurus	49%	100%
Q4Q786	Leishmania major	98%	100%
Q55D55	Dictyostelium discoideum	51%	100%
Q5R9S1	Pongo abelii	49%	100%
Q6GLE1	Xenopus tropicalis	49%	100%
Q78PG9	Mus musculus	49%	100%
Q7T312	Danio rerio	49%	100%
Q86WR0	Homo sapiens	49%	100%
V5BU08	Trypanosoma cruzi	67%	100%