RNA_pseudouridylate_synthase_putative/Pfam:PF0084 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3F6_LEIDO

TriTrypDb:

LdBPK_301530.1 , LdCL_300020700 , LDHU3_30.2010

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F6

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031118	rRNA pseudouridine synthesis	7	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.290
CLV_NRD_NRD_1	181	183	PF00675	0.210
CLV_NRD_NRD_1	212	214	PF00675	0.263
CLV_NRD_NRD_1	332	334	PF00675	0.274
CLV_NRD_NRD_1	378	380	PF00675	0.492
CLV_NRD_NRD_1	410	412	PF00675	0.494
CLV_NRD_NRD_1	49	51	PF00675	0.403
CLV_NRD_NRD_1	89	91	PF00675	0.293
CLV_PCSK_KEX2_1	128	130	PF00082	0.290
CLV_PCSK_KEX2_1	212	214	PF00082	0.263
CLV_PCSK_KEX2_1	289	291	PF00082	0.326
CLV_PCSK_KEX2_1	332	334	PF00082	0.274
CLV_PCSK_KEX2_1	378	380	PF00082	0.492
CLV_PCSK_KEX2_1	408	410	PF00082	0.489
CLV_PCSK_KEX2_1	49	51	PF00082	0.381
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.326
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.489
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.368
CLV_PCSK_PC7_1	208	214	PF00082	0.263
CLV_PCSK_SKI1_1	175	179	PF00082	0.326
CLV_PCSK_SKI1_1	241	245	PF00082	0.272
CLV_PCSK_SKI1_1	279	283	PF00082	0.326
CLV_PCSK_SKI1_1	34	38	PF00082	0.395
CLV_PCSK_SKI1_1	386	390	PF00082	0.367
CLV_PCSK_SKI1_1	402	406	PF00082	0.482
CLV_PCSK_SKI1_1	411	415	PF00082	0.508
CLV_PCSK_SKI1_1	52	56	PF00082	0.204
DEG_Nend_Nbox_1	1	3	PF02207	0.333
DEG_ODPH_VHL_1	326	338	PF01847	0.526
DOC_CYCLIN_RxL_1	238	247	PF00134	0.472
DOC_CYCLIN_RxL_1	383	392	PF00134	0.456
DOC_MAPK_gen_1	279	288	PF00069	0.508
DOC_MAPK_gen_1	332	338	PF00069	0.474
DOC_MAPK_gen_1	406	416	PF00069	0.498
DOC_MAPK_gen_1	46	56	PF00069	0.507
DOC_MAPK_gen_1	87	96	PF00069	0.474
DOC_MAPK_MEF2A_6	250	259	PF00069	0.444
DOC_MAPK_RevD_3	395	409	PF00069	0.492
DOC_PP1_RVXF_1	248	255	PF00149	0.427
DOC_PP1_RVXF_1	339	346	PF00149	0.535
DOC_PP1_RVXF_1	50	57	PF00149	0.474
DOC_PP2B_LxvP_1	325	328	PF13499	0.526
DOC_PP2B_LxvP_1	387	390	PF13499	0.367
DOC_USP7_MATH_1	127	131	PF00917	0.441
DOC_USP7_MATH_1	151	155	PF00917	0.502
DOC_USP7_MATH_1	248	252	PF00917	0.474
DOC_USP7_MATH_1	275	279	PF00917	0.495
DOC_USP7_MATH_1	281	285	PF00917	0.465
DOC_USP7_MATH_1	364	368	PF00917	0.528
DOC_USP7_UBL2_3	48	52	PF12436	0.481
DOC_WW_Pin1_4	310	315	PF00397	0.512
DOC_WW_Pin1_4	391	396	PF00397	0.467
LIG_14-3-3_CanoR_1	128	133	PF00244	0.467
LIG_14-3-3_CanoR_1	180	189	PF00244	0.452
LIG_Actin_WH2_2	256	272	PF00022	0.472
LIG_APCC_ABBAyCdc20_2	250	256	PF00400	0.427
LIG_BRCT_BRCA1_1	250	254	PF00533	0.477
LIG_BRCT_BRCA1_1	436	440	PF00533	0.638
LIG_DCNL_PONY_1	1	4	PF03556	0.245
LIG_deltaCOP1_diTrp_1	430	434	PF00928	0.453
LIG_FHA_1	247	253	PF00498	0.463
LIG_FHA_1	281	287	PF00498	0.473
LIG_FHA_1	320	326	PF00498	0.472
LIG_FHA_1	392	398	PF00498	0.485
LIG_FHA_1	430	436	PF00498	0.597
LIG_FHA_1	62	68	PF00498	0.488
LIG_FHA_2	155	161	PF00498	0.427
LIG_FHA_2	182	188	PF00498	0.490
LIG_FHA_2	240	246	PF00498	0.519
LIG_FHA_2	262	268	PF00498	0.474
LIG_FHA_2	439	445	PF00498	0.518
LIG_LIR_Gen_1	184	192	PF02991	0.504
LIG_LIR_Gen_1	251	261	PF02991	0.567
LIG_LIR_Gen_1	430	438	PF02991	0.417
LIG_LIR_Nem_3	184	189	PF02991	0.504
LIG_LIR_Nem_3	237	243	PF02991	0.485
LIG_LIR_Nem_3	251	257	PF02991	0.544
LIG_LIR_Nem_3	430	434	PF02991	0.453
LIG_LIR_Nem_3	437	443	PF02991	0.516
