RNA_pseudouridylate_synthase_putative/Pfam:PF0084 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA pseudouridylate synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7X3F6_LEIDO

TriTrypDb:

LdBPK_301530.1 , LdCL_300020700 , LDHU3_30.2010

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F6

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000154	rRNA modification	6	1
GO:0000455	enzyme-directed rRNA pseudouridine synthesis	8	1
GO:0001522	pseudouridine synthesis	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009451	RNA modification	5	7

Previous1 2 3Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0009982	pseudouridine synthase activity	4	7
GO:0016853	isomerase activity	2	7
GO:0016866	intramolecular transferase activity	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.290
CLV_NRD_NRD_1	181	183	PF00675	0.210
CLV_NRD_NRD_1	212	214	PF00675	0.263
CLV_NRD_NRD_1	332	334	PF00675	0.274
CLV_NRD_NRD_1	378	380	PF00675	0.492
CLV_NRD_NRD_1	410	412	PF00675	0.494
CLV_NRD_NRD_1	49	51	PF00675	0.403
CLV_NRD_NRD_1	89	91	PF00675	0.293
CLV_PCSK_KEX2_1	128	130	PF00082	0.290
CLV_PCSK_KEX2_1	212	214	PF00082	0.263

Previous1 2 3 4 5…17Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P976	Leptomonas seymouri	52%	100%
A4HI97	Leishmania braziliensis	72%	100%
A4I5I1	Leishmania infantum	100%	100%
E9B0S6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q7F2	Leishmania major	89%	100%

Previous1Next