Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3F8_LEIDO

TriTrypDb:

LdBPK_301200.1 , LdCL_300017200 , LDHU3_30.1570

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7X3F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.433
CLV_NRD_NRD_1	173	175	PF00675	0.704
CLV_PCSK_KEX2_1	133	135	PF00082	0.429
CLV_PCSK_KEX2_1	173	175	PF00082	0.704
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.429
CLV_PCSK_SKI1_1	137	141	PF00082	0.418
DEG_Nend_UBRbox_3	1	3	PF02207	0.716
DEG_ODPH_VHL_1	129	142	PF01847	0.604
DEG_SPOP_SBC_1	50	54	PF00917	0.552
DEG_SPOP_SBC_1	62	66	PF00917	0.371
DOC_CYCLIN_RxL_1	149	158	PF00134	0.441
DOC_MAPK_gen_1	133	144	PF00069	0.621
DOC_MAPK_MEF2A_6	137	146	PF00069	0.470
DOC_PP1_RVXF_1	150	157	PF00149	0.441
DOC_PP2B_LxvP_1	128	131	PF13499	0.617
DOC_USP7_MATH_1	51	55	PF00917	0.451
DOC_USP7_MATH_1	62	66	PF00917	0.448
DOC_WW_Pin1_4	63	68	PF00397	0.529
DOC_WW_Pin1_4	98	103	PF00397	0.717
LIG_FHA_1	103	109	PF00498	0.741
LIG_FHA_1	122	128	PF00498	0.722
LIG_FHA_1	32	38	PF00498	0.332
LIG_FHA_1	64	70	PF00498	0.509
LIG_FHA_1	84	90	PF00498	0.308
LIG_LIR_Gen_1	71	81	PF02991	0.332
LIG_LIR_LC3C_4	41	44	PF02991	0.339
LIG_LIR_LC3C_4	8	11	PF02991	0.603
LIG_LIR_Nem_3	155	159	PF02991	0.332
LIG_LIR_Nem_3	27	32	PF02991	0.524
LIG_LIR_Nem_3	71	76	PF02991	0.332
LIG_LIR_Nem_3	88	94	PF02991	0.623
LIG_Pex14_2	153	157	PF04695	0.309
LIG_Rb_pABgroove_1	7	15	PF01858	0.601
LIG_SH2_CRK	91	95	PF00017	0.710
LIG_SH2_STAT5	107	110	PF00017	0.717
LIG_SH2_STAT5	24	27	PF00017	0.702
LIG_SH3_3	113	119	PF00018	0.620
LIG_SH3_3	96	102	PF00018	0.709
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.441
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.599
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.338
LIG_SUMO_SIM_par_1	33	38	PF11976	0.438
LIG_SUMO_SIM_par_1	8	15	PF11976	0.619
LIG_SUMO_SIM_par_1	80	86	PF11976	0.422
LIG_TYR_ITIM	89	94	PF00017	0.628
LIG_WRC_WIRS_1	153	158	PF05994	0.345
LIG_WRC_WIRS_1	70	75	PF05994	0.332
MOD_CDK_SPK_2	98	103	PF00069	0.717
MOD_CK1_1	155	161	PF00069	0.481
MOD_CK1_1	38	44	PF00069	0.472
MOD_CK1_1	53	59	PF00069	0.422
MOD_CK1_1	72	78	PF00069	0.339
MOD_CK1_1	80	86	PF00069	0.345
MOD_CK2_1	2	8	PF00069	0.635
MOD_CK2_1	98	104	PF00069	0.717
MOD_CMANNOS	167	170	PF00535	0.503
MOD_GlcNHglycan	53	56	PF01048	0.653
MOD_GlcNHglycan	58	61	PF01048	0.653
MOD_GSK3_1	31	38	PF00069	0.421
MOD_GSK3_1	49	56	PF00069	0.442
MOD_GSK3_1	68	75	PF00069	0.335
MOD_GSK3_1	98	105	PF00069	0.640
MOD_NEK2_1	1	6	PF00069	0.621
MOD_NEK2_1	12	17	PF00069	0.617
MOD_NEK2_1	140	145	PF00069	0.383
MOD_NEK2_1	68	73	PF00069	0.322
MOD_NEK2_1	85	90	PF00069	0.336
MOD_NEK2_2	168	173	PF00069	0.491
MOD_PIKK_1	12	18	PF00454	0.691
MOD_PKA_2	102	108	PF00069	0.692
MOD_Plk_1	121	127	PF00069	0.723
MOD_Plk_4	152	158	PF00069	0.332
MOD_Plk_4	18	24	PF00069	0.689
MOD_Plk_4	38	44	PF00069	0.362
MOD_Plk_4	77	83	PF00069	0.365
MOD_Plk_4	85	91	PF00069	0.275
MOD_ProDKin_1	63	69	PF00069	0.529
MOD_ProDKin_1	98	104	PF00069	0.717
TRG_DiLeu_BaEn_2	148	154	PF01217	0.309
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.472
TRG_ENDOCYTIC_2	91	94	PF00928	0.706
TRG_ER_diArg_1	172	174	PF00400	0.508
TRG_NES_CRM1_1	16	27	PF08389	0.651
TRG_NES_CRM1_1	2	14	PF08389	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Z6	Leptomonas seymouri	55%	100%
A4HI68	Leishmania braziliensis	76%	100%
A4I5E5	Leishmania infantum	100%	100%
E9B0P3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q7I9	Leishmania major	92%	100%