LIG_PCNA_PIPBox_1	86	95	PF02747	0.526
LIG_SH2_CRK	240	244	PF00017	0.474
LIG_SH2_PTP2	93	96	PF00017	0.474
LIG_SH2_SRC	381	384	PF00017	0.346
LIG_SH2_STAT3	176	179	PF00017	0.445
LIG_SH2_STAT5	176	179	PF00017	0.445
LIG_SH2_STAT5	292	295	PF00017	0.526
LIG_SH2_STAT5	353	356	PF00017	0.460
LIG_SH2_STAT5	381	384	PF00017	0.346
LIG_SH2_STAT5	93	96	PF00017	0.474
LIG_SH3_3	221	227	PF00018	0.504
LIG_SH3_3	252	258	PF00018	0.474
LIG_SUMO_SIM_anti_2	283	289	PF11976	0.476
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.483
LIG_TYR_ITIM	238	243	PF00017	0.526
LIG_UBA3_1	1	6	PF00899	0.245
LIG_UBA3_1	285	289	PF00899	0.474
MOD_CDK_SPK_2	391	396	PF00069	0.450
MOD_CK1_1	119	125	PF00069	0.546
MOD_CK1_1	154	160	PF00069	0.464
MOD_CK1_1	162	168	PF00069	0.494
MOD_CK1_1	211	217	PF00069	0.545
MOD_CK1_1	218	224	PF00069	0.483
MOD_CK1_1	246	252	PF00069	0.460
MOD_CK1_1	315	321	PF00069	0.524
MOD_CK1_1	367	373	PF00069	0.611
MOD_CK2_1	154	160	PF00069	0.460
MOD_CK2_1	181	187	PF00069	0.521
MOD_CK2_1	219	225	PF00069	0.477
MOD_CK2_1	239	245	PF00069	0.427
MOD_CK2_1	261	267	PF00069	0.474
MOD_CK2_1	424	430	PF00069	0.602
MOD_Cter_Amidation	330	333	PF01082	0.274
MOD_GlcNHglycan	153	156	PF01048	0.268
MOD_GlcNHglycan	157	160	PF01048	0.267
MOD_GlcNHglycan	161	164	PF01048	0.275
MOD_GlcNHglycan	213	216	PF01048	0.272
MOD_GlcNHglycan	221	224	PF01048	0.283
MOD_GlcNHglycan	416	419	PF01048	0.544
MOD_GlcNHglycan	424	427	PF01048	0.598
MOD_GlcNHglycan	64	67	PF01048	0.274
MOD_GSK3_1	116	123	PF00069	0.512
MOD_GSK3_1	151	158	PF00069	0.490
MOD_GSK3_1	211	218	PF00069	0.527
MOD_GSK3_1	239	246	PF00069	0.471
MOD_GSK3_1	271	278	PF00069	0.490
MOD_GSK3_1	310	317	PF00069	0.526
MOD_GSK3_1	364	371	PF00069	0.669
MOD_GSK3_1	420	427	PF00069	0.618
MOD_GSK3_1	434	441	PF00069	0.485
MOD_N-GLC_2	137	139	PF02516	0.326
MOD_NEK2_1	2	7	PF00069	0.445
MOD_NEK2_1	219	224	PF00069	0.463
MOD_NEK2_1	243	248	PF00069	0.575
MOD_NEK2_1	288	293	PF00069	0.503
MOD_NEK2_1	365	370	PF00069	0.557
MOD_NEK2_1	414	419	PF00069	0.491
MOD_NEK2_1	424	429	PF00069	0.591
MOD_NEK2_1	62	67	PF00069	0.499
MOD_NEK2_2	14	19	PF00069	0.490
MOD_PKA_1	128	134	PF00069	0.490
MOD_PKA_2	127	133	PF00069	0.459
MOD_PKA_2	181	187	PF00069	0.410
MOD_PKA_2	211	217	PF00069	0.485
MOD_Plk_1	14	20	PF00069	0.490
MOD_Plk_1	349	355	PF00069	0.515
MOD_Plk_1	420	426	PF00069	0.565
MOD_Plk_4	14	20	PF00069	0.487
MOD_Plk_4	201	207	PF00069	0.510
MOD_Plk_4	22	28	PF00069	0.434
MOD_Plk_4	281	287	PF00069	0.474
MOD_Plk_4	319	325	PF00069	0.474
MOD_ProDKin_1	310	316	PF00069	0.512
MOD_ProDKin_1	391	397	PF00069	0.463
MOD_SUMO_rev_2	119	127	PF00179	0.490
MOD_SUMO_rev_2	276	284	PF00179	0.472
TRG_DiLeu_BaEn_2	429	435	PF01217	0.426
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.354
TRG_ENDOCYTIC_2	240	243	PF00928	0.474
TRG_ENDOCYTIC_2	93	96	PF00928	0.474
TRG_ER_diArg_1	378	380	PF00400	0.490
TRG_ER_diArg_1	409	411	PF00400	0.508
TRG_NLS_MonoCore_2	405	410	PF00514	0.485
TRG_NLS_MonoCore_2	48	53	PF00514	0.473
TRG_NLS_MonoExtC_3	405	410	PF00514	0.485
TRG_NLS_MonoExtN_4	406	411	PF00514	0.487
TRG_NLS_MonoExtN_4	46	53	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P976	Leptomonas seymouri	52%	100%
A4HI97	Leishmania braziliensis	72%	100%
A4I5I1	Leishmania infantum	100%	100%
E9B0S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7F2	Leishmania major	89%	100%