Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7X3F3_LEIDO

TriTrypDb:

LdBPK_301980.1 , LdCL_300025100 , LDHU3_30.2710

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7X3F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7X3F3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.643
CLV_C14_Caspase3-7	278	282	PF00656	0.530
CLV_C14_Caspase3-7	75	79	PF00656	0.578
CLV_NRD_NRD_1	15	17	PF00675	0.716
CLV_NRD_NRD_1	18	20	PF00675	0.713
CLV_PCSK_FUR_1	16	20	PF00082	0.597
CLV_PCSK_KEX2_1	15	17	PF00082	0.716
CLV_PCSK_KEX2_1	18	20	PF00082	0.713
CLV_PCSK_SKI1_1	18	22	PF00082	0.583
CLV_PCSK_SKI1_1	192	196	PF00082	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DEG_SPOP_SBC_1	286	290	PF00917	0.518
DOC_MAPK_gen_1	3	13	PF00069	0.587
DOC_MAPK_MEF2A_6	192	200	PF00069	0.542
DOC_PP1_RVXF_1	63	69	PF00149	0.563
DOC_PP2B_PxIxI_1	195	201	PF00149	0.447
DOC_PP4_FxxP_1	108	111	PF00568	0.561
DOC_PP4_FxxP_1	283	286	PF00568	0.476
DOC_USP7_MATH_1	138	142	PF00917	0.521
DOC_USP7_MATH_1	218	222	PF00917	0.664
DOC_USP7_MATH_1	275	279	PF00917	0.538
DOC_USP7_MATH_1	310	314	PF00917	0.697
DOC_WW_Pin1_4	192	197	PF00397	0.477
DOC_WW_Pin1_4	78	83	PF00397	0.572
LIG_14-3-3_CanoR_1	146	151	PF00244	0.687
LIG_14-3-3_CanoR_1	235	242	PF00244	0.532
LIG_14-3-3_CanoR_1	298	302	PF00244	0.546
LIG_14-3-3_CanoR_1	6	13	PF00244	0.601
LIG_Actin_WH2_2	179	194	PF00022	0.418
LIG_BRCT_BRCA1_1	289	293	PF00533	0.488
LIG_CSL_BTD_1	283	286	PF09270	0.378
LIG_deltaCOP1_diTrp_1	281	287	PF00928	0.539
LIG_deltaCOP1_diTrp_1	315	319	PF00928	0.514
LIG_FHA_1	167	173	PF00498	0.511
LIG_FHA_1	193	199	PF00498	0.472
LIG_FHA_1	318	324	PF00498	0.580
LIG_FHA_1	6	12	PF00498	0.597
LIG_FHA_2	210	216	PF00498	0.663
LIG_FHA_2	82	88	PF00498	0.693
LIG_Integrin_RGD_1	225	227	PF01839	0.638
LIG_LIR_Apic_2	281	286	PF02991	0.493
LIG_LIR_Gen_1	128	139	PF02991	0.457
LIG_LIR_Gen_1	262	271	PF02991	0.422
LIG_LIR_Nem_3	128	134	PF02991	0.458
LIG_LIR_Nem_3	262	268	PF02991	0.422
LIG_LIR_Nem_3	281	287	PF02991	0.431
LIG_NRBOX	129	135	PF00104	0.460
LIG_Pex14_2	283	287	PF04695	0.476
LIG_PTB_Apo_2	118	125	PF02174	0.501
LIG_SH2_NCK_1	279	283	PF00017	0.514
LIG_SH2_SRC	241	244	PF00017	0.541
LIG_SH2_STAT3	171	174	PF00017	0.422
LIG_SH2_STAT5	171	174	PF00017	0.484
LIG_SH2_STAT5	241	244	PF00017	0.568
LIG_SH2_STAT5	324	327	PF00017	0.531
LIG_SH3_3	108	114	PF00018	0.534
LIG_SH3_3	92	98	PF00018	0.659
LIG_SH3_3	99	105	PF00018	0.655
MOD_CDK_SPxxK_3	78	85	PF00069	0.579
MOD_CK1_1	148	154	PF00069	0.640
MOD_CK1_1	160	166	PF00069	0.611
MOD_CK1_1	270	276	PF00069	0.444
MOD_CK1_1	36	42	PF00069	0.568
MOD_CK1_1	58	64	PF00069	0.624
MOD_CK1_1	81	87	PF00069	0.696
MOD_CK2_1	146	152	PF00069	0.629
MOD_CK2_1	218	224	PF00069	0.663
MOD_CK2_1	69	75	PF00069	0.550
MOD_CK2_1	81	87	PF00069	0.689
MOD_DYRK1A_RPxSP_1	192	196	PF00069	0.519
MOD_GSK3_1	182	189	PF00069	0.468
MOD_GSK3_1	204	211	PF00069	0.616
MOD_GSK3_1	266	273	PF00069	0.440
MOD_GSK3_1	285	292	PF00069	0.409
MOD_GSK3_1	297	304	PF00069	0.469
MOD_N-GLC_1	120	125	PF02516	0.547
MOD_N-GLC_1	61	66	PF02516	0.532
MOD_NEK2_1	11	16	PF00069	0.599
MOD_NEK2_1	120	125	PF00069	0.548
MOD_NEK2_1	177	182	PF00069	0.507
MOD_NEK2_1	287	292	PF00069	0.530
MOD_NEK2_1	43	48	PF00069	0.540
MOD_PKA_2	145	151	PF00069	0.540
MOD_PKA_2	297	303	PF00069	0.631
MOD_PKA_2	317	323	PF00069	0.549
MOD_PKA_2	5	11	PF00069	0.619
MOD_Plk_1	120	126	PF00069	0.506
MOD_Plk_1	166	172	PF00069	0.643
MOD_Plk_1	186	192	PF00069	0.510
MOD_Plk_1	218	224	PF00069	0.647
MOD_Plk_1	266	272	PF00069	0.501
MOD_Plk_1	36	42	PF00069	0.634
MOD_Plk_4	114	120	PF00069	0.624
MOD_Plk_4	186	192	PF00069	0.448
MOD_Plk_4	38	44	PF00069	0.671
MOD_ProDKin_1	192	198	PF00069	0.470
MOD_ProDKin_1	78	84	PF00069	0.576
TRG_DiLeu_BaEn_1	26	31	PF01217	0.513
TRG_DiLeu_BaEn_2	126	132	PF01217	0.524
TRG_ER_diArg_1	15	18	PF00400	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P910	Leptomonas seymouri	36%	94%
A4I5M5	Leishmania infantum	99%	100%
E9B0X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q796	Leishmania major	87%	100%